Biological Psychiatry最新文献

{"title":"Reply to: Phenotype, Genetics, and Interpretation: Further Considerations on Atypical Depression.","authors":"Mirim Shin, Ian B Hickie, Jacob J Crouse","doi":"10.1016/j.biopsych.2026.03.1005","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.03.1005","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotype, Genetics, and Interpretation: Further Considerations on Atypical Depression.","authors":"Zheng-Zheng Li, Chuan-Bang Chen","doi":"10.1016/j.biopsych.2026.03.1004","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.03.1004","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk for Autism Across Generations.","authors":"Abraham Reichenberg, Diana Schendel, Mika Gissler, Michaeline Bresnahan, Richard Francis, Stephen Z Levine, Andre Sourander, Erik T Parner, Gayle C Windham, Benjamin H K Yip, Stefan N Hansen, Helen Leonard, Bernard Devlin, Magdalena Janecka, Arad Kodesh, Sven Sandin","doi":"10.1016/j.biopsych.2026.04.023","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.04.023","url":null,"abstract":"<p><strong>Background: </strong>Autism spectrum disorder (ASD) has a complex inheritance pattern and is more common in males. Etiological models suggest that majority of ASD risk is transmitted through common and rare de-novo genetic variation. It has been hypothesized that rare variation could be inherited and therefore contribute to the overall risk-burden in subsequent generations, especially through female lineage in disorders with male-skewed sex-ratios. Here we test this hypothesis using multigeneration information on paternal age, because burden of de-novo mutations has been linked to paternal age, and there is a well-established association between older age of fathers and ASD.</p><p><strong>Methods: </strong>We analyzed combined data from Sweden's, Denmark's and Finland's national registers totaling 12.6 million family-members, including information about parental ages at the time of birth of offspring in two generations, and ASD diagnosis in the third generation.</p><p><strong>Results: </strong>Among the 1,808,892 children in the third generation, 23,397 (1.29%) were diagnosed with ASD. Increased paternal age at the time of birth of a daughter was associated with increased risk of ASD in the daughter's own offspring. Increased paternal age at the time of birth of a son was not associated with increased ASD risk in the son's offspring, nor was older maternal age in the first or second generations. We observed that young maternal age at birth of a son or a daughter was associated with ASD risk in their offspring.</p><p><strong>Conclusions: </strong>Collectively, our results suggest that etiologic risk-factors for ASD could extend over multiple generations through different underlying mechanisms, suggesting new directions for research on genetic and non-genetic risk-factors.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural Brain Network Alterations in Relation to Treatment and Illness Severity in Bipolar Disorder.","authors":"Leila Nabulsi, Melody J Y Kang, Neda Jahanshad, Genevieve McPhilemy, Fiona M Martyn, Bartholomeus Haarman, Colm McDonald, Brian Hallahan, Stefani O'Donoghue, Dan J Stein, Fleur M Howells, Freda Scheffler, Henk S Temmingh, David C Glahn, Amanda Rodrigue, Edith Pomarol-Clotet, Eduard Vieta, Joaquim Radua, Raymond Salvador, Andriana Karuk, Erick J Canales-Rodríguez, Josselin Houenou, Pauline Favre, Mircea Polosan, Arnaud Pouchon, Paolo Brambilla, Marcella Bellani, Philip B Mitchell, Gloria Roberts, Udo Dannlowski, Tiana Borgers, Susanne Meinert, Kira Flinkenflügel, Jonathan Repple, Elisabeth J Leehr, Dominik Grotegerd, Tim Hahn, Michèle Wessa, Mary L Phillips, Lea Teutenberg, Tilo Kircher, Benjamin Straube, Olaf Steinstraeter, Frederike Stein, Florian Thomas-Odenthal, Nina Alexander, Paula L Usemann, Andreas Jansen, Michael Berk, Orwa Dandash, Nadine Parker, Chao Suo, Sophia I Thomopoulos, Paul M Thompson, Ole A Andreassen, Christopher R K Ching, Dara M Cannon","doi":"10.1016/j.biopsych.2026.04.020","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.04.020","url":null,"abstract":"<p><strong>Background: </strong>Large-scale T1-weighted MRI studies have established grey-matter abnormalities in bipolar disorder (BD), with our group contributing to consensus findings. However, structural connectivity, particularly within emotion- and reward-related circuits, remains poorly understood. Diffusion-weighted MRI (dMRI) enables investigation of white-matter pathways, yet prior work is constrained by small samples, methodological heterogeneity, and unclear medication effects. We conducted the largest dMRI network analysis in BD, relating symptom burden and polypharmacy to tractography-derived connectivity and graph-theoretic metrics.