Biological Psychiatry最新文献

{"title":"Epigenetic control of an auxiliary subunit of voltage-gated sodium channels regulates the strength of drug-cue associations and relapse-like cocaine seeking.","authors":"Daniel J Wood, Evgeny Tsvetkov, Susana Comte-Walters, Colin L Welsh, Michelle Bloyd, Timothy G Wood, Rose Marie Akiki, Ethan M Anderson, Rachel D Penrod, Lalima K Madan, Lauren E Ball, Makoto Taniguchi, Christopher W Cowan","doi":"10.1016/j.biopsych.2025.01.027","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.01.027","url":null,"abstract":"<p><strong>Background: </strong>Repeated use of illicit drugs produces long-lasting and prepotent drug-cue associations that increase vulnerability for relapse in individuals with a substance use disorder. Epigenetic factors, like histone deacetylase 5 (HDAC5), play a key role in regulating the formation of drug-cue associations, but the underlying mechanisms remain unclear.</p><p><strong>Methods: </strong>We used a combination of molecular biology, cultured cells, tandem mass spectrometry, deacetylase activity measurements, co-immunoprecipitation, and molecular dynamics simulations to assess HDAC5 structure-activity relationships. In male and female Long-Evans rats, we used viral-mediated expression of HDAC5 mutants in nucleus accumbens (NAc) to test effects on cocaine intravenous self-administration (SA) and cue-reinstated cocaine seeking. We also used in silico analysis of single-nucleus RNA sequencing data, quantitative RT-PCR, viral-mediated expression of Scn4b shRNA, patch-clamp electrophysiology, and rat cocaine or sucrose SA to assess Scn4b's effects on NAc intrinsic excitability and cued reward seeking.</p><p><strong>Results: </strong>We discovered that two conserved cysteines located near HDAC5's catalytic domain were required for its intrinsic deacetylase activity, and that HDAC5's deacetylase activity was required in NAc medium spiny neurons to limit relapse-like cue-reinstated cocaine seeking. Moreover, we found that HDAC5 limited cocaine, but not sucrose, seeking behavior by reducing NAc MSN intrinsic excitability through the deacetylase-dependent repression of Scn4b, which codes for an auxiliary subunit of voltage-gated sodium channels.</p><p><strong>Conclusions: </strong>Our findings suggest that HDAC5's control of NAc Scn4b expression governs the formation of cocaine-cue, but not sucrose-cue, associations through modulation of NAc MSN intrinsic excitability and drug-induced NAc plasticity mechanisms.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Critical Role of Philanthropic Support in Paving the Way to Precision Medicine for Bipolar Disorder.","authors":"Daniel L Pham, Emily G Baxi, Kelsey M Barcomb, Veronica C Beck, Katherine E Burdick, Mark A Frye, Eric J Nestler, Cara M Altimus","doi":"10.1016/j.biopsych.2025.02.002","DOIUrl":"10.1016/j.biopsych.2025.02.002","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empirical classification of neuropsychiatric symptoms and association of classes with diagnostic progression and cognitive decline in MCI and AD populations.","authors":"Jong-Il Park, Seonjoo Lee, Benjamin Huber, Davangere P Devanand, Hyun Kim, Terry E Goldberg","doi":"10.1016/j.biopsych.2025.01.026","DOIUrl":"https://doi.org/10.1016/j.biopsych.2025.01.026","url":null,"abstract":"<p><strong>Background: </strong>To identify classes of cognitively impaired older individuals based on their neuropsychiatric symptoms(NPS) and to investigate the contribution of NPS class to cognitive decline and Alzheimer's disease(AD) risk in mild cognitive impairment(MCI).</p><p><strong>Methods: </strong>Our study included 1,472 participants(age range 55-91) from the Alzheimer's Disease Neuroimaging Initiative(ADNI) who were diagnosed with MCI or mild AD and had a complete neuropsychiatric Inventory at their baseline visit. We employed latent class analysis to categorize groups by NPS patterns. Linear mixed models of repeated measures(LMMRMs) were used to compare changes in cognitive performance across 5years as a function of NPS class. Subsequently, the Cox proportional hazards model was employed in individuals with MCI to assess whether rate of conversion to AD differed across the NPS groups.</p><p><strong>Results: </strong>We identified three latent classes of NPS: No NPS (n=799, 51.7%), Apathy/Affective (n=572, 39.8%), Complex (n=108, 8.5%) NPS. In longitudinal analyses we observed interactions between class and time, indicating accelerated cognitive decline in memory and executive function in the Apathy/Affective class. In MCI, hazard ratios for conversion to AD were 1.39(95% CI: 1.10-1.76) for the Apathy/Affective class and 2.03(95% CI: 1.33-3.10) for the Complex class compared to the No NPS group after adjusting for age, sex, education, global cognition, and ApoE4 positivity.</p><p><strong>Conclusions: </strong>Among cognitively impaired elderly, empirically derived clusters of NPS profiles were associated with cognitive decline and risk of conversion from MCI to AD. Such NPS classes may reflect specific neurobiological mechanisms within or related to AD-related neurodegeneration. Further studies with biological markers are needed to clarify these neurobiological mechanisms.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting GABA Polarity During Cortical Development Improves Circuit and Sensory Deficits in Fragile X Mice","authors":"Ragunathan Padmashri,&nbsp;Anna Dunaevsky","doi":"10.1016/j.biopsych.2024.12.006","DOIUrl":"10.1016/j.biopsych.2024.12.006","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 5","pages":"Pages 420-421"},"PeriodicalIF":9.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking Neurodevelopmental Boundaries: Distinct and Overlapping Cortical Profiles in Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, and Their Comorbidity","authors":"Nóra Bunford ,&nbsp;Zoltán Vidnyánszky","doi":"10.1016/j.biopsych.2024.12.003","DOIUrl":"10.1016/j.biopsych.2024.12.003","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 5","pages":"Pages 422-424"},"PeriodicalIF":9.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143180553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S0006-3223(25)00003-4","DOIUrl":"10.1016/S0006-3223(25)00003-4","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 5","pages":"Page A1"},"PeriodicalIF":9.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143180555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxytocin Signaling Bridges Social and Appetitive Functions in the Rodent Hippocampus","authors":"Henry W. Kietzman","doi":"10.1016/j.biopsych.2024.12.010","DOIUrl":"10.1016/j.biopsych.2024.12.010","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 5","pages":"Pages 425-427"},"PeriodicalIF":9.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143180554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers Page","authors":"","doi":"10.1016/S0006-3223(25)00004-6","DOIUrl":"10.1016/S0006-3223(25)00004-6","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 5","pages":"Page A2"},"PeriodicalIF":9.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating Neuroimaging Challenges in Rare Neurogenetic Disorders: A Case Example From Girls With Fragile X Syndrome","authors":"Lauren M. Schmitt ,&nbsp;Elizabeth G. Smith","doi":"10.1016/j.biopsych.2024.12.005","DOIUrl":"10.1016/j.biopsych.2024.12.005","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 5","pages":"Pages 418-419"},"PeriodicalIF":9.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143180552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S0006-3223(25)00007-1","DOIUrl":"10.1016/S0006-3223(25)00007-1","url":null,"abstract":"","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":"97 5","pages":"Pages A5-A10"},"PeriodicalIF":9.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}