Biological Psychiatry最新文献

{"title":"Adaptive Hypervigilance Following Chronic Social Aggression: A Synapse-Specific, Subcortical Mechanism","authors":"Lindsay R. Halladay","doi":"10.1016/j.biopsych.2025.08.011","DOIUrl":"10.1016/j.biopsych.2025.08.011","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"98 10","pages":"Pages 731-732"},"PeriodicalIF":9.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basolateral Amygdala Memory in the Fourth Dimension","authors":"Hadley C. Bergstrom","doi":"10.1016/j.biopsych.2025.08.017","DOIUrl":"10.1016/j.biopsych.2025.08.017","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"98 10","pages":"Pages 726-727"},"PeriodicalIF":9.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145289594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S0006-3223(25)01466-0","DOIUrl":"10.1016/S0006-3223(25)01466-0","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"98 10","pages":"Page A1"},"PeriodicalIF":9.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145289589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S0006-3223(25)01470-2","DOIUrl":"10.1016/S0006-3223(25)01470-2","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"98 10","pages":"Pages A5-A10"},"PeriodicalIF":9.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145289592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers Page","authors":"","doi":"10.1016/S0006-3223(25)01467-2","DOIUrl":"10.1016/S0006-3223(25)01467-2","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"98 10","pages":"Page A2"},"PeriodicalIF":9.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145289590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Generational Embedding of Adverse Childhood Experiences","authors":"Moshe Szyf","doi":"10.1016/j.biopsych.2025.08.016","DOIUrl":"10.1016/j.biopsych.2025.08.016","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"98 10","pages":"Pages 728-730"},"PeriodicalIF":9.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145289595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial neural biomarkers of psychiatric symptoms and their utility for guiding neuromodulation therapy: a systematic review.","authors":"Katherine E Kabotyanski, Nicole R Provenza, Sameer A Sheth","doi":"10.1016/j.biopsych.2025.10.005","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.10.005","url":null,"abstract":"<p><p>The quest to develop and improve neuromodulatory therapies for treatment-resistant psychiatric disorders has been fueled by the discovery of intracranial neural biomarkers of symptom dimensions. These neural correlates shed light on the underlying neurophysiology of the disorder and may even be useful in guiding therapy delivery. This systematic review summarizes recent efforts in this field relating neural activity to behavior and symptomatology. For years, the majority of these neurobehavioral relationships had been studied in the hospital or clinic environment. Recent technological advances in implanted neuromodulation devices that permit not only stimulation, but also intracranial neural recording have enabled this research to move into natural settings, recording for longer periods of time in the real world. We review this combined literature to identify neurobehavioral relationships that show commonalities across these different recording strategies and environments. We also discuss potential ways to use this information for guiding neuromodulation therapy. The success of \"closed loop\" stimulation strategies for movement disorders and epilepsy has led to interest in exploring similar approaches for psychiatric disorders. Such efforts, however, need to consider the disorder-specific time constant relating changes in a neural biomarker to changes in symptoms and behavior. This relationship likely differs between Parkinson's disease and depression, OCD, or addiction. We interpret the results of our systematic review in this light to offer suggestions for future closed-loop or \"clinician in the loop\" implementations to inform the next generation of neuromodulatory therapies.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Shared Cardiovascular Factors and Genetic Overlap of Pregnancy-Related Disorders, Major Depressive Disorder, and Alzheimer's Disease.","authors":"Hannah Oppenheimer, Alexey Shadrin, Jonas Ø Andersen, Louise S Schindler, Arielle Crestol, Ole A Andreassen, Lars T Westlye, Ann-Marie G de Lange, Dennis van der Meer, Claudia Barth","doi":"10.1016/j.biopsych.2025.09.018","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.09.018","url":null,"abstract":"<p><strong>Background: </strong>Pregnancy-related disorders, such as hypertensive disorders of pregnancy (HDP) and postpartum depression, have consequences for maternal health, increasing risk for major depressive disorder (MDD) and Alzheimer's disease (AD). Observational studies show intertwined pathophysiologies and shared cardiovascular factors. However, genetic links of cardiovascular factors with pregnancy-related disorders, MDD, and AD, as well as the genetic mechanisms between the disorders, have not been fully established.