Biological Psychiatry最新文献

{"title":"Computational Therapeutics: Modeling Impulsive Decision Making to Isolate Pharmaceutical Targets","authors":"Silvia Lopez-Guzman","doi":"10.1016/j.biopsych.2024.12.008","DOIUrl":"10.1016/j.biopsych.2024.12.008","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 6","pages":"Pages 556-557"},"PeriodicalIF":9.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Affective and Social Predictors of Food Consumption During the COVID-19 Lockdown.","authors":"Ana Stijovic, Paul Forbes, Ekaterina Pronizius, Anja Feneberg, Giulio Piperno, Urs M Nater, Claus Lamm, Giorgia Silani","doi":"10.1016/j.biopsych.2025.02.007","DOIUrl":"10.1016/j.biopsych.2025.02.007","url":null,"abstract":"<p><strong>Background: </strong>COVID-19 lockdowns were linked to a surge in unhealthy food-related behaviors, potentially as an attempt to cope with disrupted social homeostasis. Here, we tested bidirectional associations between momentary psychological states and prospective food consumption and the moderation of these associations by quality and quantity of social interactions.</p><p><strong>Methods: </strong>We conducted a preregistered ecological momentary assessment study in Austria, Italy, and Germany during the first COVID-19 lockdown. Multiple times a day for 7 consecutive days, 798 participants (557 women, mean age = 31.88 years) reported on momentary stress; mood; wanting of food rich in sugar, fat, and salt; consumption and enjoyment since the last prompt; and quantity and quality of social interactions since the last prompt.</p><p><strong>Results: </strong>Momentary stress was positively linked to food wanting, but not to prospective food consumption. Mood valence and energetic arousal positively predicted prospective food consumption and enjoyment. The effect of mood valence was especially prominent when participants reported having more social interactions. Food consumption was linked to a prospective reduction in stress and an increase in calmness, suggesting that it has regulatory functions for affective states. Exploratory findings showed that some of these effects generalize to other reward types.</p><p><strong>Conclusions: </strong>During the lockdown, food may have been used to maintain an already positive affective state rather than upregulating an aversive state. Social facilitation of eating may have been especially prominent due to the prioritization of social needs at the start of an extraordinarily challenging period, possibly orchestrated by the postulated social homeostasis system.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping structural neuroimaging trajectories in bipolar disorder: neurobiological and clinical implications.","authors":"Nadine Parker, Christopher R K Ching","doi":"10.1016/j.biopsych.2025.02.009","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.02.009","url":null,"abstract":"<p><p>Neuroimaging is a powerful non-invasive method for studying brain alterations in bipolar disorder (BD). To date, most neuroimaging studies of BD include smaller cross-sectional samples reporting case versus control comparisons, revealing small to moderate effect sizes. In this narrative review, we discuss the current state of MRI-based, structural imaging studies, which inform our understanding of altered brain trajectories in BD across the lifespan. Alternative methodologies such as those that model patient deviations from age-specific norms are discussed, which may help derive new markers of BD pathophysiology. We discuss evidence from neuroimaging genetics and transcriptomics studies, which attempt to bridge the gap between macro-scale brain variations and underlying micro-scale neurodevelopmental mechanisms. We conclude with a look toward the future and how ambitious investments in longitudinal, deeply phenotyped, population-based cohorts can improve modeling of complex clinical factors and provide more clinically-actionable brain markers for BD.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards understanding and halting legacies of trauma.","authors":"William Wesley Taylor, Laura Korobkova, Nabeel Bhinderwala, Brian George Dias","doi":"10.1016/j.biopsych.2025.02.010","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.02.010","url":null,"abstract":"<p><p>Echoes of natural and anthropogenic stressors not only reverberate within the physiology, biology, and neurobiology of the generation directly exposed to them but also within the biology of future generations. With the intent of understanding this phenomenon, significant efforts have sought to establish how exposure to psychosocial stress, chemicals, over- and under-nutrition, and chemosensory experiences exert multi-generational influences. From these studies, we are gaining new appreciation for how negative environmental events experienced by one generation impact future generations. This review first outlines the need to operationally define dimensions of negative environmental events in the laboratory and the routes via which the impact of such events are felt through generations. Next, it discusses molecular processes that cause the effects of negative environmental events to be initiated in the exposed generation and then perpetuated across generations. Finally, we discuss how legacies of flourishing can be engineered to halt or reverse multi-generational influences of negative environmental events. In summary, this review synthesizes our current understanding of the concept, causes and consequences of multi-generational echoes of stress and looks to opportunities to halt them.