Biological Psychiatry最新文献_第7页

Guide for Authors 作者指南

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2025-06-11 DOI: 10.1016/S0006-3223(25)01203-X

引用次数: 0

Biological mechanisms of sleep/wake related function. 睡眠/觉醒相关功能的生物学机制。

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2025-06-10 DOI: 10.1016/j.biopsych.2025.06.002

Greene Robert

引用次数: 0

Selective insensitivity to global vs. local linguistic context in speech produced by patients with untreated psychosis and positive thought disorder. 未经治疗的精神病和积极思维障碍患者在言语中对全局和局部语言语境的选择性不敏感。

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2025-06-10 DOI: 10.1016/j.biopsych.2025.06.001

Victoria Sharpe, Michael Mackinley, Samer Nour Eddine, Lin Wang, Lena Palaniyappan, Gina R Kuperberg

{"title":"Selective insensitivity to global vs. local linguistic context in speech produced by patients with untreated psychosis and positive thought disorder.","authors":"Victoria Sharpe, Michael Mackinley, Samer Nour Eddine, Lin Wang, Lena Palaniyappan, Gina R Kuperberg","doi":"10.1016/j.biopsych.2025.06.001","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.06.001","url":null,"abstract":"Background: Early psychopathologists proposed that certain features of positive thought disorder, the disorganized language output produced by some people with schizophrenia, suggest an insensitivity to global, relative to local, discourse context. This idea has received support from carefully controlled psycholinguistic studies in language comprehension. In language production, researchers have so far remained reliant on subjective qualitative rating scales to assess and understand speech disorganization. Now, however, recent advances in large language models mean that it is possible to quantify sensitivity to global and local context objectively by probing lexical probability (the predictability of a word given its preceding context) during natural language production.Methods: For each word in speech produced by 60 first-episode psychosis patients and 35 healthy, demographically-matched controls, we extracted lexical probabilities from GPT-3 based on contexts that ranged from very local- a single preceding word: P(Wn | Wn-1)-to global-up to 50 preceding words: P(Wn|Wn-50, Wn-49, …, Wn-1).Results: We show that disorganized speech is characterized by disproportionate insensitivity to global, versus local, linguistic context. Critically, this global-versus-local insensitivity selectively predicted clinical ratings of positive thought disorder, above and beyond overall symptom severity. There was no evidence of a relationship with negative thought disorder (impoverishment).Conclusions: We provide an automated, interpretable measure that can potentially be used to quantify speech disorganization in schizophrenia. Our findings directly link the clinical phenomenology of thought disorder to neurocognitive constructs that are grounded in psycholinguistic theory and neurobiology.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emotion generation and regulation in premenstrual dysphoric disorder: dysregulation of large-scale brain networks across the menstrual cycle. 经前烦躁不安障碍的情绪产生和调节：月经周期中大规模脑网络的失调。

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2025-06-06 DOI: 10.1016/j.biopsych.2025.05.025

Louise Stiernman, Manon Dubol, Erika Comasco, Maja Johansson, Lars Stiernman, Marie Bixo

{"title":"Emotion generation and regulation in premenstrual dysphoric disorder: dysregulation of large-scale brain networks across the menstrual cycle.","authors":"Louise Stiernman, Manon Dubol, Erika Comasco, Maja Johansson, Lars Stiernman, Marie Bixo","doi":"10.1016/j.biopsych.2025.05.025","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.05.025","url":null,"abstract":"Background: Emotion regulation deficits have been highlighted as a transdiagnostic feature of multiple psychiatric disorders, including premenstrual dysphoric disorder (PMDD). In this study, we hypothesize that deficient prefrontal \"top-down\" regulation of key nodes of the salience network (SN) is a characteristic of PMDD, driven by increased levels of progesterone-derived neuroactive steroids.Methods: Functional magnetic resonance imaging (fMRI) was used to investigate menstrual-cycle related variations in brain activity and connectivity during two emotional tasks (emotion generation and regulation) in 29 women with PMDD and 27 controls. We also examined whether differential brain activation between groups is related to serum levels of progesterone-derived neuroactive steroids and premenstrual symptom severity.Results: Women with PMDD showed increased reactivity in key nodes of the SN and - at subthreshold level - in the default mode network (DMN) during the luteal phase when passively viewing negative emotional stimuli. Intriguingly, SN hyperactivity in PMDD patients was apparent also during the follicular phase and related to premenstrual symptom severity. PMDD and control women had similar network connectivity patterns and activity in regions associated with the conscious control of emotion in PMDD. No link to progesterone-derived neuroactive steroids was found.Conclusions: Multiple network aberrations during the luteal phase may explain the development of mood symptoms in the luteal phase. Furthermore, higher baseline (follicular) SN activity may render PMDD women more susceptible to severe mood symptoms in response to hormonal fluctuations. What drives increased SN activity in the follicular phase is unknown, but innate and neuroplastic mechanisms are proposed.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered neurobehavioral reward response predicts psychotic-like experiences in youth exposed to cannabis prenatally. 改变的神经行为奖励反应预示着产前接触大麻的青少年的精神病样经历。

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2025-06-02 DOI: 10.1016/j.biopsych.2025.05.019

Carolyn M Amir, Dara G Ghahremani, Sarah E Chang, Ziva D Cooper, Carrie E Bearden

