Biological Psychiatry最新文献

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Mu Opioid Receptor Activation Is Required for NMDA Receptor Antagonist Effects on Stress-Induced Maladaptive Behavior. NMDA受体拮抗剂对应激诱导的适应不良行为的作用需要Mu阿片受体激活。
IF 9 1区 医学
Biological Psychiatry Pub Date : 2025-07-07 DOI: 10.1016/j.biopsych.2025.07.004
Cory B Langreck, Briana K Chen, Victor M Luna, Mel Nelson, Gergely Turi, Rob Hill, Gilles Rubinstenn, Meritxell Canals, J Robert Lane, Christine A Denny, Jonathan A Javitch
{"title":"Mu Opioid Receptor Activation Is Required for NMDA Receptor Antagonist Effects on Stress-Induced Maladaptive Behavior.","authors":"Cory B Langreck, Briana K Chen, Victor M Luna, Mel Nelson, Gergely Turi, Rob Hill, Gilles Rubinstenn, Meritxell Canals, J Robert Lane, Christine A Denny, Jonathan A Javitch","doi":"10.1016/j.biopsych.2025.07.004","DOIUrl":"10.1016/j.biopsych.2025.07.004","url":null,"abstract":"<p><strong>Background: </strong>Contradictory evidence has emerged regarding the role of the mu opioid receptor (MOR) in the antidepressant actions of (R,S)-ketamine.</p><p><strong>Methods: </strong>Here, we used the long-acting MOR-selective antagonist methocinnamox (MCAM) to determine the contribution of MOR to the actions of (R,S)-ketamine and the more selective NMDA receptor (NMDAR) antagonist fluoroethylnormemantine (FENM) against stress-induced maladaptive behaviors. (R,S)-ketamine enantiomers and metabolites and FENM were assessed for their ability to directly activate MOR in cell signaling assays. (R,S)-ketamine and FENM were tested in various behavioral paradigms with vehicle or MCAM pretreatment. Patch clamp electrophysiology was used to determine the effects of MOR antagonism on ventral hippocampal CA3 glutamatergic activity after (R,S)-ketamine administration.</p><p><strong>Results: </strong>(R,S)-ketamine and its enantiomers showed weak partial agonism of MOR, whereas the potency and efficacy of FENM were negligible. The antinociceptive effect of (R,S)-ketamine was both more potent and more sensitive to blockade by MCAM than that of FENM. When given either before or after stress, both (R,S)-ketamine and FENM reduced behavioral despair. MCAM prevented the effects of both NMDAR antagonists given before or after stress, despite their differences in direct MOR activity and antinociception.</p><p><strong>Conclusions: </strong>MOR activation is required for the efficacy of both (R,S)-ketamine and FENM against stress-induced maladaptive behavior, suggesting that these compounds function through an indirect effect of NMDAR antagonism on endogenous opioid signaling.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Inflammation on White Matter Integrity and Functional Connectivity in Chronic Major Depressive Disorder. 慢性重度抑郁症患者炎症对白质完整性和功能连接的影响。
IF 9 1区 医学
Biological Psychiatry Pub Date : 2025-07-07 DOI: 10.1016/j.biopsych.2025.06.026
Jungho Cha, Divyaansh Raj, Ki Sueng Choi, Justin K Rajendra, Charles B Nemeroff, Jennifer C Felger, W Edward Craighead, Helen S Mayberg, Boadie W Dunlop
{"title":"Impact of Inflammation on White Matter Integrity and Functional Connectivity in Chronic Major Depressive Disorder.","authors":"Jungho Cha, Divyaansh Raj, Ki Sueng Choi, Justin K Rajendra, Charles B Nemeroff, Jennifer C Felger, W Edward Craighead, Helen S Mayberg, Boadie W Dunlop","doi":"10.1016/j.biopsych.2025.06.026","DOIUrl":"10.1016/j.biopsych.2025.06.026","url":null,"abstract":"<p><strong>Background: </strong>Inflammation is increasingly recognized as a pathophysiologic component of major depressive disorder (MDD). Concurrently, depressive episode chronicity has emerged as a significant predictor of adverse long-term outcomes.