A review on the expanding biotechnological frontier of Pedobacter

IF 12.1 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnology advances Pub Date : 2025-04-26 DOI:10.1016/j.biotechadv.2025.108588

Gonçalo Figueiredo , Hugo Osório , Marta V. Mendes , Sónia Mendo

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引用次数: 0

Abstract

The genus Pedobacter consists of Gram-negative bacteria with a broad geographic distribution, isolated from diverse habitats, including water, soil, plants, wood, rocks and animals. However, characterization efforts have been limited to a small number of species. Likewise, in the context of natural products (NP), only a small fraction of Pedobacter -derived NPs have been characterized so far. In contrast, in silico analysis of the increasing number of available genomes in the databases, suggests a wealth of yet to be discovered compounds. Notable biotechnological applications described so far include the production of heparinases and chondroitinases for therapeutic purposes, phytases and galactosidases as aquaculture feed supplements, alginate lyases for biofuel production, and secondary metabolites such as pedopeptins and isopedopeptins with antimicrobial properties. Further research integrating synthetic biology approaches, holds great promise for unlocking the hidden potential of members of this genus, thus expanding its industrial applications.

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土杆菌生物技术前沿研究进展

Pedobacter属由革兰氏阴性菌组成，具有广泛的地理分布，从包括水、土壤、植物、木材、岩石和动物在内的各种栖息地分离出来。然而，表征工作仅限于少数物种。同样，在天然产物（NP）的背景下，到目前为止，只有一小部分Pedobacter衍生的NPs被表征。相比之下，对数据库中越来越多的可用基因组进行的计算机分析表明，还有大量的化合物尚未被发现。迄今为止所描述的显著生物技术应用包括用于治疗目的的肝素酶和软骨素酶的生产，用于水产养殖饲料补充的植酸酶和半乳糖苷酶，用于生物燃料生产的海藻酸裂解酶，以及具有抗菌特性的次级代谢物，如培肽和异培肽。整合合成生物学方法的进一步研究，为解锁该属成员的隐藏潜力提供了巨大的希望，从而扩大了其工业应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biotechnology advances 工程技术-生物工程与应用微生物

CiteScore

25.50

自引率

2.50%

发文量

167

审稿时长

37 days

期刊介绍： Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.