{"title":"Altered neurobehavioral reward response predicts psychotic-like experiences in youth exposed to cannabis prenatally.","authors":"Carolyn M Amir, Dara G Ghahremani, Sarah E Chang, Ziva D Cooper, Carrie E Bearden","doi":"10.1016/j.biopsych.2025.05.019","DOIUrl":"10.1016/j.biopsych.2025.05.019","url":null,"abstract":"Background: Rates of prenatal cannabis exposure (PCE) are rising with increasingly permissive legislation, which may be a risk factor for psychosis. Disrupted reward-related neural circuitry may underlie this relationship. We aim to elucidate neural mechanisms involved in the association between PCE and youth-onset psychotic-like experiences (PLEs) by probing correlates of reward anticipation, a neurobehavioral marker of endocannabinoid-mediated dopaminergic function.Methods: This longitudinal, prospective study analyzed task-related functional neuroimaging data from baseline (n=11,368), 2-year follow-up (n=7,928), and 4-year follow-up (n=2,982) of the ongoing Adolescent Brain and Cognitive Development (ABCD) Study, which recruited children aged 9 to 10 years old at baseline from 22 sites across the United States.Results: PCE (n=652 exposed youth) is longitudinally associated with PLEs. Blunted neural response to reward anticipation is associated with PLEs, with stronger effects observed in PCE youth (all |β|> 0.5; false discovery rate [FDR]-corrected P < .05). This baseline hypoactivation predicts PLEs in middle adolescence (β=-.004; FDR-corrected P < .05) and mediates the relationship between PCE and PLEs. Dampened behavioral reward sensitivity is associated with PLEs across visits (|β| = .21; FDR-corrected P < .001). PLEs are positively associated with trait-level measures of reward motivation and impulsivity, with stronger effects for PCE youth (all |β| > 0.1; all FDR-corrected P < .05).Conclusions: Blunted striatal activation may serve as a biomarker for disrupted reward processing and increased psychosis risk during development. PCE may affect childhood behaviors and traits related to altered reward sensitivity.","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Future of Immunotherapies for Mental Illness: A Precision Medicine Perspective. 精神疾病免疫疗法的未来：精准医学视角。

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2025-06-02 DOI: 10.1016/j.biopsych.2025.05.021

Gayle M Wittenberg, Rachel Upthegrove, Wayne C Drevets, Husseini K Manji

引用次数: 0

New Genomics Discoveries Across the Bipolar Disorder Spectrum Implicate Neurobiological and Developmental Pathways 新的基因组学发现涉及双相情感障碍的神经生物学和发育途径。

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2025-05-31 DOI: 10.1016/j.biopsych.2025.05.020

Kevin S. O’Connell , Rolf Adolfsson , Till F.M. Andlauer , Michael Bauer , Bernhaud Baune , Joanna M. Biernacka , Bernardo Carpiniello , Sven Cichon , Nick Craddock , Alfredo B. Cuellar-Barboza , Udo Dannlowski , Franziska Degenhardt , Dimitris Dikeos , Panagiotis Ferentinos , Andreas J. Forstner , Mark A. Frye , Janice M. Fullerton , Maria Grigoroiu-Serbanescu , José Guzman-Parra , Lisa Jones , Ole A. Andreassen

{"title":"New Genomics Discoveries Across the Bipolar Disorder Spectrum Implicate Neurobiological and Developmental Pathways","authors":"Kevin S. O’Connell , Rolf Adolfsson , Till F.M. Andlauer , Michael Bauer , Bernhaud Baune , Joanna M. Biernacka , Bernardo Carpiniello , Sven Cichon , Nick Craddock , Alfredo B. Cuellar-Barboza , Udo Dannlowski , Franziska Degenhardt , Dimitris Dikeos , Panagiotis Ferentinos , Andreas J. Forstner , Mark A. Frye , Janice M. Fullerton , Maria Grigoroiu-Serbanescu , José Guzman-Parra , Lisa Jones , Ole A. Andreassen","doi":"10.1016/j.biopsych.2025.05.020","DOIUrl":"10.1016/j.biopsych.2025.05.020","url":null,"abstract":"<div><div>Bipolar disorder (BD) is a highly heritable mental disorder that affects millions of people worldwide. Our understanding of the genetic etiology and biological processes that underlie BD have greatly increased in recent years. Extensive progress has been made in identifying common variant signals for BD, and the polygenic score from the latest genome-wide association study (GWAS) may provide some clinical utility if combined with other risk factors for BD. The role of rare variation in BD remains to be determined, although genes annotated to common variant loci are shown to be enriched for rare variation. BD subtypes have been shown to differ in their genetic architecture, and as such, genetic studies across the subtypes of the BD spectrum will identify subtype-specific signals and reveal subtype-specific biological mechanisms. Despite this, subtype-specific GWAS sample sizes have not increased at the same rate as BD cases, and more concerted efforts are required to obtain this information for participants included in future BD GWASs. Moreover, assessment of culture, geography, and other systematic differences that may impact patient assessment will be necessary to ensure accurate inclusion of diverse ancestral groups and global representation in genetic studies of BD moving forward.</div></div>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"98 4","pages":"Pages 302-310"},"PeriodicalIF":9.6,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Guide for Authors 作者指南

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2025-05-28 DOI: 10.1016/S0006-3223(25)01156-4

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Acknowledgments 致谢

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2025-05-28 DOI: 10.1016/j.biopsych.2025.04.010

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Identifying Transdiagnostic Aggression Networks: The Role of Lesion Studies 识别跨诊断攻击网络：病变研究的作用

IF 9.6 1区医学

Biological Psychiatry Pub Date : 2025-05-28 DOI: 10.1016/j.biopsych.2025.04.006

Karim Ibrahim

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