IF 3.2 4区生物学

Biopolymers Pub Date : 2024-11-11 DOI: 10.1002/bip.23639

Marija Jovanović, Miloš Petrović, Dušica Stojanović, Nataša Radulović, Danijel Pantelić, Ivana Stajčić, Petar Uskoković

{"title":"3D-Printed Gelatin-Based Scaffold Crosslinked by Genipin: Evaluation of Mechanical Properties and Biological Effect.","authors":"Marija Jovanović, Miloš Petrović, Dušica Stojanović, Nataša Radulović, Danijel Pantelić, Ivana Stajčić, Petar Uskoković","doi":"10.1002/bip.23639","DOIUrl":"https://doi.org/10.1002/bip.23639","url":null,"abstract":"In this study, scaffolds based on natural polymer gelatin A, blended with polyvinylpyrrolidone were crosslinked by genipin (0.5 and 1 wt%), in order to investigate their mechanical performance and potential for biomedical application. Semi-solid extrusion (SSE) 3D printing technique was used, enabling in situ crosslinking of the blend during processing. Swelling test showed that the swelling ratio reduces with higher concentration of genipin due to an increased crosslinking. The FTIR analysis confirmed the crosslinking of scaffolds by genipin. DSC analysis and mechanical testing have shown improved thermal and mechanical properties. Morphological analysis of scaffolds by FESEM showed increased toughening of the material with the crosslinking. Tensile strength and microhardness showed a significant rise in scaffolds with the increase in genipin content, which was up to 93.8% and 125.3%, respectively. These findings were in accordance with morphological features present in samples. The biological effect of the scaffold matrix system was evaluated by qualitative and quantitative cytotoxicity assessment in vitro, demonstrating the absence of cytotoxicity in tested preparations in a direct test. The cytotoxicity index based on the metabolic activity of cells in an indirect test showed up to 20% reduction of viability compared with the control, confirming the absence of cytotoxicity, which was additionally verified by propidium iodine staining of the cells exposed to scaffolds. The presented gelatin-based crosslinked scaffolds obtained by 3D printing represent good candidates for biomedical application and future research that includes further in vitro and in vivo analysis.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":" ","pages":"e23639"},"PeriodicalIF":3.2,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D Printable Alginate-Chitosan Hydrogel Loaded With Ketoconazole Exhibits Anticryptococcal Activity. 3D打印藻酸盐-壳聚糖水凝胶负载酮康唑具有抗隐球菌活性

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-10-29 DOI: 10.1002/bip.23638

Manoela Almeida Martins Mace, Camila Leites Reginatto, Victória Rapack Jacinto Silva, Ana Carolina Silva Pinheiro, Laiane Souza da Silva, Dinara Jaqueline Moura, Alexandre Meneghello Fuentefria, Rosane Michele Duarte Soares

{"title":"3D Printable Alginate-Chitosan Hydrogel Loaded With Ketoconazole Exhibits Anticryptococcal Activity.","authors":"Manoela Almeida Martins Mace, Camila Leites Reginatto, Victória Rapack Jacinto Silva, Ana Carolina Silva Pinheiro, Laiane Souza da Silva, Dinara Jaqueline Moura, Alexandre Meneghello Fuentefria, Rosane Michele Duarte Soares","doi":"10.1002/bip.23638","DOIUrl":"10.1002/bip.23638","url":null,"abstract":"Natural polymers have recently been investigated for various applications, such as 3D printing and healthcare, including treating infections. Among microbial infections, fungal diseases remain overlooked, with limited therapeutic options and high recurrence. Cutaneous cryptococcosis is an opportunistic fungal infection triggered by mechanical inoculation or hematogenous dissemination of the yeast that causes cryptococcal pneumonia and meningitis. Every year, Cryptococcus neoformans endanger the lives of immunosuppressed hosts, resulting in 180,000 deaths per year. Nonetheless, healthy individuals can also be affected by this fungal infection. Cryptococcosis has a restricted and expensive therapeutic regimen with no topical approach to skin manifestations. This study sought to create a 3D printable biodegradable polymeric hydrogel carrying ketoconazole, a low-cost antifungal drug with reported anticryptococcal activity. The developed hydrogel exhibited good 3D printability and rheological properties, including a pseudoplastic behavior. The FTIR spectra of cross-linked hydrogels revealed interactions between alginate and Ca+2, referred to as the egg-box model, indicated by the decrease in peaks at 1600 and 1410 cm-1. Furthermore, the hydrogel loaded with ketoconazole showed remarkable antifungal activity against C. neoformans strains indicated by inhibition zones, which cross-linking did not seem to affect its antifungal performance. The developed material remained structurally stable for up to 12 days (288 h) in swelling studies, and preliminary cytotoxicity performed with V79 cells indicates potential for in vivo studies and topical application.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":" ","pages":"e23638"},"PeriodicalIF":3.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of Bio-Based Composite Materials for Antimicrobial Cotton Fabric With Microbial Anti-Adhesive Activity. 制造具有微生物抗粘活性的抗菌棉织物生物基复合材料。

