Biotechnology advances最新文献_第4页

Biotechnological advances in key regulatory genes of phenylpropanoid and terpenoid biosynthesis pathways in Panax ginseng: Current insights and future prospects 人参苯丙素和萜类生物合成途径关键调控基因的生物技术进展：现状和未来展望

IF 12.5 1区工程技术

Biotechnology advances Pub Date : 2026-05-01 Epub Date: 2026-02-07 DOI: 10.1016/j.biotechadv.2026.108840

Mengyang Zhang , Jia Wu , Jie Zhang , Fu Wang , Youcheng Wang , Xiujuan Lei , Yingping Wang , Jian Zhang

{"title":"Biotechnological advances in key regulatory genes of phenylpropanoid and terpenoid biosynthesis pathways in Panax ginseng: Current insights and future prospects","authors":"Mengyang Zhang , Jia Wu , Jie Zhang , Fu Wang , Youcheng Wang , Xiujuan Lei , Yingping Wang , Jian Zhang","doi":"10.1016/j.biotechadv.2026.108840","DOIUrl":"10.1016/j.biotechadv.2026.108840","url":null,"abstract":"<div><div><em>Background</em>: <em>Panax ginseng</em>, is one of the most important medicinal herbs, widely recognized for its therapeutic value in traditional and modern medicine. Its diverse pharmacological activities are primarily mediated by secondary metabolites, notably flavonoids and polyphenols from the phenylpropanoid pathway and ginsenosides from the terpenoid pathway, which exert strong antioxidant, anti-aging, and anti-inflammatory effects.</div><div><em>Aim of review</em>: This review focuses on recent biotechnological advances in elucidating and manipulating the genes underlying phenylpropanoid and terpenoid biosynthesis in <em>P. ginseng</em>. We summarize progress in gene discovery, functional characterization with particular emphasis on ginsenoside biosynthesis. Cutting-edge approaches—including genome editing, CRISPR-based regulation, metabolic engineering, and synthetic biology—are highlighted as transformative tools to reprogram metabolic fluxes and enhance metabolite production. Additionally, we discuss omics-driven strategies, systems biology models, and emerging bioreactor and cell culture platforms that bridge fundamental genetics with applied biotechnology. It provides a theoretical and practical framework for developing elite ginseng varieties with improved bioactive compound profiles and paves the way for precision breeding and industrial-scale production of high-value medicinal metabolites.</div></div>","PeriodicalId":8946,"journal":{"name":"Biotechnology advances","volume":"88 ","pages":"Article 108840"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Limitations of traditional mycotoxin control and biotechnological advances toward sustainable solutions 传统霉菌毒素控制的局限性和可持续解决方案的生物技术进步

IF 12.5 1区工程技术

Biotechnology advances Pub Date : 2026-05-01 Epub Date: 2026-02-05 DOI: 10.1016/j.biotechadv.2026.108836

Xitao Wang , Jiansong You , Xiaoyu Li , Yongping Xu , Zhongyu Li , Lili Wang

{"title":"Limitations of traditional mycotoxin control and biotechnological advances toward sustainable solutions","authors":"Xitao Wang , Jiansong You , Xiaoyu Li , Yongping Xu , Zhongyu Li , Lili Wang","doi":"10.1016/j.biotechadv.2026.108836","DOIUrl":"10.1016/j.biotechadv.2026.108836","url":null,"abstract":"<div><div>Mycotoxins are harmful fungal metabolites that contaminate food and feed, posing serious health and economic risks worldwide. Traditional control methods often fall short due to inefficiency and safety concerns, prompting the development of innovative biotechnological approaches. This review explores recent advances in mycotoxin management, focusing on engineered microbes for targeted degradation, nanotechnology-based detection and removal systems, phage therapy targeting toxin-producing fungi, CRISPR-Cas gene editing of mycotoxin biosynthesis pathways, and plant-microbe interactions that suppress fungal growth. Additionally, enzyme immobilization strategies are highlighted for improving enzyme stability and reusability in detoxification processes. These integrated biotechnological tools offer promising, sustainable solutions to mitigate mycotoxin contamination, enhancing food safety and agricultural productivity. The review also discusses current challenges and future directions for translating these advances into practical applications. Highlighting that biotechnological tools are technically feasible and increasingly close to industrial deployment in food and feed chains.</div></div>","PeriodicalId":8946,"journal":{"name":"Biotechnology advances","volume":"88 ","pages":"Article 108836"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in metabolic engineering of purple non‑sulfur photosynthetic bacteria for enhanced biohydrogen production 紫色无硫光合细菌代谢工程促进生物制氢的研究进展。

