ISRN oncology最新文献_第2页

Pediatric sclerosing rhabdomyosarcomas: a review. 儿童硬化性横纹肌肉瘤:综述。

ISRN oncology Pub Date : 2014-03-05 eCollection Date: 2014-01-01 DOI: 10.1155/2014/640195

Amandeep Kumar, Manmohan Singh, Mehar C Sharma, Sameer Bakshi, Bhawani S Sharma

{"title":"Pediatric sclerosing rhabdomyosarcomas: a review.","authors":"Amandeep Kumar, Manmohan Singh, Mehar C Sharma, Sameer Bakshi, Bhawani S Sharma","doi":"10.1155/2014/640195","DOIUrl":"https://doi.org/10.1155/2014/640195","url":null,"abstract":"Sclerosing RMS (SRMS) is a recently described subtype of RMS that has not yet been included in any of the classification systems for RMSs. We did pubmed search using keywords \"sclerosing, and rhabdomyosarcomas\" and included all pediatric cases (age ≤ 18 years) of SRMSs in this review. We also included our case of an eleven-year-old male child with skull base SRMS and discuss the clinical, histopathological, immunohistochemical, and genetic characteristics of these patients. Till now, only 20 pediatric cases of SRMSs have been described in the literature. Pediatric SRMS more commonly affects males at a mean age of 9 years. Extremeties and head/neck regions were most commonly affected. Follow-up details were available for 16 patients with mean follow-up of 25.3 months. Treatment failure rate was 43.75%. Overall amongst these 16 patients, 10 were alive without disease, 4 were alive with disease, and two died. Thus, overall and disease-free survival amongst these 16 patients were 87.5% and 62.5%, respectively. The literature regarding clinical behaviour and outcome of pediatric patients with SRMSs is patchy. Detailed molecular/genetic analysis and clinicopathological characterization with longer follow-ups of more cases may throw some light on this possibly new subtype of RMS. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2014 ","pages":"640195"},"PeriodicalIF":0.0,"publicationDate":"2014-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/640195","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32260955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Public awareness of colorectal cancer screening: knowledge, attitudes, and interventions for increasing screening uptake. 公众对结直肠癌筛查的认识：知识、态度和提高筛查率的干预措施。

ISRN oncology Pub Date : 2014-03-05 eCollection Date: 2014-01-01 DOI: 10.1155/2014/425787

Antonio Z Gimeno Garcia, Noemi Hernandez Alvarez Buylla, David Nicolas-Perez, Enrique Quintero

{"title":"Public awareness of colorectal cancer screening: knowledge, attitudes, and interventions for increasing screening uptake.","authors":"Antonio Z Gimeno Garcia, Noemi Hernandez Alvarez Buylla, David Nicolas-Perez, Enrique Quintero","doi":"10.1155/2014/425787","DOIUrl":"10.1155/2014/425787","url":null,"abstract":"Colorectal cancer ranks as one of the most incidental and death malignancies worldwide. Colorectal cancer screening has proven its benefit in terms of incidence and mortality reduction in randomized controlled trials. In fact, it has been recommended by medical organizations either in average-risk or family-risk populations. Success of a screening campaign highly depends on how compliant the target population is. Several factors influence colorectal cancer screening uptake including sociodemographics, provider and healthcare system factors, and psychosocial factors. Awareness of the target population of colorectal cancer and screening is crucial in order to increase screening participation rates. Knowledge about this disease and its prevention has been used across studies as a measurement of public awareness. Some studies found a positive relationship between knowledge about colorectal cancer, risk perception, and attitudes (perceived benefits and barriers against screening) and willingness to participate in a colorectal cancer screening campaign. The mentioned factors are modifiable and therefore susceptible of intervention. In fact, interventional studies focused on average-risk population have tried to increase colorectal cancer screening uptake by improving public knowledge and modifying attitudes. In the present paper, we reviewed the factors impacting adherence to colorectal cancer screening and interventions targeting participants for increasing screening uptake. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2014 ","pages":"425787"},"PeriodicalIF":0.0,"publicationDate":"2014-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32260954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequency and Spectrum of KRAS Mutations in Moroccan Patients with Lung Adenocarcinoma. 摩洛哥肺腺癌患者KRAS突变的频率和谱。

ISRN oncology Pub Date : 2014-03-05 eCollection Date: 2014-01-01 DOI: 10.1155/2014/192493

Ibrahim Elghissassi, Hanane Inrhaoun, Anwar Boukir, Fouad Kettani, Lamia Gamra, Amina Mestari, Lamia Jabri, Youssef Bensouda, Hind Mrabti, Hassan Errihani

