Biological Psychiatry最新文献

{"title":"Left and Right Hemispheric Lateralization as an Overlooked Variable in Psychiatric Disease: Evidence Across Species","authors":"Michael Ojo, Heather N. Allen, Benedict Kolber","doi":"10.1016/j.biopsych.2025.07.010","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.07.010","url":null,"abstract":"Despite centuries of reports documenting both anatomical and functional brain asymmetries, lateralization as an experimental variable remains largely overlooked in preclinical studies focusing on psychiatric disorders. Recent work has identified standard functional and neuroanatomical asymmetries as well as shifts in typical lateralization in the context of diseased states in model organisms. We have collected and examined studies that investigate the contributions of brain areas in the left and/or right hemisphere in the modulation of emotion and affective processing and discuss the contributions of these areas to functional lateralization of psychiatric processing. We focus our review first on describing documentation of anatomical and functional asymmetries that exist in the healthy brain as well as relevant hypotheses for the evolution of lateralization. We then dissect the literature to extract evidence for left/right differences and review these studies to highlight evidence for hemispheric lateralization in several psychiatric areas. The specific focus is on the preclinical literature to emphasize the utility of accessible model organisms to study a fundamental feature of normal and abnormal affective neural processing. As momentum continues to shift towards a renewed appreciation of lateralization across species, the study of anatomical and functional asymmetries at the preclinical level will yield novel insights into psychiatric disease in the coming years. Overall, this review summarizes the existing literature, emphasizes remaining questions, and discusses possible mechanisms for shifts in lateralization associated with psychiatric disorders.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"222 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural connectome architecture shapes cortical atrophy in major depression disorder: a Chinese DIRECT consortium study.","authors":"Yuhao Shen, Chunli Wang, Xiao Chen, Bin Lu, Xue-Ying Li, Zi-Han Wang, Li-Ping Cao, Guan-Mao Chen, Jian-Shan Chen, Tao Chen, Tao-Lin Chen, Yu-Qi Cheng, Zhao-Song Chu, Shi-Xian Cui, Xi-Long Cui, Zhao-Yu Deng, Qi-Yong Gong, Wen-Bin Guo, Can-Can He, Zheng-Jia-Yi Hu, Qian Huang, Xin-Lei Ji, Feng-Nan Jia, Li Kuang, Bao-Juan Li, Feng Li, Hui-Xian Li, Tao Li, Tao Lian, Yi-Fan Liao, Xiao-Yun Liu, Yan-Song Liu, Zhe-Ning Liu, Yi-Cheng Long, Jian-Ping Lu, Jiang Qiu, Xiao-Xiao Shan, Tian-Mei Si, Peng-Feng Sun, Chuan-Yue Wang, Hua-Ning Wang, Xiang Wang, Ying Wang, Yu-Wei Wang, Xiao-Ping Wu, Xin-Ran Wu, Yan-Kun Wu, Chun-Ming Xie, Guang-Rong Xie, Peng Xie, Xiu-Feng Xu, Zhen-Peng Xue, Hong Yang, Hua Yu, Min-Lan Yuan, Yong-Gui Yuan, Ai-Xia Zhang, Jing-Ping Zhao, Ke-Rang Zhang, Wei Zhang, Zi-Jing Zhang, Chao-Gan Yan, Jiajia Zhu, Yongqiang Yu","doi":"10.1016/j.biopsych.2025.06.030","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.06.030","url":null,"abstract":"<p><strong>Background: </strong>Cortical morphological alterations are evident in major depressive disorder (MDD), yet the underlying neurobiological processes that contribute to their characteristic spatial pattern remain unclear.</p><p><strong>Methods: </strong>Large-scale, multi-site structural MRI data from a homogeneous Chinese cohort of 1,442 MDD patients and 1,277 healthy controls were used to calculate cortical morphological measures, which were compared between groups to determine cortical morphological alterations in MDD. A connectome constraint model was then used to examine whether structural connectome shapes MDD-related cortical morphological alterations, followed by performance of a network diffusion model to identify the epicenters.</p><p><strong>Results: </strong>Group comparisons demonstrated a broadly distributed cortical thickness (CT) reduction in MDD, with the prefrontal cortex affected more prominently. Based on the normative structural connectome, we derived the estimated CT alteration of each brain node according to its connected neighbors, and found a strong spatial correlation between the empirical and estimated CT alterations, indicating structural connectome constraint on cortical atrophy in MDD. Concurrently, we identified the left lateral prefrontal cortex as the putative epicenters of cortical atrophy. Moreover, analyses across first-episode, early-stage, and chronic MDD subgroups revealed reduced connectome constraint with increasing illness duration. Additionally, our results were robust against several methodological variations and were largely reproducible in the cross-ethnic ENIGMA cohort of 1,902 MDD patients and 7,658 controls.