</p><p><strong>Methods: </strong>Utilizing data from the PReDICT (Predictors of Remission in Depression to Individual and Combined Treatments) study, our analysis included 201 participants who completed C-reactive protein (CRP) sampling and diffusion-weighted imaging scans; of these, 120 participants had usable functional magnetic resonance imaging scans. Chronicity was classified as the presence of a current depressive episode ≥2 years in duration. We examined the impact of inflammation on brain structure and function in MDD, focusing specifically on differences related to chronicity, as well as the interactions between inflammation and functional and structural alterations.</p><p><strong>Results: </strong>No significant correlations were observed between CRP concentrations and either functional connectivity (FC) or fractional anisotropy (FA). In patients with chronic, but not nonchronic, MDD, higher CRP concentrations were associated with lower FA in several neural pathways, including the cingulum and frontal aslant tracts. Significant CRP × MDD chronicity interactions were also observed for FC within the default mode network (DMN) and the salience network (SN). Moreover, mediation analyses demonstrated both direct and FA-mediated effects of CRP on FC within the SN in patients with chronic MDD.</p><p><strong>Conclusions: </strong>Interactions based on depressive episode chronicity between CRP and neurobiological function, potentially mediated by reductions in white matter integrity, suggest a potential pathophysiological process in some patients with chronic MDD. The differences in FC suggest specific compensatory adjustments within the DMN and SN among patients with chronic MDD.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Pathways Between Early Auditory Processing, Processing Speed, Social Cognition, and Negative Symptoms on Social Functioning in Individuals at Clinical High Risk for Psychosis: A Structural Equation Modeling Approach. 探索早期听觉加工、加工速度、社会认知和临床精神病高危个体社会功能阴性症状之间的通路:结构方程模型方法
IF 9 1区 医学
Biological Psychiatry Pub Date : 2025-07-07 DOI: 10.1016/j.biopsych.2025.06.033
Ricardo E Carrión, Majnu John, Sarah Dorvil, Andrea Auther, Danielle McLaughlin, Mitchell Arnovitz, Peter Bachman, Aysenil Belger, Erica Duncan, Holly Hamilton, Jason Johannesen, Benson Ku, Gregory Light, Margaret Niznikiewicz, Brian J Roach, Jean Addington, Carrie E Bearden, Kristin S Cadenhead, Tyrone D Cannon, Matcheri Keshavan, Diana O Perkins, William S Stone, Ming Tsuang, Elaine F Walker, Scott W Woods, Daniel H Mathalon, Barbara A Cornblatt
{"title":"Exploring the Pathways Between Early Auditory Processing, Processing Speed, Social Cognition, and Negative Symptoms on Social Functioning in Individuals at Clinical High Risk for Psychosis: A Structural Equation Modeling Approach.","authors":"Ricardo E Carrión, Majnu John, Sarah Dorvil, Andrea Auther, Danielle McLaughlin, Mitchell Arnovitz, Peter Bachman, Aysenil Belger, Erica Duncan, Holly Hamilton, Jason Johannesen, Benson Ku, Gregory Light, Margaret Niznikiewicz, Brian J Roach, Jean Addington, Carrie E Bearden, Kristin S Cadenhead, Tyrone D Cannon, Matcheri Keshavan, Diana O Perkins, William S Stone, Ming Tsuang, Elaine F Walker, Scott W Woods, Daniel H Mathalon, Barbara A Cornblatt","doi":"10.1016/j.biopsych.2025.06.033","DOIUrl":"10.1016/j.biopsych.2025.06.033","url":null,"abstract":"<p><strong>Background: </strong>Social functioning difficulties in adolescents and young adults at clinical high risk for psychosis (CHR-P) are among the strongest risk factors for psychosis onset. Recent research in patients with schizophrenia has demonstrated complex relationships between early auditory processing deficits as measured by the mismatch negativity (MMN) response of the auditory event-related potential, neurocognition, social cognition, negative symptoms, and social functioning. However, the interrelationships of these variables and associations with social functioning impairments prior to the onset of the illness are unclear. The present study used a structural equation modeling (SEM) approach to integrate these factors to determine the specific determinants that lead to poor social functioning in CHR-P youth.