Biopolymers最新文献_第8页

The Blue Economy's Biopolymers: Using Marine Biomass to Develop Sustainable Polymers—Overview 蓝色经济的生物聚合物：利用海洋生物质开发可持续聚合物综述。

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-11-22 DOI: 10.1002/bip.70064

Prakash Gadipelli

{"title":"The Blue Economy's Biopolymers: Using Marine Biomass to Develop Sustainable Polymers—Overview","authors":"Prakash Gadipelli","doi":"10.1002/bip.70064","DOIUrl":"10.1002/bip.70064","url":null,"abstract":"<div>\u0000 \u0000 <p>To solve the global plastic pollution challenge through sustainable polymer innovation, this review article explores the transformational potential of biopolymers generated from marine sources within the blue economy. These biopolymers provide sustainable, biodegradable substitutes for plastics made from fossil fuels by using marine biomass. Using environmentally benign techniques such as alkaline and enzymatic treatments, researchers extract polysaccharides, chitin, and collagen through a simplified procedure, attaining yields of 20%–30% for alginate and 15%–25% for chitin with 80% efficiency. Nanotechnology is used in polymer processing to enable 95% encapsulation efficiency and improve barrier and tensile strengths by 30% and 50%, respectively. The resultant biopolymers—packaging films, medical bandages made of chitosan, and agricultural mulch made from seaweed—degrade by 90% in 6 weeks, providing a sustainable substitute for traditional plastics. Marine biopolymers, which promise less ocean pollution and economic prosperity for coastal communities, are in line with Sustainable Development Goal 14 because of breakthroughs, such as carbon-negative PHAs and packaging made from seaweed.</p>\u0000 </div>","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":"117 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145572719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Homogenized Bacterial Cellulose Incorporated Polydopamine Sponges for Rapid Hemostasis in Traumatic Wounds 均质细菌纤维素复合聚多巴胺海绵在创伤伤口快速止血中的应用。

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-11-21 DOI: 10.1002/bip.70062

Kamlesh, Kaushal Shakya, Vivek Verma

{"title":"Homogenized Bacterial Cellulose Incorporated Polydopamine Sponges for Rapid Hemostasis in Traumatic Wounds","authors":"Kamlesh, Kaushal Shakya, Vivek Verma","doi":"10.1002/bip.70062","DOIUrl":"10.1002/bip.70062","url":null,"abstract":"<div>\u0000 \u0000 <p>Managing bleeding during surgical or traumatic events is crucial to prevent further complications. Traditional cotton dressings are primarily used for cleaning wounds and do not contribute to bleeding control. In this study, we demonstrate a hemostatic dressing in the form of sponges using a simple and sustainable approach. These sponges, composed of bacterial cellulose (BC) as the base matrix and coated with polydopamine (PDA) nanospheres via in situ oxidative polymerization. The BC–PDA sponges exhibited rapid fluid absorption, robust stability, excellent hemostatic ability and antioxidant properties, and biocompatibility with mammalian cells. The best in vitro blood clotting efficacy of HBC–PDA samples was 90% clotting efficacy within 90 s, highlighting their potential as effective hemostatic materials. The presence of amine groups in PDA played a critical role in activating intrinsic coagulation pathways, enhancing blood clotting. This work highlights the successful fabrication of BC/PDA hemostatic sponges with outstanding properties and safety, making them a promising material for clinical applications.</p>\u0000 </div>","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":"117 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145572729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant, Anti-HCC, and Anti-Inflammatory Activities of Novel Fabricated Carboxymethyl Xanthan Gum-Graft-Polyglycidyl Methacrylate/Multiwalled Carbon Nanotube Composites 新型制备的羧甲基黄原胶接枝聚甲基丙烯酸缩水甘油酯/多壁碳纳米管复合材料的抗氧化、抗肝癌和抗炎活性。

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-11-19 DOI: 10.1002/bip.70061

