BMC Neuroscience最新文献

{"title":"Precise Aβ clearance and antioxidant therapy in Alzheimer's disease via photoacoustic imaging-guided palladium hydride nanosheet-mediated photothermal treatment.","authors":"Lujie Yu, Mingxin Zhao, Wenjing Zhang, Zhigan Lv, Keqi Zhao, Huailiang Li, Yunjie Qi, Xin Peng, Ziliang Zheng, Weiwei Zhang","doi":"10.1186/s12868-025-00994-0","DOIUrl":"10.1186/s12868-025-00994-0","url":null,"abstract":"","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":" ","pages":"8"},"PeriodicalIF":2.3,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12874838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulating subjective and objective cognitive state fatigue in long COVID with repetitive anodal tDCS: results from a double-blinded randomized controlled trial.","authors":"Magdalena Mischke, Tino Zaehle","doi":"10.1186/s12868-025-00989-x","DOIUrl":"10.1186/s12868-025-00989-x","url":null,"abstract":"<p><strong>Background: </strong>Cognitive fatigue is a frequently reported and debilitating symptom of long COVID, yet effective therapeutic interventions remain limited. Anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (dlPFC) has been proposed as a promising approach to modulate fatigue-related neural networks. To comprehensively assess cognitive fatigue, the integration of subjective and objective behavioral and electrophysiological measures of induced state fatigue is essential.</p><p><strong>Methods: </strong>This double-blind, randomized, sham-controlled study investigated the effects of four consecutive daily sessions of 30-minute anodal tDCS over the left dlPFC on subjective and objective markers of cognitive state fatigue in individuals with long COVID. The present paper focuses on secondary outcomes, including subjective state fatigue ratings via visual analogue scales, behavioral performance indices, and electrophysiological markers such as temporal alterations of frontal theta and occipital alpha activity as well as p50 sensory gating.</p><p><strong>Results: </strong>Forty participants received either verum or sham tDCS while completing a gamified adaptive Go/No-Go task. Before and after the stimulation period, cognitive state fatigue was reliably induced using the AX-Continuous Performance Task (AX-CPT). Although tDCS did not significantly affect subjective state-fatigue ratings or behavioral performance, our findings indicate that verum stimulation may stabilize fatigue-related changes in occipital alpha power. No immediate stimulation-related improvements were found in the Go/No-Go task.</p><p><strong>Conclusions: </strong>These findings indicate that while tDCS may modulate neurophysiological correlates of cognitive state fatigue, its impact on subjective experience and behavioral performance remain limited under the current protocol. These results, however, underscore the importance of including neurophysiological endpoints in intervention research and highlight the need for developing more robust and individualized stimulation protocols. Future studies should consider extended stimulation regimens, alternative task paradigms, and more sensitive behavioral measures to further elucidate the neuromodulatory potential of tDCS in long COVID-related cognitive fatigue.</p><p><strong>Trial registration: </strong>drks.de Identifier: DRKS00031294, date of registration: 17.02.2023.</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":" ","pages":"6"},"PeriodicalIF":2.3,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12849268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146043881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Diabetes mellitus and risk of incident dementia in APOE ɛ4 carriers: an updated meta-analysis.","authors":"Ava Rashtchian, Mohammad Hossein Etemadi, Elham Asadi, Sara Binaei, Mina Abbasi, Maedeh Bayani, Erfan Izadi, Sayedeh-Fatemeh Sadat-Madani, Mahdyieh Naziri, Sahar Khoshravesh, Mahsa Shirani, Mahsa Asadi Anar, Niloofar Deravi","doi":"10.1186/s12868-026-00995-7","DOIUrl":"10.1186/s12868-026-00995-7","url":null,"abstract":"","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"27 1","pages":"1"},"PeriodicalIF":2.3,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12797609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial expression of concern: Neuroprotective effects of bis(7)-tacrine against glutamate-induced retinal ganglion cells damage.","authors":"Jia Hua Fang, Xing Hua Wang, Zhi Rong Xu, Fa Gang Jiang","doi":"10.1186/s12868-025-00990-4","DOIUrl":"10.1186/s12868-025-00990-4","url":null,"abstract":"","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"27 1","pages":"2"},"PeriodicalIF":2.3,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12797980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring extracellular vesicle surface markers and microRNA regulation following remote ischemic conditioning in patients with stroke; a randomized-controlled pilot study.","authors":"Rebecca Best Jensen, Maria Kjølhede, Jesper Just, Lee-Ann Clegg, Rikke Baek, Erik Kaadt, Betina Elfving, David C Hess, Grethe Andersen, Malene Møller Jørgensen, Rolf Ankerlund Blauenfeldt, Kim Ryun