IF 3.2 4区生物学

Biopolymers Pub Date : 2025-01-01 Epub Date: 2024-12-13 DOI: 10.1002/bip.23647

Ayşe Haliç Poslu, Gamze Koz

{"title":"Surface Decoration of Cellulose With Trifluoromethylphenyl Substituted Thiourea: A Robust Hydrogen-Bonding Catalyst in Conjunction With L-Proline for the Asymmetric Direct Mannich Reaction.","authors":"Ayşe Haliç Poslu, Gamze Koz","doi":"10.1002/bip.23647","DOIUrl":"10.1002/bip.23647","url":null,"abstract":"Cellulose is one of the most abundant biopolymers in nature. Despite being the subject of research in various fields, it is not as famous as chitosan in catalyst design. Herein, a novel thiourea-functionalized cellulose (CTU-6) was synthesized as a robust hydrogen bonding catalyst with the degree of substitution (DS) of 0.84. CTU-6 was characterized using Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), x-ray powder diffraction (XRD), proton nuclear magnetic resonance spectroscopy (1HNMR), solid-state cross-polarization magic angle spinning carbon-13 nuclear magnetic resonance (CP/MAS 13C-NMR), thermal gravimetric analysis (TGA) and elementel analysis. CTU-6 catalyzed the direct asymmetric Mannich reaction between acetone, aniline, and various aromatic aldehydes in cooperation with L-proline. The reaction exhibited excellent enantioselectivity, achieving up to 98% enantiomeric excess (ee) at room temperature. Incorporating trifluoromethylphenyl-substituted thiourea into the cellulose framework leverages its ability to form hydrogen bonds, thereby enabling precise control over the asymmetric induction. This study highlights the potential of cellulose-based catalysts in advancing asymmetric synthesis and their versatility in various organic reactions in cooperation with small chiral ligands. This synergy not only facilitates the efficient catalytic process but also improves the stereochemical outcomes of the reactions. This method underscores the importance of utilizing renewable and versatile cellulose materials in combination with chiral auxiliaries to achieve high levels of enantioselectivity.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":" ","pages":"e23647"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Influence of Additive Manufacturing and Ultrasonic Coating Parameters on Biopolymeric Scaffold Performance Using Response Surface Methodology. 利用响应面方法研究增材制造和超声波涂层参数对生物聚合物支架性能的影响

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-01-01 Epub Date: 2024-09-25 DOI: 10.1002/bip.23629

Shrutika Sharma, Abhinav Mishra, Vivek Jain, Vishal Gupta

{"title":"Investigating the Influence of Additive Manufacturing and Ultrasonic Coating Parameters on Biopolymeric Scaffold Performance Using Response Surface Methodology.","authors":"Shrutika Sharma, Abhinav Mishra, Vivek Jain, Vishal Gupta","doi":"10.1002/bip.23629","DOIUrl":"10.1002/bip.23629","url":null,"abstract":"Triply periodic minimal surface (TPMS) scaffolds have gained attention in additive manufacturing due to their unique porous structures, which are useful in biomedical applications. Unlike metallic implants that can cause stress shielding, polymeric scaffolds offer a safer alternative. This study is focused on enhancing the compressive strength of additive-manufactured polylactic acid (PLA) scaffolds with a diamond structure. The response surface methodology (RSM)-based experimental design was developed to study the influence of printing parameters. The fused deposition modeling (FDM) process parameters were optimized, achieving a compressive strength of 56.2 MPa. Subsequently, the scaffolds were fabricated at optimized parameters and underwent ultrasonic-assisted polydopamine coating. With the utilization of the RSM approach, the study examined the effects of ultrasonic vibration power, coating solution concentration, and submersion time on compressive strength. The optimal coating conditions led to a maximum compressive strength of 92.77 MPa-a 65.1% improvement over the uncoated scaffold. This enhancement is attributed to the scaffold's porous structure, which enables uniform coating deposition. Energy-dispersive x-ray spectroscopy confirmed the successful polydopamine coating, with 10.64 wt% nitrogen content. These findings demonstrate the potential of ultrasonic-assisted coating in improving the mechanical properties of PLA scaffolds, making them suitable for biomedical applications.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":" ","pages":"e23629"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the Architecture of Starch Granules Revealed by Iodine Binding and Lintnerization. Part 2: Molecular Structure of Lintnerized Starches. 通过碘结合和林特纳化揭示淀粉颗粒的结构。第 2 部分：林特纳化淀粉的分子结构。

