具有不同前额叶底物的高度焦虑对抗焦虑药、西酞普兰和氯胺酮的敏感性不同：前额叶底物和抗焦虑药敏感性

IF 9 1区医学 Q1 NEUROSCIENCES

Biological Psychiatry Pub Date : 2025-06-25 DOI:10.1016/j.biopsych.2025.06.013

Kevin G. Mulvihill, Gemma J. Cockcroft, Angela C. Roberts

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引用次数: 0

摘要

药物治疗效果的个体差异仍然是改善临床焦虑的持续障碍。这可能部分源于病理性焦虑背后的不同神经病因。为了对患者抗焦虑反应的异质性提供新的见解，我们比较了不同的抗焦虑药物，选择性5 -羟色胺再摄取抑制剂（SSRI）和氯胺酮对狨猴不同病因但来源已知的焦虑状态的疗效。

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Heightened anxiety with distinct prefrontal substrates is differentially sensitive to the anxiolytics, citalopram and ketamine: Prefrontal substrates and anxiolytic sensitivity

Individual variability in pharmacological treatment efficacy remains a persistent obstacle to ameliorating clinical anxiety. This may originate, in part, from the different neural aetiologies underlying pathological anxiety. To provide novel insights into patient heterogeneity in anxiolytic responsiveness we compare the efficacy of distinct anxiolytic drugs, a Selective Serotonin Re-uptake Inhibitor (SSRI) and ketamine on anxiety states with different aetiologies, but of known origin, in marmoset monkeys.

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来源期刊

Biological Psychiatry 医学-精神病学

CiteScore

18.80

自引率

2.80%

发文量

1398

审稿时长

33 days

期刊介绍： Biological Psychiatry is an official journal of the Society of Biological Psychiatry and was established in 1969. It is the first journal in the Biological Psychiatry family, which also includes Biological Psychiatry: Cognitive Neuroscience and Neuroimaging and Biological Psychiatry: Global Open Science. The Society's main goal is to promote excellence in scientific research and education in the fields related to the nature, causes, mechanisms, and treatments of disorders pertaining to thought, emotion, and behavior. To fulfill this mission, Biological Psychiatry publishes peer-reviewed, rapid-publication articles that present new findings from original basic, translational, and clinical mechanistic research, ultimately advancing our understanding of psychiatric disorders and their treatment. The journal also encourages the submission of reviews and commentaries on current research and topics of interest.