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-10-22 DOI: 10.1002/bip.23635

Md Ibrahim H Mondal, Firoz Ahmed, Md Hasinur Rahman

{"title":"Fabrication of Bio-Based Composite Materials for Antimicrobial Cotton Fabric With Microbial Anti-Adhesive Activity.","authors":"Md Ibrahim H Mondal, Firoz Ahmed, Md Hasinur Rahman","doi":"10.1002/bip.23635","DOIUrl":"10.1002/bip.23635","url":null,"abstract":"The development of multifunctional cotton fabrics that are stain-resistant, antimicrobial, and easy to clean has sparked scientific interest as well as practical usefulness, owing to its medical and healthcare applications. The purpose of this study was to fabricate self-cleaning and antimicrobial cotton for final use by soaking the cotton fabric in nonfluorinated hybrid formulations based on quaternary chitosan-silane using the sol-gel process. The fluorine-free cotton fabric demonstrated high self-cleaning behavior and outstanding bacterial killing efficacy against E. coli and S. aureus bacteria, without altering the desired textile properties of cotton fabric. Remarkably, cotton textiles using the hybrid formulations HTACC-VTES (N-(2-hydroxy)propyl-3-trimethylammonium chitosan chloride-vinyltriethoxy silane) and TMCC-VTES (N, N, N-trimethyl chitosan chloride-vinyltriethoxy silane) demonstrated promising water contact angles of 147° and 142° respectively, indicating a move toward superhydrophobicity. In FTIR spectra, both treated cotton textiles had an absorption peak at 1208 cm-1 (SiOC bending), indicating a stronger interaction between silane binding agents and the cotton substrate. The treated cotton fabric with desirable features retains its stability and endurance after 12 cycles of washing for antibacterial tests and 15 cycles for wettability tests. The manufactured cotton fabric has several potential applications, such as in personal hygiene items and medical applications.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":" ","pages":"e23635"},"PeriodicalIF":3.2,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Updated Review Summarizing the Anticancer Potential of Poly(Lactic-co-Glycolic Acid) (PLGA) Based Curcumin, Epigallocatechin Gallate, and Resveratrol Nanocarriers. 最新综述：基于聚乳酸-乙醇酸（PLGA）的姜黄素、表没食子儿茶素没食子酸酯和白藜芦醇纳米载体的抗癌潜力。

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-10-17 DOI: 10.1002/bip.23637

Pratibha Pandey, Meenakshi Verma, Sorabh Lakhanpal, Shivam Pandey, M Ravi Kumar, Mahakshit Bhat, Shilpa Sharma, Mir Waqas Alam, Fahad Khan

