Biological Psychiatry最新文献

{"title":"Atlas of gray matter volume differences across psychiatric conditions: A systematic review with a novel meta-analysis that considers co-occurring disorders.","authors":"Lydia Fortea, Maria Ortuño, Michele De Prisco, Vincenzo Oliva, Anton Albajes-Eizagirre, Adriana Fortea, Santiago Madero, Aleix Solanes, Enric Vilajosana, Yuanwei Yao, Lorenzo Del Fabro, Eduard Solé Galindo, Norma Verdolini, Alvar Farré-Colomés, Maria Serra-Blasco, Maria Picó-Pérez, Steve Lukito, Toby Wise, Christina Carlisi, Danilo Arnone, Matthew Kempton, Alexander Omar Hauson, Scott Wollman, Carles Soriano-Mas, Katya Rubia, Luke Norman, Paolo Fusar-Poli, David Mataix-Cols, Marc Valentí, Esther Via, Narcis Cardoner, Marco Solmi, Jintao Zhang, Pinglei Pan, Jae Il Shin, Miquel Àngel Fullana, Eduard Vieta, Joaquim Radua","doi":"10.1016/j.biopsych.2024.10.020","DOIUrl":"https://doi.org/10.1016/j.biopsych.2024.10.020","url":null,"abstract":"<p><strong>Background: </strong>Regional gray matter volume (GMV) differences between individuals with mental disorders and comparison subjects may be confounded by co-occurring disorders. To disentangle the disorder-specific GMV correlates, we conducted a large-scale multi-disorder meta-analysis using a novel approach that explicitly models co-occurring disorders.</p><p><strong>Methods: </strong>We systematically reviewed voxel-based morphometry studies indexed in PubMed and Scopus up to January 2023 comparing adults with major mental disorders (anorexia nervosa, schizophrenia-spectrum, anxiety, bipolar, major depressive, obsessive-compulsive, and post-traumatic stress disorders, plus attention-deficit/hyperactivity, autism spectrum, and borderline personality disorders) to comparison subjects. Two authors independently extracted data and assessed quality using the Newcastle-Ottawa Scale. We derived GMV correlates for each disorder using: a) a multi-disorder meta-analysis accounting for all co-occurring mental disorders simultaneously; b) separate standard meta-analyses for each disorder ignoring co-occurring disorders. We assessed the alterations' extent, intensity (effect size), and specificity (inter-disorder correlations and transdiagnostic alterations) for both approaches.</p><p><strong>Results: </strong>We included 433 studies (499 datasets) involving 19,718 patients and 16,441 comparison subjects (51% females, aged 20-67 years). We provide GMV correlate maps for each disorder using both approaches. The novel approach, which accounted for co-occurring disorders, produced GMV correlates that were more focal and disorder-specific (less correlated across disorders and fewer transdiagnostic abnormalities).</p><p><strong>Conclusions: </strong>This work offers the most comprehensive atlas of GMV correlates across major mental disorders. Modeling co-occurring disorders yielded more specific correlates, supporting this approach's validity. The atlas NIfTI maps are available online.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":9.6,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intercalated amygdala dysfunction drives avoidance extinction deficits in the Sapap3 mouse model of obsessive-compulsive disorder.","authors":"Robyn St Laurent, Kelly M Kusche, Ben Rein, Kendall B Raymond, Anatol C Kreitzer, Robert C Malenka","doi":"10.1016/j.biopsych.2024.10.021","DOIUrl":"https://doi.org/10.1016/j.biopsych.2024.10.021","url":null,"abstract":"<p><strong>Background: </strong>The avoidance of aversive stimuli through negative reinforcement learning is critical for survival in real-world environments, which demand dynamic responding to both positive and negative stimuli that often conflict with each other. Individuals with obsessive-compulsive disorder (OCD) commonly exhibit impaired negative reinforcement and extinction, perhaps involving deficits in amygdala functioning. An amygdala subregion of particular interest is the intercalated nuclei of the amygdala (ITC) which has been linked to negative reinforcement and extinction, with distinct clusters mediating separate aspects of behavior. This study focuses on the dorsal ITC cluster (ITC_d) and its role in negative reinforcement during a complex behavior that models real-world dynamic decision making.</p><p><strong>Methods: </strong>We investigated the impact of ITC_d function on negative reinforcement and extinction by applying fiber photometry measurement of GCamp6f signals and optogenetic manipulations during a platform-mediated avoidance task in a mouse model of OCD-like behavior: the Sapap3-null mouse.</p><p><strong>Results: </strong>We find impaired neural activity in the ITC_d of male and female Sapap3-null mice to the encoding of negative stimuli during platform-mediated avoidance. Sapap3-null mice also exhibit deficits in extinction of avoidant behavior, which is modulated by ITC_d neural activity.