Biological Psychiatry最新文献

{"title":"PROPHYLACTIC KETAMINE: CURRENT KNOWLEDGE AND FUTURE DIRECTIONS.","authors":"Astrid M Cardona-Acosta, Lyonna F Parise, Carlos A Bolaños-Guzmán, Eric M Parise","doi":"10.1016/j.biopsych.2025.03.015","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.03.015","url":null,"abstract":"<p><p>The prevalence of stress-induced disorders, including depression, anxiety, PTSD, and postpartum depression, has been increasing, while current treatment approaches are limited. As a result, researchers are exploring alternative treatments that include ketamine as a prophylactic against these disorders. This review provides an overview of the current knowledge on the use of ketamine as a prophylactic for stress-induced disorders, including preclinical and clinical findings on R,S-ketamine, as well as (2R,6R)- and (2S,6S)-hydroxynorketamine. We also explore the potential underlying mechanisms involved in preventing these disorders, including the brain regions/circuits, as well as glutamatergic, dopaminergic, serotonergic, and inflammatory processes known to be involved, as evidenced by studies with ketamine and its metabolites. Additionally, we highlight the limitations and risks associated with ketamine use, such as age- and sex-specific efficacy, potential long-term and adverse effects, and legal and ethical considerations. Finally, we discuss future research directions, including the implications for clinical practice, integrating ketamine into current treatment approaches, and potential advancements in ketamine-based therapies. Overall, the literature emphasizes the importance of continuing research to better understand the potential benefits and risks of ketamine as a prophylactic for stress-induced disorders.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel multimodal precision medicine approaches and the relevance of developmental trajectories in bipolar disorder.","authors":"Olav B Smeland, Cecilie Busch, Ole A Andreassen, Mirko Manchia","doi":"10.1016/j.biopsych.2025.03.010","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.03.010","url":null,"abstract":"<p><p>There is a pressing need to establish objective measures to improve diagnosis, prediction, prevention and treatment of bipolar disorder (BD). Multimodal artificial intelligence (AI) tools could provide these means by incorporating various layers of data orthogonally related to BD, including genomics and other omics, environmental exposures, imaging measures, electronic health records, cognition, sensing devices and clinical variables. These rapidly evolving AI models hold promise to capture the multidimensional complexity of BD and delineate clinically relevant developmental trajectories that could guide clinical care and therapeutic strategies. In this review, we describe the potential of mapping developmental trajectories underlying BD, outline how novel multimodal models could improve the prediction of BD and related outcomes, and discuss specific clinical use cases and key ethical and practical challenges regarding the development and potential implementation of these multimodal AI solutions to advance precision medicine approaches in BD.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian randomization reveals causalities between DNA methylation and schizophrenia.","authors":"Danni Wang, Danyang Li, Xinglun Dang, Changgai Mu, Chang Liu, Yong Zeng, Yonggui Yuan, Zhaowei Teng, Yifan Li, Xiong-Jian Luo","doi":"10.1016/j.biopsych.2025.03.012","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.03.012","url":null,"abstract":"<p><strong>Background: </strong>Epigenetic factors (such as DNA methylation) have been widely reported to be associated with schizophrenia (SCZ). However, the causal relationships between epigenetic factors and SCZ remain largely unknown.</p><p><strong>Methods: </strong>Here we conducted a Mendelian randomization study to investigate the causal relationships between DNA methylation and SCZ. Brain methylation quantitative trait loci (mQTL) (N = 1,160) and blood mQTL data (N = 27,750) were used as exposures, and genome-wide association data of SCZ (53,386 cases and 77,258 controls) were used as outcome.</p><p><strong>Results: </strong>We identified 172 (mapped to 160 genes) and 157 (mapped to 155 genes) methylation sites whose methylation levels in the brain and blood are causally associated with SCZ, respectively. Among the mapped genes, 36 overlapping genes were identified. Interestingly, three methylation sites (near BRD2, CNNM2, and RERE) showed significant associations in both brain and blood, with the same direction of effect. We further performed MR analysis using brain expression quantitative trait (eQTL) as exposures and identified 123 genes whose expression levels were causally associated with SCZ. Comparing the significant genes from eQTL and brain mQTL prioritized 15 overlapping genes, suggesting that both epigenetic modification and expression of these genes confer risk of SCZ. Finally, we validated our findings with genome editing and animal model experiments.