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-01-01 Epub Date: 2024-10-15 DOI: 10.1002/bip.23636

Eric Bertoft, George Annor, Varatharajan Vamadevan, Amy Hui-Mei Lin

{"title":"On the Architecture of Starch Granules Revealed by Iodine Binding and Lintnerization. Part 2: Molecular Structure of Lintnerized Starches.","authors":"Eric Bertoft, George Annor, Varatharajan Vamadevan, Amy Hui-Mei Lin","doi":"10.1002/bip.23636","DOIUrl":"10.1002/bip.23636","url":null,"abstract":"This investigation validated iodine binding in combination with lintnerization for studying the structural nature of the amorphous areas in starch granules. Lintners of four iodine vapor-stained and non-stained amylose-containing starches and their waxy counterparts were analyzed by high-performance anion-exchange chromatography (HPAEC). The composition of the lintners was strongly affected by the absence of amylose in barley and potato starch but not in maize and cassava starch. Iodine-stained waxy lintners possessed increased number of long B2 chains. β-Limit dextrins of the lintners were very variable in composition. Iodine inclusion complexes washed out from the granular residues in the lintners (mostly from amylose-containing barley and maize starches) were also analyzed. Acid-soluble complexes from both amylose-containing and waxy starches possessed a lot of material with a degree of polymerization (DP) around 60 and a periodicity in size of DP 8-12. Such long chains were only minor components in water-soluble complexes of amylose-containing barley and maize starch lintners, and they lacked the size periodicity. Models of the principal structure of the acid and water-soluble complexes are suggested. It is concluded that acid hydrolysis of iodine-stained starch granules is a useful tool in structural analyses of the molecular composition of amorphous parts of starch granules.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":" ","pages":"e23636"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of HEMA-Succinic Acid-PEG Bio-Based Monomers for High-Performance Hydrogels in Regenerative Medicine. 开发 HEMA-琥珀酸-PEG 生物基单体，用于再生医学中的高性能水凝胶。

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-01-01 Epub Date: 2024-10-09 DOI: 10.1002/bip.23631

Hossein Rayat Pisheh, Alireza Sabzevari, Mojtaba Ansari, Kourosh Kabiri

{"title":"Development of HEMA-Succinic Acid-PEG Bio-Based Monomers for High-Performance Hydrogels in Regenerative Medicine.","authors":"Hossein Rayat Pisheh, Alireza Sabzevari, Mojtaba Ansari, Kourosh Kabiri","doi":"10.1002/bip.23631","DOIUrl":"10.1002/bip.23631","url":null,"abstract":"In recent years, hydrogels have found a special place in regenerative medicine for tissue repair, rehabilitation, and drug delivery. To be used in regenerative medicine, hydrogels must have desirable physical, chemical, and biological properties. In this study, a new biomonomer based on hydroxyethyl methacrylate-succinic acid-polyethylene glycol 200 (HEMA-Suc-PEG) was synthesized and characterized. Then, using the synthesized monomers and different ratios of polyethylene glycol diacrylate (PEGDA) as a crosslinker, biocompatible hydrogels were synthesized through thermal and UV curing methods. The mechanical, physical, chemical, and biological properties of the hydrogels and the behavior of endothelial cells, an essential component of the cardiovascular system, were evaluated. The results showed that the hydrogel synthesized with 0.2 g of PEGDA (UV curing) has desirable mechanical and physical properties. Biological tests showed that these hydrogels are not only nontoxic to cells but also enhance cell adhesion. Therefore, the hydrogel containing the synthesized monomer HEMA-Suc-PEG and 0.2 g of PEGDA has the potential to be used in the cardiovascular system.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":" ","pages":"e23631"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Activation Energy for Pyrolytic Degradation of Poly-L-Lactide (PLA) During Artificially Accelerated Aging.

