Biofouling最新文献_第2页

Orodispersible film based on hyaluronic acid and morin for dental biofilm control. 基于透明质酸和桑里素的口腔生物膜分散膜控制。

IF 2 3区生物学

Biofouling Pub Date : 2025-09-26 DOI: 10.1080/08927014.2025.2560090

Lorena Fonseca Piovesan, Marina de Lima Fontes, Milena da Silva Gimenes, Saulo Duarte Ozelin, Gustavo Claro Monteiro, Jhonatan Miguel Silva, Maciel Lima Barbosa, Fernanda Lourenção Brighenti, Hernane da Silva Barud

{"title":"Orodispersible film based on hyaluronic acid and morin for dental biofilm control.","authors":"Lorena Fonseca Piovesan, Marina de Lima Fontes, Milena da Silva Gimenes, Saulo Duarte Ozelin, Gustavo Claro Monteiro, Jhonatan Miguel Silva, Maciel Lima Barbosa, Fernanda Lourenção Brighenti, Hernane da Silva Barud","doi":"10.1080/08927014.2025.2560090","DOIUrl":"https://doi.org/10.1080/08927014.2025.2560090","url":null,"abstract":"Orodispersible films (ODFs) are an innovative oral drug delivery method benefiting pediatric, geriatric, and non-compliant patients. They are portable, easy to swallow, and enhance bioavailability. Hyaluronic acid (HA) stands out among hydrophilic polymers for oral delivery of antimicrobial agents. This study evaluated the physicochemical properties, in vitro release profile, and antimicrobial/antibiofilm activity of HA-based ODFs combined with the flavonoid morin, known for its antimicrobial properties. Antimicrobial activity and microbial viability were assessed via biomass quantification. The films were thin (12-27 µm), flexible, homogeneous, and mechanically resistant. A burst release of morin was observed, reaching complete release at 210 min. Cytotoxicity analysis confirmed the non-toxic profile, showing cell viability. HA-morin films significantly reduced Streptococcus mutans biofilm mass, viability, and acidogenicity compared to the controls. Findings confirmed the non-toxic, and their significant antibiofilm activity against S. mutans. This innovative mucoadhesive system has potential for managing dental diseases and oral drug delivery.","PeriodicalId":8898,"journal":{"name":"Biofouling","volume":" ","pages":"1-12"},"PeriodicalIF":2.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utilization of physicochemical approach to propose a strategy for biofilm inhibition. 利用物理化学方法提出一种生物膜抑制策略。

IF 2 3区生物学

Biofouling Pub Date : 2025-09-19 DOI: 10.1080/08927014.2025.2559318

Ajab Khan, Muhammad Aasim, Noor Shad Bibi, Haris Saddique, Hizb Ullah, Zohaib Khan, Umar Aziz, Nadir Zaman Khan, Waqar Ali, Noor Muhammad

{"title":"Utilization of physicochemical approach to propose a strategy for biofilm inhibition.","authors":"Ajab Khan, Muhammad Aasim, Noor Shad Bibi, Haris Saddique, Hizb Ullah, Zohaib Khan, Umar Aziz, Nadir Zaman Khan, Waqar Ali, Noor Muhammad","doi":"10.1080/08927014.2025.2559318","DOIUrl":"https://doi.org/10.1080/08927014.2025.2559318","url":null,"abstract":"Biofilm development, which occurs on numerous surfaces, can reduce the efficiency and increase operating costs in bioprocesses and fermentation. The current study proposes a strategy for biofilm inhibition by investigating the interactions between microorganisms and surfaces using an extended Derjaguin-Landau-Verwey-Overbeek (xDLVO) approach and cell partition index (CPI) technique. Glass slide and Petri dish surfaces were modified with different surfactants. The results show that modification increased CPI values and altered the interaction behavior from attractive to repulsive, between microbial cells and different surfaces. Secondary energy values calculated by xDLVO theory between microbial cells and modified surfaces were repulsive. Meanwhile, the secondary energy values calculated for microbial cells and unmodified glass slide (-31 kT) and Petri dish surfaces (-27 kT) were attractive between cells and surfaces. The current study has opened a window for research in the field of biofilm inhibition through a surface energetics approach.","PeriodicalId":8898,"journal":{"name":"Biofouling","volume":" ","pages":"1-12"},"PeriodicalIF":2.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial and antibiofilm activity of ruthenium polypyridine complex against Staphylococcus strains. 多吡啶钌络合物对葡萄球菌的抑菌和抗生物膜活性。

