Biological Psychiatry最新文献_第2页

Paradoxical ventral tegmental area GABA signaling drives enhanced morphine reward after adolescent nicotine. 自相矛盾的腹侧被盖区GABA信号驱动青少年尼古丁后吗啡奖励增强。

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2025-06-24 DOI: 10.1016/j.biopsych.2025.05.027

Ruthie E Wittenberg, Sanghee Yun, Kechun Yang, Olivia K Swanson, Shannon L Wolfman, Lorianna M Colón, Amelia J Eisch, John A Dani

{"title":"Paradoxical ventral tegmental area GABA signaling drives enhanced morphine reward after adolescent nicotine.","authors":"Ruthie E Wittenberg, Sanghee Yun, Kechun Yang, Olivia K Swanson, Shannon L Wolfman, Lorianna M Colón, Amelia J Eisch, John A Dani","doi":"10.1016/j.biopsych.2025.05.027","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.05.027","url":null,"abstract":"Background: An important yet poorly understood risk factor for opioid use disorder is adolescent nicotine use. We investigated the neural mechanisms underlying this understudied interaction.Methods: Male and female adolescent mice received two-weeks of nicotine water (Adol Nic) or plain water (Adol Water). In adulthood, mice underwent three morphine tests: conditioned place preference (CPP), locomotor sensitization, and two-bottle choice. Ex vivo ventral tegmental area (VTA) brain slices were assessed via patch clamp for GABA and dopamine (DA) neuron morphine responses. Finally, VTA GABA neurons were chemogenetically inhibited during morphine CPP.Results: In adulthood, Adol Nic mice had greater morphine CPP, more morphine locomotor sensitization, and more choice-based morphine consumption vs. Adol Water mice. In contrast, adult mice given nicotine vs. water had similar morphine CPP measured a month later. Patch clamp analysis of VTA neurons from adult Adol Water mice showed canonical cell-type responses to bath-applied morphine: fewer action potentials in GABA neurons and more in DA neurons. Paradoxically, VTA GABA and DA neurons from adult Adol Nic mice did not show these morphine responses. In support of a causal relationship between GABA neuron firing and reward behavior, chemogenetic inhibition of VTA GABA neurons in Adol Water mice during pairing increased morphine CPP. In contrast, inhibition of VTA GABA neurons in Adol Nic mice brought morphine CPP down to control levels.Conclusions: These data indicate a circuitry adaptation by which adolescent nicotine intake promotes morphine reward later in life, showing that adolescent nicotine exposure alters reward circuitry well into adulthood.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular homeostasis in suicidal behavior: from molecular mechanisms to clinical implications. 自杀行为中的血管稳态：从分子机制到临床意义。

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2025-06-23 DOI: 10.1016/j.biopsych.2025.06.012

Aiste Lengvenyte, Philippe Courtet

{"title":"Vascular homeostasis in suicidal behavior: from molecular mechanisms to clinical implications.","authors":"Aiste Lengvenyte, Philippe Courtet","doi":"10.1016/j.biopsych.2025.06.012","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.06.012","url":null,"abstract":"Suicidal behaviors (SB) remain a major global health challenge, reflecting persistent gaps in understanding their neurobiological underpinnings. The scarcity of validated biological markers for diagnosis, prediction, or treatment response impedes clinical progress. Emerging evidence implicates vascular dysregulation as a contributing factor in the pathophysiology of SB. This review critically synthesizes findings from clinical and preclinical studies to explore how disruptions in vascular homeostasis - including endothelial integrity, blood-brain barrier (BBB) permeability, platelet function, and microvascular flow - are associated with SB and related phenotypes. Epidemiological and genetic data further highlight shared vulnerability between SB and cardiovascular or neurovascular conditions. Additionally, individuals with SB exhibit signs of increased BBB permeability, platelet activation, nitric oxide dysregulation, altered kynurenine metabolism, elevated matrix metalloproteinase-9 activity, and white matter hyperintensities. These vascular disturbances may promote a pro-inflammatory and oxidative environment that impairs neuroplasticity, thereby heightening vulnerability to SB through cognitive and emotional dysregulation. Emerging molecular indicators of vascular dysfunction - such as claudin-5, thrombospondins, platelet-derived growth factors, and components of the nitric oxide system - show potential for improving diagnosis and guiding therapeutic development, though further replication is needed. While the current evidence remains preliminary and subject to limitations discussed herein, vascular dysfunction may serve as a dynamic indicator of both acute suicide risk and longer-term susceptibility. This review integrates vascular homeostasis into the broader biological framework of SB, alongside stress-response pathways, inflammation, and neural dysfunction, offering novel insights into SB pathophysiology and paving the way for developing targeted diagnostic tools and interventions.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144494088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the Neurovisual Interconnection and Threat Processing in Posttraumatic Stress Disorder: New Perspectives and Future Directions. 创伤后应激障碍的神经视觉互联与威胁加工：新视角与未来发展方向。

