Biological Psychiatry最新文献

{"title":"Effect of Antidepressant Treatment on 5-HT4 Receptor Binding and Associations With Clinical Outcomes and Verbal Memory in Major Depressive Disorder","authors":"Vibeke H. Dam ,&nbsp;Kristin Köhler-Forsberg ,&nbsp;Brice Ozenne ,&nbsp;Søren V. Larsen ,&nbsp;Cheng-Teng Ip ,&nbsp;Anders Jorgensen ,&nbsp;Dea S. Stenbæk ,&nbsp;Jacob Madsen ,&nbsp;Claus Svarer ,&nbsp;Martin B. Jørgensen ,&nbsp;Gitte M. Knudsen ,&nbsp;Vibe G. Frokjaer","doi":"10.1016/j.biopsych.2024.08.009","DOIUrl":"10.1016/j.biopsych.2024.08.009","url":null,"abstract":"<div><h3>Background</h3><div>Brain serotonin 4 receptor (5-HT₄R) levels are lower in untreated patients with major depressive disorder (MDD) and are linked to verbal memory. Here, we investigated the relationship between 5-HT₄R levels, clinical outcomes, and cognitive function in patients with MDD who initiated selective serotonin reuptake inhibitor drug treatment.</div></div><div><h3>Methods</h3><div>Ninety patients with moderate to severe depression underwent molecular brain imaging to measure 5-HT₄R binding prior to antidepressant treatment with escitalopram. Pretreatment 5-HT₄R binding was assessed for its ability to predict treatment outcome at weeks 4, 8, or 12. In 40 patients who were rescanned 8 weeks posttreatment, change in cerebral 5-HT₄R binding was correlated with change in verbal memory and with change in depressive symptoms, as evaluated by the 6-item Hamilton Depression Rating Scale.</div></div><div><h3>Results</h3><div>After 8 weeks of serotonergic intervention, neostriatal 5-HT₄R binding was reduced by 9%. Global change in 5-HT₄R binding from baseline was associated with verbal memory outcomes, but not with overall clinical depressive symptom outcomes. Pretreatment 5-HT₄R binding did not predict clinical recovery status at week 8 and was not associated with change in the 6-item Hamilton Depression Rating Scale scores.</div></div><div><h3>Conclusions</h3><div>In patients with moderate to severe MDD, treatment with selective serotonin reuptake inhibitors downregulated neostriatal 5-HT₄R levels, which is consistent with the notion that the drugs increase cerebral extracellular serotonin. The less global brain 5-HT₄R levels were downregulated after selective serotonin reuptake inhibitors, the more verbal memory improved, highlighting the potential importance of 5-HT₄R as a treatment target in MDD. The findings offer insights into mechanisms that underlie antidepressant effects and point to new directions for precision medicine treatments for MDD.</div></div>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 3","pages":"Pages 261-268"},"PeriodicalIF":9.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142054844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of Glutathione and Its Associated Spontaneous Neuronal Activity in Major Depressive Disorder and Obsessive-Compulsive Disorder","authors":"Sang Won Lee ,&nbsp;Seungho Kim ,&nbsp;Yongmin Chang ,&nbsp;Hyunsil Cha ,&nbsp;Ralph Noeske ,&nbsp;Changho Choi ,&nbsp;Seung Jae Lee","doi":"10.1016/j.biopsych.2024.08.018","DOIUrl":"10.1016/j.biopsych.2024.08.018","url":null,"abstract":"<div><h3>Background</h3><div>Glutathione (GSH) is a crucial antioxidant in the human brain. Although proton magnetic resonance spectroscopy using the Mescher-Garwood point-resolved spectroscopy sequence is highly recommended, limited literature has measured cortical GSH using this method in major psychiatric disorders.</div></div><div><h3>Methods</h3><div>By combining magnetic resonance spectroscopy and resting-state functional magnetic resonance imaging, we quantified brain GSH and glutamate in the medial prefrontal cortex and precuneus and explored relationships between GSH levels and intrinsic neuronal activity as well as clinical symptoms among healthy control (HC) participants (<em>n</em> = 30), people with major depressive disorder (MDD) (<em>n</em> = 28), and people with obsessive-compulsive disorder (OCD) (<em>n</em> = 28).</div></div><div><h3>Results</h3><div>GSH concentrations were lower in the medial prefrontal cortex and precuneus in both the MDD and OCD groups than in the HC group. In the HC group, positive correlations were noted between GSH and glutamate levels and between GSH and fractional amplitude of low-frequency fluctuations in both regions. However, while these correlations were absent in both patient groups, there was a weak positive correlation between glutamate and fractional amplitude of low-frequency fluctuations. Moreover, GSH levels were negatively correlated with depressive and compulsive symptoms in MDD and OCD, respectively.</div></div><div><h3>Conclusions</h3><div>These findings suggest that reduced GSH levels and an imbalance between GSH and glutamate could increase oxidative stress and alter neurotransmitter signaling, thereby leading to disruptions in GSH-related neurochemical-neuronal coupling and psychopathologies across MDD and OCD. Understanding these mechanisms could provide valuable insights into the processes that underlie these disorders and potentially become a springboard for future directions and advancing our knowledge of their neurobiological foundations.