IF 12.5 1区工程技术

Biotechnology advances Pub Date : 2026-05-01 Epub Date: 2026-02-04 DOI: 10.1016/j.biotechadv.2026.108832

Wen Cao , Jiyan Lu , Youmin Jiang, Maosen Yuan, Minmin Wang, Xuefang Mu, Zixuan Gao, Siyi Yang, Tengteng Li, Xuan Wei, Liejin Guo

{"title":"Recent advances in metabolic engineering of purple non‑sulfur photosynthetic bacteria for enhanced biohydrogen production","authors":"Wen Cao , Jiyan Lu , Youmin Jiang, Maosen Yuan, Minmin Wang, Xuefang Mu, Zixuan Gao, Siyi Yang, Tengteng Li, Xuan Wei, Liejin Guo","doi":"10.1016/j.biotechadv.2026.108832","DOIUrl":"10.1016/j.biotechadv.2026.108832","url":null,"abstract":"<div><div>Photo-fermentative hydrogen production from lignocellulosic biomass offers a sustainable and carbon-neutral route for bioenergy conversion, providing an effective strategy to mitigate fossil resource depletion and greenhouse gas emissions. Among diverse microbial candidates, purple non‑sulfur bacteria (PNSB) have emerged as promising photosynthetic platforms owing to their broad substrate utilization, intrinsic tolerance to lignocellulose-derived inhibitors, and high hydrogen yields under light-anaerobic conditions. Their metabolic versatility allows dynamic redistribution of carbon and electron fluxes, facilitating efficient energy conversion. Recent progress in metabolic engineering has substantially advanced the hydrogen-producing capacity of PNSB through targeted manipulation of photosynthetic metabolism, redox balance and stress response pathways. Engineering strategies have focused on optimizing pigment biosynthesis to enhance light harvesting, reinforcing redox homeostasis and adenosine triphosphate (ATP) generation, and improving tolerance to environmental stresses such as ammonia, pH, and temperature fluctuations. These efforts have led to engineered strains exhibiting extraordinary improvement in hydrogen yield, stability and robustness. This review provides an overview of the fundamental mechanisms underlying photo-fermentative hydrogen metabolism in PNSB, summarizes recent advances in the metabolic and systems-level engineering strategies, and outlines the prospects of developing strains capable of approaching the theoretical limit of hydrogen yield through integrated engineering strategies, advanced tools such as CRISPR-Cas, and adaptive laboratory evolution methods.</div></div>","PeriodicalId":8946,"journal":{"name":"Biotechnology advances","volume":"88 ","pages":"Article 108832"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146130972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New horizons of nanotechnology-enabled phage therapies for effective management of bacterial infections 纳米技术使噬菌体疗法有效管理细菌感染的新视野

IF 12.5 1区工程技术

Biotechnology advances Pub Date : 2026-05-01 Epub Date: 2026-02-05 DOI: 10.1016/j.biotechadv.2026.108839

Muhammad Babar Malook , Munazza Ijaz , Jiayi Zhang , Xuefang Huang , Temoor Ahmed , Alhassan Alrafaie , Muhammad Noman , Humera Rani , Bin Li