Drasbek","doi":"10.1186/s12868-025-00993-1","DOIUrl":"10.1186/s12868-025-00993-1","url":null,"abstract":"","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":" ","pages":"10"},"PeriodicalIF":2.3,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12888686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145958599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative and histopathological changes in the hippocampus and prefrontal cortex following light-at-night and methamphetamine exposure.","authors":"Smart Ikechukwu Mbagwu, Usende Ifukibot Levi, Ndubuisi Paris Obi, Francis Elochukwu Chinwuba, Clinton Onyekachi Anokwa, Usende Ephraim Utopejit","doi":"10.1186/s12868-025-00992-2","DOIUrl":"10.1186/s12868-025-00992-2","url":null,"abstract":"","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":" ","pages":"9"},"PeriodicalIF":2.3,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12882393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145931987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the neuroprotective effects of alpha lipoic acid-loaded folate-conjugated chitosan nanoparticles against 6-OHDA-induced apoptosis and oxidative stress in an in vitro Parkinson's disease model.","authors":"Elaheh Gheybi, Mohammad Jalili-Nik, Pejman Hosseinzadeh, Seyedeh Mozhdeh Mirzaei, Abbas AlAlikhan, Mohammad Soukhtanloo","doi":"10.1186/s12868-025-00991-3","DOIUrl":"10.1186/s12868-025-00991-3","url":null,"abstract":"","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":" ","pages":"7"},"PeriodicalIF":2.3,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12870293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145905490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural substrates associated with the acquisition of fine finger force control.","authors":"Aoki Takahashi, Riku Ishizaka, Kodai Minami, Yuki Tanaka, Taisei Miyazaki, Kenta Oguma, Nodoka Shimizume, Tatsunori Watanabe","doi":"10.1186/s12868-025-00986-0","DOIUrl":"10.1186/s12868-025-00986-0","url":null,"abstract":"<p><strong>Background: </strong>Precise finger force control is essential for performing everyday tasks such as writing, buttoning, and eating. While the neurophysiological basis of cognitive skill learning has been extensively studied, much less is known about the neural mechanisms supporting the acquisition of fine motor skills involving finger force control. This study aimed to investigate changes in cortical oscillatory activity and event-related potentials (ERPs) associated with the acquisition of fine finger force control.</p><p><strong>Results: </strong>Eighteen right-handed healthy young adults practiced a visual target-matching task using a left-hand pinch grip. Force control performance and electroencephalogram (EEG) recordings were assessed before and after training. Behavioral analyses revealed significant improvements in time to target, velocity to target, mean force error, and force variability, with no changes in reaction time. EEG analysis showed enhanced alpha- and beta-band event-related desynchronization after learning. ERP analysis further revealed a significant reduction in N2 amplitude and a significant increase in P3 amplitude following learning.</p><p><strong>Conclusions: </strong>These results suggest that learning fine finger force control is accompanied by enhanced visuomotor processing, more efficient stimulus discrimination, and greater attentional allocation. This study provides novel insights into the neurophysiological underpinnings of fine motor skill acquisition.</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":" ","pages":"5"},"PeriodicalIF":2.3,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12821804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145751666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific cypermethrin-induced hippocampal neurotoxicity is associated with alterations in signaling molecules for antioxidant defense, membrane integrity, apoptosis, and GABAergic integrity.","authors":"Aminu Imam, Maryam Busari, Christianah Oyegbola, Balogun Faith Moyinoluwa, Owoeye Faith, Ajayi P G Samuel, Ibrahim Bolaji Ibrahim, Ghazal T Atiyatul-Hanan, Ajibola M Iyiola, Omamuyovwi M Ijomone, Moyosore S Ajao","doi":"10.1186/s12868-025-00988-y","DOIUrl":"10.1186/s12868-025-00988-y","url":null,"abstract":"","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":" ","pages":"4"},"PeriodicalIF":2.3,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12817701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145740831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guanidino compounds with native GABA(A) δ receptor selectivity: a tale of homeostatic compensation in δ-KO mice.","authors":"Pratap Meera, Mikko Uusi-Oukari, Martin Wallner, Gerald S Lipshutz","doi":"10.1186/s12868-025-00987-z","DOIUrl":"10.1186/s12868-025-00987-z","url":null,"abstract":"","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":" ","pages":"3"},"PeriodicalIF":2.3,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12801676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145720916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}