</p><p><strong>Methods: </strong>Cross-sectional structural and diffusion MRI scans from 449 individuals with BD (35.7±12.6 years) and 510 controls (33.3±12.6 years), aged 18-65, were analyzed across 16 ENIGMA-BD sites. Standardized segmentation/parcellation and constrained spherical deconvolution tractography generated individual structural connectivity matrices. Graph-theoretic metrics of global and subnetwork organization were related to symptom severity and medications.</p><p><strong>Results: </strong>BD showed widespread network alterations (lower density and efficiency, longer path length, and higher betweenness centrality), altered microstructural organization in a limbic-basal ganglia circuit, and abnormal streamline counts in a default-mode/salience/fronto-limbic-basal ganglia network. Longer illness duration, later onset, and psychosis history were associated with greater abnormalities in network architecture, whereas more manic episodes were associated with greater fronto-limbic connectivity. Antidepressant (particularly SSRI), anticonvulsant, and antipsychotic use related to poorer global and fronto-limbic connectivity; no clear lithium effects emerged.</p><p><strong>Conclusions: </strong>As the largest structural connectivity study in BD, we reveal widespread disruption in reward and emotion-regulation networks influenced by illness severity and medication use. Results show that multisite harmonization is feasible and highlight ENIGMA-BD as a scalable framework for identifying reproducible neurobiological markers.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive Symptoms Are Associated with Altered Development of Amygdala-Ventrolateral Prefrontal Connectivity During Implicit Emotion Regulation Across Adolescence.","authors":"Jessica P Uy, Justin P Yuan, Julian Joachimsthaler, Ian H Gotlib","doi":"10.1016/j.biopsych.2026.04.021","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.04.021","url":null,"abstract":"<p><strong>Background: </strong>Adolescence is characterized by extensive development in neural circuits that support emotion processing and regulation, and by increased risk for depression. While altered frontolimbic functioning during emotion processing has been implicated in youth with depression relative to healthy controls, the directions of the associations have been inconsistent.</p><p><strong>Methods: </strong>We examined the longitudinal association between depressive symptoms and frontoamygdala connectivity during implicit regulation of negative emotions (affect labeling) across adolescence in 193 participants (116F/77M) who completed four assessments (age 9-13 years at baseline), each two years apart. We first used latent class mixed modeling to identify classes (groups) with similar trajectories of depressive symptom development. We then conducted generalized additive mixed models to test whether these groups differed in trajectories of amygdala-ventrolateral prefrontal cortex (VLPFC) connectivity during negative affect labeling using psychophysiological interaction analysis.</p><p><strong>Results: </strong>We identified two groups: a group with consistently lower symptoms (\"low symptoms\") and a group with higher and steeper increases in symptoms (\"high symptoms\"). These groups differed in their trajectories of right amygdala-left VLPFC connectivity during affect labeling. Right amygdala-left VLPFC connectivity during implicit regulation of negative emotions decreased over time for the high symptoms group, becoming more strongly negative by mid-to-late adolescence relative to the low symptoms group, for whom connectivity was relatively stable across adolescence.</p><p><strong>Conclusions: </strong>The functioning of the right amygdala-left VLPFC circuit during implicit emotion regulation might be an age-dependent neurobiological marker and target of intervention for depressive symptoms in adolescence.