{"title":"Frequency and Spectrum of KRAS Mutations in Moroccan Patients with Lung Adenocarcinoma.","authors":"Ibrahim Elghissassi, Hanane Inrhaoun, Anwar Boukir, Fouad Kettani, Lamia Gamra, Amina Mestari, Lamia Jabri, Youssef Bensouda, Hind Mrabti, Hassan Errihani","doi":"10.1155/2014/192493","DOIUrl":"https://doi.org/10.1155/2014/192493","url":null,"abstract":"Background. In lung adenocarcinoma, the frequency of KRAS mutations is ethnicity dependent with a higher proportion in African Americans and white Caucasians than in Asians. The prevalence of these mutations among North Africans patients is unknown. The objective of this study was to report the frequency and spectrum of KRAS mutations in a group of Moroccan lung adenocarcinoma patients. Methods. Tumor specimens from 117 Moroccan patients with lung adenocarcinoma were selected to determine frequency and spectrum of KRAS mutations. KRAS mutations in codons 12 and 13 of exon 2 were analyzed using conventional DNA sequencing. Results. The overall frequency of the KRAS mutations was 9% (11/117). In the population with KRAS mutations, there was a trend towards more male (P = 0.06) and more smokers (P = 0.08) compared to patients with wild type KRAS. KRAS mutations were located at codon 12 in 10 out of 11 patients (91%). The G12C mutation was the most frequent KRAS mutation (73%). Conclusion. This is the first study to date examining the frequency and spectrum of KRAS mutations in lung adenocarcinomas in North African and Arab populations. KRAS mutation frequency in Moroccan patients was comparable with the frequency observed in East-Asian population. KRAS mutations are more likely observed in males and smokers and to be transversions. Further studies, in larger numbers of patients, are needed to confirm these findings. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2014 ","pages":"192493"},"PeriodicalIF":0.0,"publicationDate":"2014-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/192493","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32260952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Association of mammographic breast density with dairy product consumption, sun exposure, and daily activity. 乳房x线摄影乳房密度与乳制品消费、日晒和日常活动的关系。

ISRN oncology Pub Date : 2014-03-04 eCollection Date: 2014-01-01 DOI: 10.1155/2014/159049

Sadaf Alipour, Azin Saberi, Afsaneh Alikhassi, Leila Bayani, Ladan Hosseini

{"title":"Association of mammographic breast density with dairy product consumption, sun exposure, and daily activity.","authors":"Sadaf Alipour, Azin Saberi, Afsaneh Alikhassi, Leila Bayani, Ladan Hosseini","doi":"10.1155/2014/159049","DOIUrl":"https://doi.org/10.1155/2014/159049","url":null,"abstract":"Background. Mammographic density is a risk factor, for breast cancer and its association with various factors is under investigation; we carried out a study to assess its relationship with daily dairy intake, sun exposure, and physical activities. Patients and Methods. Women ≥40 years of age were interviewed about habits of dairy product consumption, daily sun exposure and physical activity. Exclusion criteria consisted of history of breast cancer, consumption of calcium and vitamin D supplements, hormone replacement therapy, or renal disease. Mammographic densities were classified according to the classification system of the American College of Radiologists into 4 classes. Results. Overall 703 cases were entered in the study. The mean age was 48.2 ± 6.2 years. The most common and least frequent classes of mammographic density were classes 2 and 4, respectively. There was no significant association between mammographic density and rate of dairy consumption, amount of sunlight exposure, and daily physical activity. Conclusion. Relation of sunlight exposure and intake of milk products with mammographic density need further study, while the subject of physical activity can be evaluated by a systematic review and meta-analysis of the existing literature. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2014 ","pages":"159049"},"PeriodicalIF":0.0,"publicationDate":"2014-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/159049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32260951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Undiagnosed diabetes in breast, colorectal, lung, and prostate cancer: incidence and risk factors. 乳腺癌、结直肠癌、肺癌和前列腺癌中未确诊的糖尿病：发病率和危险因素。

ISRN oncology Pub Date : 2014-03-04 eCollection Date: 2014-01-01 DOI: 10.1155/2014/607850

Robert I Griffiths, Karla J Lindquist, Cynthia D O'Malley, Michelle L Gleeson, Jennifer L Duryea, José M Valderas, Mark D Danese

