Blood Pressure Monitoring最新文献

{"title":"Comments on 'Validation of the automated oscillometric upper-arm cuff home blood pressure monitor Microlife BP3KV1-5X (BP B6 Connect)...'","authors":"Klavs Würgler Hansen","doi":"10.1097/MBP.0000000000000784","DOIUrl":"https://doi.org/10.1097/MBP.0000000000000784","url":null,"abstract":"","PeriodicalId":8950,"journal":{"name":"Blood Pressure Monitoring","volume":"31 2","pages":"101"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147289091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Child weight status and high blood pressure from 6 to 12 years of age: results from the PREDI cohort study.","authors":"Aline Krein Moletta, Cecilia Burigo Corrêa, Silmara S B S Mastroeni, Marco F Mastroeni","doi":"10.1097/MBP.0000000000000786","DOIUrl":"10.1097/MBP.0000000000000786","url":null,"abstract":"<p><strong>Aim: </strong>To examine the effect of excess body weight on the blood pressure (BP) of children aged 6-12 years.</p><p><strong>Methods: </strong>This was a prospective longitudinal study conducted with 187 children at the participants' home in southern Brazil. BP was measured using the auscultatory method. Generalized linear mixed models, including fixed and random effects and adjusted for important covariates, were used to estimate the relative risk (RR) of excess body weight on the incidence of high BP in children throughout the three follow-ups of the study (at ages 6, 9, and 12 years).</p><p><strong>Results: </strong>The prevalence of high BP increased from 25.0 to 66.7% in children with excess body weight from 6 to 12 years of age. For every 1 kg/m 2 increase in the child's BMI, there was an 8% increase (RR = 1.08, 95% confidence interval: 1.00-1.16, P  = 0.042) in the risk of the child having high BP from 6 to 12 years of age, even after adjusting for prepregnancy BMI.</p><p><strong>Conclusion: </strong>Excessive BMI in children increased the risk of high BP in Brazilian children from 6 to 12 years of age. Special attention must be paid to children under 12 years of age with excess body weight to mitigate the onset of cardiovascular diseases throughout life.</p>","PeriodicalId":8950,"journal":{"name":"Blood Pressure Monitoring","volume":" ","pages":"61-70"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the B.Well TH-75 oscillometric upper-arm blood pressure monitor in general population according to the AAMI/ESH/ISO universal standard (ISO 81060-2:2018+Amd1:2020+Amd2:2024).","authors":"Yage Wang, Jialiang Ma, Yang Zhang, Jieqiong Zhang","doi":"10.1097/MBP.0000000000000797","DOIUrl":"https://doi.org/10.1097/MBP.0000000000000797","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to evaluate the accuracy of the B.Well TH-75 oscillometric upper-arm blood pressure (BP) monitor in general population according to the AAMI/ESH/ISO universal standard (ISO 81060-2 : 2018+Amd1 : 2020+Amd2 : 2024), and the device is expected to be used for home BP monitoring, with its measurements serving as a clinical reference.</p><p><strong>Methods: </strong>Subjects were recruited among the adult population to fulfill the age, gender, BP, and cuff distributions of the AAMI/ESH/ISO universal standard (ISO 81060-2 : 2018+Amd1 : 2020+Amd2 : 2024), and the study was approved by the Ethics Committee of the hospital. A single cuff 22-42 cm was used on the B.Well TH-75, and the validation was performed using the same-arm sequential BP measurement method.</p><p><strong>Results: </strong>Data from 85 subjects were analyzed. According to Criterion 1, the mean difference of systolic blood pressure (SBP) and diastolic blood pressure (DBP) between the test and reference device was 2.36 ± 7.40 and 0.85 ± 6.47 mmHg, respectively, which met the requirements of less than 5 and 8 mmHg for mean difference and SD, respectively. According to Criterion 2, SD of SBP was 6.20 mmHg, which was less than 6.51 mmHg and met the requirements. The SD of DBP was 5.28 mmHg, which was less than 6.88 mmHg and met the requirements.</p><p><strong>Conclusion: </strong>The B.Well TH-75 upper-arm BP monitor fulfilled the requirements of the AAMI/ESH/ISO universal standard (ISO 81060-2 : 2018+Amd1 : 2020+Amd2 : 2024) and can be recommended for use in general population.