Nadia A. Mohamed, Nahed A. Abd El-Ghany, Ahmed M. Elgamal

{"title":"Antioxidant, Anti-HCC, and Anti-Inflammatory Activities of Novel Fabricated Carboxymethyl Xanthan Gum-Graft-Polyglycidyl Methacrylate/Multiwalled Carbon Nanotube Composites","authors":"Nadia A. Mohamed, Nahed A. Abd El-Ghany, Ahmed M. Elgamal","doi":"10.1002/bip.70061","DOIUrl":"10.1002/bip.70061","url":null,"abstract":"<div>\u0000 \u0000 <p>A novel carboxymethyl xanthan gum-based glycidyl methacrylate copolymer (CMXG-g-PGMA) was successfully synthesized using the graft copolymerization technique. During the grafting process, the epoxide ring of GMA was opened by the carboxylic groups of the CMXG, inducing crosslinking of their chains. The percentages of graft, graft efficiency, and homopolymer were 260%, 85%, and 35%, respectively. Two different concentrations of multiwalled carbon nanotubes (CNTs) were impregnated into the copolymer to obtain CMXG-g-PGMA/CNTs-3% and CMXG-g-PGMA/CNTs-5% composites. The topography, chemical, and inner structure of CMXG-g-PGMA and its CNTs composites were investigated employing FTIR, XRD, SEM, TEM, and BET. DPPH scavenging activity of CMXG-g-PGMA/CNTs-5% is higher than that of CMXG-g-PGMA, since their IC<sub>50</sub> values were 57.88 and 201.8 μg/mL, respectively. The CMXG-g-PGMA/CNTs-5% has better inhibition performance against the HepG-2 cancer cells growth than CMXG-g-PGMA, since their IC<sub>50</sub> values were 52.1 and 269.8 μg/mL, respectively. CMXG-g-PGMA/CNTs-5% showed better anti-inflammatory activity than CMXG-g-PGMA with IC<sub>50</sub> values of 10.9 and 217.8 μg/mL, respectively. CMXG-g-PGMA/CNTs-5% exhibited good biocompatibility, showing no cytotoxic effects on normal human lung fibroblast cells at concentrations below 62.5 μg/mL. Thus, the incorporation of both GMA and CNTs into CMXG appreciably reinforced its antioxidant, anticancer, and anti-inflammatory features. This represents a good way to achieve adequate formulations to contend with the classical medications employed for such implementations.</p>\u0000 </div>","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":"117 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145556284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tailored Metal Oxide Nanoparticles Interfaced With Corn Husk Lignocellulose for High-Performance Sustainable Packaging 量身定制的金属氧化物纳米颗粒与玉米壳木质纤维素界面，用于高性能可持续包装。

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-11-11 DOI: 10.1002/bip.70060

Rubalya Valantina Sathianathan, Jasline Joseph, Janane Ramesh Kannan, Anusuya Krishnamoorthy

{"title":"Tailored Metal Oxide Nanoparticles Interfaced With Corn Husk Lignocellulose for High-Performance Sustainable Packaging","authors":"Rubalya Valantina Sathianathan, Jasline Joseph, Janane Ramesh Kannan, Anusuya Krishnamoorthy","doi":"10.1002/bip.70060","DOIUrl":"10.1002/bip.70060","url":null,"abstract":"<div>\u0000 \u0000 <p>To cope with the increased plastic production rate and the upsurge in hazards to the Earth, natural, eco-friendly packaging is urged as an alternative. Nanotechnology impresses a prime contribution to improving foods' shelf life and biodegradability of packaging film. ZnO nanoparticles (NPs) with three different molar concentrations (0.3, 0.6, 0.9 M) were synthesised using the sol–gel process. A fibrous, degradable, bio-active corn husks (CH) biocomposite was used in the packaging film. Four films, CZ0-0 M (CZ-Corn Zinc), CZ1-0.3, CZ2-0.6, and CZ3-0.9 M, were prepared with a biodegradable plasticiser and CH. The particle sizes of NPs synthesised with different molar concentrations were investigated to be 24, 31, and 29 nm using the XRD (X-ray diffraction) analysis, and their effective stability was estimated using zeta potential analysis. FTIR (Fourier transform infrared spectrometer) analysis confirmed the presence of ZnO with a peak observed at 510–490 cm<sup>−1</sup>. An upsurge in the molar concentration of NPs in the prepared film increases its hydrophobicity to 103.44°, UV (Ultra Violet) blocking > 50%, Young's Modulus between 11.23 and 24.11 MPa, and dielectric constant with a range between 14.94 and 25.57 was observed. Homogeneity, biodegradability, antibacterial activity, and insulation properties of the films enhance their suitability for storing foodstuffs, industrial applications, and for electrical and electronic packaging.</p>\u0000 </div>","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":"116 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145487475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Progress in Preparation, Improvement and Applications of Green Polymer Composites 绿色高分子复合材料的制备、改进及应用研究进展