IF 2 3区生物学

Biofouling Pub Date : 2025-09-17 DOI: 10.1080/08927014.2025.2558627

Leonardo Silva de Sousa, Alexandre Lopes Andrade, Aryane de Azevedo Pinheiro, Felipe Diógenes Abreu, Eduardo Henrique Silva Sousa, Idalina Maria Moreira de Carvalho, Débora S C M Castelo-Branco, Mayron Alves de Vasconcelos, Edson Holanda Teixeira

{"title":"Antibacterial and antibiofilm activity of ruthenium polypyridine complex against Staphylococcus strains.","authors":"Leonardo Silva de Sousa, Alexandre Lopes Andrade, Aryane de Azevedo Pinheiro, Felipe Diógenes Abreu, Eduardo Henrique Silva Sousa, Idalina Maria Moreira de Carvalho, Débora S C M Castelo-Branco, Mayron Alves de Vasconcelos, Edson Holanda Teixeira","doi":"10.1080/08927014.2025.2558627","DOIUrl":"https://doi.org/10.1080/08927014.2025.2558627","url":null,"abstract":"This study reports the synthesis of a new polypyridine ruthenium(II) complex, [Ru(anth)3]2+, which generates singlet oxygen (ΦΔ = 0.98) and binds DNA (Kb = 9.8 × 104 M-1), leading to bacterial damage. The compound exhibited minimum inhibitory concentrations (MICs) of 31.25 µg mL-1 against S. aureus ATCC 700698 and S. epidermidis ATCC 35984, and 125 µg mL-1 against S. aureus ATCC 25923 and S. epidermidis ATCC 12228. The compound showed synergistic effects with ampicillin and additive effects with tetracycline. The complex significantly reduced biofilm biomass, viable cell counts, and metabolic activity. Scanning electron and confocal laser microscopy confirmed surface disruption and reduced viability. Gel electrophoresis indicated light-induced DNA photocleavage. Cytotoxicity in L929 fibroblasts was observed only above 125 µg mL-1. These findings suggest that [Ru(anth)3]2+ is a promising antimicrobial agent with multi-target activity, supporting its potential for antimicrobial drug development.","PeriodicalId":8898,"journal":{"name":"Biofouling","volume":" ","pages":"1-17"},"PeriodicalIF":2.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioprospecting seaweed derived bio-oil as a marine biofouling mitigating agent. 海藻生物油作为海洋生物污染缓蚀剂的生物勘探。

IF 2 3区生物学

Biofouling Pub Date : 2025-09-01 Epub Date: 2025-07-21 DOI: 10.1080/08927014.2025.2527774

Sainath Gopinathan, Srividhya Krishnan, Sowndarya Jothipandiyan, Subramaniyasharma Sivaraman, Lakkakula Satish, Ponnusami Venkatachalam, Saravanan Ramiah Shanmugam, Nithyanand Paramasivam

{"title":"Bioprospecting seaweed derived bio-oil as a marine biofouling mitigating agent.","authors":"Sainath Gopinathan, Srividhya Krishnan, Sowndarya Jothipandiyan, Subramaniyasharma Sivaraman, Lakkakula Satish, Ponnusami Venkatachalam, Saravanan Ramiah Shanmugam, Nithyanand Paramasivam","doi":"10.1080/08927014.2025.2527774","DOIUrl":"10.1080/08927014.2025.2527774","url":null,"abstract":"Mitigating marine biofouling using marine resources has become a research hotspot as it is considered an environmentally friendly approach. Hence, this study investigated the biofilm mitigating property and antifouling activity of bio-oil extracted from the pyrolysis of seaweed biomass. The bio-oil inhibited up to 73-80% of biofilm and extracellular polymeric substance (EPS) formation of the predominant marine microfoulers Nitratireductor kimnyeongensis, Nitratireductor aquibiodomus and Stutzerimonas stutzeri. Gas chromatography-mass spectrometry (GC-MS) analysis of the bio-oil identified that 13-Docosenamide (Z) is a prominent compound that accounts for about 27.42% of the total bio-oil composition which might be responsible for its antibiofilm property. The bio-oil was further formulated into antifouling paint equivalent to the consistency of traditional antifouling paints and coated on titanium plates. The water contact angle results showed that bio-oil and antifouling paint exhibit hydrophilic surfaces, effectively reducing bacterial attachment. Scanning electron microscopic analysis revealed that the anti-fouling paint coated on titanium plates against mixed species of microfoulers significantly reduced biofilms. Molecular docking of 13-Docosenamide (Z) against the mussel adhesive foot protein of Perna viridis (Pvfp-5b) exhibited favorable binding scores, indicating that it may reduce the bio-adhesion of macrofoulers to the substrate.","PeriodicalId":8898,"journal":{"name":"Biofouling","volume":" ","pages":"767-782"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of antifouling surfaces using a method that employs mussel larvae settlement quantified by machine learning. 使用机器学习量化贻贝幼虫沉降的方法评估防污表面。

