Biological Psychiatry最新文献

{"title":"Subscribers Page","authors":"","doi":"10.1016/S0006-3223(25)00998-9","DOIUrl":"10.1016/S0006-3223(25)00998-9","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 8","pages":"Page A2"},"PeriodicalIF":9.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Brain Stimulation response circuits in Obsessive Compulsive Disorder.","authors":"Andreas Horn, Ningfei Li, Garance M Meyer, Ron Gadot, Nicole R Provenza, Sameer A Sheth","doi":"10.1016/j.biopsych.2025.03.008","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.03.008","url":null,"abstract":"<p><p>In the field of deep brain stimulation (DBS), two major themes are currently making significant progress. First, the framework of connectomic DBS, in which circuits that are associated with improvements of specific symptoms are described and targeted to improve and potentially personalize treatment. Second, the concept of brain sensing and adaptive DBS, which aims at identifying neural biomarkers that may guide stimulation in a closed-loop fashion. In DBS for Obsessive Compulsive Disorder (OCD), substantial progress has been made on both ends, over the last five years. Together, results begin to draw a picture of exactly which circuit is associated with treatment response, and how it may be affected by dysfunctional brain activity that may be attenuated using DBS. In turn, this knowledge, if further refined and validated, will define where, when, and how to stimulate which patients with OCD. We review the key studies from recent years with the aim to aggregate and condense findings along both spatial and temporal domains. The result is a concept that anatomically defines a circuit that is likely dysfunctional in patients with typical OCD phenotypes, and which may be adaptively targeted using DBS to maximally improve symptoms.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Stability and Specificity of Polygenic Risk Scores for Major Psychiatric Disorders Limit their Clinical Utility.","authors":"Josephine Mollon, Laura M Schultz, Emma Em Knowles, Sebastien Jacquemont, David C Glahn, Laura Almasy","doi":"10.1016/j.biopsych.2025.03.006","DOIUrl":"10.1016/j.biopsych.2025.03.006","url":null,"abstract":"<p><strong>Background: </strong>There has been little examination of the stability and validity of polygenic risk scores (PRS) i.e., whether individuals identified as high-risk for a disorder with one PRS are identified as high-risk with another PRS, and whether high-risk individuals have the disorder.</p><p><strong>Methods: </strong>The UK Biobank recruited 502,534 individuals aged 37-73 in the UK between 2006-2010. PRS were calculated for 408,853 white British individuals. PRS-CS, which uses SNP effect sizes under continuous shrinkage, was used to calculate three different PRS for major depressive disorder (MDD), alcohol use disorder (AUD), and type 2 diabetes (T2D), and two different PRS for schizophrenia (SCZ). PRS stability was measured using correlations between different PRS for the same disorder, and percentage of individuals consistently identified as high-risk (top 5% PRS). Sensitivity and specificity were used to measure PRS validity.</p><p><strong>Results: </strong>Correlations between PRS ranged from low to high (SCZ: r=0.78; MDD: r=0.16-0.78; AUD: r=0.13-0.90; T2D r=0.29-0.77). Percentage of individuals consistently identified as high-risk (top 5% PRS) for schizophrenia with different SCZ PRS was 47.7%, i.e., less than half of individuals identified as high-risk with one PRS were identified as high-risk with another PRS. Percentages of individuals consistently identified as high-risk were 9.5-47.0% for MDD, 8.3-63.5% for AUD, and 14.1-45.2% for T2D. Sensitivity of PRS was moderate for MDD (66.1-74.4%) and AUD (72.3-74.2%), moderate/good for T2D (77.3-96.3%), and good for SCZ (90.2-93.3%). Specificity was low for all PRS (50.7-56.4%).</p><p><strong>Conclusions: </strong>Limited stability and specificity of PRS highlight their lack of clinical utility in psychiatry.