Biological Psychiatry最新文献

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The Interplay Between Sleep and Mental Health: A Genetic Perspective. 睡眠和心理健康之间的相互作用:遗传学的观点。
IF 9.6 1区 医学
Biological Psychiatry Pub Date : 2025-07-04 DOI: 10.1016/j.biopsych.2025.06.024
Nataliia Kozhemiako, Carol Mita, Georgia M Panagiotaropoulou, Katie Js Lewis, Tamar Sofer, Shaun M Purcell
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引用次数: 0
Mapping cerebellar connectivity to cognition in psychosis: Convergent evidence from fMRI and TMS. 在精神病中绘制小脑连通性与认知:来自fMRI和TMS的趋同证据。
IF 9.6 1区 医学
Biological Psychiatry Pub Date : 2025-07-03 DOI: 10.1016/j.biopsych.2025.06.023
Hengyi Cao, Miklos Argyelan, Joanna Yan, Halil Aziz Velioglu, Franky Fang, Andrea Joanlanne, Simran Kang, Lara Prizgint, Jenna Schugart, Kadeem Brown, John Cholewa, Philip Watson, Sunny X Tang, Ricardo Carrion, Jose Rubio, Moein Foroughi, Todd Lencz, Anil K Malhotra
{"title":"Mapping cerebellar connectivity to cognition in psychosis: Convergent evidence from fMRI and TMS.","authors":"Hengyi Cao, Miklos Argyelan, Joanna Yan, Halil Aziz Velioglu, Franky Fang, Andrea Joanlanne, Simran Kang, Lara Prizgint, Jenna Schugart, Kadeem Brown, John Cholewa, Philip Watson, Sunny X Tang, Ricardo Carrion, Jose Rubio, Moein Foroughi, Todd Lencz, Anil K Malhotra","doi":"10.1016/j.biopsych.2025.06.023","DOIUrl":"10.1016/j.biopsych.2025.06.023","url":null,"abstract":"<p><strong>Background: </strong>Cerebellar dysfunction is strongly implicated in both cognition and psychosis, and the \"cognitive dysmetria\" hypothesis posits cognition as the intermediary in the pathway from cerebellar dysfunction to psychopathology. However, the nuanced cerebellum-behavior relationships in psychosis remain unclear. Establishing such link is crucial to understand cerebellar mechanisms and to identify treatment target for cognitive deficits in patients.</p><p><strong>Methods: </strong>We studied 100 patients with early psychosis from the Human Connectome Project Early Psychosis study. Connectome-based predictive modeling was conducted to probe cognitive functions most predicted by cerebellar connectivity. Mediation analysis was performed to test a mediating role of cognition between cerebellar connectivity and symptoms. To further support the causality of the findings, we additionally recruited 16 psychotic patients for a 2-week randomized, sham-controlled cerebellar transcranial magnetic stimulation (TMS) trial.</p><p><strong>Results: </strong>Cerebellar connectivity significantly predicted three cognitive functions, namely, verbal ability, working memory, and cognitive flexibility. Verbal ability fully mediated the relationship between cerebellar connectivity and negative symptoms, in particular alogia. While each cognitive function was predicted by a distinct cerebellar connectivity pattern, the left crus I/II appeared to be a common area with connectivity consistently predicting all three functions. Stimulating this region via TMS showed significantly improved cognitive composite score and medium-to-large effects on scores for memory, verbal, and executive functions.</p><p><strong>Conclusions: </strong>These findings suggest a potential causal pathway from cerebellar connectivity to domain-specific cognitive deficits and psychopathology in schizophrenia. Moreover, they also point to the cerebellum as a potential target for the treatment of cognitive dysfunction in psychotic disorders.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological Psychiatry: A Brief Note of Thanks. 生物精神病学:简短的感谢。
IF 9.6 1区 医学
Biological Psychiatry Pub Date : 2025-07-02 DOI: 10.1016/j.biopsych.2025.06.019
John H Krystal
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引用次数: 0
Blind Mice, African Clawed Frogs, and the Missing Link Between Circadian Rhythms and Psychiatry 盲鼠,非洲爪蛙,昼夜节律和精神病学之间缺失的一环
IF 9.6 1区 医学
Biological Psychiatry Pub Date : 2025-06-25 DOI: 10.1016/j.biopsych.2025.05.004
Alexandra Saali , David A. Ross , Joseph J. Cooper , Andrew M. Novick