IF 2 3区生物学

Biofouling Pub Date : 2025-09-01 Epub Date: 2025-07-24 DOI: 10.1080/08927014.2025.2534051

Thomas B LeFevre, Joseph D Daddona, Wilaiwan Chouyyok, Gordon King, Samuel M Pennell, Andrew E Plymale, Stony Akins, Lance W Miller, Navaj Nune, Clare N Hermanson, George T Bonheyo, Curtis Larimer, R Shane Addleman

{"title":"Evaluation of antifouling surfaces using a method that employs mussel larvae settlement quantified by machine learning.","authors":"Thomas B LeFevre, Joseph D Daddona, Wilaiwan Chouyyok, Gordon King, Samuel M Pennell, Andrew E Plymale, Stony Akins, Lance W Miller, Navaj Nune, Clare N Hermanson, George T Bonheyo, Curtis Larimer, R Shane Addleman","doi":"10.1080/08927014.2025.2534051","DOIUrl":"10.1080/08927014.2025.2534051","url":null,"abstract":"Antifouling coating development requires extensive performance testing. Coatings that prevent aquatic larval settlement are of interest because many forms of macrofouling begin at the larval stage. However, field testing can be time consuming and poorly controlled. Herein is reported a screening tool, Settlement of Larvae Assay using Mussels (SLAM), for down-selecting materials prior to field testing. The method entails using a dense concentration of mussel larvae that are allowed to settle on submerged test surfaces. Settled larvae are then quantified to provide a measure of antifouling performance. The SLAM test differentiated coatings with only slight differences in formulation. To enable efficient quantification of dense larvae settlement, an automated counting method was developed that combines two analyses: a color thresholding identifies larvae clumps, and a machine learning algorithm identifies non-clumped larvae. This automated 'hybrid' approach rapidly quantifies settled larvae as effectively as manual counting but in a fraction of the time.","PeriodicalId":8898,"journal":{"name":"Biofouling","volume":" ","pages":"783-797"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial activity of diazepam against planktonic and biofilm strains of methicillin-resistant Staphylococcus aureus. 地西泮对耐甲氧西林金黄色葡萄球菌浮游菌和生物膜菌的抑菌活性。

IF 2 3区生物学

Biofouling Pub Date : 2025-09-01 Epub Date: 2025-08-01 DOI: 10.1080/08927014.2025.2540534

Thaís Lima Ferreira, Lívia Gurgel do Amaral Valente Sá, Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Lara Elloyse Almeida Moreira, Beatriz Oliveira de Souza, Bruno Coêlho Cavalcanti, Hemerson Iury Ferreira Magalhães, Iri Sandro Pampolha Lima, Amanda Cavalcante Leitão, Manoel Odorico de Moraes, João Batista de Andrade Neto, Hélio Vitoriano Nobre Júnior, Cecília Rocha da Silva

{"title":"Antibacterial activity of diazepam against planktonic and biofilm strains of methicillin-resistant Staphylococcus aureus.","authors":"Thaís Lima Ferreira, Lívia Gurgel do Amaral Valente Sá, Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Lara Elloyse Almeida Moreira, Beatriz Oliveira de Souza, Bruno Coêlho Cavalcanti, Hemerson Iury Ferreira Magalhães, Iri Sandro Pampolha Lima, Amanda Cavalcante Leitão, Manoel Odorico de Moraes, João Batista de Andrade Neto, Hélio Vitoriano Nobre Júnior, Cecília Rocha da Silva","doi":"10.1080/08927014.2025.2540534","DOIUrl":"10.1080/08927014.2025.2540534","url":null,"abstract":"The aim was to evaluate the antibacterial activity of diazepam against methicillin-susceptible (MSSA) and methicillin-resistant (MRSA) strains of Staphylococcus aureus and its possible mechanism of action. The broth microdilution assay was used to determine the minimum inhibitory concentration (MIC) of diazepam. A checkerboard assay was used to evaluate the interaction of diazepam with different antibiotics. Colorimetric assays with MTT were used to evaluate the effect of diazepam against the biofilms by MSSA and MRSA. Flow cytometry and fluorescence microscopy were used to evaluate the possible mechanism of action of diazepam against MRSA. Diazepam had a MIC of 256 µg/mL. It only had indifferent interactions with the analyzed antibiotics. Diazepam significantly reduced the viability of MSSA and MRSA biofilms. Diazepam caused fragmentation of bacterial DNA and carbonylation of proteins, resulting in reduced cell viability. Therefore, diazepam has in vitro antimicrobial activity against planktonic and biofilm strains of MRSA and MSSA.","PeriodicalId":8898,"journal":{"name":"Biofouling","volume":" ","pages":"846-856"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phthalocyanine derivative as an antimicrobial agent against periodontitis-related multispecies biofilms. 酞菁衍生物对牙周炎相关多物种生物膜的抗菌作用。