{"title":"An Updated Review Summarizing the Anticancer Potential of Poly(Lactic-co-Glycolic Acid) (PLGA) Based Curcumin, Epigallocatechin Gallate, and Resveratrol Nanocarriers.","authors":"Pratibha Pandey, Meenakshi Verma, Sorabh Lakhanpal, Shivam Pandey, M Ravi Kumar, Mahakshit Bhat, Shilpa Sharma, Mir Waqas Alam, Fahad Khan","doi":"10.1002/bip.23637","DOIUrl":"https://doi.org/10.1002/bip.23637","url":null,"abstract":"The utilization of nanoformulations derived from natural products for the treatment of many human diseases, including cancer, is a rapidly developing field. Conventional therapies used for cancer treatment have limited efficacy and a greater number of adverse effects. Hence, it is imperative to develop innovative anticancer drugs with superior effectiveness. Among the diverse array of natural anticancer compounds, resveratrol, curcumin, and epigallocatechin gallate (EGCG) have gained considerable attention in recent years. Despite their strong anticancer properties, medicinally significant phytochemicals such as resveratrol, curcumin, and EGCG have certain disadvantages, such as limited solubility in water, stability, and bioavailability problems. Encapsulating these phytochemicals in poly(lactic-co-glycolic acid) (PLGA), a polymer that is nontoxic, biodegradable, and biocompatible, is an effective method for delivering medication to the tumor location. In addition, PLGA nanoparticles can be modified with targeting molecules to specifically target cancer cells, thereby improving the effectiveness of phytochemicals in fighting tumors. Combining plant-based medicine (phytotherapy) with nanotechnology in a clinical environment has the potential to enhance the effectiveness of drugs and improve the overall health outcomes of patients. Therefore, it is crucial to have a comprehensive understanding of the different aspects and recent advancements in using PLGA-based nanocarriers for delivering anticancer phytochemicals. This review addresses the most recent advancements in PLGA-based delivery systems for resveratrol, EGCG, and curcumin, emphasizing the possibility of resolving issues related to the therapeutic efficacy and bioavailability of these compounds.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":" ","pages":"e23637"},"PeriodicalIF":3.2,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the Architecture of Starch Granules Revealed by Iodine Binding and Lintnerization. Part 2: Molecular Structure of Lintnerized Starches. 通过碘结合和林特纳化揭示淀粉颗粒的结构。第 2 部分：林特纳化淀粉的分子结构。

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-10-15 DOI: 10.1002/bip.23636

Eric Bertoft, George Annor, Varatharajan Vamadevan, Amy Hui-Mei Lin

{"title":"On the Architecture of Starch Granules Revealed by Iodine Binding and Lintnerization. Part 2: Molecular Structure of Lintnerized Starches.","authors":"Eric Bertoft, George Annor, Varatharajan Vamadevan, Amy Hui-Mei Lin","doi":"10.1002/bip.23636","DOIUrl":"https://doi.org/10.1002/bip.23636","url":null,"abstract":"This investigation validated iodine binding in combination with lintnerization for studying the structural nature of the amorphous areas in starch granules. Lintners of four iodine vapor-stained and non-stained amylose-containing starches and their waxy counterparts were analyzed by high-performance anion-exchange chromatography (HPAEC). The composition of the lintners was strongly affected by the absence of amylose in barley and potato starch but not in maize and cassava starch. Iodine-stained waxy lintners possessed increased number of long B2 chains. β-Limit dextrins of the lintners were very variable in composition. Iodine inclusion complexes washed out from the granular residues in the lintners (mostly from amylose-containing barley and maize starches) were also analyzed. Acid-soluble complexes from both amylose-containing and waxy starches possessed a lot of material with a degree of polymerization (DP) around 60 and a periodicity in size of DP 8-12. Such long chains were only minor components in water-soluble complexes of amylose-containing barley and maize starch lintners, and they lacked the size periodicity. Models of the principal structure of the acid and water-soluble complexes are suggested. It is concluded that acid hydrolysis of iodine-stained starch granules is a useful tool in structural analyses of the molecular composition of amorphous parts of starch granules.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":" ","pages":"e23636"},"PeriodicalIF":3.2,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of HEMA-Succinic Acid-PEG Bio-Based Monomers for High-Performance Hydrogels in Regenerative Medicine. 开发 HEMA-琥珀酸-PEG 生物基单体，用于再生医学中的高性能水凝胶。

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-10-09 DOI: 10.1002/bip.23631