{"title":"Undiagnosed diabetes in breast, colorectal, lung, and prostate cancer: incidence and risk factors.","authors":"Robert I Griffiths, Karla J Lindquist, Cynthia D O'Malley, Michelle L Gleeson, Jennifer L Duryea, José M Valderas, Mark D Danese","doi":"10.1155/2014/607850","DOIUrl":"10.1155/2014/607850","url":null,"abstract":"Our study describes the incidence and risk factors for undiagnosed diabetes in elderly cancer patients. Using Surveillance, Epidemiology, and End Results-Medicare data, we followed patients with breast, colorectal, lung, or prostate cancer from 24 months before to 3 months after cancer diagnosis. Medicare claims were used to exclude patients with diabetes 24 to 4 months before cancer (look-back period), identify those with diabetes undiagnosed until cancer, and construct indicators of preventive services, physician contact, and comorbidity during the look-back period. Logistic regression analyses were performed to identify factors associated with undiagnosed diabetes. Overall, 2,678 patients had diabetes undiagnosed until cancer. Rates were the highest in patients with both advanced-stage cancer and low prior primary care/medical specialist contact (breast 8.2%, colorectal 5.9%, lung 4.4%). Nonwhite race/ethnicity, living in a census tract with a higher percent of the population in poverty and a lower percent college educated, lower prior preventive services use, and lack of primary care and/or medical specialist care prior to cancer all were associated with higher (P ≤ 0.05) adjusted odds of undiagnosed diabetes. Undiagnosed diabetes is relatively common in selected subgroups of cancer patients, including those already at high risk of poor outcomes due to advanced cancer stage. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2014 ","pages":"607850"},"PeriodicalIF":0.0,"publicationDate":"2014-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32260953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Racial disparities in survival and age-related outcome in postsurgery breast cancer patients in a new york city community hospital. 纽约市社区医院乳腺癌术后患者生存和年龄相关结果的种族差异

ISRN oncology Pub Date : 2014-02-12 eCollection Date: 2014-01-01 DOI: 10.1155/2014/694591

Stacey Martindale, Awinder Singh, Hua Wang, Ashley Steinberg, Amer Homsi, Haidi Zhang, Alan Go, Peter Pappas

{"title":"Racial disparities in survival and age-related outcome in postsurgery breast cancer patients in a new york city community hospital.","authors":"Stacey Martindale, Awinder Singh, Hua Wang, Ashley Steinberg, Amer Homsi, Haidi Zhang, Alan Go, Peter Pappas","doi":"10.1155/2014/694591","DOIUrl":"https://doi.org/10.1155/2014/694591","url":null,"abstract":"Breast cancer survival has significantly improved over the past two decades. However, the diagnosis of breast cancer is lower and the mortality rate remains higher, in African American women (AA) compared to Caucasian-American women. The purpose of this investigation is to analyze postoperative events that may affect breast cancer survival. This is a retrospective analysis of prospectively collected data from The Brooklyn Hospital Center cancer registry from 1997 to 2010. Of the 1538 patients in the registry, 1226 are AA and 269 are Caucasian. The study was divided into two time periods, 1997-2004 (period A) and 2005-2010 (period B), in order to assess the effect of treatment outcomes on survival. During period A, 5-year survival probabilities of 75.37%, 74.53%, and 78.70% were seen among all patients, AA women and Caucasian women, respectively. These probabilities increased to 87.62%, 87.15% and 89.99% in period B. Improved survival in AA women may be attributed to the use of adjuvant chemotherapy, radiation, and hormonal therapy. Improved survival in Caucasian patients was attributed to the use of radiation therapy, as well as earlier detection resulting in more favorable tumor grades and pathological stages. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2014 ","pages":"694591"},"PeriodicalIF":0.0,"publicationDate":"2014-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/694591","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32227545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Comparison of reverse transcription quantitative real-time PCR, flow cytometry, and immunohistochemistry for detection of monoclonality in lymphomas. 反转录实时定量PCR、流式细胞术和免疫组织化学检测淋巴瘤单克隆的比较。

ISRN oncology Pub Date : 2014-02-04 eCollection Date: 2014-01-01 DOI: 10.1155/2014/796210

Anders Ståhlberg, Pierre Aman, Linda Strömbom, Neven Zoric, Alfredo Diez, Olle Nilsson, Mikael Kubista, Börje Ridell