</p>","PeriodicalId":8950,"journal":{"name":"Blood Pressure Monitoring","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Hanvon KSY3600 Korotkoff-sound electronic blood pressure monitor in the general population according to the ISO 81060-2:2018.","authors":"Jian Wang, Yingjian Liu, Chongjie Chen","doi":"10.1097/MBP.0000000000000800","DOIUrl":"10.1097/MBP.0000000000000800","url":null,"abstract":"<p><p>This study aims to evaluate the accuracy of the Hanvon KSY3600 Korotkoff-sound electronic blood pressure (BP) monitor in the adult population, in accordance with the ISO 81060-2:2018. A total of 90 participants were recruited for this clinical study. After excluding 3 individuals due to excessive BP variability, the remaining 87 participants were enrolled for the evaluation. All enrolled participants met the inclusion criteria, which specified ranges for arm circumference, SBP, and DBP. According to ISO 81060-2:2018 + Amd 1:2020, the mean ± SD of the differences between the test device and the reference BP measurements were -0.3 ± 2.35/-0.3 ± 1.72 mmHg (SBP/DBP), thus meeting the requirements of Criterion 1 (≤5 mmHg mean difference and ≤8 mmHg SD). The mean difference in SBP was -0.3 ± 1.11 mmHg, while that in DBP was -0.3 ± 0.90 mmHg; this also fulfilled the requirements of Standard 2, with standard deviations within the limits of ≤6.95 mmHg for both SBP and DBP. Both ISO criteria were therefore satisfied, showing that the Hanvon KSY3600 Korotkoff-sound electronic BP monitor conforms to the ISO 81060-2:2018 + Amd 1:2020. It can thus be recommended for BP measurements in adults, both in clinical settings and for home use.</p>","PeriodicalId":8950,"journal":{"name":"Blood Pressure Monitoring","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of atrial fibrillation detection using Hanvon Korotkoff sound blood pressure monitor.","authors":"Jian Wang, Yingjian Liu, Chongjie Chen","doi":"10.1097/MBP.0000000000000799","DOIUrl":"https://doi.org/10.1097/MBP.0000000000000799","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation is one of the most common cardiac arrhythmias. It is a condition that significantly increases the risk of stroke and cardiac complications, making its early diagnosis and intervention a crucial part of improving long-term patient prognosis. This study evaluates the accuracy of an atrial fibrillation detection algorithm in a Korotkoff sound blood pressure (BP) monitor.</p><p><strong>Methods: </strong>A total of 312 inpatients and outpatients were recruited for this study, with a Korotkoff sound BP monitor used to measure the BP and screen for atrial fibrillation. The study cohort included 148 patients with atrial fibrillation (mean age 73.3 ± 9.0 years) and 164 controls with sinus rhythm (mean age 44.7 ± 14.6 years). During BP measurement, a hand-held single-lead ECG device was used to simultaneously record ECGs for evaluating the accuracy of the atrial fibrillation detection algorithm.</p><p><strong>Results: </strong>The device accurately identified all 148 confirmed atrial fibrillation patients, reliably triggering 'AFib' alerts in every instance. Throughout the evaluation of 164 non-atrial fibrillation subjects, the device maintained perfect specificity with zero false positive events. These results demonstrate 100% sensitivity and 100% specificity for atrial fibrillation detection.</p><p><strong>Conclusion: </strong>The Korotkoff sound BP monitor with atrial fibrillation detection algorithm exhibits excellent diagnostic accuracy. This device is of significant clinical value for early atrial fibrillation screening, serving as a convenient, efficient, and reliable tool for both home and primary medical institutions. Its capability for timely atrial fibrillation detection may contribute to reduced risks of stroke and other atrial fibrillation-related cardiovascular complications.</p>","PeriodicalId":8950,"journal":{"name":"Blood Pressure Monitoring","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the automated oscillometric upper-arm cuff home blood pressure monitor Microlife BP3KT1-4X (BP B3 Comfort PC) in a general population according to the Association for the Advancement of Medical Instrumentation/European Society of Hypertension/International Organization for Standardization Universal Standard (ISO 81060-2:2018).","authors":"Dimitrios Mariglis, Ariadni Menti, Vasileios Ntousopoulos, Petroula Lempidaki, Konstantina-Rozalia Bakalakou, Aikaterini Komnianou, Konstantinos G Kyriakoulis, Anastasios Kollias, George S Stergiou","doi":"10.1097/MBP.0000000000000773","DOIUrl":"10.1097/MBP.0000000000000773","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated the accuracy of the automated oscillometric upper-arm cuff blood pressure (BP) device Microlife BP3KT1-4X (BP B3 Comfort PC) for home use in a general population according to the Association for the Advancement of Medical Instrumentation/European Society of Hypertension/International Organization for Standardization (AAMI/ESH/ISO) Universal Standard (ISO 81060-2:2018) and its amendments (1:2020 and 2:2024).</p><p><strong>Methods: </strong>Participants were recruited to fulfill the age, sex, BP, and arm distribution criteria of the AAMI/ESH/ISO Universal Standard (ISO 81060-2:2018) and its amendments (1:2020 and 2:2024) in a general population using the same arm sequential measurement method. A single wide-range cuff of the test device was used for arm circumference 22-42 cm.