{"title":"Blind Mice, African Clawed Frogs, and the Missing Link Between Circadian Rhythms and Psychiatry","authors":"Alexandra Saali ,&nbsp;David A. Ross ,&nbsp;Joseph J. Cooper ,&nbsp;Andrew M. Novick","doi":"10.1016/j.biopsych.2025.05.004","DOIUrl":"10.1016/j.biopsych.2025.05.004","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"98 2","pages":"Pages 102-104"},"PeriodicalIF":9.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Board Page 编委会页面
IF 9.6 1区 医学
Biological Psychiatry Pub Date : 2025-06-25 DOI: 10.1016/S0006-3223(25)01226-0
{"title":"Editorial Board Page","authors":"","doi":"10.1016/S0006-3223(25)01226-0","DOIUrl":"10.1016/S0006-3223(25)01226-0","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"98 2","pages":"Page A1"},"PeriodicalIF":9.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating the Causal Landscape of Psychiatric Disorders With PsyRiskMR 使用PsyRiskMR导航精神疾病的因果图景
IF 9.6 1区 医学
Biological Psychiatry Pub Date : 2025-06-25 DOI: 10.1016/j.biopsych.2025.04.024
Shenggeng Lin , Yi Xiong
{"title":"Navigating the Causal Landscape of Psychiatric Disorders With PsyRiskMR","authors":"Shenggeng Lin ,&nbsp;Yi Xiong","doi":"10.1016/j.biopsych.2025.04.024","DOIUrl":"10.1016/j.biopsych.2025.04.024","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"98 2","pages":"Pages 96-98"},"PeriodicalIF":9.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscribers Page 用户页面
IF 9.6 1区 医学
Biological Psychiatry Pub Date : 2025-06-25 DOI: 10.1016/S0006-3223(25)01227-2
{"title":"Subscribers Page","authors":"","doi":"10.1016/S0006-3223(25)01227-2","DOIUrl":"10.1016/S0006-3223(25)01227-2","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"98 2","pages":"Page A2"},"PeriodicalIF":9.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heightened anxiety with distinct prefrontal substrates is differentially sensitive to the anxiolytics, citalopram and ketamine: Prefrontal substrates and anxiolytic sensitivity 具有不同前额叶底物的高度焦虑对抗焦虑药、西酞普兰和氯胺酮的敏感性不同:前额叶底物和抗焦虑药敏感性
IF 10.6 1区 医学
Biological Psychiatry Pub Date : 2025-06-25 DOI: 10.1016/j.biopsych.2025.06.013
Kevin G. Mulvihill, Gemma J. Cockcroft, Angela C. Roberts
{"title":"Heightened anxiety with distinct prefrontal substrates is differentially sensitive to the anxiolytics, citalopram and ketamine: Prefrontal substrates and anxiolytic sensitivity","authors":"Kevin G. Mulvihill, Gemma J. Cockcroft, Angela C. Roberts","doi":"10.1016/j.biopsych.2025.06.013","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.06.013","url":null,"abstract":"Individual variability in pharmacological treatment efficacy remains a persistent obstacle to ameliorating clinical anxiety. This may originate, in part, from the different neural aetiologies underlying pathological anxiety. To provide novel insights into patient heterogeneity in anxiolytic responsiveness we compare the efficacy of distinct anxiolytic drugs, a Selective Serotonin Re-uptake Inhibitor (SSRI) and ketamine on anxiety states with different aetiologies, but of known origin, in marmoset monkeys.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"70 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144503874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guide for Authors 作者指南
IF 9.6 1区 医学
Biological Psychiatry Pub Date : 2025-06-25 DOI: 10.1016/S0006-3223(25)01230-2
{"title":"Guide for Authors","authors":"","doi":"10.1016/S0006-3223(25)01230-2","DOIUrl":"10.1016/S0006-3223(25)01230-2","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"98 2","pages":"Pages A5-A10"},"PeriodicalIF":9.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ascribing Molecular Context to Functional Brain Changes in Psychosis 精神病患者脑功能改变的分子背景
IF 9.6 1区 医学
Biological Psychiatry Pub Date : 2025-06-25 DOI: 10.1016/j.biopsych.2025.05.008
Maria A. Di Biase
{"title":"Ascribing Molecular Context to Functional Brain Changes in Psychosis","authors":"Maria A. Di Biase","doi":"10.1016/j.biopsych.2025.05.008","DOIUrl":"10.1016/j.biopsych.2025.05.008","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"98 2","pages":"Pages 99-101"},"PeriodicalIF":9.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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