{"title":"The Long Shadow of Early-Life Adversity: Adult Reward Circuit Signatures of Maternal Attention in Infancy","authors":"Gregory A. Fonzo , Charles B. Nemeroff","doi":"10.1016/j.biopsych.2024.09.012","DOIUrl":"10.1016/j.biopsych.2024.09.012","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"96 12","pages":"Pages 904-906"},"PeriodicalIF":9.6,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Importance of Neuroimaging Studies in Early Childhood: Prefrontal Cortex Supports Emotional Development in Infants","authors":"Kathryn Manning, Catherine Lebel","doi":"10.1016/j.biopsych.2024.09.011","DOIUrl":"10.1016/j.biopsych.2024.09.011","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"96 12","pages":"Pages 907-908"},"PeriodicalIF":9.6,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"When ChatGPT Met RDoC: Leveraging Artificial Intelligence to Bridge the Gap Between Data and Prognosis","authors":"Olusola A. Ajilore","doi":"10.1016/j.biopsych.2024.09.020","DOIUrl":"10.1016/j.biopsych.2024.09.020","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"96 12","pages":"Pages 902-903"},"PeriodicalIF":9.6,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Electroconvulsive Therapy and Brain Network Reorganization: Dynamic Connectivity Insights and Implications for the Treatment of Depression and Suicidal Ideation","authors":"Artemis Zavaliangos-Petropulu","doi":"10.1016/j.biopsych.2024.09.007","DOIUrl":"10.1016/j.biopsych.2024.09.007","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"96 12","pages":"Pages e25-e27"},"PeriodicalIF":9.6,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Austin C Korgan, Kathryn Prendergast, Anna M Rosenhauer, Kathleen E Morrison, Tanja Jovanovic, Tracy L Bale
{"title":"Trauma and sensory systems: Biological mechanisms involving the skin and the 17q21 gene cluster.","authors":"Austin C Korgan, Kathryn Prendergast, Anna M Rosenhauer, Kathleen E Morrison, Tanja Jovanovic, Tracy L Bale","doi":"10.1016/j.biopsych.2024.11.003","DOIUrl":"https://doi.org/10.1016/j.biopsych.2024.11.003","url":null,"abstract":"<p><p>Childhood trauma experience increases risk for neuropsychiatric and neurodevelopmental disorders, including posttraumatic stress disorder (PTSD), autism spectrum disorders (ASDs), and attention deficit/hyperactivity disorder (ADHD). While the biological mechanisms connecting adverse experiences with later disease presentation are not clear, the concept of Gene x Environment x Development (GxExD) interactions has significant implications for improving our understanding of these diseases. We recently utilized this approach in a study where we found that women exposed to interpersonal violence trauma (the E) uniquely during adolescence (the D), but not childhood or adulthood, had novel protein biomarkers (the G) associated with a sensory cell system in the skin, Merkel cells. Merkel cell mechanosensory signaling is important in gentle and social touch, inflammation-induced pain, and the skin's neuroendocrine stress response. Further, keratinocyte-derived Merkel cell final maturation occurs during the identified vulnerable period of adolescence. Interestingly, many of the genes identified in our study belong to a known 17q21 gene cluster, suggesting an identifiable location in the genome permanently altered by adolescent trauma. These results form a potential functional link between mechanosensory Merkel cells and the pathology and sensory symptomatology in PTSD. Future research directions could identify specific mechanisms involved in tactile alterations following trauma in hopes of revealing additional biomarkers and potentially leading to novel tactile-involved therapies (e.g., massage, electroacupuncture, or focused ultrasound).</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lydia Fortea, Maria Ortuño, Michele De Prisco, Vincenzo Oliva, Anton Albajes-Eizagirre, Adriana Fortea, Santiago Madero, Aleix Solanes, Enric Vilajosana, Yuanwei Yao, Lorenzo Del Fabro, Eduard Solé Galindo, Norma Verdolini, Alvar Farré-Colomés, Maria Serra-Blasco, Maria Picó-Pérez, Steve Lukito, Toby Wise, Christina Carlisi, Danilo Arnone, Matthew Kempton, Alexander Omar Hauson, Scott Wollman, Carles Soriano-Mas, Katya Rubia, Luke Norman, Paolo Fusar-Poli, David Mataix-Cols, Marc Valentí, Esther Via, Narcis Cardoner, Marco Solmi, Jintao Zhang, Pinglei Pan, Jae Il Shin, Miquel Àngel Fullana, Eduard Vieta, Joaquim Radua
{"title":"Atlas of gray matter volume differences across psychiatric conditions: A systematic review with a novel meta-analysis that considers co-occurring disorders.","authors":"Lydia Fortea, Maria Ortuño, Michele De Prisco, Vincenzo Oliva, Anton Albajes-Eizagirre, Adriana Fortea, Santiago Madero, Aleix Solanes, Enric Vilajosana, Yuanwei Yao, Lorenzo Del Fabro, Eduard Solé Galindo, Norma Verdolini, Alvar Farré-Colomés, Maria Serra-Blasco, Maria Picó-Pérez, Steve Lukito, Toby Wise, Christina Carlisi, Danilo Arnone, Matthew Kempton, Alexander Omar Hauson, Scott Wollman, Carles Soriano-Mas, Katya Rubia, Luke Norman, Paolo Fusar-Poli, David Mataix-Cols, Marc Valentí, Esther Via, Narcis Cardoner, Marco Solmi, Jintao Zhang, Pinglei Pan, Jae Il Shin, Miquel Àngel Fullana, Eduard Vieta, Joaquim Radua","doi":"10.1016/j.biopsych.2024.10.020","DOIUrl":"https://doi.org/10.1016/j.biopsych.2024.10.020","url":null,"abstract":"<p><strong>Background: </strong>Regional gray matter volume (GMV) differences between individuals with mental disorders and comparison subjects may be confounded by co-occurring disorders. To disentangle the disorder-specific GMV correlates, we conducted a large-scale multi-disorder meta-analysis using a novel approach that explicitly models co-occurring disorders.</p><p><strong>Methods: </strong>We systematically reviewed voxel-based morphometry studies indexed in PubMed and Scopus up to January 2023 comparing adults with major mental disorders (anorexia nervosa, schizophrenia-spectrum, anxiety, bipolar, major depressive, obsessive-compulsive, and post-traumatic stress disorders, plus attention-deficit/hyperactivity, autism spectrum, and borderline personality disorders) to comparison subjects. Two authors independently extracted data and assessed quality using the Newcastle-Ottawa Scale. We derived GMV correlates for each disorder using: a) a multi-disorder meta-analysis accounting for all co-occurring mental disorders simultaneously; b) separate standard meta-analyses for each disorder ignoring co-occurring disorders. We assessed the alterations' extent, intensity (effect size), and specificity (inter-disorder correlations and transdiagnostic alterations) for both approaches.</p><p><strong>Results: </strong>We included 433 studies (499 datasets) involving 19,718 patients and 16,441 comparison subjects (51% females, aged 20-67 years). We provide GMV correlate maps for each disorder using both approaches. The novel approach, which accounted for co-occurring disorders, produced GMV correlates that were more focal and disorder-specific (less correlated across disorders and fewer transdiagnostic abnormalities).</p><p><strong>Conclusions: </strong>This work offers the most comprehensive atlas of GMV correlates across major mental disorders. Modeling co-occurring disorders yielded more specific correlates, supporting this approach's validity. The atlas NIfTI maps are available online.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}