{"title":"New horizons of nanotechnology-enabled phage therapies for effective management of bacterial infections","authors":"Muhammad Babar Malook , Munazza Ijaz , Jiayi Zhang , Xuefang Huang , Temoor Ahmed , Alhassan Alrafaie , Muhammad Noman , Humera Rani , Bin Li","doi":"10.1016/j.biotechadv.2026.108839","DOIUrl":"10.1016/j.biotechadv.2026.108839","url":null,"abstract":"<div><div>Bacterial infections continue to persist as a major global healthcare challenge, exacerbated by the alarming rise of antimicrobial resistance (AMR) that renders conventional antibiotics increasingly ineffective. In response, bacteriophage therapy has re-emerged as a viable alternative to antibiotics, leveraging the natural ability of phages to target and lyse specific bacterial pathogens. However, phage therapy is subjected to diverse challenges such as phage stability, targeted delivery, and bacterial resistance limiting its clinical applications. Recent mechanistic advancements in nanotechnology present a groundbreaking solution by enabling precise nano-based engineering of phages with enhanced therapeutic properties. This review examines the integration of nanotechnology tools and products with phage therapy, highlighting innovative strategies such as nanomaterial-based encapsulation, functionalization, improve stability, precise delivery and inhibit toxicological exposure. Furthermore, nanotechnology facilitates controlled release, prolonged circulation, and synergistic combinations with dynamic phage therapies. The review also investigates perspectives related to the challenges such as standardization, scalability, immunogenicity, and regulatory barriers of phage therapy, encompassing the future emphasis on the development of biocompatible carriers. By overcoming these obstacles, nanotechnology-enabled phage therapy has the potential to improve the treatment of multidrug-resistant bacteria, offering a more targeted, adaptable, and sustainable approach to combating the growing threat of AMR.</div></div>","PeriodicalId":8946,"journal":{"name":"Biotechnology advances","volume":"88 ","pages":"Article 108839"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rational assembly of multi-enzyme cascades: A paradigm shift from stochastic immobilization to precision assembly engineering 多酶级联的合理装配：从随机固定到精密装配工程的范式转变

IF 12.5 1区工程技术

Biotechnology advances Pub Date : 2026-05-01 Epub Date: 2026-02-15 DOI: 10.1016/j.biotechadv.2026.108842

Yong-Kang Jiang , Huan Chen , Xue-Ning Qiao , Liang-Jun Li , Ya-Ping Xue , Shu-Ping Zou , Yu-Guo Zheng

{"title":"Rational assembly of multi-enzyme cascades: A paradigm shift from stochastic immobilization to precision assembly engineering","authors":"Yong-Kang Jiang , Huan Chen , Xue-Ning Qiao , Liang-Jun Li , Ya-Ping Xue , Shu-Ping Zou , Yu-Guo Zheng","doi":"10.1016/j.biotechadv.2026.108842","DOIUrl":"10.1016/j.biotechadv.2026.108842","url":null,"abstract":"<div><div>Multi-enzyme cascade catalysis has become a pivotal technology in green biomanufacturing and the synthesis of fine chemicals, facilitating efficient and highly selective transformations through the mimicry of natural metabolic pathways. Despite considerable advances in single-enzyme engineering, substantial challenges persist in enhancing the overall catalytic efficiency of multi-enzyme systems. Limitations such as inadequate inter-enzyme synergy and low operational stability significantly impede their scalable implementation. Thus, achieving precise spatial organization of multi-enzyme systems to emulate synergistic functions and improve stability within artificial environments has emerged as a crucial strategy to overcome existing bottlenecks. This review systematically categorizes multi-enzyme cascade reactions into five modular types (linear, parallel, orthogonal, cyclic, and triangular) and classifies assembly materials into non-biological (synthetic polymer and inorganic material) and biological categories (polysaccharide, nucleic acid, protein, and organism). Drawing on current literature, we systematically examine diverse enzyme assembly strategies, highlight state-of-the-art engineering methodologies, and introduce “ordered assembly” as a novel paradigm for constructing advanced multi-enzyme systems. In consideration of the distinct features of various cascade modules, we further elaborate on design principles for customized assembly strategies and illustrate their implementation through representative case studies. Finally, the current challenges and future directions of multi-enzyme assembly technology are discussed. This study aims to establish a theoretical foundation and propose innovative strategies for enhancing the application of multi-enzyme assembly in biocatalysis, thereby contributing to the sustainable manufacturing of fine chemicals.</div></div>","PeriodicalId":8946,"journal":{"name":"Biotechnology advances","volume":"88 ","pages":"Article 108842"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146209897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glycobiohydrolases at the forefront of lignocellulose saccharification: A review on substrate specificities and structure-function properties 糖生物水解酶在木质纤维素糖化的前沿：底物特异性和结构功能特性的综述

IF 12.5 1区工程技术

Biotechnology advances Pub Date : 2026-05-01 Epub Date: 2026-02-04 DOI: 10.1016/j.biotechadv.2026.108830