</p><p><strong>Methods: </strong>A total of 518 CHR-P individuals from the NAPLS2 (North American Prodrome Longitudinal Study) were used to evaluate SEMs with pathways starting from MMN to social functioning. The intervening variables included processing speed, social cognition, and negative symptoms.</p><p><strong>Results: </strong>A final trimmed model revealed that early auditory processing (MMN) had a direct effect on processing speed, and both processing speed and negative symptoms had direct effects on social functioning. The direct effect from social cognition to social functioning was not significant.</p><p><strong>Conclusions: </strong>Our findings suggest that neurophysiological deficits are associated with social functioning by way of processing speed impairments, which fully accounted for the relationship in CHR-P youths prior to psychosis onset. These results may have implications for early intervention strategies that target early information-processing deficits with the aim of improving social trajectories and limiting psychosis onset in young CHR-P individuals.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biologically Annotated Heterogeneity of Depression Through Neuroimaging Normative Modeling. 通过神经影像学规范模型分析抑郁症的生物学注释异质性。
IF 9 1区 医学
Biological Psychiatry Pub Date : 2025-07-07 DOI: 10.1016/j.biopsych.2025.07.002
Jiao Li, Huafu Chen, Wei Liao
{"title":"Biologically Annotated Heterogeneity of Depression Through Neuroimaging Normative Modeling.","authors":"Jiao Li, Huafu Chen, Wei Liao","doi":"10.1016/j.biopsych.2025.07.002","DOIUrl":"10.1016/j.biopsych.2025.07.002","url":null,"abstract":"<p><p>Depression is not a unitary disorder; it is heterogeneous in nature. Likewise, no 2 individuals with depression are entirely alike, and therefore their associated symptoms are highly personalized. Over the past decade, numerous approaches have been developed to identify neuroimaging-derived biomarkers to advance our understanding of the neurobiology of patients with depression at the group level. However, substantial clinical heterogeneity among individuals with depression hinders the development of biomarkers for personalized interventions. Recently, publicly available resources have enabled researchers to investigate precision neuromarkers for depression using integrative multineuroimaging approaches. In this review, we systematically revisit previous findings and discuss the advances in data-driven neuroimaging analyses for depression heterogeneity, including the disentangling of dimensional and overlapping strategies, individual-specific abnormal patterns based on normative modeling frameworks, and associations between multiscale organizations. We also discuss the limitations, challenges, and future directions for depression heterogeneity. A summary of these advances is crucial for enhancing the understanding of the neurobiology of depression and will facilitate more accurate diagnoses and personalized interventions.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shedding Light on Brain Function and Mood: A Role for the Retinoraphe Pathway in Regulating Serotonin. 揭示脑功能和情绪:视网膜反射通路在调节血清素中的作用。
IF 9 1区 医学
Biological Psychiatry Pub Date : 2025-07-07 DOI: 10.1016/j.biopsych.2025.06.029
Kornelija Vitkute, Francesca Borghese, Roelof A Hut, Robbert Havekes, Peter Meerlo
{"title":"Shedding Light on Brain Function and Mood: A Role for the Retinoraphe Pathway in Regulating Serotonin.","authors":"Kornelija Vitkute, Francesca Borghese, Roelof A Hut, Robbert Havekes, Peter Meerlo","doi":"10.1016/j.biopsych.2025.06.029","DOIUrl":"10.1016/j.biopsych.2025.06.029","url":null,"abstract":"<p><p>Light has the capacity for immediate and long-term modulation of complex neuronal systems and brain function. While correct timing of light exposure is essential for optimal physical and mental performance, insufficient light or light at the wrong time has been associated with mood-related detriments. In humans, affective disorders have been linked to a dysfunction of the serotonergic system, but the neuronal correlates linking mood and serotonin with effects of light remain elusive. In