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-11-08 DOI: 10.1002/bip.70059

Kobe Samuel Mojapelo, Williams Kehinde Kupolati, Everardt Andre Burger, Julius Musyoka Ndambuki, Jacques Snyman, Emmanuel Rotimi Sadiku

{"title":"Recent Progress in Preparation, Improvement and Applications of Green Polymer Composites","authors":"Kobe Samuel Mojapelo, Williams Kehinde Kupolati, Everardt Andre Burger, Julius Musyoka Ndambuki, Jacques Snyman, Emmanuel Rotimi Sadiku","doi":"10.1002/bip.70059","DOIUrl":"https://doi.org/10.1002/bip.70059","url":null,"abstract":"<p>Green polymer composites (GPCs) are increasingly recognised as sustainable alternatives to traditional petroleum-based materials, effectively addressing critical environmental challenges, such as plastic pollution and carbon emissions. These composites include biodegradable polymers, natural fibres, and nanomaterials, which enhance their mechanical properties, durability, and eco-friendly disposal options. However, their widespread industrial adoption faces challenges related to cost, scalability, fibre-matrix compatibility, and regulatory compliance. This study provides a comprehensive review of recent advancements in GPCs, focusing on the preparation methods, reinforcement strategies, and significant performance improvements. Techniques such as melt blending, compression moulding, and additive manufacturing have notably enhanced interfacial bonding and thermal stability. Comparative analyses indicate that GPCs can achieve up to a 30% increase in tensile strength and a 40% reduction in carbon footprint compared with conventional composites. Despite these advantages, ongoing concerns regarding manufacturing costs, processing limitations, and recyclability highlight the necessity for further optimisation. GPCs have diverse applications in various industries, including the automotive sector, biomedicine and scaffolds, packaging and coatings, and constructing reinforced polymer composites for structural applications. Practical implementation must overcome cost barriers and ensure compliance with the global sustainability regulations. Future research should prioritise enhancing the economic viability of GPCs and conducting life cycle assessments (LCA).</p>","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":"116 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bip.70059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145470109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of Polysaccharides/Proteins Combine With Metals: A New Strategy for Wound Healing Therapy 多糖/蛋白质与金属结合：伤口愈合治疗的新策略

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-11-05 DOI: 10.1002/bip.70058

Lukman Mahdi, Ronny Martien, Retno Murwanti, Akhmad Kharis Nugroho

{"title":"Review of Polysaccharides/Proteins Combine With Metals: A New Strategy for Wound Healing Therapy","authors":"Lukman Mahdi, Ronny Martien, Retno Murwanti, Akhmad Kharis Nugroho","doi":"10.1002/bip.70058","DOIUrl":"10.1002/bip.70058","url":null,"abstract":"<div>\u0000 \u0000 <p>Wound dressing is crucial for managing wound healing, protecting wounds from the environment, and accelerating the healing process. Recently, wound dressing is evolving from traditional to modern-interactive design. The main problem with traditional wound dressings is their limited effectiveness, which hinders optimal wound therapy. Wound dressings can be developed into modern wound dressings (film, sponge, injectable hydrogel, and nanofiber). They can be fabricated using natural polymers, such as chitosan, alginate, cellulose, gelatin, and collagen, combined with metals. Natural polymers, known as biopolymers, offer beneficial properties for wound healing, including bioactivity, biocompatibility, and biodegradability. Additionally, metals like silver, copper, cerium, and zinc also exhibit potential pharmacological activity in the medical field. The fabrication of these materials holds significant potential for addressing wound healing challenges. This article discusses the development of natural polymer/metal-based scaffolds and their potential for wound healing management therapy. This innovative approach stands to offer an alternative to the existing strategies and enhance the effectiveness of wound healing management.</p>\u0000 </div>","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":"116 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145443851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Roles of Biopolymers in Seed Science and Technology 生物聚合物在种子科学与技术中的新作用。

