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IF 2.4 4区医学 Q3 NEUROSCIENCES

BMC Neuroscience Pub Date : 2025-03-06 DOI:10.1186/s12868-025-00936-w

Masoud Eslami, Alireza Raji-Amirhasani, Mohammad Khaksari, Zakieh Keshavarzi, Farzaneh Rostamzadeh, Nazanin Sabet, Elham Jafari, Zahra Soltani, Saeed Karamouzian

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引用次数: 0

摘要

背景和目的：粘液间充质干细胞可迁移至受损部位，其应用被认为是治疗疾病的一种新方法。本研究旨在探讨口腔间充质干细胞（OMSCs）对创伤性脑损伤（TBI）后胃、肠和结肠组织的炎症、氧化应激和组织病理学指标的影响：成年雄性大鼠随机分为四组：方法：将成年雄性大鼠随机分为四组：假体组、创伤性脑损伤组、药物组（Veh）和干细胞组（SC）。损伤后 1 小时和 24 小时分别静脉注射 OMSCs。损伤 48 小时后评估胃、小肠和结肠组织的炎症、氧化应激和组织病理学指标：结果：创伤性胃炎后，胃、小肠和结肠组织中的 IL-1β 和 IL-6 水平升高，IL-10 水平降低，但服用 OMSCS 在很大程度上阻止了这些变化。氧化应激指数（MDA、PC、TAC、SOD 和 CAT）显示创伤后氧化应激增加，但 OMSC 组的氧化应激程度较轻。在创伤性脑损伤后服用 OMSCs 可改善胃、小肠和结肠组织的病理结果：结论：给创伤性脑损伤大鼠注射 OMSCs 可改善胃、小肠和结肠组织的炎症、氧化应激和组织病理学指标，这表明 OMSCs 在创伤性脑损伤中的有益作用。

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The changes of digestive system inflammatory, oxidative stress, and histopathology factors following oral mesenchymal stem cells administration in rats with traumatic brain injury.

Background and aims: Mucous mesenchymal stem cells can migrate to damaged areas, and their use is proposed as a new approach to treating diseases. The present study aimed to investigate the effect of oral mesenchymal stem cells (OMSCs) on inflammatory, oxidative stress, and histopathological indices in the tissues of the stomach, intestine, and colon after traumatic brain injury (TBI).

Methods and materials: Adult male rats were randomly divided into four groups: Sham, TBI, Vehicle (Veh), and Stem cell (SC). Intravenous injection of OMSCs was performed at 1 and 24 h after injury. The inflammatory, oxidative stress, and histopathological indices of the tissues of the stomach, small intestine, and colon were evaluated 48 h after injury.

Results: After TBI, IL-1β and IL-6 levels increased and IL-10 levels decreased in the tissues of the stomach, small intestine, and colon, but the administration of OMSCS prevented these changes to a large extent. Oxidative stress indices (MDA, PC, TAC, SOD, and CAT) showed an increase in oxidative stress after TBI, but oxidative stress was less severe in the OMSC group. The administration of OMSCs after TBI improved the histopathological outcome in the tissues of the stomach, small intestine, and colon.

Conclusion: Administration of OMSCs in rats suffering from TBI can improve inflammatory, oxidative stress, and histopathological indices in the tissues of the stomach, small intestine, and colon, which shows the beneficial effect of using OMSCs in TBI.

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来源期刊

BMC Neuroscience 医学-神经科学

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

16 months

期刊介绍： BMC Neuroscience is an open access, peer-reviewed journal that considers articles on all aspects of neuroscience, welcoming studies that provide insight into the molecular, cellular, developmental, genetic and genomic, systems, network, cognitive and behavioral aspects of nervous system function in both health and disease. Both experimental and theoretical studies are within scope, as are studies that describe methodological approaches to monitoring or manipulating nervous system function.