Biological Psychiatry最新文献

{"title":"Altered neurobehavioral reward response predicts psychotic-like experiences in youth exposed to cannabis prenatally.","authors":"Carolyn M Amir, Dara G Ghahremani, Sarah E Chang, Ziva D Cooper, Carrie E Bearden","doi":"10.1016/j.biopsych.2025.05.019","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.05.019","url":null,"abstract":"<p><strong>Background: </strong>Rates of prenatal cannabis exposure (PCE) are rising with increasingly permissive legislation, which may be a risk factor for psychosis. Disrupted reward-related neural circuitry may underlie this relationship. We aim to elucidate neural mechanisms involved in the association between PCE and youth-onset psychotic-like experiences (PLEs) by probing correlates of reward anticipation, a neurobehavioral marker of endocannabinoid-mediated dopaminergic function.</p><p><strong>Methods: </strong>This longitudinal, prospective study analyzed task-related functional neuroimaging data from baseline (n=11,368), 2-year follow-up (n=7,928), and 4-year follow-up (n=2,982) of the ongoing Adolescent Brain and Cognitive Development (ABCD) Study, which recruited children aged 9 to 10 years old at baseline from 22 sites across the United States.</p><p><strong>Results: </strong>PCE (n=652 exposed youth) is longitudinally associated with PLEs. Blunted neural response to reward anticipation is associated with PLEs, with stronger effects observed in PCE youth (all |β|> 0.5; false discovery rate [FDR]-corrected P < .05). This baseline hypoactivation predicts PLEs in middle adolescence (β=-.004; FDR-corrected P < .05) and mediates the relationship between PCE and PLEs. Dampened behavioral reward sensitivity is associated with PLEs across visits (|β| = .21; FDR-corrected P < .001). PLEs are positively associated with trait-level measures of reward motivation and impulsivity, with stronger effects for PCE youth (all |β| > 0.1; all FDR-corrected P < .05).</p><p><strong>Conclusions: </strong>Blunted striatal activation may serve as a biomarker for disrupted reward processing and increased psychosis risk during development. PCE may affect childhood behaviors and traits related to altered reward sensitivity.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Future of Immunotherapies for Mental Illness: A Precision Medicine Perspective.","authors":"Gayle M Wittenberg, Rachel Upthegrove, Wayne C Drevets, Husseini K Manji","doi":"10.1016/j.biopsych.2025.05.021","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.05.021","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New genomics discoveries across the bipolar disorder spectrum implicate neurobiological and developmental pathways.","authors":"Kevin S O'Connell, Rolf Adolfsson, Till F M Andlauer, Michael Bauer, Bernhaud Baune, Joanna M Biernacka, Bernardo Carpiniello, Sven Cichon, Nick Craddock, Alfredo B Cuellar-Barboza, Udo Dannlowski, Franziska Degenhardt, Dimitris Dikeos, Panagiotis Ferentinos, Andreas J Forstner, Mark A Frye, Janice M Fullerton, Maria Grigoroiu-Serbanescu, José Guzman-Parra, Lisa Jones, Lina Jonsson, Tilo Kircher, Manolis Kogevinas, Mikael Landén, Jolanta Lissowska, Christine Lochner, Mirko Manchia, Fermin Mayoral, Susan L McElroy, Nathaniel W McGregor, Andreas Meyer-Lindenberg, Philip B Mitchell, Bertram Müller-Myhsok, Markus M Nöthen, George P Patrinos, Joanna M Pawlak, Andreas Reif, Marcella Rietschel, Peter R Schofield, Thomas G Schulze, Alessandro Serretti, Jordan W Smoller, Alessio Squassina, Dan J Stein, Fabian Streit, Beata Świątkowska, Leonardo Tondo, Eduard Vieta, Irwin D Waldman, Anders M Dale, Ole A Andreassen","doi":"10.1016/j.biopsych.2025.05.020","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.05.020","url":null,"abstract":"<p><p>Bipolar disorder (BD) is a highly heritable mental disorder that affects millions of people worldwide. Our understanding of the genetic etiology and biological processes underlying BD have greatly increased in recent years. Extensive progress has been made in identifying common variant signal for BD, and the PGS from the latest GWAS may provide some clinical utility if combined with other risk factors for BD. The role of rare variation in bipolar disorder remains to be determined, although genes annotated to common variant loci are shown to be enriched for rare variation. BD subtypes are shown to differ in their genetic architecture, and as such, genetic studies across the subtypes of the BD spectrum will identify subtype-specific signals and reveal subtype-specific biological mechanisms. Despite this, subtype-specific GWAS sample sizes have not increased at the same rate as BD cases and more concerted efforts are required to obtain this information for participants included in future BD GWAS studies. Moreover, assessment of culture, geography and other systematic differences that might impact patient assessment will be necessary to ensure accurate inclusion of diverse ancestral groups and global representation in genetic studies of BD moving forward.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S0006-3223(25)01156-4","DOIUrl":"10.1016/S0006-3223(25)01156-4","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 12","pages":"Pages A5-A10"},"PeriodicalIF":9.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgments","authors":"","doi":"10.1016/j.biopsych.2025.04.010","DOIUrl":"10.1016/j.biopsych.2025.04.010","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 12","pages":"Pages 1195-1202"},"PeriodicalIF":9.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying Transdiagnostic Aggression Networks: The Role of Lesion Studies","authors":"Karim Ibrahim","doi":"10.1016/j.biopsych.2025.04.006","DOIUrl":"10.1016/j.biopsych.2025.04.006","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 12","pages":"Pages 1113-1115"},"PeriodicalIF":9.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers Page","authors":"","doi":"10.1016/S0006-3223(25)01153-9","DOIUrl":"10.1016/S0006-3223(25)01153-9","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 12","pages":"Page A2"},"PeriodicalIF":9.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Beacon of Hope: Deep Brain Stimulation for Treatment-Refractory Self-Injurious Behavior in Children","authors":"Jordan J. Lo ,&nbsp;Stephen Z. Shapiro ,&nbsp;Lora W. Kahn","doi":"10.1016/j.biopsych.2025.04.005","DOIUrl":"10.1016/j.biopsych.2025.04.005","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 12","pages":"Pages 1106-1107"},"PeriodicalIF":9.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering the Genetic Architecture of Differentiation Between Childhood Behavioral and Emotional Problems: A Predominant Overlap With Neurodevelopmental Conditions","authors":"Geneviève Morneau-Vaillancourt","doi":"10.1016/j.biopsych.2025.04.004","DOIUrl":"10.1016/j.biopsych.2025.04.004","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 12","pages":"Pages 1111-1112"},"PeriodicalIF":9.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S0006-3223(25)01152-7","DOIUrl":"10.1016/S0006-3223(25)01152-7","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 12","pages":"Page A1"},"PeriodicalIF":9.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}