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global diversity in bipolar disorder: the role of cultural and social differences with a view to genomics.","authors":"Janice M Fullerton, Markos Tesfaye","doi":"10.1016/j.biopsych.2025.02.008","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.02.008","url":null,"abstract":"<p><p>As global gene discovery efforts turn away from a historic Eurocentric focus and advance towards embracing more diverse populations, consideration of sociocultural aspects of bipolar disorder become critical to their success. Diversity can be leveraged to accelerate gene discovery, via different patterns of linkage disequilibrium that lead to greater resolution of mapping association signals, and convergence of genes and pathways implicated within and across diverse ancestral groups improving our understanding of the molecular underpinnings of disease. However it is not just the differences in linkage disequilibrium structure and allele frequency that drive differences in genomic signals between populations. This review focuses on the role of social, cultural and societal factors on bipolar disorder, and their potential impact on disease prevalence, clinical course and outcome, and disease burden. Social, cultural, and geographical differences in expression of symptoms, and frequency of clinical subtypes in bipolar disorder present both opportunities and challenges to the field. In this era of global multi-ancestry research, resources that facilitate the collection and harmonization of data from culturally and ancestrally-diverse population groups will enhance our ability to gain true biological understanding. Such resources are essential to disambiguate the genetic and environmental components of disease risk, as well as inform effective lifestyle interventions to improve outcome for global citizens living with bipolar disorder.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Drug Discovery Drought in Bipolar Disorder: Barriers and Solutions.","authors":"Jee Hyun Kim, Ken Walder, Bruna Panizzutti, Lana J Williams, Michael Berk","doi":"10.1016/j.biopsych.2025.02.006","DOIUrl":"10.1016/j.biopsych.2025.02.006","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of treatment outcome in bipolar disorder - when can we expect clinical relevance?","authors":"Katie Scott, Anouar Khayachi, Martin Alda, Abraham Nunes","doi":"10.1016/j.biopsych.2025.02.005","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.02.005","url":null,"abstract":"<p><p>Long-term pharmacological treatment is the cornerstone of the management of bipolar disorder (BD). Clinicians typically select mood stabilizing medications from among several options through trial-and-error. This process could be optimized by using robust predictors of treatment response. We review clinical features and biological markers studied in relation to outcome of long-term treatment of BD. To date, the literature focused mostly on lithium and to a lesser extent on anticonvulsants valproate and lamotrigine. The most promising results show association of lithium response with certain clinical features (episodic clinical course and absence of rapid cycling, low rates of comorbid conditions, family history of bipolar disorder and lithium response) as well as low polygenic risk for schizophrenia and major depression. The clinical application of these findings remains limited, however, due to heterogeneity of the illness as well as unanswered questions about specificity of the effects of different medications.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Specific Alterations of the Kynurenine Pathway in Association With Risk for and Remission of Depression in Adolescence.","authors":"Naghmeh Nikkheslat, Zuzanna Zajkowska, Cristina Legido-Quigley, Jin Xu, Pedro H Manfro, Laila Souza, Rivka Pereira, Fernanda Rohrsetzer, Jader Piccin, Anna Viduani, Brandon A Kohrt, Helen L Fisher, Christian Kieling, Valeria Mondelli","doi":"10.1016/j.biopsych.2024.11.020","DOIUrl":"https://doi.org/10.1016/j.biopsych.2024.11.020","url":null,"abstract":"<p><strong>Background: </strong>The imbalance between neurotoxic and neuroprotective metabolites of the kynurenine pathway has been implicated in the pathophysiology of major depressive disorder (MDD) in adulthood but has not been fully investigated among adolescents. In this study, we tested the association of kynurenine pathway metabolites with risk for and remission of adolescent depression and whether abnormalities in the kynurenine pathway are sex specific.</p><p><strong>Methods: </strong>Kynurenine pathway metabolites were measured in plasma at baseline in the IDEA-RiSCo (Identifying Depression Early in Adolescence Risk-Stratified Cohort), a longitudinal study of adolescents (15.6 ± 0.8 years; 50% female) stratified into 3 groups (each n = 50): 1) at low risk for developing depression, 2) at high risk for developing depression, or 3) with MDD. Adolescents with MDD at baseline were followed up after 3 years (n = 41) to assess remission or persistence of MDD.</p><p><strong>Results: </strong>Cross-sectional analyses at baseline showed that adolescents at high risk for depression and adolescents with MDD had lower kynurenic acid concentrations and kynurenic acid/quinolinic acid ratio than low-risk adolescents. These differences were not present in males but appeared to be driven by females. Proinflammatory cytokines positively correlated with neurotoxic metabolites, specifically in the high-risk and MDD groups. Female individuals with persistent MDD at the 3-year follow-up showed lower baseline kynurenine and higher 3-hydroxykynurenine/kynurenine ratio than those who experienced remission at 3-year follow-up.