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2025-06-23 DOI: 10.1016/j.biopsych.2025.04.022

Rizky Andana Pohan, Dian Oktary, Siti Kulsum, Ririn Dwi Astuti, Putri Bunga Aisyah Pohan

引用次数: 0

Why is Clozapine uniquely Effective in Treatment Resistant Schizophrenia? 为什么氯氮平对治疗难治性精神分裂症特别有效？

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2025-06-23 DOI: 10.1016/j.biopsych.2025.06.011

Robin M Murray, Alice Egerton, Yueming Gao, Anthony A Grace, Oliver Howes, Sameer Jauhar, Stefan Leucht, Eric Y H Chen, James H MacCabe, Robert A McCutcheon, Sridhar Natesan, David Taylor

{"title":"Why is Clozapine uniquely Effective in Treatment Resistant Schizophrenia?","authors":"Robin M Murray, Alice Egerton, Yueming Gao, Anthony A Grace, Oliver Howes, Sameer Jauhar, Stefan Leucht, Eric Y H Chen, James H MacCabe, Robert A McCutcheon, Sridhar Natesan, David Taylor","doi":"10.1016/j.biopsych.2025.06.011","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.06.011","url":null,"abstract":"Much is known about the use, benefits, and side-effects, of clozapine in treatment resistant schizophrenia (TRS). However, why clozapine is more effective than other antipsychotics in TRS remains unclear. This paper addresses this question. TRS patients show glutamate abnormalities, and clozapine has widespread effects on glutamate. However, these actions have not been proven different to those of other antipsychotics. Immune dysfunction is also reported in TRS, and clozapine has anti-inflammatory actions, but these have not been correlated with clinical improvement. Currently, there is much interest in muscarinic abnormalities in psychosis. Unlike most antipsychotics, clozapine has important effects on muscarinic receptors, particularly M1 and M4, and its major metabolite, N-desmethylclozapine, is a full agonist at M1. These effects are likely crucial to clozapine's effectiveness. In addition, clozapine's lower D2 receptor occupancy has been postulated to allow gradual resolution of dopamine receptor supersensitivity in the minority of patients with TRS who initially respond to antipsychotics but become resistant following long-term dopamine blockade. This hypothesis, however, remains controversial. Clozapine's multi-receptor profile enables it to have beneficial actions on the non-psychotic symptoms common in TRS: its ability to bind to histamine H1, serotonin 5-HT1A and GABA-B receptors offers an explanation for its anxiolytic actions while effects on 5-HT1A, 5-HT2A and 5-HT7 receptors likely underly its antidepressant properties. Clozapine shares these properties with olanzapine and quetiapine but its affinity for muscarinic receptors may be the mechanism by which it is more effective in TRS.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144494089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of single-cell and spatial omics to study copy number variants 利用单细胞和空间组学研究拷贝数变异