</div></div>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 3","pages":"Pages 279-289"},"PeriodicalIF":9.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insomnia Subtypes Have Differentiating Deviations in Brain Structural Connectivity","authors":"Tom Bresser ,&nbsp;Tessa F. Blanken ,&nbsp;Siemon C. de Lange ,&nbsp;Jeanne Leerssen ,&nbsp;Jessica C. Foster-Dingley ,&nbsp;Oti Lakbila-Kamal ,&nbsp;Rick Wassing ,&nbsp;Jennifer R. Ramautar ,&nbsp;Diederick Stoffers ,&nbsp;Martijn P. van den Heuvel ,&nbsp;Eus J.W. Van Someren","doi":"10.1016/j.biopsych.2024.06.014","DOIUrl":"10.1016/j.biopsych.2024.06.014","url":null,"abstract":"<div><h3>Background</h3><div>Insomnia disorder is the most common sleep disorder. A better understanding of insomnia-related deviations in the brain could inspire better treatment. Insufficiently recognized heterogeneity within the insomnia population could obscure detection of involved brain circuits. In the current study, we investigated whether structural brain connectivity deviations differed between recently discovered and validated insomnia subtypes.</div></div><div><h3>Methods</h3><div>Structural and diffusion-weighted 3T magnetic resonance imaging data from 4 independent studies were harmonized. The sample consisted of 73 control participants without sleep complaints and 204 participants with insomnia who were grouped into 5 insomnia subtypes based on their fingerprint of mood and personality traits assessed with the Insomnia Type Questionnaire. Linear regression correcting for age and sex was used to evaluate group differences in structural connectivity strength, indicated by fractional anisotropy, streamline volume density, and mean diffusivity and evaluated within 3 different atlases.</div></div><div><h3>Results</h3><div>Insomnia subtypes showed differentiating profiles of deviating structural connectivity that were concentrated in different functional networks. Permutation testing against randomly drawn heterogeneous subsamples indicated significant specificity of deviation profiles in 4 of the 5 subtypes: highly distressed, moderately distressed reward sensitive, slightly distressed low reactive, and slightly distressed high reactive. Connectivity deviation profile significance ranged from <em>p</em> = .001 to <em>p</em> = .049 for different resolutions of brain parcellation and connectivity weight.</div></div><div><h3>Conclusions</h3><div>Our results provide an initial indication that different insomnia subtypes exhibit distinct profiles of deviations in structural brain connectivity. Subtyping insomnia may be essential for a better understanding of brain mechanisms that contribute to insomnia vulnerability.</div></div>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 3","pages":"Pages 302-312"},"PeriodicalIF":9.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional Structural-Functional Connectivity Coupling in Major Depressive Disorder Is Associated With Neurotransmitter and Genetic Profiles","authors":"Tongpeng Chu ,&nbsp;Xiaopeng Si ,&nbsp;Haizhu Xie ,&nbsp;Heng Ma ,&nbsp;Yinghong Shi ,&nbsp;Wei Yao ,&nbsp;Dong Xing ,&nbsp;Feng Zhao ,&nbsp;Fanghui Dong ,&nbsp;Qun Gai ,&nbsp;Kaili Che ,&nbsp;Yuting Guo ,&nbsp;Danni Chen ,&nbsp;Dong Ming ,&nbsp;Ning Mao","doi":"10.1016/j.biopsych.2024.08.022","DOIUrl":"10.1016/j.biopsych.2024.08.022","url":null,"abstract":"<div><h3>Background</h3><div>Abnormalities in structural-functional connectivity (SC-FC) coupling have been identified globally in patients with major depressive disorder (MDD). However, investigations have neglected the variability and hierarchical distribution of these abnormalities across different brain regions. Furthermore, the biological mechanisms that underlie regional SC-FC coupling patterns are not well understood.</div></div><div><h3>Methods</h3><div>We enrolled 182 patients with MDD and 157 healthy control participants and quantified the intergroup differences in regional SC-FC coupling. Extreme gradient boosting (XGBoost), support vector machine, and random forest models were constructed to assess the potential of SC-FC coupling as biomarkers for MDD diagnosis and symptom prediction. Then, we examined the link between changes in regional SC-FC coupling in patients with MDD, neurotransmitter distributions, and gene expression.