IF 3.2 4区生物学

Biopolymers Pub Date : 2024-10-22 DOI: 10.1002/bip.23635

Md Ibrahim H Mondal, Firoz Ahmed, Md Hasinur Rahman

{"title":"Fabrication of Bio-Based Composite Materials for Antimicrobial Cotton Fabric With Microbial Anti-Adhesive Activity.","authors":"Md Ibrahim H Mondal, Firoz Ahmed, Md Hasinur Rahman","doi":"10.1002/bip.23635","DOIUrl":"https://doi.org/10.1002/bip.23635","url":null,"abstract":"The development of multifunctional cotton fabrics that are stain-resistant, antimicrobial, and easy to clean has sparked scientific interest as well as practical usefulness, owing to its medical and healthcare applications. The purpose of this study was to fabricate self-cleaning and antimicrobial cotton for final use by soaking the cotton fabric in nonfluorinated hybrid formulations based on quaternary chitosan-silane using the sol-gel process. The fluorine-free cotton fabric demonstrated high self-cleaning behavior and outstanding bacterial killing efficacy against E. coli and S. aureus bacteria, without altering the desired textile properties of cotton fabric. Remarkably, cotton textiles using the hybrid formulations HTACC-VTES (N-(2-hydroxy)propyl-3-trimethylammonium chitosan chloride-vinyltriethoxy silane) and TMCC-VTES (N, N, N-trimethyl chitosan chloride-vinyltriethoxy silane) demonstrated promising water contact angles of 147° and 142° respectively, indicating a move toward superhydrophobicity. In FTIR spectra, both treated cotton textiles had an absorption peak at 1208 cm-1 (SiOC bending), indicating a stronger interaction between silane binding agents and the cotton substrate. The treated cotton fabric with desirable features retains its stability and endurance after 12 cycles of washing for antibacterial tests and 15 cycles for wettability tests. The manufactured cotton fabric has several potential applications, such as in personal hygiene items and medical applications.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Updated Review Summarizing the Anticancer Potential of Poly(Lactic-co-Glycolic Acid) (PLGA) Based Curcumin, Epigallocatechin Gallate, and Resveratrol Nanocarriers. 最新综述：基于聚乳酸-乙醇酸（PLGA）的姜黄素、表没食子儿茶素没食子酸酯和白藜芦醇纳米载体的抗癌潜力。

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-10-17 DOI: 10.1002/bip.23637

Pratibha Pandey, Meenakshi Verma, Sorabh Lakhanpal, Shivam Pandey, M Ravi Kumar, Mahakshit Bhat, Shilpa Sharma, Mir Waqas Alam, Fahad Khan

{"title":"An Updated Review Summarizing the Anticancer Potential of Poly(Lactic-co-Glycolic Acid) (PLGA) Based Curcumin, Epigallocatechin Gallate, and Resveratrol Nanocarriers.","authors":"Pratibha Pandey, Meenakshi Verma, Sorabh Lakhanpal, Shivam Pandey, M Ravi Kumar, Mahakshit Bhat, Shilpa Sharma, Mir Waqas Alam, Fahad Khan","doi":"10.1002/bip.23637","DOIUrl":"https://doi.org/10.1002/bip.23637","url":null,"abstract":"The utilization of nanoformulations derived from natural products for the treatment of many human diseases, including cancer, is a rapidly developing field. Conventional therapies used for cancer treatment have limited efficacy and a greater number of adverse effects. Hence, it is imperative to develop innovative anticancer drugs with superior effectiveness. Among the diverse array of natural anticancer compounds, resveratrol, curcumin, and epigallocatechin gallate (EGCG) have gained considerable attention in recent years. Despite their strong anticancer properties, medicinally significant phytochemicals such as resveratrol, curcumin, and EGCG have certain disadvantages, such as limited solubility in water, stability, and bioavailability problems. Encapsulating these phytochemicals in poly(lactic-co-glycolic acid) (PLGA), a polymer that is nontoxic, biodegradable, and biocompatible, is an effective method for delivering medication to the tumor location. In addition, PLGA nanoparticles can be modified with targeting molecules to specifically target cancer cells, thereby improving the effectiveness of phytochemicals in fighting tumors. Combining plant-based medicine (phytotherapy) with nanotechnology in a clinical environment has the potential to enhance the effectiveness of drugs and improve the overall health outcomes of patients. Therefore, it is crucial to have a comprehensive understanding of the different aspects and recent advancements in using PLGA-based nanocarriers for delivering anticancer phytochemicals. This review addresses the most recent advancements in PLGA-based delivery systems for resveratrol, EGCG, and curcumin, emphasizing the possibility of resolving issues related to the therapeutic efficacy and bioavailability of these compounds.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the Architecture of Starch Granules Revealed by Iodine Binding and Lintnerization. Part 2: Molecular Structure of Lintnerized Starches. 通过碘结合和林特纳化揭示淀粉颗粒的结构。第 2 部分：林特纳化淀粉的分子结构。