</p><p><strong>Conclusions: </strong>These findings represent a substantial advance in our understanding of the network-based spread of cortical atrophy in MDD and highlight the prospect of the left prefrontal cortex as a key target for early interventions.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nicotine disrupts top down habenular control over cholinergic inputs to the ventral tegmental area to increase motivational valence of food rewards","authors":"Renan C. Campos, Fabio Marti, Daiana Rigoni, Hugo Fofo, Paula Pousinha, Vanesa Ortiz, Léa Royon, Marion Violain, Nicolas Heck, Philippe Faure, Mariano Soiza-Reilly, Sebastian P. Fernandez, Jacques Barik","doi":"10.1016/j.biopsych.2025.06.036","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.06.036","url":null,"abstract":"Tobacco use significantly impacts reward-driven behavior, leading to comorbidities across a lifetime. While the addictive properties of nicotine are well-studied, its effects on cellular mechanisms beyond drug-seeking behaviors remain elusive. Here we investigate the circuit alterations that parallel drug-related behaviors.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"23 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytokines as neuromodulators: insights from experimental studies in humans and non-human primates","authors":"Daniel Martins, Neil A. Harrison","doi":"10.1016/j.biopsych.2025.06.037","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.06.037","url":null,"abstract":"Beyond their role in immune signalling, cytokines have emerged as key neuromodulators influencing processes including neurotransmitter function, neuronal excitability, synaptic plasticity, neurogenesis, myelination, and cortical sleep-state. These roles are observed in both the healthy brain and during infections when they reorient motivational, cognitive, and emotional responses. Experimental evidence from human and non-human primate immune challenge studies has been pivotal to understanding these effects. By showing that elevated cytokines readily induce transdiagnostic symptoms, including anhedonia, social withdrawal, psychomotor slowing, and cognitive impairment, they have also helped demonstrate that inflammation contributes to the shared neural dysfunction observed across psychiatric and neurological disorders. Cytokines modulate glutamatergic and GABAergic neurotransmission, impair dopaminergic and serotonergic signalling, and regulate homeostatic synaptic scaling, leading to altered network connectivity and behavioural deficits. While research has often focused on single cytokines in isolation, neuroimmune signalling occurs through combinatorial cytokine codes, requiring systems-level approaches to understand their interactive effects. Advances in neuroimaging, molecular neuroscience, and biophysical modelling offer opportunities to link cellular cytokine action with macroscale network dysfunction, enabling mechanistic insights into cytokine-mediated neuromodulation. Clinically, cytokine-targeting therapies hold promise for treating inflammation-driven cognitive and mood disorders, but their long-term impact on neuroplasticity remains uncertain. Future research should characterize immune signatures predictive of neuropsychiatric symptoms, identify cell-type-specific cytokine effects, and integrate multiscale modelling to refine understanding of neuroimmune interactions. Reconceptualising cytokines as fundamental regulators of neural function rather than merely inflammatory mediators is crucial for developing precision medicine to mitigate immune-driven brain dysfunction and improve mental health outcomes.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"14 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain metabolite levels in the post-acute stage of anti-NMDA receptor encephalitis and schizophrenia: a longitudinal case-control study.","authors":"Adriana Fortea, María Ortuño, Mireia Masias, Mar Guasp, Elena De la Serna, Thais Armangue, Inmaculada Baeza, Roger Borràs, Laia Prades, Mirea Rosa-Justicia, Heike Stein, Eloy Martínez-Heras, Albert Compte, Sara Llufriu, Josep Dalmau, Josefina Castro-Fornieles, Gisela Sugranyes","doi":"10.1016/j.biopsych.2025.07.006","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.07.006","url":null,"abstract":"In-vivo assessment of glutamatergic metabolites in patients with anti-NMDA receptor (NMDAR) encephalitis compared to schizophrenia may help understand the pathophysiology of both conditions.