</div></div><div><h3>Results</h3><div>We observed increased regional SC-FC coupling in the default mode network (<em>t</em>₃₃₇ = 3.233) and decreased coupling in the frontoparietal network (<em>t</em>₃₃₇ = −3.471) in patients with MDD compared with healthy control participants. XGBoost (area under the receiver operating characteristic curve = 0.853), support vector machine (area under the receiver operating characteristic curve = 0.832), and random forest (<em>p</em> &lt; .05) models exhibited good prediction performance. The alterations in regional SC-FC coupling in patients with MDD were correlated with the distributions of 4 neurotransmitters (<em>p</em> &lt; .05) and expression maps of specific genes. These enriched genes were implicated in excitatory neurons, inhibitory neurons, cellular metabolism, synapse function, and immune signaling. These findings were replicated on 2 brain atlases.</div></div><div><h3>Conclusions</h3><div>This work enhances our understanding of MDD and paves the way for the development of additional targeted therapeutic interventions.</div></div>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 3","pages":"Pages 290-301"},"PeriodicalIF":9.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Astroglial Basis of Major Depressive Disorder: Molecular, Cellular, and Circuit Features","authors":"Cheng-Lin Lu ,&nbsp;Jing Ren ,&nbsp;Xiong Cao","doi":"10.1016/j.biopsych.2024.07.017","DOIUrl":"10.1016/j.biopsych.2024.07.017","url":null,"abstract":"<div><div>Major depressive disorder is a common psychiatric disorder and a leading cause of disability worldwide. Astrocytes play a role in the maintenance of the function of the central nervous system, both physiologically and pathologically. Accumulated evidence indicates that the astrocyte is an important contributor to the pathophysiology of major depressive disorder including blood-brain barrier integrity, gap junctions, gliotransmission, glutamate homeostasis, and energy metabolism. Here, we comprehensively summarize an astroglial basis for major depressive disorder based on molecular, cellular, and circuit properties, suggesting that astrocytes appear to be highly sensitive to stress and are likely to be uniquely positioned to integrate peripheral and central stress responses.</div></div>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 3","pages":"Pages 217-226"},"PeriodicalIF":9.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers Page","authors":"","doi":"10.1016/S0006-3223(24)01765-7","DOIUrl":"10.1016/S0006-3223(24)01765-7","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 3","pages":"Page A2"},"PeriodicalIF":9.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-Month Cognitive Changes Enhance Prediction of Non-Remission in Clinical High-Risk Individuals.","authors":"TianHong Zhang, YanYan Wei, XiaoChen Tang, LiHua Xu, HuiRu Cui, YeGang Hu, HaiChun Liu, ZiXuan Wang, Tao Chen, YingYing Tang, ZhengHui Yi, ChunBo Li, JiJun Wang","doi":"10.1016/j.biopsych.2025.01.021","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.01.021","url":null,"abstract":"<p><strong>Background: </strong>Longitudinal changes in cognitive function may be crucial in predicting clinical outcomes in clinical high risk (CHR) individuals. This study aims to investigate the predictive value of baseline cognitive impairment and short-term cognitive changes for non-remission and conversion to psychosis in individuals at CHR for psychosis, compared with healthy controls (HC).</p><p><strong>Methods: </strong>This study employed a multiple-group prospective design with a 3-year follow-up. CHR individuals and HCs were assessed at baseline and at a 2-month follow-up. Neuropsychological performance was evaluated using the Chinese version of the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery.</p><p><strong>Results: </strong>The study included 310 CHR individuals and 93 HCs. Significant improvements in predicting non-remission in CHR individuals were observed when incorporating cognitive changes over 2 months (AUC for baseline cognition, 0.690; AUC for changes, 0.819; Z=3.365, p<0.001). Key predictors included the Revised Hopkins Verbal Learning Test (HVLT-R; β=0.083, p=0.003), Wechsler Memory Scale-III spatial span (WMS-3; β=0.330, p<0.001), and Revised Brief Visuospatial Memory Test (BVMT-R; β=0.127, p<0.001). Conversely, predicting conversion to psychosis showed no significant difference between baseline and 2-month cognitive changes (AUC for baseline cognition, 0.667; AUC for changes, 0.666; Z=0.021, p=0.242).</p><p><strong>Conclusions: </strong>The findings underscore the importance of dynamic cognitive monitoring in CHR individuals. Short-term cognitive changes significantly enhance the prediction of non-remission but do not add predictive value for conversion to psychosis beyond baseline assessments. Specific cognitive domains, such as verbal learning and working memory, are particularly valuable for predicting clinical outcomes.