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-10-15 DOI: 10.1002/bip.23636

Eric Bertoft, George Annor, Varatharajan Vamadevan, Amy Hui-Mei Lin

{"title":"On the Architecture of Starch Granules Revealed by Iodine Binding and Lintnerization. Part 2: Molecular Structure of Lintnerized Starches.","authors":"Eric Bertoft, George Annor, Varatharajan Vamadevan, Amy Hui-Mei Lin","doi":"10.1002/bip.23636","DOIUrl":"https://doi.org/10.1002/bip.23636","url":null,"abstract":"This investigation validated iodine binding in combination with lintnerization for studying the structural nature of the amorphous areas in starch granules. Lintners of four iodine vapor-stained and non-stained amylose-containing starches and their waxy counterparts were analyzed by high-performance anion-exchange chromatography (HPAEC). The composition of the lintners was strongly affected by the absence of amylose in barley and potato starch but not in maize and cassava starch. Iodine-stained waxy lintners possessed increased number of long B2 chains. β-Limit dextrins of the lintners were very variable in composition. Iodine inclusion complexes washed out from the granular residues in the lintners (mostly from amylose-containing barley and maize starches) were also analyzed. Acid-soluble complexes from both amylose-containing and waxy starches possessed a lot of material with a degree of polymerization (DP) around 60 and a periodicity in size of DP 8-12. Such long chains were only minor components in water-soluble complexes of amylose-containing barley and maize starch lintners, and they lacked the size periodicity. Models of the principal structure of the acid and water-soluble complexes are suggested. It is concluded that acid hydrolysis of iodine-stained starch granules is a useful tool in structural analyses of the molecular composition of amorphous parts of starch granules.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of HEMA-Succinic Acid-PEG Bio-Based Monomers for High-Performance Hydrogels in Regenerative Medicine. 开发 HEMA-琥珀酸-PEG 生物基单体，用于再生医学中的高性能水凝胶。

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-10-09 DOI: 10.1002/bip.23631

Hossein Rayat Pisheh, Alireza Sabzevari, Mojtaba Ansari, Kourosh Kabiri

{"title":"Development of HEMA-Succinic Acid-PEG Bio-Based Monomers for High-Performance Hydrogels in Regenerative Medicine.","authors":"Hossein Rayat Pisheh, Alireza Sabzevari, Mojtaba Ansari, Kourosh Kabiri","doi":"10.1002/bip.23631","DOIUrl":"https://doi.org/10.1002/bip.23631","url":null,"abstract":"In recent years, hydrogels have found a special place in regenerative medicine for tissue repair, rehabilitation, and drug delivery. To be used in regenerative medicine, hydrogels must have desirable physical, chemical, and biological properties. In this study, a new biomonomer based on hydroxyethyl methacrylate-succinic acid-polyethylene glycol 200 (HEMA-Suc-PEG) was synthesized and characterized. Then, using the synthesized monomers and different ratios of polyethylene glycol diacrylate (PEGDA) as a crosslinker, biocompatible hydrogels were synthesized through thermal and UV curing methods. The mechanical, physical, chemical, and biological properties of the hydrogels and the behavior of endothelial cells, an essential component of the cardiovascular system, were evaluated. The results showed that the hydrogel synthesized with 0.2 g of PEGDA (UV curing) has desirable mechanical and physical properties. Biological tests showed that these hydrogels are not only nontoxic to cells but also enhance cell adhesion. Therefore, the hydrogel containing the synthesized monomer HEMA-Suc-PEG and 0.2 g of PEGDA has the potential to be used in the cardiovascular system.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitosan/Fibroin Biopolymer-Based Hydrogels for Potential Angiogenesis in Developing Chicks and Accelerated Wound Healing in Mice. 壳聚糖/纤维素生物聚合物水凝胶用于发育中雏鸡的潜在血管生成和加速小鼠的伤口愈合

