BMC Neuroscience最新文献

{"title":"Memantine mitigates methamphetamine-induced impairments in social and recognition memories in rats.","authors":"Mehdi Khodamoradi, Yasaman Allameh, Melika Sarani, Shahab A Zarei, Sara Faaliat, Hamed Ghazvini","doi":"10.1186/s12868-025-00955-7","DOIUrl":"10.1186/s12868-025-00955-7","url":null,"abstract":"<p><strong>Background: </strong>Methamphetamine (METH) is a widely abused neurotoxic substance that can lead to neurocognitive disabilities. Recent studies have shown that memantine (MEM), an NMDA receptor antagonist, can improve cognitive function across various disorders. Given that previous studies have revealed that exposure to METH leads to several social and cognitive impairments, this research aimed to investigate the effects of MEM on social memory, social behavior, and novel object recognition impairments caused by chronic METH exposure. Adult male Wistar rats received a regimen of METH, which causes neurotoxicity (four injections of 6 mg/kg, s.c., at 2-h intervals). After one week, the effects of MEM (5 mg/kg, i.p.) on novel object recognition memory and social behaviors in the experimental groups were examined.</p><p><strong>Results: </strong>Animals exposed to the METH regimen exhibited significant impairments in the acquisition, consolidation, and retrieval stages of novel object recognition memory. However, treatment with MEM ameliorated the detrimental effects of METH on the acquisition, consolidation, and retrieval, but not the reconsolidation, of novel object recognition memory. Additionally, the results revealed that METH-triggered deficits in social interaction and behavior were improved by MEM treatment.</p><p><strong>Conclusions: </strong>In conclusion, this study demonstrated that MEM administration effectively ameliorated memory impairments induced by chronic METH exposure. These findings provide valuable insights into the neuroprotective effects of MEM on novel object memory, social memory, and social behaviors.</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"26 1","pages":"36"},"PeriodicalIF":2.4,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pro-cognitive efficacy of Prospekta in a rat model of age-associated cognitive impairment.","authors":"Elena Kardash, Nataliya Petrova, Ksenia Ganina, Sergey Tarasov, Oleg Epstein","doi":"10.1186/s12868-025-00958-4","DOIUrl":"10.1186/s12868-025-00958-4","url":null,"abstract":"<p><strong>Background: </strong>Ageing is associated with lower levels of cognitive performance, and novel therapeutics are warranted to correct this defect. Aged rats represent a favourable model of human ageing. The aim of the present study is to examine the effect of a novel neurotropic S100B-targeted drug, Prospekta, on the parameters of delayed alternation in the aged rats compared to responses in the young animals.</p><p><strong>Methods: </strong>A spatial working memory task in an operant chamber, where aged and young animals (21 and 2 months old, respectively) needed to alternate between two retractable levers on a trial-by-trial basis to receive a food reward, was tested. We also assessed the Prospekta's effect on expression of some biomarkers of ageing by measuring their levels in the brains of aged rats using Western blot.</p><p><strong>Results: </strong>Treatment with Prospekta ameliorated cognitive functions, which resulted in a significant reduction of simple and choice reaction times for aged rats. The drug also decreased the number of omission errors at the beginning of the acquisition phase, which indicated the influence of treatment on attention and decision-making process. At the same time, Prospekta did not affect the majority of parameters measured in young animals. The analysis of ageing biomarker expression did not reveal any significant differences between aged rats treated with Prospekta or placebo.</p><p><strong>Conclusions: </strong>The findings of this study underscore the potential of Prospekta as a promising pro-cognitive agent for the treatment of age-related cognitive decline. However, further research is imperative to elucidate the precise mechanisms underlying its therapeutic effects and validate its efficacy in vivo.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"26 1","pages":"35"},"PeriodicalIF":2.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophils differentially affect early and delayed neurological deterioration after mechanical thrombectomy in stroke.","authors":"Shuhong Yu, Jinping Yang, Xiaoting Han, Jijun Shi, Guodong Xiao, Zhiliang Guo","doi":"10.1186/s12868-025-00954-8","DOIUrl":"10.1186/s12868-025-00954-8","url":null,"abstract":"<p><strong>Background: </strong>To investigate the effect of eosinophils on early (END) and delayed neurological deterioration (DND) after mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS).