{"title":"静止和运动模式的重复性机械触觉刺激干预对成对脉冲抑制的影响。","authors":"Hiraku Watanabe, Sho Kojima, Naofumi Otsuru, Hideaki Onishi","doi":"10.1186/s12868-025-00960-w","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Repetitive somatosensory stimulation (RSS) reduces paired-pulse depression (PPD), reflecting GABAergic inhibition in the primary somatosensory cortex (S1). This effect may vary by tactile stimulation pattern. Therefore, this study aimed to clarify the effects of RSS intervention with stationary and moving pattern tactile stimulation on PPD.</p><p><strong>Results: </strong>In a crossover study of 15 healthy males, RSS with a stationary pattern showed a non-significant trend toward increased PPD (corrected p = 0.088), while the moving pattern showed no effect. A strong negative correlation was found between baseline PPD and its change rate (r = - 0.837, p < 0.001), indicating that greater baseline S1 inhibition predicted a larger reduction after RSS.</p><p><strong>Conclusion: </strong>RSS effects on GABAergic inhibition in S1 depend on the tactile stimulation pattern, emphasizing the importance of tactile stimulus design in modulating somatosensory cortex activity.</p>","PeriodicalId":9031,"journal":{"name":"BMC Neuroscience","volume":"26 1","pages":"46"},"PeriodicalIF":2.3000,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12297507/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effects of repetitive mechanical tactile stimulation interventions with stationary and moving patterns on paired-pulse depression.\",\"authors\":\"Hiraku Watanabe, Sho Kojima, Naofumi Otsuru, Hideaki Onishi\",\"doi\":\"10.1186/s12868-025-00960-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Repetitive somatosensory stimulation (RSS) reduces paired-pulse depression (PPD), reflecting GABAergic inhibition in the primary somatosensory cortex (S1). This effect may vary by tactile stimulation pattern. Therefore, this study aimed to clarify the effects of RSS intervention with stationary and moving pattern tactile stimulation on PPD.</p><p><strong>Results: </strong>In a crossover study of 15 healthy males, RSS with a stationary pattern showed a non-significant trend toward increased PPD (corrected p = 0.088), while the moving pattern showed no effect. A strong negative correlation was found between baseline PPD and its change rate (r = - 0.837, p < 0.001), indicating that greater baseline S1 inhibition predicted a larger reduction after RSS.</p><p><strong>Conclusion: </strong>RSS effects on GABAergic inhibition in S1 depend on the tactile stimulation pattern, emphasizing the importance of tactile stimulus design in modulating somatosensory cortex activity.</p>\",\"PeriodicalId\":9031,\"journal\":{\"name\":\"BMC Neuroscience\",\"volume\":\"26 1\",\"pages\":\"46\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-07-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12297507/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12868-025-00960-w\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12868-025-00960-w","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Effects of repetitive mechanical tactile stimulation interventions with stationary and moving patterns on paired-pulse depression.
Background: Repetitive somatosensory stimulation (RSS) reduces paired-pulse depression (PPD), reflecting GABAergic inhibition in the primary somatosensory cortex (S1). This effect may vary by tactile stimulation pattern. Therefore, this study aimed to clarify the effects of RSS intervention with stationary and moving pattern tactile stimulation on PPD.
Results: In a crossover study of 15 healthy males, RSS with a stationary pattern showed a non-significant trend toward increased PPD (corrected p = 0.088), while the moving pattern showed no effect. A strong negative correlation was found between baseline PPD and its change rate (r = - 0.837, p < 0.001), indicating that greater baseline S1 inhibition predicted a larger reduction after RSS.
Conclusion: RSS effects on GABAergic inhibition in S1 depend on the tactile stimulation pattern, emphasizing the importance of tactile stimulus design in modulating somatosensory cortex activity.
期刊介绍：
BMC Neuroscience is an open access, peer-reviewed journal that considers articles on all aspects of neuroscience, welcoming studies that provide insight into the molecular, cellular, developmental, genetic and genomic, systems, network, cognitive and behavioral aspects of nervous system function in both health and disease. Both experimental and theoretical studies are within scope, as are studies that describe methodological approaches to monitoring or manipulating nervous system function.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
