Effects of repetitive transcranial magnetic stimulation on learning and memory cognitive function in rats with vascular cognitive impairment and its neural induction mechanism.

IF 2.4 4区医学 Q3 NEUROSCIENCES

BMC Neuroscience Pub Date : 2025-03-18 DOI:10.1186/s12868-025-00933-z

Jiati Wang, Huan Gao

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引用次数: 0

Abstract

Background: The treatment of vascular cognitive impairment (VCI) is challenging, and its neurological mechanisms are not yet fully understood. Repetitive transcranial magnetic stimulation (rTMS) offers a new non-invasive treatment approach.

Methods: One hundred male SD rats were grouped: intervention group (IG), model group (MG), sham group (SG), and control group (CG), to prepare the rat model of VCI. The Morris water maze (MWM) test was conducted, and oxidative stress (OS) markers, neurotrophic factors, apoptosis factors, and the amplitude of postsynaptic potential (PSP) in the hippocampus of rats were measured.

Results: Post-intervention, IG's escape latency was lower than MG but higher than SG and CG. IG's hippocampal malondialdehyde (MDA) content, Bax, and Caspase-3 (Cas-3) were lower than MG but higher than SG and CG, while the tendency was opposite for Bcl-2 expression and the content of glutathione (GSH) and superoxide dismutase (SOD). IG's brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and N-methyl-D-aspartate receptor 1 (NMDAR1) in the hippocampus were higher than MG but lower than SG and CG; The changes in the amplitude of PSP in the hippocampal region of IG at 10, 30, and 60 min were all higher than those in MG but lower than those in SG and CG (P < 0.05).

Conclusion: Low-frequency rTMS visibly improved the learning and memory abilities of VCI rats and reduced OS levels.

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重复经颅磁刺激对血管性认知障碍大鼠学习记忆认知功能的影响及其神经诱导机制。

背景：血管性认知障碍（VCI）的治疗具有挑战性，其神经机制尚未完全了解。重复经颅磁刺激（rTMS）提供了一种新的无创治疗方法。方法：雄性SD大鼠100只，分为干预组（IG）、模型组（MG）、假手术组（SG）和对照组（CG），制备VCI大鼠模型。采用Morris水迷宫（MWM）实验，测定大鼠海马氧化应激（OS）标志物、神经营养因子、细胞凋亡因子及突触后电位（PSP）振幅。结果：干预后IG的逃避潜伏期低于MG，高于SG和CG。IG大鼠海马丙二醛（MDA）含量、Bax、Caspase-3 （cas3）含量低于MG大鼠，高于SG和CG大鼠，Bcl-2表达、谷胱甘肽（GSH）、超氧化物歧化酶（SOD）含量则相反。IG大鼠海马脑源性神经营养因子（BDNF）、胶质细胞系源性神经营养因子（GDNF）和n-甲基-d -天冬氨酸受体1 （NMDAR1）含量高于MG，低于SG和CG；大鼠海马区PSP在10、30、60 min的振幅变化均高于MG组，但低于SG组和CG组(P)。结论：低频rTMS能明显改善VCI大鼠的学习记忆能力，降低OS水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Neuroscience 医学-神经科学

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

16 months

期刊介绍： BMC Neuroscience is an open access, peer-reviewed journal that considers articles on all aspects of neuroscience, welcoming studies that provide insight into the molecular, cellular, developmental, genetic and genomic, systems, network, cognitive and behavioral aspects of nervous system function in both health and disease. Both experimental and theoretical studies are within scope, as are studies that describe methodological approaches to monitoring or manipulating nervous system function.