IF 10.6 1区医学

Biological Psychiatry Pub Date : 2025-06-20 DOI: 10.1016/j.biopsych.2025.06.010

Susmita Malwade, Andres Ingason, Konstantin Khodosevich

{"title":"The use of single-cell and spatial omics to study copy number variants","authors":"Susmita Malwade, Andres Ingason, Konstantin Khodosevich","doi":"10.1016/j.biopsych.2025.06.010","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.06.010","url":null,"abstract":"Copy number variants (CNVs) are structural genomic rearrangements that alter the number of gene copies in genome. Some CNVs are highly penetrant for psychiatric disorders, where the total CNV impact to a neuropsychiatric phenotype is based on potential contribution from every gene it encompasses. However, it can be challenging to associate the typically numerous genes within the CNV to a mechanistic understanding of how brain dysfunction arises. Thus, open questions in CNV research are: how can the genes driving a phenotype be identified from all genes in a CNV and how can molecular mechanisms that lead to brain dysfunction with numerous potential candidate genes be determined? Until recently, these questions could be addressed only by highly laborious experimental setups that include screening individual and combinatorial knockouts of genes within a CNV. With the advance of single-cell and spatial omics, published high-resolution transcriptional data in space and time can help predict those genes that have the highest potential to drive a phenotype and thus pave the way for more efficient studies from genotype to phenotype. In this review, we discuss current progress in single-cell and spatial omics and propose a strategy for implementing these technologies in CNV research.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"45 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Successful Evidence-Based Parenting Programs are Associated With Brain Changes and Improved Reward Processing in Boys With Conduct Problems 成功的基于证据的养育计划与有行为问题的男孩的大脑变化和改善的奖励处理有关

IF 10.6 1区医学

Biological Psychiatry Pub Date : 2025-06-18 DOI: 10.1016/j.biopsych.2025.06.008

Arjun Sethi, Suzanne O’Brien, James Blair, Essi Viding, Daniel Shani, Oliver Robinson, Mitul Mehta, Christine Ecker, Marija-Magdalena Petrinovic, Marco Catani, Nigel Blackwood, Moira Doolan, Declan G.M. Murphy, Stephen Scott, Michael C. Craig

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A Longitudinal and Reproducible Anti-coactivation Pattern Between the Cerebellum and the Ventral Tegmental Area Relates to Apathy in Schizophrenia 小脑和腹侧被盖区之间的纵向和可重复的抗共激活模式与精神分裂症的冷漠有关

IF 10.6 1区医学

Biological Psychiatry Pub Date : 2025-06-18 DOI: 10.1016/j.biopsych.2025.06.009

Jade Awada, Farnaz Delavari, Thomas A.W. Bolton, Fares Alouf, Fabien Carruzzo, Noemie Kuenzi, Mariia Kaliuzhna, Tal Geffen, Teresa Katthagen, Florian Schlagenhauf, Dimitri Van De Ville, Stephan Eliez, Stefan Kaiser, Indrit Bègue

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Network localization of functional brain changes associated with ketamine's therapeutic effects in depression 与氯胺酮治疗抑郁症相关的脑功能变化的网络定位

IF 10.6 1区医学

Biological Psychiatry Pub Date : 2025-06-13 DOI: 10.1016/j.biopsych.2025.06.006

Shaoqiang Han, Ya Tian, Huiting Yang, Ruiping Zheng, Shuying Li, Keke Fang, Baohong Wen, Liang Liu, Yarui Wei, Yuan Chen, Huafu Chen, Jingliang Cheng, Yong Zhang

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Effect of natural rewards on substance use disorder: an incentive sensitization perspective 自然奖励对物质使用障碍的影响：激励敏化的视角

IF 10.6 1区医学

Biological Psychiatry Pub Date : 2025-06-13 DOI: 10.1016/j.biopsych.2025.05.026

Wei Zheng, Xiaoxing Liu, Tangsheng Lu, Kai Yuan, Xue Li, Yanxue Xue, Qingqing Yin, Jie Shi, Guichang Zou, Jeffrey W. Grimm, Lin Lu

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Neonatal Hippocampal Volume and Parent Structuring at 18 months in Relation to Cortisol Stress Regulation Across Early Childhood and Executive Functions at Age 4 Years in Children Born Very Preterm 新生儿海马体体积和父母在18个月时的结构与早期儿童皮质醇应激调节和4岁时的执行功能有关

IF 10.6 1区医学

Biological Psychiatry Pub Date : 2025-06-13 DOI: 10.1016/j.biopsych.2025.06.005

Mia A. McLean, Joanne Weinberg, Jillian V. Miller, Ting Guo, Anne R. Synnes, Steven P. Miller, Ruth E. Grunau

引用次数: 0