this review, we discuss the potential importance of the retinoraphe pathway, a direct neuronal connection between the retina and the dorsal raphe, the largest serotonergic nucleus in the brainstem. We discuss current knowledge on the cellular composition, innervation patterns, working mechanisms, and functional outputs of the retinoraphe system across different animal species. While this connection has not been extensively investigated in humans, indirect evidence suggests that the retinoraphe pathway may be at the center of the mechanistic wiring that mediates the effects of light on physiology and mood.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Attraction Through Similarity in Autistic Traits: A Group Communication Study Using the Social Relations Model and Functional Near-Infrared Spectroscopy Hyperscanning. 孤独症特征的相似性吸引:基于社会关系模型和近红外超扫描的群体交流研究。
IF 9 1区 医学
Biological Psychiatry Pub Date : 2025-07-07 DOI: 10.1016/j.biopsych.2025.06.031
Shuyuan Feng, Mingliang Wang, Jianing Zhang, Lin Ding, Yuqing Yuan, Peng Zhang, Xuejun Bai
{"title":"Attraction Through Similarity in Autistic Traits: A Group Communication Study Using the Social Relations Model and Functional Near-Infrared Spectroscopy Hyperscanning.","authors":"Shuyuan Feng, Mingliang Wang, Jianing Zhang, Lin Ding, Yuqing Yuan, Peng Zhang, Xuejun Bai","doi":"10.1016/j.biopsych.2025.06.031","DOIUrl":"10.1016/j.biopsych.2025.06.031","url":null,"abstract":"<p><strong>Background: </strong>The double empathy problem (DEP) reconceptualizes the social challenges of autism as bidirectional differences rather than unidirectional deficits. Following the DEP, the dialectical misattunement hypothesis (DMH) predicts that interaction between people with similar autistic traits will be smoother and reflected in neural synchronization. However, evidence remains inconsistent due to methodological limitations in dyadic designs and unstructured tasks, and it remains unclear whether neural mechanisms differ between passive and active social contexts across autistic trait levels.</p><p><strong>Methods: </strong>Using the social relations model, we measured the relational attraction within 4-person groups (20 female and 10 male groups) composed of 2 individuals with high autistic traits and 2 individuals with low autistic traits following a turn-taking discussion. Simultaneously, we recorded brain activity using functional near-infrared spectroscopy during both passive story listening and active turn-taking discussion.</p><p><strong>Results: </strong>Individuals with similar autistic traits reported higher interpersonal attraction when sharing consistent opinions. Neural analyses revealed context-dependent interbrain coupling patterns: During passive story listening, low-autistic-trait dyads exhibited higher intersubject correlation compared with high-autistic-trait dyads. In contrast, during active communication, low-autistic-trait dyads exhibited higher interbrain synchronization (IBS) in the right temporoparietal junction, while high-autistic-trait dyads showed higher IBS in the right dorsolateral prefrontal cortex, suggesting distinct neural mechanisms underlying social interaction across autistic trait levels.</p><p><strong>Conclusions: </strong>Our findings support the DMH and reveal that neural synchronization mechanisms vary across both autistic trait levels and social contexts. These context-dependent patterns challenge deficit-based models of autism, suggesting that individuals with high autistic traits may employ alternative but effective neural strategies during social interaction, particularly in active communication contexts.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obesity During Pregnancy and Deficits in Offspring Neurobehavioral Flexibility: The CONFINE Model. 孕期肥胖和后代神经行为灵活性缺陷:限制模型。
IF 9 1区 医学
Biological Psychiatry Pub Date : 2025-07-07 DOI: 10.1016/j.biopsych.2025.06.032
John E Krzeczkowski, Neda Mortaji, Ryan J Van Lieshout