Hossein Rayat Pisheh, Alireza Sabzevari, Mojtaba Ansari, Kourosh Kabiri

{"title":"Development of HEMA-Succinic Acid-PEG Bio-Based Monomers for High-Performance Hydrogels in Regenerative Medicine.","authors":"Hossein Rayat Pisheh, Alireza Sabzevari, Mojtaba Ansari, Kourosh Kabiri","doi":"10.1002/bip.23631","DOIUrl":"https://doi.org/10.1002/bip.23631","url":null,"abstract":"In recent years, hydrogels have found a special place in regenerative medicine for tissue repair, rehabilitation, and drug delivery. To be used in regenerative medicine, hydrogels must have desirable physical, chemical, and biological properties. In this study, a new biomonomer based on hydroxyethyl methacrylate-succinic acid-polyethylene glycol 200 (HEMA-Suc-PEG) was synthesized and characterized. Then, using the synthesized monomers and different ratios of polyethylene glycol diacrylate (PEGDA) as a crosslinker, biocompatible hydrogels were synthesized through thermal and UV curing methods. The mechanical, physical, chemical, and biological properties of the hydrogels and the behavior of endothelial cells, an essential component of the cardiovascular system, were evaluated. The results showed that the hydrogel synthesized with 0.2 g of PEGDA (UV curing) has desirable mechanical and physical properties. Biological tests showed that these hydrogels are not only nontoxic to cells but also enhance cell adhesion. Therefore, the hydrogel containing the synthesized monomer HEMA-Suc-PEG and 0.2 g of PEGDA has the potential to be used in the cardiovascular system.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":" ","pages":"e23631"},"PeriodicalIF":3.2,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitosan/Fibroin Biopolymer-Based Hydrogels for Potential Angiogenesis in Developing Chicks and Accelerated Wound Healing in Mice. 壳聚糖/纤维素生物聚合物水凝胶用于发育中雏鸡的潜在血管生成和加速小鼠的伤口愈合

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-10-09 DOI: 10.1002/bip.23633

Hafiza Zubia Dawood, Chaman Ara, Asmatullah, Sehrish Jabeen, Atif Islam, Zunaira Huma Ghauri

{"title":"Chitosan/Fibroin Biopolymer-Based Hydrogels for Potential Angiogenesis in Developing Chicks and Accelerated Wound Healing in Mice.","authors":"Hafiza Zubia Dawood, Chaman Ara, Asmatullah, Sehrish Jabeen, Atif Islam, Zunaira Huma Ghauri","doi":"10.1002/bip.23633","DOIUrl":"https://doi.org/10.1002/bip.23633","url":null,"abstract":"Potential therapies for wound management remain one of the most challenging affairs to date. Biopolymer hydrogels possess inherent properties that facilitate the healing of damaged tissue by creating a supportive and hydrated environment. Chitosan/fibroin hydrogels were formulated with poly (vinyl pyrrolidone) and cross-linked using 3-aminopropyl (diethoxy) methylsilane (APDEMS) for the aforementioned function. The hydrogels were characterized through Fourier transform infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy, and their swelling response was observed using a variety of solvents. Additionally, hydrogels were investigated for biomedical applications. As the amount of fibroin added to the hydrogels increased, the swelling ratio decreased. The analysis of chorioallantoic membrane (CAM) assay revealed that higher concentrations of fibroin in the hydrogel were directly correlated with increased angiogenesis. The intragroup comparison showed that the vascular number in the CPF5 group was significantly increased (p ≤ 0.05) compared to other hydrogel groups. The wound healing efficiency of the prepared hydrogels showed that the rate of wound reduction (99.06%) was remarkably (p ≤ 0.05) high in the hydrogel group with a greater fibroin content against control (67.03%). Histological findings of wounded tissues corroborate the abovementioned results, showing dense fibrous connective tissues in the fibroin group compared to the control. The results of this work provide thorough preclinical evidence that chitosan-fibroin biopolymers are involved in enhanced angiogenesis in growing chicks and speed up wound healing in mice without any obvious toxicity.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":" ","pages":"e23633"},"PeriodicalIF":3.2,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing the Production of Bacterial Cellulose Nanofibers and Nanocrystals Through Strategic Fiber Pretreatment. 通过战略性纤维预处理优化细菌纤维素纳米纤维和纳米晶体的生产。

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-10-03 DOI: 10.1002/bip.23634

