Biological Psychiatry最新文献

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Biological Psychiatry Pub Date : 2024-09-30 DOI: 10.1016/S0006-3223(24)01564-6

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Biological Psychiatry Pub Date : 2024-09-30 DOI: 10.1016/S0006-3223(24)01567-1

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Leaving an Impression: Morphine-Induced Disruptions to Brain Connectivity Persist Through Abstinence to Prime Future Drug Responses 留下深刻印象：吗啡引起的大脑连接紊乱在戒断后仍会持续，为未来的药物反应打下基础

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Biological Psychiatry Pub Date : 2024-09-30 DOI: 10.1016/j.biopsych.2024.08.012

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Biological Psychiatry Pub Date : 2024-09-30 DOI: 10.1016/S0006-3223(24)01563-4

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Wrapping Our Minds Around Perineuronal Nets: Brevican Influences Nucleus Accumbens Parvalbumin Interneuron Synaptic and Behavioral Plasticity 围绕神经元网络展开讨论：布雷维卡对凹凸核阈下缬氨中间神经元突触和行为可塑性的影响

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Biological Psychiatry Pub Date : 2024-09-30 DOI: 10.1016/j.biopsych.2024.08.013

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Under the Microscope: Nerve Glue and the Evolution of Psychiatric Neuroscience 显微镜下神经胶水与精神神经科学的演变

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Biological Psychiatry Pub Date : 2024-09-30 DOI: 10.1016/j.biopsych.2024.08.017

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Electroencephalographic Analysis of Sleep-Related Subcortical Neuron Activity: A Biomarker for Cocaine Addiction? 睡眠相关皮层下神经元活动的脑电图分析：可卡因成瘾的生物标志物？

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Biological Psychiatry Pub Date : 2024-09-30 DOI: 10.1016/j.biopsych.2024.08.002

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Substance- and Cell-Specific Roles of Mesolimbic Dopamine D3 Receptors 间叶多巴胺 D3 受体的物质和细胞特异性作用

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Biological Psychiatry Pub Date : 2024-09-30 DOI: 10.1016/j.biopsych.2024.08.011

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Value modulation of self-defeating impulsivity. 自我挫败冲动的价值调节。

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Biological Psychiatry Pub Date : 2024-09-28 DOI: 10.1016/j.biopsych.2024.09.017

Zhe Liu, Robert Reiner, Yonatan Loewenstein, Eran Lottem

{"title":"Value modulation of self-defeating impulsivity.","authors":"Zhe Liu, Robert Reiner, Yonatan Loewenstein, Eran Lottem","doi":"10.1016/j.biopsych.2024.09.017","DOIUrl":"https://doi.org/10.1016/j.biopsych.2024.09.017","url":null,"abstract":"Background: Impulse control is a critical aspect of cognitive functioning. Intuitively, whether an action is executed prematurely depends on its associated reward, yet the link between value and impulsivity remains poorly understood. Three frameworks for impulsivity offer contrasting views: impulsive behavior may be valuable because it is associated with hidden internal reward (e.g., reduction of mental effort). Alternatively, it can emerge from exploration, which is disadvantageous in the short term, but can yield long-term benefits. Finally, impulsivity may reflect Pavlovian bias, an inherent tendency that occurs even when its outcome is negative.Methods: To test these hypotheses, we trained seventeen male mice to withhold licking while anticipating variable rewards. We then measured and optogenetically manipulated dopamine release in the ventral striatum.Results: We found that higher reward magnitudes correlated with increased impulsivity. This behavior was well explained by a Pavlovian-bias model. Furthermore, we observed negative dopamine signals during premature licking, suggesting that in this task, impulsivity is not merely an unsuccessful attempt at obtaining a reward. Rather, it is a failure to overcome the urge to act prematurely despite knowledge of the negative consequences of such impulsive action.Conclusion: Our findings underscore the integral role value plays in regulating impulsivity and suggest that the dopaminergic system influences impulsivity through the mediation of value learning.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":9.6,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Sex-Specific Effects of Anxiety on Cognition and Activity-Dependent Neural Networks: Insights from (Female) Mice and (Wo)Men. 焦虑对认知和活动依赖性神经网络的性别特异性影响：来自（雌性）小鼠和（雄性）男子的启示

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2024-09-28 DOI: 10.1016/j.biopsych.2024.09.016

Holly C Hunsberger, Seonjoo Lee, Michelle Jin, Marcos Lanio, Alicia Whye, Jiook Cha, Miranda Scarlata, Louise C Matthews, Keerthana Jayaseelan, Christine A Denny

{"title":"Sex-Specific Effects of Anxiety on Cognition and Activity-Dependent Neural Networks: Insights from (Female) Mice and (Wo)Men.","authors":"Holly C Hunsberger, Seonjoo Lee, Michelle Jin, Marcos Lanio, Alicia Whye, Jiook Cha, Miranda Scarlata, Louise C Matthews, Keerthana Jayaseelan, Christine A Denny","doi":"10.1016/j.biopsych.2024.09.016","DOIUrl":"https://doi.org/10.1016/j.biopsych.2024.09.016","url":null,"abstract":"Introduction: Neuropsychiatric symptoms (NPS), such as depression and anxiety, are observed in 90% of Alzheimer's disease (AD) patients, two-thirds of whom are women. NPS usually manifest long before AD onset creating a therapeutic opportunity. Here, we examined the impact of anxiety on AD progression and the underlying brain-wide neuronal mechanisms.Methods: To gain mechanistic insight into how anxiety impacts AD progression, we performed a cross-sectional analysis on mood, cognition, and neural activity utilizing the ArcCreERT2 x enhanced yellow fluorescent protein (eYFP) x APP/PS1 (AD) mice. The ADNI dataset was used to determine the impact of anxiety on AD progression in human subjects.Results: Female APP/PS1 mice exhibited anxiety-like behavior and cognitive decline at an earlier age than control (Ctrl) mice and male mice. Brain-wide analysis of c-Fos+ revealed changes in regional correlations and overall network connectivity in APP/PS1 mice. Sex-specific eYFP+/c-Fos+ changes were observed; female APP/PS1 mice exhibited less eYFP+/c-Fos+ cells in dorsal CA3 (dCA3), while male APP/PS1 mice exhibited less eYFP+/c-Fos+ cells in the dorsal dentate gyrus (dDG). In the ADNI dataset, anxiety predicted transition to dementia. Female subjects positive for anxiety and amyloid transitioned more quickly to dementia than male subjects.Conclusions: While future studies are needed to understand whether anxiety is a predictor, a neuropsychiatric biomarker, or a comorbid symptom that occurs during disease onset, these results suggest that there are sex differences in AD network dysfunction, and that personalized medicine may benefit male and female AD patients rather than a one size fits all approach.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":9.6,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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