</p><p><strong>Methods: </strong>A total of 442 consecutive AIS patients experiencing MT between May 2017 and January 2023 were analyzed. END and DND were defined as a rise of ≥ 2 points on the National Institutes of Health Stroke Scale (NIHSS) or a fall of ≥ 1 point on the Glasgow Coma Scale or death from baseline to 24 h and from 24 to 72 h, respectively. Multivariate regression analysis, generalize additive models and mediation analysis were used to assess the effect of eosinophils on END and DND and the underlying mechanisms.</p><p><strong>Results: </strong>113 (25.17%) and 47 (10.63%) patients had END and DND, respectively. Eosinophils was independently associated with END after adjusting potential confounders (odds ratio, 0.00; 95% CI, 0.00-0.80; P = 0.0441), which is consistent with the result of eosinophils (dichotomous) as a categorical variable (odds ratio, 0.40; 95% CI, 0.24-0.68; P = 0.0006). In assessing the relationship between eosinophils and DND, the inflection point was found to be 0.02, and eosinophils were independently correlated with DND at less than 0.02 (odds ratio, 0.00, 95% CI: 0.00-0.00, P = 0.0038); however, eosinophils ceased to be independently correlated with DND after exceeding 0.02 (P = 0.3519). Mediation analyses confirmed that eosinophils contribute to END in patients through symptomatic intracranial hemorrhage (indirect effect: -0.463; 95%CI: -0.902-0.19; P < 0.001).</p><p><strong>Conclusions: </strong>The effects of eosinophils on END and DND are not identical.</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"26 1","pages":"34"},"PeriodicalIF":2.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Association between apolipoprotein E Ε4 status and the risk of Alzheimer's disease: a meta-analysis.","authors":"Zijun Ren, Zhenting Guan, Qingliang Guan, Hongjian Guan, Huiying Che","doi":"10.1186/s12868-025-00952-w","DOIUrl":"10.1186/s12868-025-00952-w","url":null,"abstract":"","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"26 1","pages":"32"},"PeriodicalIF":2.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The short-term spinal cord stimulation improves the rates of tracheal decannulation in patients of brain injury with disorders of consciousness.","authors":"Guanlin Huang, Dong Wang, Qiang Chen, Qi Zhong, Weilong Huang, Xiaoping Zhou, Qiuhua Jiang","doi":"10.1186/s12868-025-00951-x","DOIUrl":"10.1186/s12868-025-00951-x","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of short-term spinal cord stimulation (stSCS) in promoting tracheal decannulation among patients with brain injury-induced disorders of consciousness(DoC).</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on 81 tracheotomized brain injury patients with DoC treated at Ganzhou People's Hospital between June 2021 and June 2022.Patients were divided into two groups: the stSCS group (n = 46) receiving stSCS intervention and the control group (n = 35) receiving standard care. Decannulation success rates were compared using chi-square tests.</p><p><strong>Results: </strong>The stSCS group demonstrated a significantly higher decannulation rate compared to the control group (50.0%vs.25.7%, χ²=5.24, p = 0.022).</p><p><strong>Conclusion: </strong>stSCS significantly enhances tracheal decannulation success in brain injury patients with DoC, suggesting its potential as a therapeutic neuromodulation strategy.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"26 1","pages":"33"},"PeriodicalIF":2.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of the contralesional primary motor cortex in upper limb recovery after stroke: a scoping review following PRISMA-ScR guidelines.","authors":"Peerapat Suputtitada, Valton Costa, Felipe Fregni","doi":"10.1186/s12868-025-00950-y","DOIUrl":"10.1186/s12868-025-00950-y","url":null,"abstract":"<p><strong>Background: </strong>Stroke often results in motor impairments, with recovery involving complex interactions between the lesioned (ipsilesional) and non-lesioned (contralesional) hemispheres. This scoping review investigates the role of the contralesional primary motor cortex (M1) in motor recovery of the paretic upper limb following stroke, examining its structural and functional changes and compensatory roles.</p><p><strong>Methods: </strong>A systematic search for scoping review was conducted in PubMed, Embase, Web of Science, and Google Scholar following PRISMA-ScR guidelines. Studies examining contralesional M1 contributions to upper limb recovery in humans and animal models were included. Data were extracted, synthesized qualitatively, and assessed for risk of bias using SYRCLE and Cochrane tools.