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-01-01 Epub Date: 2024-12-06 DOI: 10.1002/bip.23642

Margarita Reit, Natalie Krug, Jan-Christoph Zarges, Hans-Peter Heim

{"title":"Evaluation of the Activation Energy for Pyrolytic Degradation of Poly-L-Lactide (PLA) During Artificially Accelerated Aging.","authors":"Margarita Reit, Natalie Krug, Jan-Christoph Zarges, Hans-Peter Heim","doi":"10.1002/bip.23642","DOIUrl":"10.1002/bip.23642","url":null,"abstract":"In the course of this study, the pyrolytic degradation characteristics of three poly(lactic acid) (PLA) types were investigated under inert conditions using dynamic thermogravimetric analysis (TGA) across the temperature range of 23°C-600°C with four heating rates. Specifically, the activation energy and its implications were determined at different stages of degradation. For this purpose, a comparative analysis of various isoconversional methods, including Kissinger, Flynn-Wall-Ozawa (FWO), Friedman, and Kissinger-Akahira-Sunnose (KAS) was undertaken to evaluate the reliability of each. The results indicate a decrease in thermal stability, indicated by a shift of the derived mass loss curves to lower temperatures, as confirmed by an increased water content and decreased crystallinity of the test specimen during aging. The study also highlights that if crystallinity and moisture content increase moderately, the thermal degradation curves remain unchanged. Additionally, kinetic analyses using mentioned models indicate a multi-step degradation process of PLA. The activation energy fluctuates with the conversion rate, suggesting complex underlying kinetics. These findings emphasize the need for dynamic adjustment of predictive models for material lifespan. The three PLA types were characterized by Differential Scanning Calorimetry (DSC), moisture absorption measurement and Gel permeation chromatography (GPC).","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":" ","pages":"e23642"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitosan/Fibroin Biopolymer-Based Hydrogels for Potential Angiogenesis in Developing Chicks and Accelerated Wound Healing in Mice. 壳聚糖/纤维素生物聚合物水凝胶用于发育中雏鸡的潜在血管生成和加速小鼠的伤口愈合

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-01-01 Epub Date: 2024-10-09 DOI: 10.1002/bip.23633

Hafiza Zubia Dawood, Chaman Ara, Asmatullah, Sehrish Jabeen, Atif Islam, Zunaira Huma Ghauri

{"title":"Chitosan/Fibroin Biopolymer-Based Hydrogels for Potential Angiogenesis in Developing Chicks and Accelerated Wound Healing in Mice.","authors":"Hafiza Zubia Dawood, Chaman Ara, Asmatullah, Sehrish Jabeen, Atif Islam, Zunaira Huma Ghauri","doi":"10.1002/bip.23633","DOIUrl":"10.1002/bip.23633","url":null,"abstract":"Potential therapies for wound management remain one of the most challenging affairs to date. Biopolymer hydrogels possess inherent properties that facilitate the healing of damaged tissue by creating a supportive and hydrated environment. Chitosan/fibroin hydrogels were formulated with poly (vinyl pyrrolidone) and cross-linked using 3-aminopropyl (diethoxy) methylsilane (APDEMS) for the aforementioned function. The hydrogels were characterized through Fourier transform infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy, and their swelling response was observed using a variety of solvents. Additionally, hydrogels were investigated for biomedical applications. As the amount of fibroin added to the hydrogels increased, the swelling ratio decreased. The analysis of chorioallantoic membrane (CAM) assay revealed that higher concentrations of fibroin in the hydrogel were directly correlated with increased angiogenesis. The intragroup comparison showed that the vascular number in the CPF5 group was significantly increased (p ≤ 0.05) compared to other hydrogel groups. The wound healing efficiency of the prepared hydrogels showed that the rate of wound reduction (99.06%) was remarkably (p ≤ 0.05) high in the hydrogel group with a greater fibroin content against control (67.03%). Histological findings of wounded tissues corroborate the abovementioned results, showing dense fibrous connective tissues in the fibroin group compared to the control. The results of this work provide thorough preclinical evidence that chitosan-fibroin biopolymers are involved in enhanced angiogenesis in growing chicks and speed up wound healing in mice without any obvious toxicity.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":" ","pages":"e23633"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyhydroxybutyrate Synthesis by the Halophilic Bacterium, Halomonas boliviensis, in Oil Palm Empty Fruit Bunch Hydrolysate.