</p><p><strong>Results: </strong>A total of 122 individuals were recruited, and 85 were analyzed [mean age 54.5 ± 15.7 (SD) years, 34 men (40%), arm circumference 31.6 ± 5.4 cm, range 22.8-41.8 cm]. For validation criterion 1, the mean difference ± SD between the test device and reference BP readings ( N  = 255) was -0.1 ± 7.5/-2.3 ± 5.3 mmHg (systolic/diastolic; threshold ≤5 ± 8 mmHg). For criterion 2, the SD of the averaged BP differences between the test device and reference BP per individual ( N  = 85) was 6.36/4.71 mmHg (systolic/diastolic; threshold ≤6.95/6.55 mmHg).</p><p><strong>Conclusion: </strong>The automated oscillometric home BP monitor Microlife BP3KT1-4X (BP B3 Comfort PC) fulfilled all the requirements of the AAMI/ESH/ISO Universal Standard (ISO 81060-2:2018) and its amendments (1:2020 and 2:2024) in a general population and therefore can be recommended for self-monitoring of BP at home.</p>","PeriodicalId":8950,"journal":{"name":"Blood Pressure Monitoring","volume":" ","pages":"39-42"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Errors and negative outcomes in home blood pressure monitoring by hypertensive individuals: a scoping review.","authors":"Francisco M L Cavalcante, Odézio D Brito, Ana C S Estácio, Ana R S O Kumakura, Anne F L Chaves, Nelson M Galindo Neto, Lívia M Barros","doi":"10.1097/MBP.0000000000000778","DOIUrl":"10.1097/MBP.0000000000000778","url":null,"abstract":"<p><p>Home blood pressure monitoring (HBPM) is a valuable tool in the diagnosis and management of hypertension; however, patients often perform inaccurate measurements because of inadequate technique, which may lead to adverse health outcomes. This scoping review aimed to map the errors and negative outcomes associated with HBPM in individuals with hypertension. This scoping review was conducted in accordance with the Joanna Briggs Institute methodology. Fifteen databases were searched from April to May 2025. The review included primary studies, literature reviews, theses, and dissertations that addressed errors and negative outcomes of HBPM. Independent researchers assessed eligibility and performed data extraction. The data were analyzed descriptively. The search yielded 18 391 studies, 14 of which met the inclusion criteria. In total, 35 distinct HBPM errors were identified. The most prevalent errors reported were failure to follow the recommended number or schedule for daily blood pressure (BP) measurements (57.14%), failure to support the back during measurement (35.71%), inadequate interval between meals or coffee consumption and BP measurement (35.71%), talking during measurement (35.71%) and failure to record the measured BP values (35.71%). The most frequently cited negative outcomes were anxiety, uncontrolled hypertension, self-medication, and an increased number of unplanned emergency room visits (40.0% each). This review highlights that many patients with hypertension perform HBPM inaccurately, committing errors that can be mitigated with professional guidance during consultations. Therefore, healthcare professionals and services must dedicate efforts to properly train and empower patients in the correct execution of this procedure.</p>","PeriodicalId":8950,"journal":{"name":"Blood Pressure Monitoring","volume":" ","pages":"6-13"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the direction of the blood pressure discrepancy and vascular aging in a large-scale screening population.","authors":"Masahito Katahira, Shu Imai, Satoko Ono, Shigeaki Moriura","doi":"10.1097/MBP.0000000000000772","DOIUrl":"10.1097/MBP.0000000000000772","url":null,"abstract":"<p><strong>Objective: </strong>Recent guidelines recommend measuring blood pressure (BP) multiple times and averaging the results. The direction of the discrepancy between the first and second readings varies. This study aimed to examine whether directionality is associated with vascular aging indicators.</p><p><strong>Methods: </strong>43 807 participants who underwent health checkups were first stratified by average systolic BP (SBP < 120, 120-129, 130-139, or ≥140 mmHg) and diastolic BP (DBP < 80, 80-89, or ≥90 mmHg). They were then categorized into three groups based on the absolute difference between the first and second BP readings (ΔBP): ΔBP < 5 mmHg (group A), 5-9 mmHg (group B), and greater than or equal to 10 mmHg (group C). Clinical parameters and vascular aging markers were compared between groups.</p><p><strong>Results: </strong>In participants with SBP less than 130 mmHg or DBP less than 80 mmHg, the first BP reading tended to be lower than the second. In contrast, among those with SBP greater than or equal to 130 mmHg or DBP greater than or equal to 90 mmHg, the first reading was often higher. Group C showed a significantly higher prevalence of hypertension, obesity, diabetes, and dyslipidemia, along with increased brachial-ankle pulse wave velocity and maximum carotid intima-media thickness.</p><p><strong>Conclusion: </strong>The direction and magnitude of the discrepancy between the first and second BP measurements may reflect the underlying vascular aging. BP discrepancy patterns could serve as simple, noninvasive indicators of subclinical atherosclerosis.