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RAs) for Mood Disorders and Suicide Risk.","authors":"Roger S McIntyre","doi":"10.1016/j.biopsych.2026.04.019","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.04.019","url":null,"abstract":"<p><p>A strategic imperative in mood disorders is to identify innovative mechanisms that translate into improved therapeutics when compared to the extant options. More specifically, there is a need for treatments with greater efficacy, shorter time-to-peak efficacy, greater durability of effect as well as improved tolerability profiles. Moreover, priority has also shifted towards identifying mood disorder therapeutics capable of targeting domains of psychopathology that are most pervasive, debilitating and inadequately treated by conventional pharmacology (e.g., anhedonia, cognitive impairment). Available preclinical, translational, observational and clinical data suggest that glucagon-like peptide-1 receptor agonists (GLP-1 RAs) hold promise as potentially mechanistically-informed therapeutics in persons with mood disorder. Although metabolic effectors are implicated as a putative mechanism of action of GLP-1RAs, non-mutually exclusive targets also include direct effects on neuroplasticity, neurogenesis, neurodifferentiation, neuroprotection, anti-apoptotic and autophagy mechanisms. Available evidence does support origination of adequate and well-controlled clinical studies in both major depressive disorder and bipolar disorder as acute and/or maintenance treatments. Although association with suicidality and GLP-1RAs have been reported, causality has not been established. Moreover, preliminary evidence suggests that GLP-1RAs may benefit aspects of mood disorder psychopathology (e.g., reward) that may be predictive of potential beneficial effects on aspects of suicidality.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facilitating Thought Progression: A Neurocognitive Framework Linking Thought Dynamics and Mood Disorders.","authors":"Moshe Bar, Shira Baror","doi":"10.1016/j.biopsych.2026.04.018","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.04.018","url":null,"abstract":"<p><p>Mood and thought are tightly coupled, but the mechanisms linking them are not understood. This link is particularly important when considering mood disorders such as depression. We propose the Facilitating Thought Progression (FTP) framework, which characterizes depression as a disorder of thought dynamics, encompassing both the temporal evolution and semantic expanse of mental activity. Five parameters jointly determine the fluency of thought progression: breadth, speed, flexibility, novelty, and scope. Diminished progression, reflected by repetitive, slow, and narrowed thinking, is associated with excessive inhibition, reduced plasticity, blunted reward signalling, and overly deep attractor dynamics. Conversely, interventions that enhance associative expansion, cognitive flexibility, and exploratory behaviour restore adaptive brain dynamics. FTP reframes depression as a disorder of cognitive flow rather than content, and provides a mechanistic, testable model for translational research.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Ventral Tegmental Local Field Potentials in Treatment-Resistant Depression and Obsessive-Compulsive Disorder.","authors":"Juan Carlos Baldermann, Selina S Rolker, Manuel Czornik, Dora M Meyer-Doll, Bastian E A Sajonz, Marie Kost, Stefan Vestring, Claus Normann, Dominique Endres, Katharina Domschke, Thomas E Schlaepfer, Volker A Coenen","doi":"10.1016/j.biopsych.2026.04.015","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.04.015","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Biological Psychiatry Family of Journals Is Rewarding Its Reviewers.","authors":"John H Krystal, Cameron S Carter, Rhiannon M Bugno, Deanna Barch","doi":"10.1016/j.biopsych.2026.04.014","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.04.014","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"753. Childhood Adversity and Mood Disorders: The Mediating Role of Relationship Styles","authors":"Luka Vukovic, Van-Han-Alex Chung, Florian Marais, Warren Caldwell, Nancy Low","doi":"10.1016/j.biopsych.2026.03.990","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.03.990","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"6 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147752692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}