{"title":"Comparison of reverse transcription quantitative real-time PCR, flow cytometry, and immunohistochemistry for detection of monoclonality in lymphomas.","authors":"Anders Ståhlberg, Pierre Aman, Linda Strömbom, Neven Zoric, Alfredo Diez, Olle Nilsson, Mikael Kubista, Börje Ridell","doi":"10.1155/2014/796210","DOIUrl":"https://doi.org/10.1155/2014/796210","url":null,"abstract":"In healthy humans, 60–70% of the B lymphocytes produce kappa light chains, while the remaining cells produce lambda light chains. Malignant transformation and clonal expansion of B lymphocytes lead to an altered kappa : lambda expression ratio, which is an important diagnostic criteria of lymphomas. Here, we compared three methods for clonality determination of suspected B cell lymphomas. Tumor biopsies from 55 patients with B cell malignancies, 5 B-lymphoid tumor cell lines, and 20 biopsies from patients with lymphadenitis were analyzed by immunohistochemistry, flow cytometry, and reverse transcription quantitative real-time PCR. Clonality was determined by immunohistochemistry in 52/53 cases, flow cytometry in 30/39 cases, and reverse transcription quantitative real-time PCR in 33/55 cases. In conclusion, immunohistochemistry was superior to flow cytometry and reverse transcription quantitative real-time PCR for clonality identification. Flow cytometry and reverse transcription quantitative real-time PCR analysis has complementary values. In a considerable number of cases tumor cells produced both kappa and lambda light chain transcripts, but only one type of light chain peptide was produced.","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2014 ","pages":"796210"},"PeriodicalIF":0.0,"publicationDate":"2014-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/796210","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32191990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Ultrasound Guided Core Biopsy versus Fine Needle Aspiration for Evaluation of Axillary Lymphadenopathy in Patients with Breast Cancer. 超声引导下的核心活检与细针穿刺对乳腺癌患者腋窝淋巴结病变的评价。

ISRN oncology Pub Date : 2014-02-04 eCollection Date: 2014-01-01 DOI: 10.1155/2014/703160

Marie A Ganott, Margarita L Zuley, Gordon S Abrams, Amy H Lu, Amy E Kelly, Jules H Sumkin, Mamatha Chivukula, Gloria Carter, R Marshall Austin, Andriy I Bandos

{"title":"Ultrasound Guided Core Biopsy versus Fine Needle Aspiration for Evaluation of Axillary Lymphadenopathy in Patients with Breast Cancer.","authors":"Marie A Ganott, Margarita L Zuley, Gordon S Abrams, Amy H Lu, Amy E Kelly, Jules H Sumkin, Mamatha Chivukula, Gloria Carter, R Marshall Austin, Andriy I Bandos","doi":"10.1155/2014/703160","DOIUrl":"https://doi.org/10.1155/2014/703160","url":null,"abstract":"Rationale and Objectives. To compare the sensitivities of ultrasound guided core biopsy and fine needle aspiration (FNA) for detection of axillary lymph node metastases in patients with a current diagnosis of ipsilateral breast cancer. Materials and Methods. From December 2008 to December 2010, 105 patients with breast cancer and abnormal appearing lymph nodes in the ipsilateral axilla consented to undergo FNA of an axillary node immediately followed by core biopsy of the same node, both with ultrasound guidance. Experienced pathologists evaluated the aspirate cytology without knowledge of the core histology. Cytology and core biopsy results were compared to sentinel node excision or axillary dissection pathology. Sensitivities were compared using McNemar's test. Results. Of 70 patients with axillary node metastases, FNA was positive in 55/70 (78.6%) and core was positive in 61/70 (87.1%) (P = 0.18). The FNA and core results were discordant in 14/70 (20%) patients. Ten cases were FNA negative/core positive. Four cases were FNA positive/core negative. Conclusion. Core biopsy detected six (8.6%) more cases of metastatic lymphadenopathy than FNA but the difference in sensitivities was not statistically significant. Core biopsy should be considered if the node is clearly imaged and readily accessible. FNA is a good alternative when a smaller needle is desired due to node location or other patient factors. This trial is registered with NCT01920139. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2014 ","pages":"703160"},"PeriodicalIF":0.0,"publicationDate":"2014-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/703160","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32191989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 53

[ (11) C]-methionine positron emission tomography in the postoperative imaging and followup of patients with primary and recurrent gliomas. [11] C -蛋氨酸正电子发射断层扫描在原发性和复发性胶质瘤患者术后影像学及随访中的应用。

ISRN oncology Pub Date : 2014-02-04 eCollection Date: 2014-01-01 DOI: 10.1155/2014/463152