</p><p><strong>Results: </strong>A total of 38 studies were included in the analysis, consisting of 34 focused on stroke patients and 4 utilizing animal models. The findings revealed the dual and task-specific role of the contralesional primary motor cortex (M1) in upper limb recovery after stroke. In patients with severe motor impairments, contralesional M1 supported recovery through compensatory mechanisms, such as increased neuronal recruitment and functional reorganization. However, in cases with mild impairments, its activation was associated with inhibitory effects on ipsilesional reorganization, potentially delaying optimal recovery. Animal studies provided evidence of structural and functional plasticity, including dendritic remodeling and enhanced neuronal connectivity, which paralleled improvements in motor function. In human studies, contralesional M1 activation was task-dependent, with pronounced engagement during demanding tasks and unimanual movements. Ipsilateral motor deficits, including reduced dexterity, strength, and coordination, were commonly reported and underscored the disrupted interhemispheric dynamics influencing recovery. Neuromodulation techniques showed promise in modulating interhemispheric interactions and enhancing motor outcomes. These results emphasize the complex interplay between compensatory and inhibitory processes mediated by contralesional M1 in stroke recovery.</p><p><strong>Conclusion: </strong>The contralesional M1 plays a complex, task-specific role in upper limb recovery after stroke, acting as both a compensatory resource and a potential inhibitory factor. Future research should stratify patients by impairment severity to refine therapeutic approaches.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"26 1","pages":"31"},"PeriodicalIF":2.4,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body weight-supported treadmill training reduces glial scar overgrowth in SCI rats by decreasing the reactivity of astrocytes during the subacute phase.","authors":"Jili Cai, Yu Wang, Chenyuan Zhai, Kunmao Jiang, Zun Wang, Lu Fang, Xiangzhe Li, Chenchen Zhu, Wentao Liu, Tong Wang, Qi Wu","doi":"10.1186/s12868-025-00947-7","DOIUrl":"https://doi.org/10.1186/s12868-025-00947-7","url":null,"abstract":"<p><strong>Background: </strong>Spinal cord injury is followed by glial scar formation, which was long seen mainly as a physical barrier preventing axonal regeneration. Glial scar astrocytes lead to glial scar formation and produce inhibitory factors to prevent axons from growing through the scar, while inhibiting the conversion of reactive astrocytes into glial scar-forming astrocytes may represent an ideal treatment for CNS injury. Exercise is a non-invasive and effective therapeutic intervention for clinical rehabilitation of spinal cord injury. However, its precise therapeutic mechanisms still need to be continuously explored.</p><p><strong>Methods: </strong>30 rats were randomly assigned to three groups (Sham, SCI, SCI + BWSTT; n = 10 rats per group). In this study, we employed the BBB scales and gait analysis system to examine the behavioral functions of the rats in each group. Furthermore, we utilized immunoblotting of spinal cord tissue at the injury site, in addition to histological staining and immunofluorescence staining, to explore glial scar aggregation and axonal regeneration in each group of rats.</p><p><strong>Results: </strong>Our results revealed that hindlimb motor function was significantly improved in SCI rats after a sustained subacute period of BWSTT, accompanied by the promotion of histological repair and nerve regeneration. Subsequent immunofluorescence staining and immunoblotting showed diminished astrocyte reactivity in the region surrounding the spinal cord injury as well as reduced expression and distribution of collagen fibers near the lesion after BWSTT. Additionally, a significant decrease in the expression of MMP-2/9, which is closely related to astrocyte migration, was observed in the vicinity of spinal cord tissue lesions.</p><p><strong>Conclusion: </strong>Our study demonstrates that a sustained BWSTT intervention during the subacute phase of spinal cord injury can effectively reduce astrocyte reactivity and glial scarring overgrowth, thereby facilitating functional recovery after SCI.</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"26 1","pages":"30"},"PeriodicalIF":2.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHIRP-Seq: FOXP2 transcriptional targets in zebra finch brain include numerous speech and language-related genes.","authors":"Gregory L Gedman, Todd H Kimball, Lee L Atkinson, Daniella Factor, Gabriela Vojtova, Madza Farias-Virgens, Timothy F Wright, Stephanie A White","doi":"10.1186/s12868-025-00948-6","DOIUrl":"https://doi.org/10.1186/s12868-025-00948-6","url":null,"abstract":"<p><strong>Background: </strong>Vocal learning is a rare, convergent trait that is fundamental to both human speech and birdsong. The Forkhead Box P2 (FOXP2) transcription factor appears necessary for both types of learned signals, as human mutations in FOXP2 result in speech deficits, and disrupting its expression in zebra finches impairs male-specific song learning. In juvenile and adult male finches, striatal FOXP2 mRNA and protein decline acutely within song-dedicated neurons during singing, indicating that its transcriptional targets are also behaviorally regulated. The identities of these targets in songbirds, and whether they differ across sex, development and/or behavioral conditions, are largely unknown.