</p><p><strong>Conclusions: </strong>Our study identified methylation sites whose methylation levels are causally associated with SCZ and demonstrated the important roles of epigenetic factors in SCZ. Besides, our findings also reveal pivotal risk genes whose expression and epigenetic regulation are causally associated with SCZ.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurochemical and Circuit Heterogeneity of Cognition-Modulating Prefrontal Corticotropin-Releasing Factor Neurons.","authors":"Spencer K Cooke, Andrea J Martin, Robert C Spencer, Shannon E Nicol, Craig W Berridge","doi":"10.1016/j.biopsych.2025.03.011","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.03.011","url":null,"abstract":"<p><strong>Background: </strong>Impairment of prefrontal cortex (PFC)-dependent cognition is associated with multiple psychiatric disorders. Development of more effective treatments for this form of cognitive dysfunction is hindered by our limited understanding of the neurobiology underlying PFC-dependent cognition. We previously identified a robust population of corticotropin releasing factor (CRF) neurons in the caudal dorsomedial PFC (dmPFC) of rats that impair both working memory and sustained attention. Although the working memory actions of these neurons involved local CRF release, the sustained attention actions were not. These results suggest potential heterogeneity within this population of CRF neurons, including the potential existence of both GABAergic (CRF_GABA) interneurons and glutamatergic (CRF_Glu) CRF projection neurons.</p><p><strong>Methods: </strong>Immunohistochemical analyses first identified both CRF_GABA and CRF_Glu neurons in the caudal dmPFC. Intersectional viral vector chemogenetic approaches were then used to assess the effects of activating caudal dmPFC CRF_Glu and CRF_GABA neurons on working memory and sustained attention in males and females (tested outside of proestrus).</p><p><strong>Results: </strong>CRF_Glu neurons comprised a majority (85%) of caudal dmPFC CRF neurons, while remaining were identified as CRF_GABA neurons. For both females and males, activation of caudal dmPFC CRF_GABA neurons impaired working memory but not sustained attention, while activation of CRF_Glu neurons impaired both working memory and sustained attention. Interestingly, the working memory actions of both CRF_GABA and CRF_Glu neurons were dependent on local CRF receptors.</p><p><strong>Conclusion: </strong>These results advance our understanding of the neurobiology of PFC-dependent cognition and potential mechanisms through which cognitive dysfunction could arise.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S0006-3223(25)00997-7","DOIUrl":"10.1016/S0006-3223(25)00997-7","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 8","pages":"Page A1"},"PeriodicalIF":9.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not All Neuroinflammation Is Created Equal: The Dual Nature of Astrogliosis","authors":"Ebrahim Haroon ,&nbsp;Jennifer C. Felger ,&nbsp;Andrew H. Miller","doi":"10.1016/j.biopsych.2025.01.025","DOIUrl":"10.1016/j.biopsych.2025.01.025","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 8","pages":"Pages 758-760"},"PeriodicalIF":9.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S0006-3223(25)01001-7","DOIUrl":"10.1016/S0006-3223(25)01001-7","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 8","pages":"Pages A5-A10"},"PeriodicalIF":9.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response Quantitative Trait Loci Unveiling Gene-Environment Interactions in Diseases","authors":"Yu Chen ,&nbsp;Xueying Wang ,&nbsp;Chao Chen","doi":"10.1016/j.biopsych.2025.02.003","DOIUrl":"10.1016/j.biopsych.2025.02.003","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 8","pages":"Pages 756-757"},"PeriodicalIF":9.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonic Modulation of Depression-Related Brain Circuits","authors":"Benjamin Zebley,&nbsp;Conor Liston","doi":"10.1016/j.biopsych.2025.02.011","DOIUrl":"10.1016/j.biopsych.2025.02.011","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 8","pages":"Pages 761-763"},"PeriodicalIF":9.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers Page","authors":"","doi":"10.1016/S0006-3223(25)00998-9","DOIUrl":"10.1016/S0006-3223(25)00998-9","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 8","pages":"Page A2"},"PeriodicalIF":9.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}