{"title":"Obesity During Pregnancy and Deficits in Offspring Neurobehavioral Flexibility: The CONFINE Model.","authors":"John E Krzeczkowski, Neda Mortaji, Ryan J Van Lieshout","doi":"10.1016/j.biopsych.2025.06.032","DOIUrl":"10.1016/j.biopsych.2025.06.032","url":null,"abstract":"<p><p>Exposure to maternal prenatal obesity is associated with multiple psychiatric and cognitive problems in children. However, it is unclear how and why these children are at risk for such a wide range of difficulties. Prenatal obesity may alter fetal neurodevelopment in ways that shape broad traits that underlie the etiology and symptomatology of the multiple problems observed in children. Novel theoretical frameworks that identify these traits are critical to developing a more complete understanding of how and why prenatal obesity adversely impacts children's psychiatric and cognitive functioning. In this review, we propose the CONFINE (Confined Offspring Neurobehavioral Flexibility following INtrauterine obesity Exposure) model, which posits that prenatal exposure to maternal obesity leads to neurobehavioral flexibility deficits in children. It is argued that prenatal obesity alters the fetal 1) hypothalamic energy balance system in ways that constrain child behavior toward food seeking/consumption; 2) central reward systems (μ opioid and mesocorticolimbic dopamine system), making it difficult for children to disengage from reward-seeking/consuming behaviors; and 3) higher-order salience and cognitive control networks, constraining children's attention toward reward cues and contributing to problems with altering goal-directed behaviors. Together, these changes contribute to neurobehavioral flexibility deficits that, depending on postnatal conditions, may increase children's risk for multiple psychiatric and cognitive problems. The CONFINE model aims to integrate the effects of prenatal obesity on children from neural systems to observed behaviors and enable researchers to develop testable hypotheses to gain a more comprehensive understanding of the associations, mechanisms, and risk trajectories of children prenatally exposed to obesity.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histone Deacetylase 5 in Prelimbic Prefrontal Cortex Limits Context-Associated Cocaine Seeking. 前边缘前额叶皮层组蛋白去乙酰化酶5限制情境相关的可卡因寻求。
IF 9 1区 医学
Biological Psychiatry Pub Date : 2025-07-07 DOI: 10.1016/j.biopsych.2025.06.027
Sarah M Barry, Jessica L Huebschman, Derek M Devries, Lauren M McCue, Evgeny Tsvetkov, Rose Marie Akiki, Caroline Limbaker, Ethan M Anderson, Daniel J Wood, Benjamin M Siemsen, Stefano Berto, Michael D Scofield, Makoto Taniguchi, Rachel D Penrod, Christopher W Cowan
{"title":"Histone Deacetylase 5 in Prelimbic Prefrontal Cortex Limits Context-Associated Cocaine Seeking.","authors":"Sarah M Barry, Jessica L Huebschman, Derek M Devries, Lauren M McCue, Evgeny Tsvetkov, Rose Marie Akiki, Caroline Limbaker, Ethan M Anderson, Daniel J Wood, Benjamin M Siemsen, Stefano Berto, Michael D Scofield, Makoto Taniguchi, Rachel D Penrod, Christopher W Cowan","doi":"10.1016/j.biopsych.2025.06.027","DOIUrl":"10.1016/j.biopsych.2025.06.027","url":null,"abstract":"<p><strong>Background: </strong>Repeated cocaine use produces neuroadaptations that support drug craving and relapse in substance use disorders (SUDs). Powerful associations formed with drug use environments can promote a return to active drug use in patients with SUD, but the molecular mechanisms that control the formation of these prepotent drug-context associations remain unclear.</p><p><strong>Methods: </strong>In an animal model of intravenous cocaine self-administration (SA), we used male Sprague Dawley rats to examine the role of histone deacetylase 5 (HDAC5) in the prelimbic cortex (PrL) and infralimbic cortex in context-associated drug seeking. To this end, we employed viral molecular tools, chemogenetics, RNA sequencing, electrophysiology, and immunohistochemistry.