Biological Psychiatry最新文献_第2页

Intercalated amygdala dysfunction drives avoidance extinction deficits in the Sapap3 mouse model of obsessive-compulsive disorder. Sapap3强迫症小鼠模型的杏仁核间功能障碍导致回避消退障碍。

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2024-11-02 DOI: 10.1016/j.biopsych.2024.10.021

Robyn St Laurent, Kelly M Kusche, Ben Rein, Kendall B Raymond, Anatol C Kreitzer, Robert C Malenka

{"title":"Intercalated amygdala dysfunction drives avoidance extinction deficits in the Sapap3 mouse model of obsessive-compulsive disorder.","authors":"Robyn St Laurent, Kelly M Kusche, Ben Rein, Kendall B Raymond, Anatol C Kreitzer, Robert C Malenka","doi":"10.1016/j.biopsych.2024.10.021","DOIUrl":"https://doi.org/10.1016/j.biopsych.2024.10.021","url":null,"abstract":"Background: The avoidance of aversive stimuli through negative reinforcement learning is critical for survival in real-world environments, which demand dynamic responding to both positive and negative stimuli that often conflict with each other. Individuals with obsessive-compulsive disorder (OCD) commonly exhibit impaired negative reinforcement and extinction, perhaps involving deficits in amygdala functioning. An amygdala subregion of particular interest is the intercalated nuclei of the amygdala (ITC) which has been linked to negative reinforcement and extinction, with distinct clusters mediating separate aspects of behavior. This study focuses on the dorsal ITC cluster (ITCd) and its role in negative reinforcement during a complex behavior that models real-world dynamic decision making.Methods: We investigated the impact of ITCd function on negative reinforcement and extinction by applying fiber photometry measurement of GCamp6f signals and optogenetic manipulations during a platform-mediated avoidance task in a mouse model of OCD-like behavior: the Sapap3-null mouse.Results: We find impaired neural activity in the ITCd of male and female Sapap3-null mice to the encoding of negative stimuli during platform-mediated avoidance. Sapap3-null mice also exhibit deficits in extinction of avoidant behavior, which is modulated by ITCd neural activity.Conclusions: Sapap3-null mice fail to extinguish avoidant behavior in platform-mediated avoidance, due to heightened ITCd activity. This deficit can be rescued by optogenetically inhibiting ITCd during extinction. Together, our results provide insight into the neural mechanisms underpinning negative reinforcement deficits in the context of OCD, emphasizing the necessity of ITCd in responding to negative stimuli in complex environments.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Atomoxetine reduces decisional impulsivity in human cocaine addiction. 阿托莫西汀可降低人类可卡因成瘾的决策冲动性。

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2024-10-29 DOI: 10.1016/j.biopsych.2024.10.018

Tsen Vei Lim, Rudolf N Cardinal, Hisham Ziauddeen, Ralf Regenthal, Barbara J Sahakian, Trevor W Robbins, Karen D Ersche

{"title":"Atomoxetine reduces decisional impulsivity in human cocaine addiction.","authors":"Tsen Vei Lim, Rudolf N Cardinal, Hisham Ziauddeen, Ralf Regenthal, Barbara J Sahakian, Trevor W Robbins, Karen D Ersche","doi":"10.1016/j.biopsych.2024.10.018","DOIUrl":"https://doi.org/10.1016/j.biopsych.2024.10.018","url":null,"abstract":"Background: Impulsivity is a well-known determinant of maladaptive behaviour in cocaine use disorder, but there are currently no effective strategies for managing excessive impulsivity. Growing evidence from preclinical and clinical studies suggests that atomoxetine, a selective noradrenaline reuptake inhibitor, is effective in improving impulse control in both health and neuropsychiatric conditions.Methods: We investigated the effects of atomoxetine on decisional impulsivity in patients with cocaine use disorder. In a randomised, double-blind, placebo-controlled, crossover study, 28 patients diagnosed with moderate-to-severe cocaine use disorder and 28 matched healthy control participants completed the Cambridge Gamble Task in two separate sessions, where they either received placebo or a single dose of 40 mg atomoxetine on each session. Computational modelling was used to decompose decision-making into three separable components: value, probability, and decisional impulsivity.Results: Our analyses revealed that patients with cocaine use disorder were impaired in all components of decision-making. Atomoxetine selectively reduced decisional impulsivity in cocaine use disorder patients by reducing their risk-seeking tendencies whilst enhancing their ability to tolerate delays. By contrast, atomoxetine did not affect impulsivity in control participants, but increased their sensitivity to prospective losses.Conclusion: Taken together, our findings support the hypothesis of noradrenergic dysfunction in patients with cocaine use disorder and provide novel translational evidence for the efficacy of atomoxetine in remediating decisional impulsivity in cocaine use disorder.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Loneliness and Social Connection in the Mental Health Crisis. 心理健康危机中的孤独感和社会联系。