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-11-04 DOI: 10.1002/bip.70056

Anu, Manonmani Velusamy, Sivakumar Rathinavelu, Vanitha Shanmugam, Preetha Gnanadhas, Sravya Karre

{"title":"Emerging Roles of Biopolymers in Seed Science and Technology","authors":"Anu, Manonmani Velusamy, Sivakumar Rathinavelu, Vanitha Shanmugam, Preetha Gnanadhas, Sravya Karre","doi":"10.1002/bip.70056","DOIUrl":"10.1002/bip.70056","url":null,"abstract":"<div>\u0000 \u0000 <p>Biopolymers are naturally occurring macromolecules derived from renewable biological sources such as plants, animals, and microorganisms. Their intrinsic biodegradability, biocompatibility, and reduced reliance on fossil resources render them environmentally sustainable alternatives to conventional synthetic polymers. Owing to their diverse physicochemical properties, biopolymers have found extensive applications in sectors like pharmaceuticals, food packaging, and biomedicine. In recent years, their relevance in agriculture, particularly in seed science and technology, has gained momentum. Biopolymer-based interventions such as seed coatings, priming agents, and encapsulation systems are being increasingly employed to enhance seed germination, vigor, and resilience under a variety of abiotic and biotic stress conditions. These treatments offer multiple benefits, including protection from pathogens, moisture retention, and the controlled release of nutrients and bioactive compounds to optimize early seedling development. The emergence of novel techniques such as nano-priming and the valorization of agricultural waste for biopolymer extraction further reinforces their role in sustainable agriculture. Additionally, the integration of traceability tools such as molecular markers and embedded digital identifiers into biopolymer seed coatings supports robust quality assurance, supply chain transparency, and regulatory compliance. To advance these aims, future research should focus on seed-responsive, climate-resilient biopolymers with scalable, eco-friendly formulations, field validation, and built-in traceability. This review critically examines current advancements in biopolymer-assisted seed enhancement technologies, identifies prevailing challenges, and explores their expanding potential in promoting climate-resilient and sustainable crop production systems.</p>\u0000 </div>","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":"116 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145443819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-Targeted Pt@Ce-MOF Nanoplatform Enhances Radiotherapy Efficacy via Tumor-Specific Delivery and Mitochondrial Dysfunction in Breast Cancer 双靶向Pt@Ce-MOF纳米平台通过肿瘤特异性传递和线粒体功能障碍增强乳腺癌放疗疗效

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-11-01 DOI: 10.1002/bip.70054