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-01-01 Epub Date: 2024-12-06 DOI: 10.1002/bip.23644

Diana Catalina Arcila-Echavarría, Thelmo Alejandro Lu-Chau, Natalia Andrea Gómez-Vanegas

{"title":"Polyhydroxybutyrate Synthesis by the Halophilic Bacterium, Halomonas boliviensis, in Oil Palm Empty Fruit Bunch Hydrolysate.","authors":"Diana Catalina Arcila-Echavarría, Thelmo Alejandro Lu-Chau, Natalia Andrea Gómez-Vanegas","doi":"10.1002/bip.23644","DOIUrl":"10.1002/bip.23644","url":null,"abstract":"Polyhydroxyalkanoates are biodegradable, natural polyesters with the potential to replace petroleum-based plastics. However, high production costs limit their competitiveness. This study assessed the ability of Halomonas boliviensis, a halophilic bacterium, to synthesize polyhydroxybutyrate (PHB) from an agricultural residue, oil palm empty fruit bunch (OPEFB), in highly saline solutions that minimize contamination risk. OPEFB, containing glucose, xylose, and arabinose, offers a cost-effective alternative to pure sugar substrates and aids in waste management. PHB production from OPEFB was compared with fermentations using these sugars. H. boliviensis successfully synthesized PHB from all substrates, achieving the highest PHB content from glucose (54.63%), followed by xylose (40.18%), OPEFB (33.59%), and arabinose (33.52%). Glucose in the OPEFB hydrolysate was entirely depleted after 72 h, while xylose showed minimal consumption. This research highlights the potential of using low-cost carbon sources like OPEFB for PHB production. Future research should focus on optimizing the fermentation process to increase PHB yields, making it a more viable alternative to traditional plastics.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":" ","pages":"e23644"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication and Characterization of Agar- and Seaweed-Derived Biomembrane Films for Biomedical and Other Applications.

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-01-01 Epub Date: 2024-12-10 DOI: 10.1002/bip.23643

Muthiyal Prabakaran Sudhakar, Sureshkumar Ambika Nived, Gopal Dharani

{"title":"Fabrication and Characterization of Agar- and Seaweed-Derived Biomembrane Films for Biomedical and Other Applications.","authors":"Muthiyal Prabakaran Sudhakar, Sureshkumar Ambika Nived, Gopal Dharani","doi":"10.1002/bip.23643","DOIUrl":"10.1002/bip.23643","url":null,"abstract":"This study focused on seaweed-based biomembrane development. The physical, mechanical, thermal, and biological properties of the fabricated films with different combinations of materials, such as agar, chitosan, poly(vinyl) alcohol (PVA), and quercetin, were characterized. The surface morphology of the films was analyzed using SEM. The maximum tensile strength (53.11 N/mm2), elongation at break (3.42%), and Young's modulus (15.52) of the biomembrane were recorded for the agar + chitosan combination. FT-Raman analysis confirmed the functional groups shift between the biopolymer and plasticizer used in this study. TG-DSC analysis of the biomembranes revealed a Tg in the range of 92.80°C-115°C. The maximum antioxidant activity was reported for quercetin (58.62%), and the maximum antimicrobial activity was observed for the chitosan and quercetin compounds against E. coli. A minimum hemolysis of 0.95% was achieved for the combination of agar + quercetin (AQ), agar + PEG (APE), Gracilaria corticata extract + PVA + quercetin (GCPQ) and agar + chitosan (AC) biomembranes. The minimum cytotoxicity of the biomembrane was 62.51% and 63.87% for Gracilaria corticata extract + PVA + quercetin (GCPQ), and agar + PVA, respectively. The proposed biomembrane films were found to be suitable for biomedical and packaging applications.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":" ","pages":"e23643"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing the Production of Bacterial Cellulose Nanofibers and Nanocrystals Through Strategic Fiber Pretreatment. 通过战略性纤维预处理优化细菌纤维素纳米纤维和纳米晶体的生产。