Christina Pentari , Eleni Krassa , Anastasia Zerva , Evangelos Topakas

{"title":"Glycobiohydrolases at the forefront of lignocellulose saccharification: A review on substrate specificities and structure-function properties","authors":"Christina Pentari , Eleni Krassa , Anastasia Zerva , Evangelos Topakas","doi":"10.1016/j.biotechadv.2026.108830","DOIUrl":"10.1016/j.biotechadv.2026.108830","url":null,"abstract":"<div><div>Glycobiohydrolases are key components of microbial systems for biomass utilization, attacking the chain ends of biopolymers to produce disaccharide units. While for decades glycobiohydrolases have been investigated against cellulose, starch and chitin, these biocatalysts are brought again to the spotlight thanks to the discovery of novel specificities for hemicellulosic and pectic substrates such as xylan, mannan, levan and galactan. Glycobiohydrolases demonstrate several interesting features that arouse scientific interest, such as the exo-acting catalytic mechanism or, in some cases, a bi-functional exo−/ endo-mode of action, the processive hydrolysis of substrates, and their involvement in the cooperative degradation of recalcitrant polymeric structures. This review summarizes the distinct glycobiohydrolase activities involved in the biodegradation of native polysaccharides. Particular focus is given to the substrate of each enzymatic activity, as well as its functional-structural determinants. Finally, this review aims to identify research gaps regarding the various glycobiohydrolase activities and indicate new potential research perspectives.</div></div>","PeriodicalId":8946,"journal":{"name":"Biotechnology advances","volume":"88 ","pages":"Article 108830"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146110545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing prime editing: Advances in efficiency enhancement 优化主要编辑：提高效率的进展

IF 12.5 1区工程技术

Biotechnology advances Pub Date : 2026-05-01 Epub Date: 2026-02-02 DOI: 10.1016/j.biotechadv.2026.108815

Ying Qu , Yingying Li , Tong Shao , Jingyu Kuang , Yanhua Qi , Junru Yang , Yu Liu , Jingyang Wang , Xuechao Fu , Jiali Liu , Xiaoyu Zhang , Tianhuan Peng , Quan Yuan , Lvyun Zhu

{"title":"Optimizing prime editing: Advances in efficiency enhancement","authors":"Ying Qu , Yingying Li , Tong Shao , Jingyu Kuang , Yanhua Qi , Junru Yang , Yu Liu , Jingyang Wang , Xuechao Fu , Jiali Liu , Xiaoyu Zhang , Tianhuan Peng , Quan Yuan , Lvyun Zhu","doi":"10.1016/j.biotechadv.2026.108815","DOIUrl":"10.1016/j.biotechadv.2026.108815","url":null,"abstract":"<div><div>Prime editing (PE) enables the precise installation of targeted insertions, deletions, and all possible base-to-base conversions without introducing double-strand breaks or donor DNA templates. However, its efficiency remains highly variable across genomic contexts. To address this, multi-faceted optimization strategies have been developed: protein engineering has yielded editor variants with enhanced reverse transcriptase activity and stability; structural refinements to pegRNA design improve its functional integrity and resistance to degradation; regulation of the PE-Flap-mismatch repair (MMR) process favors the retention of desired edits; and the development of protospacer adjacent motif (PAM)-relaxed Cas variants dramatically expands targetable sites. This review systematically consolidates these advances, illustrating how the integration of structural, mechanistic and targeting enhancements is overcoming fundamental bottlenecks. Together, these developments establish PE as a versatile and efficient system for precision genome engineering, paving the way for its reliable application in diverse biological settings.</div></div>","PeriodicalId":8946,"journal":{"name":"Biotechnology advances","volume":"88 ","pages":"Article 108815"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146110547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial collaboration in bioelectrochemical systems: Mechanisms and advances towards sustainable biobased products 生物电化学系统中的微生物合作：可持续生物基产品的机制和进展。

IF 12.5 1区工程技术

Biotechnology advances Pub Date : 2026-05-01 Epub Date: 2026-02-18 DOI: 10.1016/j.biotechadv.2026.108845