</p><p><strong>Conclusions: </strong>The findings suggest a sex-specific kynurenine pathway alteration in adolescent depression. Female adolescents at higher risk for or with depression showed a reduction in neuroprotective metabolites. An increased diversion of kynurenine toward production of neurotoxic metabolites predicted persistent depression in female adolescents with MDD.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE PROMISE OF INVESTIGATING NEURAL VARIABILITY IN PSYCHIATRIC DISORDERS.","authors":"Konstantinos Tsikonofilos, Arvind Kumar, Konstantinos Ampatzis, Douglas D Garrett, Kristoffer N T Månsson","doi":"10.1016/j.biopsych.2025.02.004","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.02.004","url":null,"abstract":"<p><p>The synergy of psychiatry and neuroscience has recently sought to identify biomarkers that can diagnose mental health disorders, predict their progression, and forecast treatment efficacy. However, biomarkers have achieved limited success to date, potentially due to a narrow focus on specific aspects of brain signals. This highlights a critical need for methodologies that can fully exploit the potential of neuroscience to transform psychiatric practice. In recent years, there is emerging evidence of the ubiquity and importance of moment-to-moment neural variability for brain function. Single-neuron recordings and computational models have demonstrated the significance of variability even at the microscopic level. Concurrently, studies involving healthy humans using neuroimaging recording techniques have strongly indicated that neural variability, once dismissed as undesirable noise, is an important substrate for cognition. Given the cognitive disruption in several psychiatric disorders, neural variability is a promising biomarker in this context and careful consideration of design choices is necessary to advance the field. This review provides an overview of the significance and substrates of neural variability across different recording modalities and spatial scales. We also review the existing evidence supporting its relevance in the study of psychiatric disorders. Finally, we advocate for future research to investigate neural variability within disorder-relevant, task-based paradigms and longitudinal designs. Supported by computational models of brain activity, this framework holds the potential for advancing precision psychiatry in a powerful and experimentally feasible manner.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptional and neurochemical signatures of cerebral blood flow alterations in schizophrenia and individuals at clinical high-risk for psychosis.","authors":"Samuel R Knight, Leyla Abbasova, Yashar Zeighami, Justine Y Hansen, Daniel Martins, Fernando Zelaya, Ottavia Dipasquale, Thomas Liu, David Shin, Matthijs Bossong, Matilda Azis, Mathilde Antoniades, Oliver D Howes, Ilaria Bonoldi, Alice Egerton, Paul Allen, Owen O'Daly, Philip McGuire, Gemma Modinos","doi":"10.1016/j.biopsych.2025.01.028","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.01.028","url":null,"abstract":"<p><strong>Background: </strong>The brain integrates multiple scales of description, from the level of cells and molecules to large-scale networks and behaviour. Understanding relationships across these scales may be fundamental to advancing understanding of brain function in health and disease. Recent neuroimaging research has shown that functional brain alterations that are associated with schizophrenia spectrum disorders (SSD) are already present in young adults at clinical high-risk for psychosis (CHR-P), yet the cellular and molecular determinants of these alterations remain unclear.</p><p><strong>Methods: </strong>Here, we used regional cerebral blood flow (rCBF) data from 425 individuals (122 SSD compared to 116 HCs, and 129 CHR-P compared to 58 HCs) and applied a novel pipeline to integrate brain-wide rCBF case-control maps with publicly available transcriptomic data (17,205 gene maps) and neurotransmitter atlases (19 maps) from 1074 healthy volunteers.</p><p><strong>Results: </strong>We identified significant correlations between astrocyte, oligodendrocyte precursor cell, and vascular leptomeningeal cell gene modules for both SSD and CHR-P rCBF phenotypes, and additionally microglia and oligodendrocytes in CHR-P. Receptor distribution significantly predicted case-control rCBF differences, with dominance analysis highlighting dopamine (D₁, D₂, DAT), acetylcholine (VAChT, M₁), GABA_A, and NMDA receptors as key predictors for SSD (R²_adj=.58, P_FDR<.05) and CHR-P (R²_adj=.6, P_FDR<.05) rCBF phenotypes. These associations were primarily localised in subcortical regions and implicate cell-types involved in stress response and inflammation, alongside specific neuroreceptor systems, in shared and distinct rCBF phenotypes in psychosis.</p><p><strong>Conclusions: </strong>Our findings underscore the value of integrating multi-scale data as a promising hypothesis-generating approach towards decoding biological pathways involved in neuroimaging-based psychosis phenotypes, potentially guiding novel interventions.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}