</p><p><strong>Results: </strong>In the PrL, reduction of endogenous HDAC5 augmented context-associated but not cue- or drug prime-reinstated cocaine seeking, whereas overexpression of HDAC5 in the PrL, but not in the infralimbic cortex, reduced context-associated cocaine seeking but had no effects on sucrose seeking. In contrast, PrL HDAC5 overexpression following acquisition had no effects on future cocaine seeking. We found that HDAC5 and cocaine SA altered expression of numerous PrL genes, including many synapse-associated genes. HDAC5 significantly increased inhibitory synaptic transmission onto PrL deep-layer pyramidal neurons and reduced the induction of FOS-positive neurons in the cocaine SA environment.</p><p><strong>Conclusions: </strong>Our findings reveal an essential and selective role for PrL HDAC5 to limit associations formed in cocaine, but not sucrose, SA environments, and that PrL HDAC5 alters the PrL excitatory/inhibitory balance, possibly through epigenetic regulation of synaptic genes. These results further position HDAC5 as a key factor regulating reward-circuit neuroadaptations that underlie common relapse triggers in SUDs.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Interplay Between Sleep and Mental Health: A Genetic Perspective. 睡眠和心理健康之间的相互作用:遗传学的观点。
IF 9 1区 医学
Biological Psychiatry Pub Date : 2025-07-05 DOI: 10.1016/j.biopsych.2025.06.024
Nataliia Kozhemiako, Carol Mita, Georgia M Panagiotaropoulou, Katie J S Lewis, Tamar Sofer, Shaun M Purcell
{"title":"The Interplay Between Sleep and Mental Health: A Genetic Perspective.","authors":"Nataliia Kozhemiako, Carol Mita, Georgia M Panagiotaropoulou, Katie J S Lewis, Tamar Sofer, Shaun M Purcell","doi":"10.1016/j.biopsych.2025.06.024","DOIUrl":"10.1016/j.biopsych.2025.06.024","url":null,"abstract":"<p><p>Although many facets of sleep, including subjective, behavioral, and neurophysiological features, are closely linked with psychiatric disorders, the natures of these relationships are generally unclear. A given alteration in sleep could reflect a cause (that may mediate genetic risk), consequence, symptom, trigger, epiphenomenon due to shared determinants, or some combination of these. In principle, genetic approaches can be informative: 1) by identifying specific genetic influences on disease mediated by or shared with sleep, which could help the search for biological mechanisms and therapeutic targets, and 2) by providing evidence for causality, which could suggest interventions for modifiable sleep traits. Here, we summarize recent human quantitative and molecular genetic studies on sleep and psychiatric disease, including twin and genome-wide association studies. Despite evidence for shared heritability across many domains, notably depression and insomnia, the field is in its early stages and faces significant challenges including the following: 1) putative causal effects are small, phenotypically nonspecific, not resolved to specific gene pathways, and often bidirectional; 2) most current discovery cohorts are demographically biased and do not capture profound age-related changes in sleep and its genetic architecture; 3) group-level analyses ignore patient-to-patient heterogeneity, including the presence or absence of specific sleep alterations; and 4) a paucity of objective, brain-based data in genetically informative samples hampers making connections with sleep neurophysiology. Nonetheless, as ever-growing genetic tools and resources still hold great potential for translational bridges between basic model systems, human epidemiology, and personalized clinical care, genetic approaches will still likely be needed to reveal sleep's roles in maintaining mental health.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How Does Altered Function of the Hippocampus Contribute to the Development of Psychosis? 海马体功能的改变如何促进精神病的发展?
IF 9 1区 医学
Biological Psychiatry Pub Date : 2025-07-05 DOI: 10.1016/j.biopsych.2025.06.022
Valentina Mancini, Farnaz Delavari, Tae-Yeon Eom, Stanislav S Zakharenko, Eric Schmitt, Stephan Eliez
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