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astrocytes control cocaine-induced synaptic plasticity and reward through the matricellular protein hevin.","authors":"Raphaële Mongrédien, Augusto Anesio, Gustavo J D Fernandes, Andrew L Eagle, Steeve Maldera, Cuong Pham, Séverine Robert, Fernando Bezerra, Adèle Vilette, Paula Bianchi, Clara Franco, Franck Louis, Carole Gruszczynski, Marie-Laure Niépon, Catalina Betancur, Amaia M Erdozain, Alfred J Robison, Antony A Boucard, Fabio C Cruz, Dongdong Li, Nicolas Heck, Sophie Gautron, Vincent Vialou","doi":"10.1016/j.biopsych.2025.02.904","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.02.904","url":null,"abstract":"<p><strong>Background: </strong>Astrocytes in the nucleus accumbens (NAc) play a dynamic role in regulating synaptic plasticity induced by drugs of abuse through modulation of glutamatergic neurotransmission. Astrocyte-secreted factors may also contribute to the reprogramming of brain circuitry leading to drug-seeking behavior. Here we investigated the role of astrocyte Ca²⁺ signals in vivo and of the astrocyte-secreted protein hevin in the rewarding properties of cocaine.</p><p><strong>Methods: </strong>Ca²⁺ signals in NAc astrocytes were measured by in vivo fiber photometry during conditioned place preference (CPP) to cocaine. Depletion of Ca²⁺ and chemogenetic activation were employed to evaluate the contribution of astrocyte Ca²⁺ signals to cocaine CPP. The effects of cocaine in hevin-null mice and after hevin knockdown in NAc astrocytes were evaluated by imaging of medium spiny neuron spines, electrophysiology and CPP. Hevin secretion was monitored by light-sheet imaging in brain slices.</p><p><strong>Results: </strong>Cocaine increased the amplitude of Ca²⁺ signals in astrocytes during conditioning. Attenuating Ca²⁺ signals in astrocytes prevented cocaine CPP, whereas augmenting these signals potentiated this conditioning. Astrocyte activation induced a surge in hevin secretion ex vivo. Hevin knockdown in NAc astrocytes led to a decrease in CPP and in structural and synaptic plasticity in medium spiny neurons induced by cocaine.</p><p><strong>Conclusions: </strong>These findings reveal a fine-tuning by cocaine of in vivo Ca²⁺ signals in NAc astrocytes. Astrocyte Ca²⁺ signals are sufficient and necessary for the acquisition of cocaine-seeking behavior. Hevin can be released upon astrocyte activation, and is a major effector of the action of cocaine and Ca²⁺ signals on reward and neuronal plasticity.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum.","authors":"","doi":"10.1016/j.biopsych.2025.02.896","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.02.896","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conduct disorder is associated with heightened action initiation and reduced learning from punishment but not reward.","authors":"Ruth Pauli, Inti Brazil, Gregor Kohls, Tobias U Hauser, Lisa Gistelinck, Dimitris Dikeos, Roberta Dochnal, Graeme Fairchild, Aranzazu Fernández-Rivas, Beate Herpertz-Dahlmann, Amaia Hervas, Kerstin Konrad, Arne Popma, Christina Stadler, Christine M Freitag, Stephane A De Brito, Patricia L Lockwood","doi":"10.1016/j.biopsych.2025.03.005","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.03.005","url":null,"abstract":"<p><strong>Background: </strong>Theoretical and empirical accounts of conduct disorder (CD) suggest problems with reinforcement learning as well as heightened impulsivity. These two facets can manifest in similar behaviour, such as risk-taking. Computational models that can dissociate learning from impulsively initiating actions are essential for understanding the cognitive mechanisms underlying CD.</p><p><strong>Methods: </strong>A large, international sample of youths from 11 European countries (N = 1418, typically developing (TD) n = 742, CD n = 676) completed a learning task. We used computational modelling to disentangle reward and punishment learning from action initiation.</p><p><strong>Results: </strong>Punishment learning rates were significantly reduced in youths with CD compared to their TD peers, suggesting that they did not update their actions based on punishment outcomes as strongly. Intriguingly, those with CD also had a greater tendency to initiate actions regardless of outcomes, although their ability to learn from reward was comparable to their TD peers. We additionally observed that variability in action initiation correlated with self-reported impulsivity in youths with CD.</p><p><strong>Conclusions: </strong>These findings provide empirical support for a reduced ability to learn from punishment in CD, while reward learning is typical. Our results also suggest that behaviours appearing superficially to reflect reward learning differences could reflect heightened impulsive action initiation instead. Such asymmetric learning from reward and punishment, with increased action initiation, could have important implications for tailoring learning-based interventions to help those with CD.