Biological Psychiatry最新文献

{"title":"Multimodal investigations of structural and functional brain alterations in anorexia and bulimia nervosa and their relationships to psychopathology.","authors":"Xinyang Yu, Lauren Robinson, Marina Bobou, Zuo Zhang, Tobias Banaschewski, Gareth J Barker, Arun L W Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Hervé Lemaître, Luise Poustka, Sarah Hohmann, Nathalie Holz, Christian Bäuchl, Michael N Smolka, Argyris Stringaris, Henrik Walter, Robert Whelan, Julia Sinclair, Gunter Schumann, Ulrike Schmidt, Sylvane Desrivières","doi":"10.1016/j.biopsych.2024.11.008","DOIUrl":"https://doi.org/10.1016/j.biopsych.2024.11.008","url":null,"abstract":"<p><strong>Background: </strong>Neurobiological understanding of eating disorders (EDs) is limited. This study presents the first comparative multi-modal magnetic resonance imaging (MRI) assessments of anorexia nervosa (AN) and bulimia nervosa (BN), uncovering neurobiological differences associated with these disorders.</p><p><strong>Methods: </strong>This female case-control study included 57 healthy controls (HC) and 130 participants with EDs (BN and AN subtypes). Structural and functional MRI assessed gray matter volume (GMV), cortical thickness (CT), and task-based activities related to reward processing, social-emotional functioning, and response inhibition. Whole-brain group differences were correlated to ED psychopathology.</p><p><strong>Results: </strong>Significant structural differences were observed in the ED group compared to HCs, including reduced GMV in the left lateral orbitofrontal cortex and lower CT in the left rostral middle frontal gyrus and precuneus, after adjusting for BMI. Specific structural alterations were only evident in AN subgroups. GMV reductions in the orbitofrontal cortex were linked to impulsivity, while lower CT in the frontal gyrus correlated with cognitive restraint in eating, suggesting these regions may play key roles in ED psychopathology. Functional MRI also revealed notable differences. During reward anticipation, participants with EDs exhibited deactivations in the cerebellum and right superior frontal gyrus, alongside reduced activation in the left lingual gyrus. These functional changes were associated with heightened neuroticism. Mediation analyses suggested that starvation-related GMV reductions in EDs disrupt reward-related brain function, increase neuroticism, and reinforce cognitive restraint, likely contributing to the persistence of ED symptoms.</p><p><strong>Conclusions: </strong>These findings illuminate key neurobehavioral mechanisms underlying EDs, pointing to potential brain-based targets for developing specialized treatment.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Can Early Stress Influence Later Alzheimer's Disease Risk? Possible Mediators and Underlying Mechanisms.","authors":"Paul J Lucassen, Aniko Korosi, Susanne R de Rooij, August B Smit, Anne-Marie Van Dam, Nikolaos P Daskalakis, Ronald E Van Kesteren, Mark H G Verheijen, Sylvie L Lesuis, Helmut W Kessels, Harm J Krugers","doi":"10.1016/j.biopsych.2024.11.007","DOIUrl":"10.1016/j.biopsych.2024.11.007","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a progressive, age-related neurodegenerative disorder to which genetic mutations and risk factors contribute. Evidence is increasing that environmental and lifestyle-related factors, such as exercise, nutrition, education, and exposure to (early-life) stress modify the onset, incidence, and progression of AD. Here, we discuss recent preclinical findings on putative substrates that can explain or contribute to the effects of stress early in life on the risk of developing AD. We focus in particular on stress hormones, neural networks, synapses, mitochondria, nutrient and lipid metabolism, adult neurogenesis, engram cell ensembles, and neuroinflammation. We discuss the idea that stress exposure early in life can alter these processes, either combined or in isolation, thereby reducing the capacity of the brain to resist deleterious consequences of, for example, amyloid-β accumulation, thereby accelerating cognitive decline and progression of Alzheimer-related changes in model systems of the disease. A better understanding of whether experiences early in life also modify trajectories of cognitive decline and pathology in AD and how the substrates discussed translate to humans may help develop novel preventive and/or therapeutic strategies to mitigate the consequences of stressors early in life and increase resilience to developing dementia.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S0006-3223(24)01675-5","DOIUrl":"10.1016/S0006-3223(24)01675-5","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"96 12","pages":"Pages A7-A12"},"PeriodicalIF":9.6,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Long Shadow of Early-Life Adversity: Adult Reward Circuit Signatures of Maternal Attention in Infancy","authors":"Gregory A. Fonzo ,&nbsp;Charles B. Nemeroff","doi":"10.1016/j.biopsych.2024.09.012","DOIUrl":"10.1016/j.biopsych.2024.09.012","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"96 12","pages":"Pages 904-906"},"PeriodicalIF":9.6,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S0006-3223(24)01671-8","DOIUrl":"10.1016/S0006-3223(24)01671-8","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"96 12","pages":"Page A1"},"PeriodicalIF":9.6,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Importance of Neuroimaging Studies in Early Childhood: Prefrontal Cortex Supports Emotional Development in Infants","authors":"Kathryn Manning,&nbsp;Catherine Lebel","doi":"10.1016/j.biopsych.2024.09.011","DOIUrl":"10.1016/j.biopsych.2024.09.011","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"96 12","pages":"Pages 907-908"},"PeriodicalIF":9.6,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When ChatGPT Met RDoC: Leveraging Artificial Intelligence to Bridge the Gap Between Data and Prognosis","authors":"Olusola A. Ajilore","doi":"10.1016/j.biopsych.2024.09.020","DOIUrl":"10.1016/j.biopsych.2024.09.020","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"96 12","pages":"Pages 902-903"},"PeriodicalIF":9.6,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgments","authors":"","doi":"10.1016/j.biopsych.2024.10.002","DOIUrl":"10.1016/j.biopsych.2024.10.002","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"96 12","pages":"Pages 972-978"},"PeriodicalIF":9.6,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroconvulsive Therapy and Brain Network Reorganization: Dynamic Connectivity Insights and Implications for the Treatment of Depression and Suicidal Ideation","authors":"Artemis Zavaliangos-Petropulu","doi":"10.1016/j.biopsych.2024.09.007","DOIUrl":"10.1016/j.biopsych.2024.09.007","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"96 12","pages":"Pages e25-e27"},"PeriodicalIF":9.6,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers Page","authors":"","doi":"10.1016/S0006-3223(24)01672-X","DOIUrl":"10.1016/S0006-3223(24)01672-X","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"96 12","pages":"Page A2"},"PeriodicalIF":9.6,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}