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Mapping the genetic landscape of psychiatric disorders with the MiXeR toolset.
IF 9.6 1区 医学
Biological Psychiatry Pub Date : 2025-02-19 DOI: 10.1016/j.biopsych.2025.02.886
Dennis van der Meer, Guy Hindley, A Shadrin, Olav B Smeland, Alexey Nadine Parker, Anders M Dale, Oleksandr Frei, Ole A Andreassen
{"title":"Mapping the genetic landscape of psychiatric disorders with the MiXeR toolset.","authors":"Dennis van der Meer, Guy Hindley, A Shadrin, Olav B Smeland, Alexey Nadine Parker, Anders M Dale, Oleksandr Frei, Ole A Andreassen","doi":"10.1016/j.biopsych.2025.02.886","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.02.886","url":null,"abstract":"<p><p>Psychiatric disorders have complex genetic architectures with substantial genetic overlap across conditions, which may partly explain their high levels of comorbidity. This presents significant challenges to research; genome-wide association studies (GWAS) have uncovered hundreds of loci associated with single disorders, yet the genetic landscape of psychiatric disorders has remained largely obscured. By moving beyond the conventional infinitesimal model, uni-, bi-, and trivariate MiXeR tools, applied to GWAS summary statistics, have enabled us to more comprehensively describe the genetic architecture of complex disorders and traits, and their overlap. Further, the GSA-MiXeR tool improves biological interpretation of GWAS findings to better understand causal mechanisms. Here, we outline the methodology underlying the MiXeR tools, together with instructions for their optimal use. We review results from studies investigating the genetic architecture of psychiatric disorders and their overlap using the MiXeR toolset. These studies have revealed generally high polygenicity and low discoverability among psychiatric disorders, particularly in contrast to somatic disorders. There is also pervasive genetic overlap across psychiatric disorders and behavioral traits, while their overlap with somatic traits is smaller, in line with differences in polygenicity. Finally, GSA-MiXeR has quantified the contribution of gene-sets to the heritability of psychiatric disorders, prioritizing small, biologically coherent gene-sets. Together, these findings have implications for our understanding of the complex relationships between psychiatric disorders and related traits. MiXeR tools have provided new insights into the genetic architecture of psychiatric disorders, generating a better understanding of their underlying biological mechanisms and potential for clinical utility.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methodological and Interpretational Issues in the PsyRiskMR Database.
IF 9.6 1区 医学
Biological Psychiatry Pub Date : 2025-02-19 DOI: 10.1016/j.biopsych.2025.01.029
Jiawei Zhao
{"title":"Methodological and Interpretational Issues in the PsyRiskMR Database.","authors":"Jiawei Zhao","doi":"10.1016/j.biopsych.2025.01.029","DOIUrl":"10.1016/j.biopsych.2025.01.029","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Society of Biological Psychiatry's 2025 Meeting.
IF 9.6 1区 医学
Biological Psychiatry Pub Date : 2025-02-18 DOI: 10.1016/j.biopsych.2025.02.013
Sophia Frangou, Dost Öngür
{"title":"Society of Biological Psychiatry's 2025 Meeting.","authors":"Sophia Frangou, Dost Öngür","doi":"10.1016/j.biopsych.2025.02.013","DOIUrl":"10.1016/j.biopsych.2025.02.013","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscribers Page
IF 9.6 1区 医学
Biological Psychiatry Pub Date : 2025-02-17 DOI: 10.1016/S0006-3223(25)00034-4
{"title":"Subscribers Page","authors":"","doi":"10.1016/S0006-3223(25)00034-4","DOIUrl":"10.1016/S0006-3223(25)00034-4","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 6","pages":"Page A2"},"PeriodicalIF":9.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guide for Authors
IF 9.6 1区 医学
Biological Psychiatry Pub Date : 2025-02-17 DOI: 10.1016/S0006-3223(25)00037-X
{"title":"Guide for Authors","authors":"","doi":"10.1016/S0006-3223(25)00037-X","DOIUrl":"10.1016/S0006-3223(25)00037-X","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 6","pages":"Pages A5-A10"},"PeriodicalIF":9.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Epigenetic Mechanism Promoting Heroin Relapse After Prolonged Abstinence
IF 9.6 1区 医学
Biological Psychiatry Pub Date : 2025-02-17 DOI: 10.1016/j.biopsych.2024.12.013
Rose Marie Akiki , Makoto Taniguchi
{"title":"An Epigenetic Mechanism Promoting Heroin Relapse After Prolonged Abstinence","authors":"Rose Marie Akiki ,&nbsp;Makoto Taniguchi","doi":"10.1016/j.biopsych.2024.12.013","DOIUrl":"10.1016/j.biopsych.2024.12.013","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 6","pages":"Pages 552-553"},"PeriodicalIF":9.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Control From Above: Orbitofrontal Cortical Inputs to Striatal Cholinergic Interneurons Influence Cognitive Flexibility and Alcohol-Seeking Behavior
IF 9.6 1区 医学
Biological Psychiatry Pub Date : 2025-02-17 DOI: 10.1016/j.biopsych.2024.12.002
David M. Lovinger
{"title":"Control From Above: Orbitofrontal Cortical Inputs to Striatal Cholinergic Interneurons Influence Cognitive Flexibility and Alcohol-Seeking Behavior","authors":"David M. Lovinger","doi":"10.1016/j.biopsych.2024.12.002","DOIUrl":"10.1016/j.biopsych.2024.12.002","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 6","pages":"Pages 554-555"},"PeriodicalIF":9.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adult Hippocampal Neurogenesis and the Landscape of Plasticity in the Human Brain
IF 9.6 1区 医学
Biological Psychiatry Pub Date : 2025-02-17 DOI: 10.1016/j.biopsych.2024.12.018
Chloe E. Page , David A. Ross
{"title":"Adult Hippocampal Neurogenesis and the Landscape of Plasticity in the Human Brain","authors":"Chloe E. Page ,&nbsp;David A. Ross","doi":"10.1016/j.biopsych.2024.12.018","DOIUrl":"10.1016/j.biopsych.2024.12.018","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 6","pages":"Pages 558-560"},"PeriodicalIF":9.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Few but Not Futile: A Sparse Nucleus Accumbens Corticotropin-Releasing Factor Population Regulates Reward Learning
IF 9.6 1区 医学
Biological Psychiatry Pub Date : 2025-02-17 DOI: 10.1016/j.biopsych.2025.01.004
Alison V. Roland
{"title":"Few but Not Futile: A Sparse Nucleus Accumbens Corticotropin-Releasing Factor Population Regulates Reward Learning","authors":"Alison V. Roland","doi":"10.1016/j.biopsych.2025.01.004","DOIUrl":"10.1016/j.biopsych.2025.01.004","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 6","pages":"Pages 561-562"},"PeriodicalIF":9.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Board Page
IF 9.6 1区 医学
Biological Psychiatry Pub Date : 2025-02-17 DOI: 10.1016/S0006-3223(25)00033-2
{"title":"Editorial Board Page","authors":"","doi":"10.1016/S0006-3223(25)00033-2","DOIUrl":"10.1016/S0006-3223(25)00033-2","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 6","pages":"Page A1"},"PeriodicalIF":9.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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