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early manifestations of neurodevelopmental copy number variants in children: A population-based investigation.","authors":"Charlotte A Dennison, Joanna Martin, Amy Shakeshaft, Lucy Riglin, Victoria Powell, George Kirov, Michael J Owen, Michael C O'Donovan, Anita Thapar","doi":"10.1016/j.biopsych.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.03.004","url":null,"abstract":"<p><strong>Background: </strong>There is clinical interest in recognising copy number variants (CNVs) in children as many have immediate and long-term health implications. Neurodevelopmental CNVs are associated with intellectual disability, autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), conditions typically diagnosed by medical practitioners. However, neurodevelopmental CNVs may have additional, early developmental impacts that have yet to be examined in unselected populations.</p><p><strong>Methods: </strong>Carriers of known ND CNVs were identified in two UK birth cohorts: the Avon Longitudinal Study of Parents and Children (ALSPAC) (carriers=144, controls=6217) and the Millennium Cohort Study (MCS) (carriers=151, controls=6559). In ALSPAC, we assessed associations between CNV carrier status and: birth complications, preschool development, cognitive ability, neurodevelopmental conditions (ASD, ADHD, reading, language, and motor difficulties), psychiatric, social and educational outcomes. Corresponding phenotypes were identified in MCS and meta-analysed, where available.</p><p><strong>Results: </strong>In ALSPAC, neurodevelopmental CNVs were associated with low cognitive ability, ADHD and ASD. Neurodevelopmental CNV carriers showed greater likelihood of preterm birth, fine and gross motor delay, difficulties in motor coordination, language, and reading, and special educational needs (SEND). Meta-analysis with available measures in MCS identified elevated likelihood of ASD, ADHD, low birthweight, reading difficulties, SEND, and peer problems.</p><p><strong>Discussion: </strong>Neurodevelopmental CNVs are associated with a broad range of developmental impacts. While clinicians who see children with intellectual disability, ASD, or ADHD may be aware of the impacts of CNVs and consider genetic testing, our investigation suggests that this training and awareness may need to extend to other professional groups (e.g. speech and language therapists).</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prosocial Helping Behavior: Conceptual Issues and Neural Mechanisms.","authors":"Nicole Rigney, Weizhe Hong","doi":"10.1016/j.biopsych.2025.03.003","DOIUrl":"10.1016/j.biopsych.2025.03.003","url":null,"abstract":"<p><p>Prosocial helping behavior, characterized by voluntary actions taken to benefit others, plays a vital role in promoting cooperation and maintaining social bonds across human and animal social groups. In this review, we examine key conceptual issues surrounding prosocial behavior, focusing specifically on targeted helping and comforting actions. We outline the behavioral paradigms used to study these two types of prosocial behaviors and summarize recent insights into their underlying neural mechanisms. Drawing on findings across species and with an emphasis on rodent models, we discuss how these behaviors are regulated by molecularly and anatomically defined neural systems and how distinct neuronal populations and circuits may differentially regulate targeted helping and comforting behaviors. Lastly, we discuss the clinical relevance of this research by addressing the implications of prosocial deficits in psychiatric disorders.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Implicit Bias to Reconciliation: A Neuroscience-Informed Perspective on Racism","authors":"Thara M. Nagarajan ,&nbsp;Bernice N. Yau ,&nbsp;David A. Ross","doi":"10.1016/j.biopsych.2025.01.023","DOIUrl":"10.1016/j.biopsych.2025.01.023","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 7","pages":"Pages 666-668"},"PeriodicalIF":9.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Safe Step in the Right Direction: Focused Ultrasound in Obsessive-Compulsive Disorder and Depression","authors":"Patricio Riva-Posse ,&nbsp;Martijn Figee","doi":"10.1016/j.biopsych.2025.01.024","DOIUrl":"10.1016/j.biopsych.2025.01.024","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 7","pages":"Pages 664-665"},"PeriodicalIF":9.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}