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Perspectives on Neuropeptide Function and Social Isolation.","authors":"Kenta Asahina, Moriel Zelikowsky","doi":"10.1016/j.biopsych.2025.01.019","DOIUrl":"10.1016/j.biopsych.2025.01.019","url":null,"abstract":"<p><p>Chronic social isolation alters behavior across animal species. Genetic model organisms such as mice and flies provide crucial insight into the molecular and physiological effects of social isolation on brain cells and circuits. Here, we comparatively review recent findings regarding the function of conserved neuropeptides in social isolation in mice and flies. Analogous functions of 3 classes of neuropeptides-tachykinins, cholecystokinins, and neuropeptide Y/F-in the two model organisms suggest that these molecules may be involved in modulating behavioral changes induced by social isolation across a wider range of species, including humans. Comparative approaches armed with tools to dissect neuropeptidergic function can lead to an integrated understanding of the impacts of social isolation on brain circuits and behavior.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Contribution of Coding Variants in Alcohol Use Disorder Using Whole-Exome Sequencing Across Ancestries.","authors":"Lu Wang, Henry R Kranzler, Joel Gelernter, Hang Zhou","doi":"10.1016/j.biopsych.2025.01.020","DOIUrl":"10.1016/j.biopsych.2025.01.020","url":null,"abstract":"<p><strong>Background: </strong>Alcohol use disorder (AUD) is a leading cause of death and disability worldwide. There has been substantial progress in identifying genetic variants that underlie AUD. However, whole-exome sequencing studies of AUD have been hampered by the lack of available samples.</p><p><strong>Methods: </strong>We analyzed whole-exome sequencing data of 4530 samples from the Yale-Penn cohort and 469,835 samples from the UK Biobank, which represent an unprecedented resource for exploring the contribution of coding variants in AUD. After quality control, 1750 African-ancestry (1142 cases) and 2039 European-ancestry (1420 cases) samples from the Yale-Penn and 6142 African-ancestry (130 cases), 415,617 European-ancestry (12,861‬ cases), and 4607 South Asian (130 cases) samples from the UK Biobank cohorts were included in the analyses.</p><p><strong>Results: </strong>We confirmed the well-known functional variant rs1229984 in ADH1B (p = 4.88 × 10^-31) and several other variants in ADH1C. Gene-based collapsing tests that considered the high allelic heterogeneity revealed the previously unreported genes CNST (p = 1.19 × 10^-6), attributable to rare variants with allele frequency < 0.001, and IFIT5 (p = 3.74 × 10^-6), driven by the burden of both common and rare loss-of-function and missense variants.</p><p><strong>Conclusions: </strong>This study extends our understanding of the genetic architecture of AUD by providing insights into the contribution of rare coding variants, separately and convergently with common variants in AUD.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette disorder.","authors":"Yifan Wang, Liana Fasching, Feinan Wu, Milovan Suvakov, Anita Huttner, Sabina Berretta, Rosalinda Roberts, James F Leckman, Thomas V Fernandez, Alexej Abyzov, Flora M Vaccarino","doi":"10.1016/j.biopsych.2024.12.022","DOIUrl":"10.1016/j.biopsych.2024.12.022","url":null,"abstract":"<p><strong>Background: </strong>Tourette disorder is characterized by motor hyperactivity and tics that are believed to originate in basal ganglia. Postmortem immunocytochemical analyses previously revealed decreases in cholinergic, parvalbumin, and somatostatin interneurons (IN) within the caudate/putamen of individuals with TS.</p><p><strong>Methods: </strong>We obtained transcriptome and open chromatin datasets by snRNAseq and snATAC-seq, respectively, from caudate/putamen postmortem specimens of 6 adult TS and 6 matched normal control (NC). Differential gene expression and differential chromatin accessibility analyses were performed in identified cell types.</p><p><strong>Results: </strong>The data reproduced the known cellular composition of the human striatum, including a majority of medium spiny neurons (MSN) and small populations of GABAergic and cholinergic IN. IN were decreased by ∼50% in TS brains, with no difference in other cell types. Differential gene expression analysis suggested that mitochondrial oxidative metabolism in MSN and synaptic adhesion and function in IN were both decreased in TS subjects, while there was activation of immune response in microglia. Gene expression changes correlated with changes in activity of cis-regulatory elements, suggesting a relationship of transcriptomic and regulatory abnormalities in MSN, OL and AST of TS brains.</p><p><strong>Conclusions: </strong>This initial analysis of the TS basal ganglia transcriptome at the single cell level confirms the loss and synaptic dysfunction of basal ganglia IN, consistent with in vivo basal ganglia hyperactivity. In parallel, oxidative metabolism was decreased in MSN and correlated with activation of microglia cells, attributable at least in part to dysregulated activity of putative enhancers, implicating altered epigenomic regulation in TS.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}