Matteo Santoni, Cristina Nanni, Alessandro Bittoni, Gabriele Polonara, Alessandro Paccapelo, Roberto Trignani, Mariagrazia De Lisa, Franco Rychlicki, Luciano Burattini, Rossana Berardi, Stefano Fanti, Stefano Cascinu

{"title":"[ (11) C]-methionine positron emission tomography in the postoperative imaging and followup of patients with primary and recurrent gliomas.","authors":"Matteo Santoni, Cristina Nanni, Alessandro Bittoni, Gabriele Polonara, Alessandro Paccapelo, Roberto Trignani, Mariagrazia De Lisa, Franco Rychlicki, Luciano Burattini, Rossana Berardi, Stefano Fanti, Stefano Cascinu","doi":"10.1155/2014/463152","DOIUrl":"https://doi.org/10.1155/2014/463152","url":null,"abstract":"We investigated the sensitivity and specificity of [(11)C]-methionine positron emission tomography ([(11)C]-MET PET) in the management of glioma patients. We retrospectively analysed data from 53 patients with primary gliomas (16 low grade astrocytomas, 15 anaplastic astrocytomas and 22 glioblastomas) and Karnofsky Performance Status (KPS) > 70. Patients underwent [(11)C]-MET PET scans (N = 249) and parallel contrast-enhanced MRI (N = 193) and/or CT (N = 113) controls. In low grade glioma patients, MRI or CT findings associated with [(11)C]-MET PET additional data allowed discrimination residual disease from postsurgical changes in 96.22% of these cases. [(11)C]-MET PET early allowed detection of malignant progression from low grade to anaplastic astrocytoma with high sensitivity (91.56%) and specificity (95.18%). In anaplastic astrocytomas, we registered high sensitivity (93.97%) and specificity (95.18%) in the postoperative imaging and during the followup of these patients. In GBM patients, CT and/or MRI scans with additional [(11)C]-MET PET data registered a sensitivity of 96.92% in the postsurgical evaluation and in the tumour assessment during temozolomide therapy. A significant correlation was found between [(11)C]-MET mean uptake index and histologic grading (P < 0.001). These findings support the notion that complementary information derived from [(11)C]-MET PET may be helpful in postoperative and successive tumor assessment of glioma patients. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2014 ","pages":"463152"},"PeriodicalIF":0.0,"publicationDate":"2014-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/463152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32191988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Magnitude and Implications of Interfraction Variations in Organ Doses during High Dose Rate Brachytherapy of Cervix Cancer: A CT Based Planning Study. 宫颈癌高剂量率近距离放疗期间器官剂量干扰变化的幅度和意义:一项基于CT的计划研究。

ISRN oncology Pub Date : 2014-02-03 eCollection Date: 2014-01-01 DOI: 10.1155/2014/687365

Santam Chakraborty, Firuza D Patel, Vijay M Patil, Arun S Oinam, Suresh C Sharma

{"title":"Magnitude and Implications of Interfraction Variations in Organ Doses during High Dose Rate Brachytherapy of Cervix Cancer: A CT Based Planning Study.","authors":"Santam Chakraborty, Firuza D Patel, Vijay M Patil, Arun S Oinam, Suresh C Sharma","doi":"10.1155/2014/687365","DOIUrl":"https://doi.org/10.1155/2014/687365","url":null,"abstract":"Background. Quantifying the interfraction dose variations in the organs at risk (OAR) in HDR intracavitary brachytherapy (HDR ICBT). Methods. Rectum and bladder were contoured in 44 patients of cervical carcinoma on CT after each fraction of HDR ICBT (9 Gy/2 fractions). Interfraction dose variations (VARact) were calculated. Rigid image registration of consecutive fraction images allowed quantification of the hypothetical variation in dose (VARhypo) arising exclusively due to changes in applicator placement and geometry. VARhypo was regressed against the VARact to find out to what extent the applicator variation could explain the VARact in the OAR. The rest of the variation was assumed to be due to organ deformation. Results. The VARact in the dose to 2 cc of bladder and rectum were 1.46 and 1.16 Gy, respectively. Increased dose was seen in 16 and 23 patients in the subsequent fraction for bladder and rectum, respectively. Doses to OAR would have exceeded constraints in 16% patients if second fraction was not imaged. VARhypo explained 19% and 47% of the VARact observed for the bladder and rectum respectively. Conclusions. Significant interfraction variations in OAR doses can occur in HDR ICBT. Organ deformations are mostly responsible for this variation. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2014 ","pages":"687365"},"PeriodicalIF":0.0,"publicationDate":"2014-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/687365","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32227544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17