Yanyan Wang, Xinxin Han, Song Zhang, Lin Wang, Siyu Sun, Chun Xue, Tingjing Yao

{"title":"Dual-Targeted Pt@Ce-MOF Nanoplatform Enhances Radiotherapy Efficacy via Tumor-Specific Delivery and Mitochondrial Dysfunction in Breast Cancer","authors":"Yanyan Wang, Xinxin Han, Song Zhang, Lin Wang, Siyu Sun, Chun Xue, Tingjing Yao","doi":"10.1002/bip.70054","DOIUrl":"https://doi.org/10.1002/bip.70054","url":null,"abstract":"<div>\u0000 \u0000 <p>The development of multifunctional nanoplatforms capable of enhancing the efficacy and precision of cancer radiochemotherapy remains a significant clinical need. Here, we report a dual-targeted cerium-based metal–organic framework nanoplatform (Pt@Ce-MOF-RGD/FA) designed for synergistic radiosensitization and chemotherapeutic delivery in breast cancer. The Ce-MOF core acts as a reactive oxygen species (ROS) amplifier under radiotherapy, while encapsulated cisplatin (Pt) serves as a chemotherapeutic agent. Surface modification with RGD and folic acid (FA) enables active targeting of tumor cells via αvβ3 integrin and folate receptor pathways. Comprehensive physicochemical characterization confirmed successful construction of the nanocomposite. In vitro, Pt@Ce-MOF-RGD/FA exhibited potent cytotoxicity, enhanced cellular uptake, inhibition of tumor cell migration, and robust ROS generation and mitochondrial membrane depolarization. In vivo fluorescence imaging demonstrated superior tumor accumulation of the dual-ligand-modified formulation. Under radiotherapy, Pt@Ce-MOF-RGD/FA achieved significant tumor growth suppression in a 4T1 murine breast cancer model without inducing systemic toxicity, as confirmed by blood biochemistry, hematological analysis, and histopathology. Collectively, this work presents a rationally engineered nanoplatform with precise tumor targeting, efficient drug delivery, and enhanced radiosensitization, offering a promising strategy for safe and effective cancer treatment.</p>\u0000 </div>","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":"116 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145406615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyacrylamide–Sodium Alginate Hydrogel Scaffolds With Calcium Aminopolycarboxylate Coordination Polymers for Enhanced Calcium Mineralisation in Osteoblast-Like Cells 聚丙烯酰胺-海藻酸钠水凝胶支架与氨基聚羧酸钙配位聚合物增强成骨细胞样细胞钙矿化。

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-10-22 DOI: 10.1002/bip.70057

Sabitha Mohan M. R., Rani Pavithran

引用次数: 0

Edible Bird's Nest Peptide- an Active Peptide With Potential in Promoting Skin Repair 食用燕窝肽-一种具有促进皮肤修复潜力的活性肽。

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-10-01 DOI: 10.1002/bip.70055

Weijuan Bai, Fang Zheng, Xuncai Liu, Baozhong Guo, Xiaoqian Yin, Jianmei Lian, Qunyan Fan, Fenghong Deng

{"title":"Edible Bird's Nest Peptide- an Active Peptide With Potential in Promoting Skin Repair","authors":"Weijuan Bai, Fang Zheng, Xuncai Liu, Baozhong Guo, Xiaoqian Yin, Jianmei Lian, Qunyan Fan, Fenghong Deng","doi":"10.1002/bip.70055","DOIUrl":"10.1002/bip.70055","url":null,"abstract":"<div>\u0000 \u0000 <p>Skin damage and aging are caused by various factors, including UV radiation and air pollution. Edible bird's nest peptide (EBNP) was a type of safe short molecule peptide that could protect the skin by providing anti-oxidation and anti-inflammatory properties. In this study, the effect of EBNP on pro-tissue regeneration was examined. The findings revealed that EBNP contained epidermal growth factor (EGF) and could stimulate wound healing in cells and zebrafish larvae. The mechanism of skin repairing was further investigated. On the one hand, EBNP increased the synthesis of structural proteins and remodelled the extracellular matrix (ECM) by up-regulating the expression of COL1A1 gene in cells as well as col1a1b, eln1, and eln2 genes in zebrafish larvae. Furthermore, EBNP had an anti-inflammatory effect, as evidenced by its capacity to reduce the production of NO and ROS, as well as the levels of IL-1, IL-6, and TNF-α and the count of neutrophils. Therefore, it was suggested that EBNP accelerated wound healing by reducing inflammation, as well as enhancing ECM remodeling through EGF-like activity, including promoting the synthesis of collagen and elastin to quickly mend wounds. It could be concluded that the EBNP had the potential to promote tissue regeneration and skin repair in the fields of food, medicine and cosmetics.</p>\u0000 </div>","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":"116 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0