</p><p><strong>Results: </strong>Here we used chromatin immunoprecipitation followed by sequencing (ChIP-Seq) to identify genomic sites bound by FOXP2 in male and female, juvenile and adult, and singing and non-singing birds. Our results suggest robust FOXP2 binding concentrated in putative promoter regions of genes. The number of genes likely to be bound by FOXP2 varied across conditions, suggesting specialized roles of the candidate targets related to sex, age, and behavioral state. We interrogated these binding targets both bioinformatically, with comparisons to previous studies, and biochemically, with immunohistochemistry using an antibody for a putative target gene. Gene ontology analyses revealed enrichment for human speech- and language-related functions in males only, consistent with the sexual dimorphism of song learning in this species. Fewer such targets were found in juveniles relative to adults, suggesting an expansion of this regulatory network with maturation. The fewest speech-related targets were found in the singing condition, consistent with the well-documented singing-driven down-regulation of FOXP2 in the songbird striatum.</p><p><strong>Conclusions: </strong>Overall, these data provide an initial catalog of the regulatory landscape of FOXP2 in an avian vocal learner, offering dozens of target genes for future study and providing insight into the molecular underpinnings of vocal learning.</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"26 1","pages":"29"},"PeriodicalIF":2.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: MK801 attenuates secondary injury in a mouse experimental compression model of spinal cord trauma.","authors":"Emanuela Esposito, Irene Paterniti, Emanuela Mazzon, Tiziana Genovese, Maria Galuppo, Rosaria Meli, Placido Bramanti, Salvatore Cuzzocrea","doi":"10.1186/s12868-025-00949-5","DOIUrl":"https://doi.org/10.1186/s12868-025-00949-5","url":null,"abstract":"","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"26 1","pages":"28"},"PeriodicalIF":2.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampal functional imaging-derived radiomics features for diagnosing cognitively impaired patients with Parkinson's disease.","authors":"Wei Zeng, Xiao Liang, Jiali Guo, Weiling Cheng, Zhibiao Yin, Daojun Hong, Fangjun Li, Fuqing Zhou, Xin Fang","doi":"10.1186/s12868-025-00938-8","DOIUrl":"10.1186/s12868-025-00938-8","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this retrospective study was to investigate whether radiomics features derived from hippocampal functional imaging can effectively differentiate cognitively impaired patients from cognitively preserved patients with Parkinson's disease (PD).</p><p><strong>Methods: </strong>The study included a total of 89 clinically definite PD patients, comprising 55 who werecognitively impaired and 34 who were cognitively preserved. All participants underwent functional magnetic resonance imaging and clinical assessments. Preprocessed functional data were utilized to derive the amplitude of the low-frequency fluctuations (ALFF), regional homogeneity (ReHo), voxel-mirrored homotopic connectivity (VMHC), and degree centrality (DC). A standardized set of radiomics features was subsequently extracted from the bilateral hippocampi, resulting in a total of 819 features. Following feature selection, the radiomics score (rad-score) and logistic regression (LR) models were trained. Additionally, the Shapley additive explanations (SHAP) algorithm was employed to elucidate and interpret the predictions made by the LR models. Finally, the relationships between the radiomics features derived from hippocampal functional imaging and the scores of the clinical measures were explored to assess their clinical significance.</p><p><strong>Results: </strong>The rad-score and LR algorithm models constructed using a combination of wavelet features extracted from ReHo and VMHC data exhibited superior classification efficiency. These models demonstrated exceptional accuracy, sensitivity, and specificity in distinguishing cognitively impaired PD patients (CI-PD) from cognitively preserved PD (CP-PD) patients, with values of 0.889, 0.900, and 0.882, respectively. Furthermore, SHAP values indicated that wavelet features derived from ReHo and VMHC were critical for classifying CI-PD patients. Importantly, our findings revealed significant associations between radiomics wavelet features and scores on the Hamilton Anxiety Scale, Non-Motor Symptom Scale, and Montreal Cognitive Assessment in CI-PD patients (P < 0.05, with Bonferroni correction).</p><p><strong>Conclusions: </strong>Our novel rad-score model and LR model, which utilize radiomics features derived from hippocampal functional imaging, have demonstrated their value in diagnosing CI-PDpatients. These models can enhance the accuracy and efficiency of functional MRI diagnosis, suggesting potential clinical applications.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"26 1","pages":"27"},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}