Jade Awada, Farnaz Delavari, Thomas A.W. Bolton, Fares Alouf, Fabien Carruzzo, Noemie Kuenzi, Mariia Kaliuzhna, Tal Geffen, Teresa Katthagen, Florian Schlagenhauf, Dimitri Van De Ville, Stephan Eliez, Stefan Kaiser, Indrit Bègue
{"title":"A Longitudinal and Reproducible Anti-coactivation Pattern Between the Cerebellum and the Ventral Tegmental Area Relates to Apathy in Schizophrenia","authors":"Jade Awada, Farnaz Delavari, Thomas A.W. Bolton, Fares Alouf, Fabien Carruzzo, Noemie Kuenzi, Mariia Kaliuzhna, Tal Geffen, Teresa Katthagen, Florian Schlagenhauf, Dimitri Van De Ville, Stephan Eliez, Stefan Kaiser, Indrit Bègue","doi":"10.1016/j.biopsych.2025.06.009","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.06.009","url":null,"abstract":"Negative symptoms of schizophrenia lack effective treatments. Anomalies in the reward system and cerebellum have been linked to these symptoms. The cerebellum modulates reward circuitry via the ventral tegmental area (VTA). The \"cognitive dysmetria theory\" posits that reduced cerebellar inhibition in schizophrenia may underlie striatal hyperdopaminergia. However, the role of cerebellum-VTA connectivity in negative symptoms remains unclear.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"186 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wei Zheng, Xiaoxing Liu, Tangsheng Lu, Kai Yuan, Xue Li, Yanxue Xue, Qingqing Yin, Jie Shi, Guichang Zou, Jeffrey W. Grimm, Lin Lu
{"title":"Effect of natural rewards on substance use disorder: an incentive sensitization perspective","authors":"Wei Zheng, Xiaoxing Liu, Tangsheng Lu, Kai Yuan, Xue Li, Yanxue Xue, Qingqing Yin, Jie Shi, Guichang Zou, Jeffrey W. Grimm, Lin Lu","doi":"10.1016/j.biopsych.2025.05.026","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.05.026","url":null,"abstract":"In substance use disorder (SUD)/drug addiction, individuals often seek drug rewards at a large cost. Recent findings demonstrate that natural rewards may offer significant therapeutic potential against SUD. However, the mechanism by which natural rewards counteract SUD remains unclear. While the incentive sensitization theory provides valuable insights, a comprehensive understanding is still lacking. In this review, we first summarize the evidence and potential neurobiological mechanisms that support the protective effect of natural rewards against SUD, such as palatable food, social interaction, physical exercise, and environmental enrichment. We then propose an updated incentive sensitization framework to explain how natural rewards resist SUD by modulating “wanting” and “liking”. This review contributes to our understanding of the interaction between natural rewards and drug rewards, potentially facilitating the development of novel therapeutic strategies for SUD.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"42 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mia A. McLean, Joanne Weinberg, Jillian V. Miller, Ting Guo, Anne R. Synnes, Steven P. Miller, Ruth E. Grunau
{"title":"Neonatal Hippocampal Volume and Parent Structuring at 18 months in Relation to Cortisol Stress Regulation Across Early Childhood and Executive Functions at Age 4 Years in Children Born Very Preterm","authors":"Mia A. McLean, Joanne Weinberg, Jillian V. Miller, Ting Guo, Anne R. Synnes, Steven P. Miller, Ruth E. Grunau","doi":"10.1016/j.biopsych.2025.06.005","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.06.005","url":null,"abstract":"Children born very preterm (≤ 32 weeks gestational age) display altered neonatal brain maturation and physiological stress regulation which may be related to executive function difficulties. Supportive parent behaviors are related to better neurodevelopment, but children may vary in their susceptibility to such behaviors. We investigated whether supportive parenting in toddlerhood (1.5, 3 years) may moderate the relationship between neonatal hippocampal volume, stress dysregulation across childhood and executive functions.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"9 1","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Computational Clarity and Validation of Shisa7 in Heroin-Seeking Behavior","authors":"BaDoi N. Phan , Samara J. Vilca","doi":"10.1016/j.biopsych.2025.05.001","DOIUrl":"10.1016/j.biopsych.2025.05.001","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"98 1","pages":"Pages 5-6"},"PeriodicalIF":9.6,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Low-Intensity Focused Ultrasound for Opioid Use Disorder: Early Evidence and Open Questions","authors":"Zoë Panchal","doi":"10.1016/j.biopsych.2025.04.019","DOIUrl":"10.1016/j.biopsych.2025.04.019","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"98 1","pages":"Pages 9-10"},"PeriodicalIF":9.6,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Conducting the Molecular Symphony: Network-Based Approaches to Substance Use Disorders","authors":"Anna S. Warden , R. Dayne Mayfield","doi":"10.1016/j.biopsych.2025.04.017","DOIUrl":"10.1016/j.biopsych.2025.04.017","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"98 1","pages":"Pages 2-4"},"PeriodicalIF":9.6,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel Insights Into the Role of Coding Variants in Alcohol Use Disorder","authors":"Wei Cheng , Jianfeng Feng","doi":"10.1016/j.biopsych.2025.04.016","DOIUrl":"10.1016/j.biopsych.2025.04.016","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"98 1","pages":"Pages 7-8"},"PeriodicalIF":9.6,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}