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-10-09 DOI: 10.1002/bip.23633

Hafiza Zubia Dawood, Chaman Ara, Asmatullah, Sehrish Jabeen, Atif Islam, Zunaira Huma Ghauri

{"title":"Chitosan/Fibroin Biopolymer-Based Hydrogels for Potential Angiogenesis in Developing Chicks and Accelerated Wound Healing in Mice.","authors":"Hafiza Zubia Dawood, Chaman Ara, Asmatullah, Sehrish Jabeen, Atif Islam, Zunaira Huma Ghauri","doi":"10.1002/bip.23633","DOIUrl":"https://doi.org/10.1002/bip.23633","url":null,"abstract":"Potential therapies for wound management remain one of the most challenging affairs to date. Biopolymer hydrogels possess inherent properties that facilitate the healing of damaged tissue by creating a supportive and hydrated environment. Chitosan/fibroin hydrogels were formulated with poly (vinyl pyrrolidone) and cross-linked using 3-aminopropyl (diethoxy) methylsilane (APDEMS) for the aforementioned function. The hydrogels were characterized through Fourier transform infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy, and their swelling response was observed using a variety of solvents. Additionally, hydrogels were investigated for biomedical applications. As the amount of fibroin added to the hydrogels increased, the swelling ratio decreased. The analysis of chorioallantoic membrane (CAM) assay revealed that higher concentrations of fibroin in the hydrogel were directly correlated with increased angiogenesis. The intragroup comparison showed that the vascular number in the CPF5 group was significantly increased (p ≤ 0.05) compared to other hydrogel groups. The wound healing efficiency of the prepared hydrogels showed that the rate of wound reduction (99.06%) was remarkably (p ≤ 0.05) high in the hydrogel group with a greater fibroin content against control (67.03%). Histological findings of wounded tissues corroborate the abovementioned results, showing dense fibrous connective tissues in the fibroin group compared to the control. The results of this work provide thorough preclinical evidence that chitosan-fibroin biopolymers are involved in enhanced angiogenesis in growing chicks and speed up wound healing in mice without any obvious toxicity.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing the Production of Bacterial Cellulose Nanofibers and Nanocrystals Through Strategic Fiber Pretreatment. 通过战略性纤维预处理优化细菌纤维素纳米纤维和纳米晶体的生产。

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-10-03 DOI: 10.1002/bip.23634

Fulya Şahin, Neslihan Kayra, Ali Özhan Aytekin

{"title":"Optimizing the Production of Bacterial Cellulose Nanofibers and Nanocrystals Through Strategic Fiber Pretreatment.","authors":"Fulya Şahin, Neslihan Kayra, Ali Özhan Aytekin","doi":"10.1002/bip.23634","DOIUrl":"https://doi.org/10.1002/bip.23634","url":null,"abstract":"Bacterial cellulose (BC) has unique properties such as high tensile strength, high crystallinity, and high purity. The fiber length of BC causes different attributes. Therefore, the degradation of BC has been studied extensively. In this study, the fibers of BC were rearranged via a DMAc-LiCl solvent and BC was degraded in the wet state. Two different degradation methods were applied: milling with liquid nitrogen and autoclave treatment. The degraded BCs were characterized by FTIR, TEM, AFM, TGA, and XRD. The solvent helps to align the fibers, making them more crystalline. The degraded BCs had a lower crystalline ratio than untreated BC, due to increased hydrogen bonding during degradation in the wet state. Degradation with an autoclave produced two different degraded BCs: nanofibrils and spherical nanocrystals, with and without solvent pretreatment, respectively. The nanofibril lengths were between 312 and 700 nm depending on the applied method, and the spherical nanocrystal size was 56 nm. The rearrangement via solvent causes an important difference in the degradation of BC. Nanofibrils and nanocrystals can be obtained, depending on the rearrangement of fibers before the degradation process.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Carbohydrate Polymer-Based Systems for Precise Drug Delivery in Colon Cancer: Improving Treatment Effectiveness With Intelligent Biodegradable Materials. 基于碳水化合物聚合物的新型结肠癌精准给药系统：利用智能生物降解材料提高治疗效果。