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2024-10-29 DOI: 10.1016/j.biopsych.2024.10.019

Julianne Holt-Lunstad, Katy Sine

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Subscribers Page 订阅者页面

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2024-10-28 DOI: 10.1016/S0006-3223(24)01632-9

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Left to Languish: A Call to Mitigate the Risk of Intentional Self-Harm and Suicide in Body Dysmorphic Disorder Through Early Intervention 任其自生自灭：呼吁通过早期干预降低身体畸形障碍患者故意自残和自杀的风险

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2024-10-28 DOI: 10.1016/j.biopsych.2024.09.003

Michaela Flynn

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Sex Differences in Stress-Related Disorders Viewed Through a Research Domain Criteria Lens 从研究领域标准角度看压力相关疾病的性别差异

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2024-10-28 DOI: 10.1016/j.biopsych.2024.08.025

Rita Valentino

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Guide for Authors 作者指南

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2024-10-28 DOI: 10.1016/S0006-3223(24)01635-4

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Editorial Board Page 编辑委员会页面

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2024-10-28 DOI: 10.1016/S0006-3223(24)01631-7

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Stress Vulnerability Exposed by Mapping Brain Network States to Single-Cell Transcriptomes 通过将大脑网络状态映射到单细胞转录组揭示压力脆弱性

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2024-10-28 DOI: 10.1016/j.biopsych.2024.08.024

Andre Fischer , Jelena Radulovic

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Building Resilience: The Stress Response as a Driving Force for Neuroplasticity and Adaptation. 建立复原力：压力反应是神经可塑性和适应性的驱动力。

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2024-10-22 DOI: 10.1016/j.biopsych.2024.10.016

Erno J Hermans, Talma Hendler, Raffael Kalisch

{"title":"Building Resilience: The Stress Response as a Driving Force for Neuroplasticity and Adaptation.","authors":"Erno J Hermans, Talma Hendler, Raffael Kalisch","doi":"10.1016/j.biopsych.2024.10.016","DOIUrl":"https://doi.org/10.1016/j.biopsych.2024.10.016","url":null,"abstract":"People exhibit an extraordinary capacity to adjust to stressful situations. Here, we argue that the acute stress response is a major driving force behind this adaptive process. In addition to immediately freeing energy reserves, facilitating a rapid and robust neurocognitive response, and helping to reinstate homeostasis, the stress response also critically regulates neuroplasticity. Understanding the healthy acute stress response is therefore crucial for understanding stress resilience: the maintenance or rapid recovery of mental health during and after times of adversity. Contemporary resilience research distinguishes between resilience factors (RFs) and resilience mechanisms (RMs). RFs refer to a broad array of social, psychological, or biological variables that are stable but potentially malleable and predict resilient outcomes. RMs, by contrast, refer to proximate mechanisms activated during acute stress that enable individuals to effectively navigate immediate challenges. In this paper, we review literature related to how neurotransmitter and hormonal changes during acute stress regulate the activation of RMs. We integrate literature on the timing-dependent and neuromodulator-specific regulation of neurocognition, episodic memory, and behavioral and motivational control, highlighting the distinct and often synergistic roles of catecholamines (dopamine and norepinephrine) and glucocorticoids. We conclude that stress resilience is bolstered by improved future predictions and the success-based reinforcement of effective coping strategies during acute stress. The resulting generalized memories of success, controllability, and safety constitute beneficial plasticity that lastingly improves self-control under stress. Insight into such mechanisms of resilience is critical for the development of novel interventions focused on prevention rather than treatment of stress-related disorders.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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