IF 2 3区生物学

Biofouling Pub Date : 2025-09-01 Epub Date: 2025-08-04 DOI: 10.1080/08927014.2025.2541798

Rafaela Franco Dias Bruzadelli, Pedro Luiz Rosalen, Bruno Bueno Silva, Tatiane Tiemi Macedo, Luciene C Figueiredo, Fabiano Vieira Vilhena, Leandro Araújo Fernandes, Marcelo Franchin, Masaharu Ikegaki

{"title":"Phthalocyanine derivative as an antimicrobial agent against periodontitis-related multispecies biofilms.","authors":"Rafaela Franco Dias Bruzadelli, Pedro Luiz Rosalen, Bruno Bueno Silva, Tatiane Tiemi Macedo, Luciene C Figueiredo, Fabiano Vieira Vilhena, Leandro Araújo Fernandes, Marcelo Franchin, Masaharu Ikegaki","doi":"10.1080/08927014.2025.2541798","DOIUrl":"10.1080/08927014.2025.2541798","url":null,"abstract":"The activity of iron tetracarboxyphthalocyanine (FeTcPc) was investigated in the formation of subgingival biofilm by bacterial species associated with periodontal disease. A multispecies biofilm model was developed using the Calgary biofilm device and incubated at 37 °C under anaerobic conditions for 7 days. Starting from day 3, the biofilm was treated with FeTcPc twice daily for one minute over four days, at concentrations ranging from 1,000 to 10,000 μM. Chlorhexidine at 0.12% and the vehicle used to dissolve the test agent, phosphate-buffered saline (PBS), served as positive and negative controls, respectively. After 7 days, the biofilm metabolic activity was measured using 2,3,5-triphenyl tetrazolium chloride (TTC) to differentiate metabolically active cells from inactive ones. Finally, the microbial profile of the treated biofilm was assessed using the DNA-DNA hybridisation method. FeTcPc at 10,000 μM and chlorhexidine treatments reduced the total bacterial counts, without a significant difference from each other. Additionally, FeTcPc at 10,000 μM inhibited the growth of 7 microorganisms when compared with the negative control, highlighting effects on Porphyromonas gingivalis, Tannerella forsythia and Fusobacterium nucleatum vincentii. The study demonstrated that FeTcPc, at a concentration of 10,000 μM, was as effective as chlorhexidine (0.12%) in reducing the total bacterial counts and well-recognised periodontal pathogens levels in the subgingival biofilm, highlighting the potential of FeTcPc as an alternative to conventional periodontal treatments. These findings indicate that FeTcPc has a promising impact on the inhibition of key bacteria involved in periodontal disease, which may open new perspectives for targeted and less aggressive therapies.","PeriodicalId":8898,"journal":{"name":"Biofouling","volume":" ","pages":"857-864"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic effects of sodium acetate and calcium on structure and function in multispecies biofilms. 醋酸钠和钙对多物种生物膜结构和功能的协同作用。

IF 2 3区生物学

Biofouling Pub Date : 2025-09-01 Epub Date: 2025-08-11 DOI: 10.1080/08927014.2025.2545940

Rongjing Xie, Han Yu, Yan Wang, Ka Yin Leung, Olivier Habimana

引用次数: 0

Bioadhesive liquid crystal system containing citral: effect against cariogenic biofilm and on dental enamel. 含柠檬醛的生物黏附液晶系统：对致龋生物膜和牙釉质的作用。

IF 2 3区生物学

Biofouling Pub Date : 2025-09-01 Epub Date: 2025-07-28 DOI: 10.1080/08927014.2025.2536605

Juliana Rios de Oliveira, Camila Fernanda Rodero, Gabriel Pereira Nunes, Luciana Solera Sales, Alberto Carlos Botazzo Delbem, Marlus Chorilli, Fernanda Lourenção Brighenti, Elisa Maria Aparecida Giro