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-01-01 Epub Date: 2024-10-03 DOI: 10.1002/bip.23634

Fulya Şahin, Neslihan Kayra, Ali Özhan Aytekin

{"title":"Optimizing the Production of Bacterial Cellulose Nanofibers and Nanocrystals Through Strategic Fiber Pretreatment.","authors":"Fulya Şahin, Neslihan Kayra, Ali Özhan Aytekin","doi":"10.1002/bip.23634","DOIUrl":"10.1002/bip.23634","url":null,"abstract":"Bacterial cellulose (BC) has unique properties such as high tensile strength, high crystallinity, and high purity. The fiber length of BC causes different attributes. Therefore, the degradation of BC has been studied extensively. In this study, the fibers of BC were rearranged via a DMAc-LiCl solvent and BC was degraded in the wet state. Two different degradation methods were applied: milling with liquid nitrogen and autoclave treatment. The degraded BCs were characterized by FTIR, TEM, AFM, TGA, and XRD. The solvent helps to align the fibers, making them more crystalline. The degraded BCs had a lower crystalline ratio than untreated BC, due to increased hydrogen bonding during degradation in the wet state. Degradation with an autoclave produced two different degraded BCs: nanofibrils and spherical nanocrystals, with and without solvent pretreatment, respectively. The nanofibril lengths were between 312 and 700 nm depending on the applied method, and the spherical nanocrystal size was 56 nm. The rearrangement via solvent causes an important difference in the degradation of BC. Nanofibrils and nanocrystals can be obtained, depending on the rearrangement of fibers before the degradation process.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":" ","pages":"e23634"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Carbohydrate Polymer-Based Systems for Precise Drug Delivery in Colon Cancer: Improving Treatment Effectiveness With Intelligent Biodegradable Materials. 基于碳水化合物聚合物的新型结肠癌精准给药系统：利用智能生物降解材料提高治疗效果。

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-01-01 Epub Date: 2024-09-27 DOI: 10.1002/bip.23632

Nikita Udaipuria, Sankha Bhattacharya

{"title":"Novel Carbohydrate Polymer-Based Systems for Precise Drug Delivery in Colon Cancer: Improving Treatment Effectiveness With Intelligent Biodegradable Materials.","authors":"Nikita Udaipuria, Sankha Bhattacharya","doi":"10.1002/bip.23632","DOIUrl":"10.1002/bip.23632","url":null,"abstract":"Due to their biocompatibility, biodegradability, and controlled release, carbohydrates polymers are crucial to targeted drug delivery systems, notably for colon cancer treatment. This article examines how carbohydrate polymers like chitosan, pectin, guar gum, alginate, hyaluronic acid, dextran, and chondroitin sulfate are used in improved drug delivery. Modifying these polymers improves drug loading, stability, and release patterns, enhancing chemotherapeutic drugs' therapeutic index. Chitosan nanoparticles are pH-responsive, making them perfect for cancer treatment. Pectin's resistance to gastric enzymes and colonic bacteria makes it a promising colon-specific medication delivery agent. The combination of these polymers with nanotechnology, 3D printing, and AI allows the creation of stimuli-responsive systems that release drugs precisely in response to environmental signals like pH, redox potential, or colon enzymatic activity. The review highlights intelligent delivery system design advances that reduce systemic toxicity, improve treatment efficacy, and improve patient adherence. Carbohydrate polymers will revolutionize colon cancer treatment with personalized and accurate alternatives.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":" ","pages":"e23632"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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