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-09-27 DOI: 10.1002/bip.23632

Nikita Udaipuria, Sankha Bhattacharya

{"title":"Novel Carbohydrate Polymer-Based Systems for Precise Drug Delivery in Colon Cancer: Improving Treatment Effectiveness With Intelligent Biodegradable Materials.","authors":"Nikita Udaipuria, Sankha Bhattacharya","doi":"10.1002/bip.23632","DOIUrl":"https://doi.org/10.1002/bip.23632","url":null,"abstract":"Due to their biocompatibility, biodegradability, and controlled release, carbohydrates polymers are crucial to targeted drug delivery systems, notably for colon cancer treatment. This article examines how carbohydrate polymers like chitosan, pectin, guar gum, alginate, hyaluronic acid, dextran, and chondroitin sulfate are used in improved drug delivery. Modifying these polymers improves drug loading, stability, and release patterns, enhancing chemotherapeutic drugs' therapeutic index. Chitosan nanoparticles are pH-responsive, making them perfect for cancer treatment. Pectin's resistance to gastric enzymes and colonic bacteria makes it a promising colon-specific medication delivery agent. The combination of these polymers with nanotechnology, 3D printing, and AI allows the creation of stimuli-responsive systems that release drugs precisely in response to environmental signals like pH, redox potential, or colon enzymatic activity. The review highlights intelligent delivery system design advances that reduce systemic toxicity, improve treatment efficacy, and improve patient adherence. Carbohydrate polymers will revolutionize colon cancer treatment with personalized and accurate alternatives.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Influence of Additive Manufacturing and Ultrasonic Coating Parameters on Biopolymeric Scaffold Performance Using Response Surface Methodology. 利用响应面方法研究增材制造和超声波涂层参数对生物聚合物支架性能的影响

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-09-25 DOI: 10.1002/bip.23629

Shrutika Sharma, Abhinav Mishra, Vivek Jain, Vishal Gupta

{"title":"Investigating the Influence of Additive Manufacturing and Ultrasonic Coating Parameters on Biopolymeric Scaffold Performance Using Response Surface Methodology.","authors":"Shrutika Sharma, Abhinav Mishra, Vivek Jain, Vishal Gupta","doi":"10.1002/bip.23629","DOIUrl":"https://doi.org/10.1002/bip.23629","url":null,"abstract":"Triply periodic minimal surface (TPMS) scaffolds have gained attention in additive manufacturing due to their unique porous structures, which are useful in biomedical applications. Unlike metallic implants that can cause stress shielding, polymeric scaffolds offer a safer alternative. This study is focused on enhancing the compressive strength of additive-manufactured polylactic acid (PLA) scaffolds with a diamond structure. The response surface methodology (RSM)-based experimental design was developed to study the influence of printing parameters. The fused deposition modeling (FDM) process parameters were optimized, achieving a compressive strength of 56.2 MPa. Subsequently, the scaffolds were fabricated at optimized parameters and underwent ultrasonic-assisted polydopamine coating. With the utilization of the RSM approach, the study examined the effects of ultrasonic vibration power, coating solution concentration, and submersion time on compressive strength. The optimal coating conditions led to a maximum compressive strength of 92.77 MPa-a 65.1% improvement over the uncoated scaffold. This enhancement is attributed to the scaffold's porous structure, which enables uniform coating deposition. Energy-dispersive x-ray spectroscopy confirmed the successful polydopamine coating, with 10.64 wt% nitrogen content. These findings demonstrate the potential of ultrasonic-assisted coating in improving the mechanical properties of PLA scaffolds, making them suitable for biomedical applications.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Different Ratios of Polyvinyl Alcohol-Gum Odina for the Preparation and Characterization of Biodegradable Composite Films. 不同比例的聚乙烯醇-奥迪纳胶对制备可生物降解复合膜及其特性的影响

