Biological Psychiatry最新文献

{"title":"Depressive Symptoms Are Associated With Altered Development of Amygdala-Ventrolateral Prefrontal Connectivity During Implicit Emotion Regulation Across Adolescence.","authors":"Jessica P Uy, Justin P Yuan, Julian Joachimsthaler, Ian H Gotlib","doi":"10.1016/j.biopsych.2026.04.021","DOIUrl":"10.1016/j.biopsych.2026.04.021","url":null,"abstract":"<p><strong>Background: </strong>Adolescence is characterized by extensive development in neural circuits that support emotion processing and regulation and by increased risk for depression. While altered frontolimbic functioning during emotion processing has been implicated in youths with depression relative to healthy control participants, the directions of the associations have been inconsistent.</p><p><strong>Methods: </strong>We examined the longitudinal association between depressive symptoms and frontoamygdala connectivity during implicit regulation of negative emotions (affect labeling) across adolescence in 193 participants (116 girls/77 boys) who completed 4 assessments (ages 9-13 years at baseline), each 2 years apart. We first used latent class mixed modeling to identify classes (groups) with similar trajectories of depressive symptom development. We then conducted generalized additive mixed models to test whether these groups differed in trajectories of amygdala-ventrolateral prefrontal cortex (VLPFC) connectivity during negative affect labeling using psychophysiological interaction analysis.</p><p><strong>Results: </strong>We identified 2 groups: adolescents with consistently lower symptoms (low symptoms) and adolescents with higher and steeper increases in symptoms (high symptoms). These groups differed in their trajectories of right amygdala-left VLPFC connectivity during affect labeling. Right amygdala-left VLPFC connectivity during implicit regulation of negative emotions decreased over time for the high symptoms group, becoming more strongly negative by middle to late adolescence relative to the low symptoms group, for whom connectivity was relatively stable across adolescence.</p><p><strong>Conclusions: </strong>Functioning of the right amygdala-left VLPFC circuit during implicit emotion regulation might be an age-dependent neurobiological marker and target of intervention for depressive symptoms in adolescence.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":10.3,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13245485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"753. Childhood Adversity and Mood Disorders: The Mediating Role of Relationship Styles","authors":"Luka Vukovic, Van-Han-Alex Chung, Florian Marais, Warren Caldwell, Nancy Low","doi":"10.1016/j.biopsych.2026.03.990","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.03.990","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"6 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147752692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"744. Neural Habituation Deficits in Clinical High-Risk Youth: Evidence From Auditory and Visual P300 Event-Related Potentials (ERP) in the Accelerating Medicines Partnership® Schizophrenia Project","authors":"Carlos Carrasco, Gregory Light, Spero Nicholas, Suzie Lavoie, Thomas Whitford, Brian Roach, Holly Hamilton, Rene Kahn, Patrick McGorry, John Kane, Carrie Bearden, Barnaby Nelson, Scott Woods, Martha Shenton, Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ), Daniel Mathalon","doi":"10.1016/j.biopsych.2026.03.978","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.03.978","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"259 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147752741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"729. Decreased Prefrontal Activity in Remitted Individuals With Bipolar Disorder After Repeated Photobiomodulation Treatment","authors":"Christopher Busby, Erin Logue, Amy Bichlmeier, Douglas Barrett, Farzad Salehpour, Jennifer Siegel-Ramsay, Andreana Haley, Francisco Gonzalez-Lima, Jorge R.C. Almeida","doi":"10.1016/j.biopsych.2026.03.963","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.03.963","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"4 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147752758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"730. Teasing Out the Underlying Structure of Manic Symptoms in Bipolar Disorder","authors":"Ifeoma Akwue, Ley Lacbawan, Heejong Sung, Girma Hawariat, Diana Frank, Ally Freifeld, Emily Besançon, Layla Kassem, Thomas Schulze, Francis McMahon","doi":"10.1016/j.biopsych.2026.03.964","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.03.964","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"3 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147752759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"719. A New Treatment for a New Disorder: Neurostimulation Enhanced Behavioral Therapy for Misophonia","authors":"Andrada Neacsiu, Nimesha Gerlus, Kevin LaBar, Noreen Bukhari-Parlakturk, Zach Rosenthal, Choi Jessica, Shaurya Dave","doi":"10.1016/j.biopsych.2026.03.953","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.03.953","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"21 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147752771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"736. Large-Scale, Real-World Clinical Outcomes in Intravenous (IV) Racemic Ketamine Infusions for Major Depressive Disorder and Bipolar Disorder","authors":"Benjamin Wade, Nicolas Grundmann, Vincent Leonard Holstein, Michael Kritzer, Boyu Ren, Joan Camprodon","doi":"10.1016/j.biopsych.2026.03.970","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.03.970","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"34 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147752751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"727. Test-Retest Reliability of Moment-To-Moment Neural Variability in Resting-State and Task-Based fMRI","authors":"Ondrej Zika, Amirhossein Manzouri, Phoebe Thompson, Timothy J. Silk, Kristoffer Månsson","doi":"10.1016/j.biopsych.2026.03.961","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.03.961","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"13 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147752760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"720. How Brain State Can Be Harnessed to Enhance Neuromodulation Outcomes: A Proof of Concept Discussion","authors":"Andrada Neacsiu, Nimesha Gerlus, Shaurya Dave","doi":"10.1016/j.biopsych.2026.03.954","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.03.954","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"1 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147752768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"714. Transdiagnostic Accelerated TMS: An Open-Label Pilot Study","authors":"Lauren Sanderson, Anjali Chandra, Emma Jones, Leanna Bomer, Natalie Hall, Marina Kare, David Lawson, Nicole Chiulli, Ryan Webler, Sheena Baratono, Irene Gonsalvez, Stanley Lyndon, Michael Fox, Shan Siddiqi, Joseph Taylor","doi":"10.1016/j.biopsych.2026.03.948","DOIUrl":"https://doi.org/10.1016/j.biopsych.2026.03.948","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"3 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147752772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}