</p>","PeriodicalId":8950,"journal":{"name":"Blood Pressure Monitoring","volume":" ","pages":"14-20"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of treatment intensity score and interankle diastolic blood pressure is associated with cardiovascular prognosis among adults with controlled hypertension who have pre-existing cardiovascular disease.","authors":"Zhe Zhang, Zeyuan Fan, Limin Han","doi":"10.1097/MBP.0000000000000775","DOIUrl":"10.1097/MBP.0000000000000775","url":null,"abstract":"<p><strong>Background: </strong>Despite adequate blood pressure control, many hypertensive patients remain at risk of cardiocerebral events. This study investigated the relationship between antihypertensive treatment intensity score (TIS) and interankle diastolic blood pressure difference (dIAND), and their utility in risk stratification.</p><p><strong>Methods: </strong>We analyzed 368 patients with well-controlled hypertension (24-hour ambulatory blood pressure monitoring ≤ 130/80 mmHg), and pre-existing cardiovascular disease. Patients were stratified by median TIS (0.625) into low (TIS1) and high (TIS2) intensity groups. dIAND was calculated as the absolute difference in diastolic pressure between ankles. Patients were followed for 3 years for adverse cardiocerebral events.</p><p><strong>Results: </strong>During follow-up (median 36 months), 73 major events were documented. The high TIS group exhibited significantly higher event rates (25.8 vs. 14.6%, log-rank P = 0.021), and remained an independent predictor after multivariable adjustment [adjusted hazard ratio: 1.92, 95% confidence interval (CI): 1.07-3.45, P  = 0.027]. A modest correlation was observed between TIS and dIAND ( r  = 0.26, P  < 0.001). Patients with dIAND ≥15 mmHg had higher event rates (35.0 vs. 18.0%; P  = 0.015); this association was attenuated in multivariable models. Notably, the combination of high TIS and elevated dIAND identified a subgroup with a 3.22-fold increased risk (adjusted hazard ratio: 3.22, 95% CI: 1.51-6.85, P  = 0.002) compared with the reference group (TIS ≤ 0.625 and dIAND < 15 mmHg).</p><p><strong>Conclusion: </strong>TIS independently predicts cardiocerebral risk and correlates with dIAND. The combined assessment may refine risk stratification in controlled hypertension, offering a practical approach to identify high-risk patients requiring intensified management.</p>","PeriodicalId":8950,"journal":{"name":"Blood Pressure Monitoring","volume":" ","pages":"21-28"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12736416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the BTL ambulatory blood pressure monitoring NG ambulatory blood pressure monitoring device according to the Universal Standard International Organization for Standardization 81060-2:2018.","authors":"Jan David, Xenie Budinska, Sarka Peskova, Radka Adamkova","doi":"10.1097/MBP.0000000000000776","DOIUrl":"10.1097/MBP.0000000000000776","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to validate the BTL ambulatory blood pressure monitoring NG ambulatory blood pressure (BP) monitoring device in a general population, including children aged 4-12 years, according to the International Organization for Standardization 81060-2:2018 standard with amendments A1:2020 and A2:2024.</p><p><strong>Methods: </strong>The study included both clinical and ambulatory validation. In the clinical part, 85 participants (50 adults and 35 children) underwent same-arm sequential measurements with alternating test device and reference readings. The ambulatory part involved 35 adults tested using a dynamic protocol on a bicycle ergometer with at least a 15% heart rate increase. All procedures strictly followed standard requirements, including arm circumference and BP distributions.</p><p><strong>Results: </strong>The device met all validation criteria defined by the standard. In clinical testing, mean differences were -0.52 mmHg systolic and -0.39 mmHg diastolic, with standard deviations of 4.44 and 4.17 mmHg. All cuff subgroups also met criterion 1, and criterion 2 was fulfilled with standard deviations of 3.80 mmHg systolic and 3.35 mmHg diastolic, including the children subgroup. In the ambulatory validation, mean differences were -0.40 mmHg systolic and -0.50 mmHg diastolic, with standard deviations of 5.88 and 5.05 mmHg.</p><p><strong>Conclusion: </strong>To our knowledge, this is the first published validation of an ambulatory BP monitoring device that fully followed the unified 81060-2:2018 standard, including amendments A1:2020 and A2:2024. The device fulfilled all clinical and ambulatory validation criteria across all required distributions and age groups, including children.</p>","PeriodicalId":8950,"journal":{"name":"Blood Pressure Monitoring","volume":" ","pages":"43-48"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}