Biological Psychiatry最新文献_第3页

Computational Clarity and Validation of Shisa7 in Heroin-Seeking Behavior Shisa7在海洛因寻求行为中的计算清晰度和验证

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2025-06-11 DOI: 10.1016/j.biopsych.2025.05.001

BaDoi N. Phan , Samara J. Vilca

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Low-Intensity Focused Ultrasound for Opioid Use Disorder: Early Evidence and Open Questions 阿片类药物使用障碍的低强度聚焦超声：早期证据和开放性问题

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2025-06-11 DOI: 10.1016/j.biopsych.2025.04.019

Zoë Panchal

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Conducting the Molecular Symphony: Network-Based Approaches to Substance Use Disorders 进行分子交响乐：基于网络的方法对物质使用障碍

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2025-06-11 DOI: 10.1016/j.biopsych.2025.04.017

Anna S. Warden , R. Dayne Mayfield

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Novel Insights Into the Role of Coding Variants in Alcohol Use Disorder 编码变异在酒精使用障碍中的作用的新见解

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Biological Psychiatry Pub Date : 2025-06-11 DOI: 10.1016/j.biopsych.2025.04.016

Wei Cheng , Jianfeng Feng

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Editorial Board Page 编委会页面

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Biological Psychiatry Pub Date : 2025-06-11 DOI: 10.1016/S0006-3223(25)01199-0

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Subscribers Page 用户页面

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Biological Psychiatry Pub Date : 2025-06-11 DOI: 10.1016/S0006-3223(25)01200-4

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Guide for Authors 作者指南

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Biological Psychiatry Pub Date : 2025-06-11 DOI: 10.1016/S0006-3223(25)01203-X

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Biological mechanisms of sleep/wake related function. 睡眠/觉醒相关功能的生物学机制。

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2025-06-10 DOI: 10.1016/j.biopsych.2025.06.002

Greene Robert

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Selective insensitivity to global vs. local linguistic context in speech produced by patients with untreated psychosis and positive thought disorder. 未经治疗的精神病和积极思维障碍患者在言语中对全局和局部语言语境的选择性不敏感。

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2025-06-10 DOI: 10.1016/j.biopsych.2025.06.001

Victoria Sharpe, Michael Mackinley, Samer Nour Eddine, Lin Wang, Lena Palaniyappan, Gina R Kuperberg

{"title":"Selective insensitivity to global vs. local linguistic context in speech produced by patients with untreated psychosis and positive thought disorder.","authors":"Victoria Sharpe, Michael Mackinley, Samer Nour Eddine, Lin Wang, Lena Palaniyappan, Gina R Kuperberg","doi":"10.1016/j.biopsych.2025.06.001","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.06.001","url":null,"abstract":"Background: Early psychopathologists proposed that certain features of positive thought disorder, the disorganized language output produced by some people with schizophrenia, suggest an insensitivity to global, relative to local, discourse context. This idea has received support from carefully controlled psycholinguistic studies in language comprehension. In language production, researchers have so far remained reliant on subjective qualitative rating scales to assess and understand speech disorganization. Now, however, recent advances in large language models mean that it is possible to quantify sensitivity to global and local context objectively by probing lexical probability (the predictability of a word given its preceding context) during natural language production.Methods: For each word in speech produced by 60 first-episode psychosis patients and 35 healthy, demographically-matched controls, we extracted lexical probabilities from GPT-3 based on contexts that ranged from very local- a single preceding word: P(Wn | Wn-1)-to global-up to 50 preceding words: P(Wn|Wn-50, Wn-49, …, Wn-1).Results: We show that disorganized speech is characterized by disproportionate insensitivity to global, versus local, linguistic context. Critically, this global-versus-local insensitivity selectively predicted clinical ratings of positive thought disorder, above and beyond overall symptom severity. There was no evidence of a relationship with negative thought disorder (impoverishment).Conclusions: We provide an automated, interpretable measure that can potentially be used to quantify speech disorganization in schizophrenia. Our findings directly link the clinical phenomenology of thought disorder to neurocognitive constructs that are grounded in psycholinguistic theory and neurobiology.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Emotion generation and regulation in premenstrual dysphoric disorder: dysregulation of large-scale brain networks across the menstrual cycle. 经前烦躁不安障碍的情绪产生和调节：月经周期中大规模脑网络的失调。

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2025-06-06 DOI: 10.1016/j.biopsych.2025.05.025

Louise Stiernman, Manon Dubol, Erika Comasco, Maja Johansson, Lars Stiernman, Marie Bixo

{"title":"Emotion generation and regulation in premenstrual dysphoric disorder: dysregulation of large-scale brain networks across the menstrual cycle.","authors":"Louise Stiernman, Manon Dubol, Erika Comasco, Maja Johansson, Lars Stiernman, Marie Bixo","doi":"10.1016/j.biopsych.2025.05.025","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.05.025","url":null,"abstract":"Background: Emotion regulation deficits have been highlighted as a transdiagnostic feature of multiple psychiatric disorders, including premenstrual dysphoric disorder (PMDD). In this study, we hypothesize that deficient prefrontal \"top-down\" regulation of key nodes of the salience network (SN) is a characteristic of PMDD, driven by increased levels of progesterone-derived neuroactive steroids.Methods: Functional magnetic resonance imaging (fMRI) was used to investigate menstrual-cycle related variations in brain activity and connectivity during two emotional tasks (emotion generation and regulation) in 29 women with PMDD and 27 controls. We also examined whether differential brain activation between groups is related to serum levels of progesterone-derived neuroactive steroids and premenstrual symptom severity.Results: Women with PMDD showed increased reactivity in key nodes of the SN and - at subthreshold level - in the default mode network (DMN) during the luteal phase when passively viewing negative emotional stimuli. Intriguingly, SN hyperactivity in PMDD patients was apparent also during the follicular phase and related to premenstrual symptom severity. PMDD and control women had similar network connectivity patterns and activity in regions associated with the conscious control of emotion in PMDD. No link to progesterone-derived neuroactive steroids was found.Conclusions: Multiple network aberrations during the luteal phase may explain the development of mood symptoms in the luteal phase. Furthermore, higher baseline (follicular) SN activity may render PMDD women more susceptible to severe mood symptoms in response to hormonal fluctuations. What drives increased SN activity in the follicular phase is unknown, but innate and neuroplastic mechanisms are proposed.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0