{"title":"Bioadhesive liquid crystal system containing citral: effect against cariogenic biofilm and on dental enamel.","authors":"Juliana Rios de Oliveira, Camila Fernanda Rodero, Gabriel Pereira Nunes, Luciana Solera Sales, Alberto Carlos Botazzo Delbem, Marlus Chorilli, Fernanda Lourenção Brighenti, Elisa Maria Aparecida Giro","doi":"10.1080/08927014.2025.2536605","DOIUrl":"10.1080/08927014.2025.2536605","url":null,"abstract":"This study evaluated the effects of a bioadhesive liquid crystal system containing citral on cariogenic biofilm and enamel demineralisation. Citral (C) at 10× and 15× the minimum inhibitory concentration (MIC) was incorporated into the formulation (F) (30% oleic acid, 50% alkoxylated cetyl alcohol, and 20% aqueous dispersion of poloxamer 1%), FC1 and FC2, respectively. Both formulations underwent physicochemical characterisation, including polarised light microscopy, rheology, adhesive strength, and citral release. For biofilm and enamel demineralisation analyses, polymicrobial biofilms were cultivated for 4 days on bovine enamel blocks and treated with the formulations (n = 14/group). Analyses included pH measurement, total bacteria, aciduric bacteria, and mutans streptococci quantification. Enamel demineralisation was assessed via surface hardness loss (SH%) and integrated hardness loss (KHN × µm). Data were analyzed using appropriate statistical tests, with significance set at 5%. FC1 and FC2 exhibited Newtonian fluid characteristics, releasing 22.9% and 40.7% of citral, respectively, over 24 h. FC2 released citral near the MIC between 1-3 h. FC2 treatment showed antimicrobial activity in biofilms, maintained pH levels closer to neutrality for longer periods, and reduced SH% and KHN × µm values. Thus, FC2 demonstrated adequate physicochemical properties, antimicrobial efficacy, and the ability to reduce enamel mineral loss under cariogenic conditions.","PeriodicalId":8898,"journal":{"name":"Biofouling","volume":" ","pages":"809-826"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144727291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dihydrochalcone derivatives as promising antifoulants: synthesis, bioactivity evaluation and performance in coatings. 二氢查尔酮类防污剂的合成、生物活性评价及其在涂料中的应用。

IF 2 3区生物学

Biofouling Pub Date : 2025-09-01 Epub Date: 2025-07-22 DOI: 10.1080/08927014.2025.2535419

Daniela Pereira, Érica Lima, Danilo Correia, Vitor Vasconcelos, Madalena Pinto, Marta Correia-da-Silva, Joana R Almeida, Honorina Cidade

{"title":"Dihydrochalcone derivatives as promising antifoulants: synthesis, bioactivity evaluation and performance in coatings.","authors":"Daniela Pereira, Érica Lima, Danilo Correia, Vitor Vasconcelos, Madalena Pinto, Marta Correia-da-Silva, Joana R Almeida, Honorina Cidade","doi":"10.1080/08927014.2025.2535419","DOIUrl":"10.1080/08927014.2025.2535419","url":null,"abstract":"Marine biofouling presents a major challenge for the maritime industry and marine ecosystems, traditionally managed through biocide-based antifouling (AF) coatings. However, the environmental toxicity of these biocides has intensified the search for sustainable, environmentally friendly alternatives. In this study, a novel approach using flavonoid-based compounds as environmentally safe AF agents is presented. Building on the previous identification of the prenylated dihydrochalcone (DH345P), the first reported dihydrochalcone with AF activity, here a series of dihydrochalcone analogues was synthesized and evaluated to further explore the structure-activity relationship studies (SAR). Among the compounds studied, dihydrochalcone (10) emerged as the most effective, exhibiting the best performance regarding anti-settlement activity (EC50 2.34 µM), while remaining non-toxic to A. salina. To assess real-world applicability, compound 10 was incorporated into marine polyurethane (PU)-based coatings, which resulted in significantly reduced mussel larvae adherence compared to blank control coatings. These findings highlight dihydrochalcone-based compounds as a promising scaffold for sustainable AF agents. Considering their AF potential, non-toxic profile and feasible synthesis, flavonoids such as compound 10 might be explored as an alternative for conventional AF biocides, paving the way for greener marine coatings.","PeriodicalId":8898,"journal":{"name":"Biofouling","volume":" ","pages":"798-808"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0