</p><p><strong>Conclusions: </strong>Sapap3-null mice fail to extinguish avoidant behavior in platform-mediated avoidance, due to heightened ITC_d activity. This deficit can be rescued by optogenetically inhibiting ITC_d during extinction. Together, our results provide insight into the neural mechanisms underpinning negative reinforcement deficits in the context of OCD, emphasizing the necessity of ITC_d in responding to negative stimuli in complex environments.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":9.6,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atomoxetine reduces decisional impulsivity in human cocaine addiction.","authors":"Tsen Vei Lim, Rudolf N Cardinal, Hisham Ziauddeen, Ralf Regenthal, Barbara J Sahakian, Trevor W Robbins, Karen D Ersche","doi":"10.1016/j.biopsych.2024.10.018","DOIUrl":"https://doi.org/10.1016/j.biopsych.2024.10.018","url":null,"abstract":"<p><strong>Background: </strong>Impulsivity is a well-known determinant of maladaptive behaviour in cocaine use disorder, but there are currently no effective strategies for managing excessive impulsivity. Growing evidence from preclinical and clinical studies suggests that atomoxetine, a selective noradrenaline reuptake inhibitor, is effective in improving impulse control in both health and neuropsychiatric conditions.</p><p><strong>Methods: </strong>We investigated the effects of atomoxetine on decisional impulsivity in patients with cocaine use disorder. In a randomised, double-blind, placebo-controlled, crossover study, 28 patients diagnosed with moderate-to-severe cocaine use disorder and 28 matched healthy control participants completed the Cambridge Gamble Task in two separate sessions, where they either received placebo or a single dose of 40 mg atomoxetine on each session. Computational modelling was used to decompose decision-making into three separable components: value, probability, and decisional impulsivity.</p><p><strong>Results: </strong>Our analyses revealed that patients with cocaine use disorder were impaired in all components of decision-making. Atomoxetine selectively reduced decisional impulsivity in cocaine use disorder patients by reducing their risk-seeking tendencies whilst enhancing their ability to tolerate delays. By contrast, atomoxetine did not affect impulsivity in control participants, but increased their sensitivity to prospective losses.</p><p><strong>Conclusion: </strong>Taken together, our findings support the hypothesis of noradrenergic dysfunction in patients with cocaine use disorder and provide novel translational evidence for the efficacy of atomoxetine in remediating decisional impulsivity in cocaine use disorder.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":9.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loneliness and social connection in the mental health crisis.","authors":"Julianne Holt-Lunstad, Katy Sine","doi":"10.1016/j.biopsych.2024.10.019","DOIUrl":"https://doi.org/10.1016/j.biopsych.2024.10.019","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":9.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers Page","authors":"","doi":"10.1016/S0006-3223(24)01632-9","DOIUrl":"10.1016/S0006-3223(24)01632-9","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":9.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left to Languish: A Call to Mitigate the Risk of Intentional Self-Harm and Suicide in Body Dysmorphic Disorder Through Early Intervention","authors":"Michaela Flynn","doi":"10.1016/j.biopsych.2024.09.003","DOIUrl":"10.1016/j.biopsych.2024.09.003","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":9.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in Stress-Related Disorders Viewed Through a Research Domain Criteria Lens","authors":"Rita Valentino","doi":"10.1016/j.biopsych.2024.08.025","DOIUrl":"10.1016/j.biopsych.2024.08.025","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":9.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S0006-3223(24)01635-4","DOIUrl":"10.1016/S0006-3223(24)01635-4","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":9.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S0006-3223(24)01631-7","DOIUrl":"10.1016/S0006-3223(24)01631-7","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":9.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress Vulnerability Exposed by Mapping Brain Network States to Single-Cell Transcriptomes","authors":"Andre Fischer ,&nbsp;Jelena Radulovic","doi":"10.1016/j.biopsych.2024.08.024","DOIUrl":"10.1016/j.biopsych.2024.08.024","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":9.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}