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-09-23 DOI: 10.1002/bip.23630

Mousumi Tudu, Ahana Hazra, Pankaj Paul, Abhishek Mohanta, Sohini Chatterjee, Amalesh Samanta

{"title":"Effect of Different Ratios of Polyvinyl Alcohol-Gum Odina for the Preparation and Characterization of Biodegradable Composite Films.","authors":"Mousumi Tudu, Ahana Hazra, Pankaj Paul, Abhishek Mohanta, Sohini Chatterjee, Amalesh Samanta","doi":"10.1002/bip.23630","DOIUrl":"https://doi.org/10.1002/bip.23630","url":null,"abstract":"This research investigates the production of biodegradable films using a combination of gum odina (GO) and polyvinyl alcohol (PVA) with varied ratio. The study focuses on the chemical, physical, and mechanical properties of PVA-GO composite films, emphasizing how versatile and biodegradable they may be for a range of packaging applications. Solvent-cast PVA-GO films with different ratios are subjected to a methodical analytical process to determine several parameters like mechanical qualities, thermal stability, biodegradability in soil, contact angle, transparency, water vapor permeability, moisture content, thickness, density, water solubility, microstructure, and FTIR analysis. The outcomes demonstrate that GO improves UV barrier qualities and water vapor permeability. Additionally, the films showed notable biodegradability, acceptable thermal stability, and mechanical qualities. In short, PVA-GO films can provide an eco-friendly packing substitute with adaptable qualities fit for a range of uses. Therefore, this research may further contribute promising information in the field of biodegradable packaging materials in the future.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of In Situ-Cross-Linked N-Succinyl Chitosan/Oxidized Alginate Hydrogel-Loaded Ascorbic Acid and Biphasic Calcium Phosphate for Bone Tissue Engineering 用于骨组织工程的原位交联 N-琥珀酰壳聚糖/氧化海藻酸水凝胶负载抗坏血酸和双相磷酸钙的制备方法

IF 2.9 4区生物学

Biopolymers Pub Date : 2024-09-20 DOI: 10.1002/bip.23628

Thanh-Thuong Le Duong, Binh Thanh Vu, Hanh Thi-Kieu Ta, Quan Minh Vo, Thanh Dinh Le, Thi-Hiep Nguyen

{"title":"Fabrication of In Situ-Cross-Linked N-Succinyl Chitosan/Oxidized Alginate Hydrogel-Loaded Ascorbic Acid and Biphasic Calcium Phosphate for Bone Tissue Engineering","authors":"Thanh-Thuong Le Duong, Binh Thanh Vu, Hanh Thi-Kieu Ta, Quan Minh Vo, Thanh Dinh Le, Thi-Hiep Nguyen","doi":"10.1002/bip.23628","DOIUrl":"https://doi.org/10.1002/bip.23628","url":null,"abstract":"Bone tissue engineering is a promising technology being studied globally to become an effective and sustainable method to treat the problems of damaged or diseased bones. In this work, we developed an in situ cross-linking hydrogel system that combined N-succinyl chitosan (NSC) and oxidized alginate (OA) at varying mixing ratios through Schiff base cross-linking. The hydrogel system also contains biphasic calcium phosphate (BCP) and ascorbic acid (AA), which could enhance biological characteristics and accelerate bone repair. The hydrogels' properties were examined through physicochemical tests such as scanning electron microscopy (SEM), energy-dispersive x-ray spectroscopy (EDS), Fourier transform infrared spectroscopy (FT-IR), x-ray diffraction (XRD), pore size and porosity measurement, swelling ratio, degradation rate, AA release study, as well as cytocompatibility, including live/dead and cytotoxicity assays. The results revealed that the supplementation of AA and BCP components can affect the physico-mechanical properties of the hydrogel system. However, they exhibited noncytotoxic properties. Overall, the results demonstrated that the hydrogel composed of 3% (w/v) NSC and 3% (w/v) OA (NSC: OA volume ratio is 8:2) loaded with 40% (w/w) BCP and 0.3 mg/mL AA has the potential for bone regeneration.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142265066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biopolymers最新文献