</p><p><strong>Methods: </strong>Using summary statistics from female-specific genome-wide association studies, we estimated genetic correlations and causal associations, using Mendelian randomization, between cardiovascular factors (C-reactive protein, HDL-cholesterol, LDL-cholesterol, and triglycerides), pregnancy-related disorders (HDP and postpartum depression), MDD, and AD. For significant associations, BMI, as a known confounder, was included in multivariable Mendelian randomization analyses. Further, we applied causal mixture models (MiXeR) to explore polygenic overlap between pregnancy-related disorders, MDD, and BMI.</p><p><strong>Results: </strong>We found widespread genetic correlations between cardiovascular factors, pregnancy-related disorders, and MDD. Using Mendelian randomization, higher triglycerides and lower HDL-cholesterol were causally linked to higher HDP risk, and higher LDL-cholesterol to higher AD risk. When including BMI, only the effect of triglycerides on HDP remained significant. Trivariate MiXeR estimated substantial polygenic overlap of pregnancy-related disorders with MDD and BMI.</p><p><strong>Conclusions: </strong>Using multiple genetic approaches, our findings indicate some shared cardiovascular factors associated with pregnancy-related disorders, MDD, and AD, partly driven by BMI. BMI should be further explored as a modifiable factor genetically linked to pregnancy-related, mental, and brain disorders. Our findings highlight the relevance of early prevention of genetically interconnected disorders across the female lifespan.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GABAergic neuroactive steroids and network states: relevance to peripartum depression.","authors":"Jamie Maguire, Pantelis Antonoudiou, Kristina M Deligiannidis","doi":"10.1016/j.biopsych.2025.09.019","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.09.019","url":null,"abstract":"<p><p>The Food and Drug Administration's approval of allopregnanolone analogs, which function as positive allosteric modulators at GABA_A receptors, for the treatment of postpartum depression is a major advance in neuroscience research and psychiatry. Neuroactive steroid-based antidepressant effects likely involve the ability to restore network states within and between emotional processing hubs. Here we review the role for steroid hormones and neuroactive steroids, particularly progesterone and allopregnanolone, in preparing the brain for the transition to motherhood. We highlight preclinical and clinical findings which elucidate the networks that are altered in the maternal brain. Further, we summarize the changes in brain networks implicated in peripartum depression. Preclinical and clinical evidence support disrupted network states contributing to peripartum depression and a role for altered GABAergic and neuroactive steroid signaling in its underlying pathophysiology. Recent advances continue in the identification of biomarkers for predicting peripartum depression and the development of the next generation of treatments offer additional promise for the prevention or treatment of peripartum depression.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptional profiling of the cortico-accumbal pathway reveals sex-specific alterations underlying stress susceptibility.","authors":"André Moreira Pessoni, Laila Blanc-Arabe, Luca Pancotti, Samaneh Mansouri, Marco D'Angelo, Karina Huot, Arturo Marroquin Rivera, Modesto R Peralta, Chenqi Zhao, Quentin Leboulleux, Martin Lévesque, Christophe D Proulx, Benoit Labonté","doi":"10.1016/j.biopsych.2025.10.001","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.10.001","url":null,"abstract":"<p><strong>Background: </strong>Anxiety and depressive disorders, including major depressive disorder (MDD), affect millions of people every year, imposing significant socio-economic burdens and highlighting the need to better understand their molecular mechanisms. The medial prefrontal cortex (mPFC) has been identified as a critical brain region in MDD pathology, displaying altered activity and morphology.</p><p><strong>Methods: </strong>We used RNA sequencing in RiboTag mice to uncover transcriptional profiles in mPFC neurons projecting to the nucleus accumbens (NAc) in stressed male and female mice after 21 days of chronic variable stress. Sex-specific gene expression changes were evaluated through differential expression and weighted gene co-expression network analyses. We used viral-mediated gene transfer combined with behavioral analysis, electrophysiological recording, and morphological reconstruction to evaluate the role of target gene programs on stress susceptibility in both sexes.</p><p><strong>Results: </strong>Our analyses revealed distinct transcriptional responses to chronic stress in males and females. Key findings include the identification of the Xlr4b gene as a male-specific hub gene and potential driver for stress susceptibility. The overexpression of Xlr4b in NAc-projecting mPFC neurons induced stress susceptibility in males but not females. Follow-up analyses suggested these effects were mediated by sex-specific changes in the morphological and physiological properties of the cortico-accumbal pathway.</p><p><strong>Conclusion: </strong>Chronic stress induces sex-specific transcriptional alterations in NAc-projecting mPFC neurons. Some of these alterations change the morphological and functional properties of neuronal pathways, ultimately contributing to the differential manifestation of anxiety-like and depressive-like behaviors in male and female mice.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}