J. Annie Modestra, Shaik Basha

{"title":"Microbial collaboration in bioelectrochemical systems: Mechanisms and advances towards sustainable biobased products","authors":"J. Annie Modestra, Shaik Basha","doi":"10.1016/j.biotechadv.2026.108845","DOIUrl":"10.1016/j.biotechadv.2026.108845","url":null,"abstract":"<div><div>The pursuit of sustainability in the urban world has prompted the development of innovative biobased strategies to mitigate the impact of industrial and human activities on the environment. One such strategy is leveraging microbial collaboration to minimize waste and maximize resource efficiency to unlock the production of biobased products embracing circular bioeconomy in rapidly functioning bio-electrochemical systems (BES). BES is a diversified technology with manifold applications that use microbial interactions at electrode interface to synthesize new products with enhanced substrate utilization, contributing to both environmental sustainability and industrial efficiency. Considering the significance of microbial collaboration, this review article is intended to discuss the types and benefits of microbial interactions in BES, partnerships in a mixed microbiome, between co-cultures, underlying factors, mechanisms, and approaches to enhance the yield and targeted outcome advocating sustainability. This review provides an overview of current research, advances in microbial synergy, and the challenges in optimizing microbial consortia for industrial applications. Probing and harnessing synergies between microbial groups or specific microbes is expected to play a pivotal role in advancing efficient bioelectrochemical platforms and accelerating the transition towards a resilient, biobased economy.</div></div>","PeriodicalId":8946,"journal":{"name":"Biotechnology advances","volume":"88 ","pages":"Article 108845"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146257288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Xylanases targeting unusual glycosidic bonds: Unlocking prebiotic xylooligosaccharides from macroalgae 针对不寻常糖苷键的木聚糖酶：从大型藻类中解锁益生元低聚木糖

IF 12.5 1区工程技术

Biotechnology advances Pub Date : 2026-03-01 Epub Date: 2026-01-13 DOI: 10.1016/j.biotechadv.2026.108801

Andrea Luaces , Andrea Rodríguez-Sanz , Concepción Pérez-Lamela , Clara Fuciños , Ana Torrado , Maria Luisa Rúa

{"title":"Xylanases targeting unusual glycosidic bonds: Unlocking prebiotic xylooligosaccharides from macroalgae","authors":"Andrea Luaces , Andrea Rodríguez-Sanz , Concepción Pérez-Lamela , Clara Fuciños , Ana Torrado , Maria Luisa Rúa","doi":"10.1016/j.biotechadv.2026.108801","DOIUrl":"10.1016/j.biotechadv.2026.108801","url":null,"abstract":"<div><div>The growing interest in functional foods and prebiotics has encouraged the search for novel bioactive ingredients. Macroalgae (seaweeds) represent an underexplored source of unique xylans with β-1,3 and β-1,3/1,4 glycosidic linkages, that can be enzymatically hydrolysed into novel xylooligosaccharides (XOS). These oligosaccharides, characterized by linkage patterns different from those in terrestrial biomass, may exert distinct biological effects with potential biotechnological applications in food, nutraceuticals, and health. However, current knowledge regarding these xylans and their hydrolytic enzymes remains limited. This review therefore provides a comprehensive and up-to-date overview of macroalgal species containing β-1,3-xylan and β-1,3/1,4-mixed-linkage xylan (MLX), together with the extraction methodologies currently employed to obtain these xylans as substrates for enzymatic studies. It also highlights the specific enzymes involved in their hydrolysis —endo-1,3-β-xylanases and β-1,3/1,4-mixed-linkage xylanases (MLXases)— and discuss their biochemical, kinetic and structural features as well as the current insights into substrate specificity and catalytic mechanisms. Finally, the review examines current advances in the enzymatic production of XOS from macroalgal xylans and summarizes the bioactive properties of β-1,3-XOS and β-1,3/1,4-mixed-linkage XOS (MLXOS) reported to date.</div></div>","PeriodicalId":8946,"journal":{"name":"Biotechnology advances","volume":"87 ","pages":"Article 108801"},"PeriodicalIF":12.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145962088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Midas touch: Recombinant antibodies transforming diagnostic platforms 点石成金：重组抗体改变诊断平台

IF 12.5 1区工程技术

Biotechnology advances Pub Date : 2026-03-01 Epub Date: 2026-01-06 DOI: 10.1016/j.biotechadv.2026.108799

Angela Chiew Wen Ch'ng , Jing Yi Lai , Jia Xuan Yeoh , Yee Siew Choong , Zafarina Zainuddin , Alwi bin Muhd Besari , Wan Yus Haniff Wan Isa , Janet Mary Daly , Kevin Christopher Gough , Theam Soon Lim

引用次数: 0