Stephane A De Brito, Jack C Rogers, Ruth Pauli, Gregor Kohls, Nora M Raschle, Anne Martinelli, Areti Smaragdi, Karen Gonzalez-Madruga, Harriet Cornwell, Christina Stadler, Kerstin Konrad, Christine M Freitag, Graeme Fairchild
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引用次数: 0
摘要
功能磁共振成像（fMRI）对品行障碍（CD）的研究大多局限于男性。在这里，我们研究了患有乳糜泄的男性和女性青年对情绪面孔的大脑反应是否表现出相似或不同的变化，使用了大量的混合性别的乳糜泄青年样本。我们还研究了冷酷无情（CU）特征的影响。对161名9-18岁的CD青年（74名女性）和241名典型发育（TD）青年（139名女性）对愤怒、恐惧和中性面孔的大脑反应进行了评估。分类分析测试了诊断效果（CD vs. TD和CD/HCU高水平vs. CD/LCU低水平的CD）和性别诊断相互作用。当处理一般面孔（所有面孔与基线相比）时，与TD青年相比，CD青年表现出较低的杏仁核反应，这似乎是由CD/HCU亚组驱动的。在杏仁核（CD/LCU女性、estd男性）和脑岛（CD/HCU女性、>CD/LCU女性）中发现了按性别划分的亚组相互作用；CD / HCU男性
Brain Responses During Face Processing in Conduct Disorder: Considering Sex and Callous-Unemotional Traits.
Background: Functional magnetic resonance imaging studies of conduct disorder (CD) have mostly been limited to males. Here, we examined whether male and female youths with CD showed similar or distinct alterations in brain responses to emotional faces, using a large sample of male and female youths with CD. We also investigated the influence of callous-unemotional (CU) traits.
Methods: Brain responses to angry, fearful, and neutral faces were assessed in 161 youths with CD (74 female) and 241 typically developing (TD) youths (139 female) ages 9 to 18 years. Categorical analyses tested for diagnosis effects (CD vs. TD and CD with high levels of CU traits [CD/HCU] vs. low levels of CU traits [CD/LCU] vs. TD) and sex × diagnosis interactions.
Results: When processing faces in general (all faces vs. baseline), youths with CD exhibited lower amygdala responses compared with TD youths, which seemed to be driven by the CD/HCU subgroup. Sex × CU subgroup interactions were identified in the amygdala (CD/LCU females < TD females; CD/LCU males > TD males) and anterior insula (CD/HCU females > CD/LCU females; CD/HCU males < CD/LCU males).
Conclusions: The findings for males support an influential neurocognitive model of CD. However, the association between CU traits and brain response to facial expressions differed in females and males with CD, suggesting distinct pathophysiological processes.
期刊介绍：
Biological Psychiatry is an official journal of the Society of Biological Psychiatry and was established in 1969. It is the first journal in the Biological Psychiatry family, which also includes Biological Psychiatry: Cognitive Neuroscience and Neuroimaging and Biological Psychiatry: Global Open Science. The Society's main goal is to promote excellence in scientific research and education in the fields related to the nature, causes, mechanisms, and treatments of disorders pertaining to thought, emotion, and behavior. To fulfill this mission, Biological Psychiatry publishes peer-reviewed, rapid-publication articles that present new findings from original basic, translational, and clinical mechanistic research, ultimately advancing our understanding of psychiatric disorders and their treatment. The journal also encourages the submission of reviews and commentaries on current research and topics of interest.
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