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"2 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitigating sex-related biases to elucidate the autism phenotype","authors":"Catherine A. Burrows Ph.D, Jed T. Elison Ph.D., Joseph Piven M.D.","doi":"10.1016/j.biopsych.2025.06.035","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.06.035","url":null,"abstract":"Autism spectrum disorder (ASD) is commonly considered a male-dominant condition, with epidemiological estimates finding that approximately 3-4 males are diagnosed for every female. An overwhelming majority of studies used to establish this sex ratio were conducted with participants ascertained based on having first met clinical criteria, which may obscure qualitative differences between males and females, and omits females who do not meet male-biased criteria. Our recently published data, which used a prospectively-identified sample of children at high-familial likelihood for ASD, corrected for sex-based measurement bias, and used data-driven groupings of behavior over time, were well-suited to address this issue and suggest the male-to-female ratio of autism-related concerns is closer to 1:1. In this review, we propose that research is needed that characterizes the autism phenotype, or behavioral expression of underlying genetic variation in autism-relevant traits. We describe shifts in sample ascertainment, methodological rigor, and scope of traits examined that may help elucidate the autism phenotype. A research program focusing on delineating the genetically-related, biological determinants of clinical disorders has the potential to reveal the full expression of underlying genetic liability for ASD and improve early identification of ASD-related concerns in females.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"7 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Accelerated Intermittent Theta-Burst Stimulation Targeting the Superior Frontal Gyrus on Cognitive Function in Patients with Schizophrenia: A Double-Blind, Randomized, Sham-Controlled Clinical Trial","authors":"Xingjie Peng, Chuhan Song, Yuhan Su, Dongyu Kang, Yuyan Huang, Jingmei Xiao, Jingda Cai, Chuwei Chen, Ping Shao, Renrong Wu","doi":"10.1016/j.biopsych.2025.06.034","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.06.034","url":null,"abstract":"Cognitive impairment is a core symptom of schizophrenia, significantly contributing to poor prognosis. However, effective treatments for cognitive deficits remain limited. Accelerated intermittent theta-burst stimulation (aiTBS) targeting the superior frontal gyrus (SFG) is a promising intervention for cognitive impairment in schizophrenia, though evidence remains scarce. Methods: This double-blind, randomized sham-controlled study involved 66 individuals with schizophrenia, who were randomly assigned to receive either active (<ce:italic>n</ce:italic> = 33) or sham (<ce:italic>n</ce:italic> = 33) aiTBS for 30 sessions (3 times daily for 10 consecutive days). Cognitive improvement was assessed using the MATRICS Consensus Cognitive Battery (MCCB) and additional neuropsychological tests. Voxel-wise whole-brain functional connectivity and spectral dynamic connectivity modelling were also evaluated.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"11 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Cells to Circuits: New Mechanistic Insights From Striatal Interneurons and Microglia Into the Neurobiology of Tourette Syndrome","authors":"Yulia Worbe","doi":"10.1016/j.biopsych.2025.05.022","DOIUrl":"10.1016/j.biopsych.2025.05.022","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"98 3","pages":"Pages 192-194"},"PeriodicalIF":9.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychological Spirals in Eating Disorders: Both Causes and Consequences","authors":"Carrie J. McAdams","doi":"10.1016/j.biopsych.2025.05.018","DOIUrl":"10.1016/j.biopsych.2025.05.018","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"98 3","pages":"Pages 190-191"},"PeriodicalIF":9.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S0006-3223(25)01255-7","DOIUrl":"10.1016/S0006-3223(25)01255-7","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"98 3","pages":"Page A1"},"PeriodicalIF":9.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}