Fulya Şahin, Neslihan Kayra, Ali Özhan Aytekin

{"title":"Optimizing the Production of Bacterial Cellulose Nanofibers and Nanocrystals Through Strategic Fiber Pretreatment.","authors":"Fulya Şahin, Neslihan Kayra, Ali Özhan Aytekin","doi":"10.1002/bip.23634","DOIUrl":"https://doi.org/10.1002/bip.23634","url":null,"abstract":"Bacterial cellulose (BC) has unique properties such as high tensile strength, high crystallinity, and high purity. The fiber length of BC causes different attributes. Therefore, the degradation of BC has been studied extensively. In this study, the fibers of BC were rearranged via a DMAc-LiCl solvent and BC was degraded in the wet state. Two different degradation methods were applied: milling with liquid nitrogen and autoclave treatment. The degraded BCs were characterized by FTIR, TEM, AFM, TGA, and XRD. The solvent helps to align the fibers, making them more crystalline. The degraded BCs had a lower crystalline ratio than untreated BC, due to increased hydrogen bonding during degradation in the wet state. Degradation with an autoclave produced two different degraded BCs: nanofibrils and spherical nanocrystals, with and without solvent pretreatment, respectively. The nanofibril lengths were between 312 and 700 nm depending on the applied method, and the spherical nanocrystal size was 56 nm. The rearrangement via solvent causes an important difference in the degradation of BC. Nanofibrils and nanocrystals can be obtained, depending on the rearrangement of fibers before the degradation process.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":" ","pages":"e23634"},"PeriodicalIF":3.2,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Carbohydrate Polymer-Based Systems for Precise Drug Delivery in Colon Cancer: Improving Treatment Effectiveness With Intelligent Biodegradable Materials. 基于碳水化合物聚合物的新型结肠癌精准给药系统：利用智能生物降解材料提高治疗效果。

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-09-27 DOI: 10.1002/bip.23632

Nikita Udaipuria, Sankha Bhattacharya

{"title":"Novel Carbohydrate Polymer-Based Systems for Precise Drug Delivery in Colon Cancer: Improving Treatment Effectiveness With Intelligent Biodegradable Materials.","authors":"Nikita Udaipuria, Sankha Bhattacharya","doi":"10.1002/bip.23632","DOIUrl":"https://doi.org/10.1002/bip.23632","url":null,"abstract":"Due to their biocompatibility, biodegradability, and controlled release, carbohydrates polymers are crucial to targeted drug delivery systems, notably for colon cancer treatment. This article examines how carbohydrate polymers like chitosan, pectin, guar gum, alginate, hyaluronic acid, dextran, and chondroitin sulfate are used in improved drug delivery. Modifying these polymers improves drug loading, stability, and release patterns, enhancing chemotherapeutic drugs' therapeutic index. Chitosan nanoparticles are pH-responsive, making them perfect for cancer treatment. Pectin's resistance to gastric enzymes and colonic bacteria makes it a promising colon-specific medication delivery agent. The combination of these polymers with nanotechnology, 3D printing, and AI allows the creation of stimuli-responsive systems that release drugs precisely in response to environmental signals like pH, redox potential, or colon enzymatic activity. The review highlights intelligent delivery system design advances that reduce systemic toxicity, improve treatment efficacy, and improve patient adherence. Carbohydrate polymers will revolutionize colon cancer treatment with personalized and accurate alternatives.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":" ","pages":"e23632"},"PeriodicalIF":3.2,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Influence of Additive Manufacturing and Ultrasonic Coating Parameters on Biopolymeric Scaffold Performance Using Response Surface Methodology. 利用响应面方法研究增材制造和超声波涂层参数对生物聚合物支架性能的影响

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-09-25 DOI: 10.1002/bip.23629

Shrutika Sharma, Abhinav Mishra, Vivek Jain, Vishal Gupta

{"title":"Investigating the Influence of Additive Manufacturing and Ultrasonic Coating Parameters on Biopolymeric Scaffold Performance Using Response Surface Methodology.","authors":"Shrutika Sharma, Abhinav Mishra, Vivek Jain, Vishal Gupta","doi":"10.1002/bip.23629","DOIUrl":"https://doi.org/10.1002/bip.23629","url":null,"abstract":"Triply periodic minimal surface (TPMS) scaffolds have gained attention in additive manufacturing due to their unique porous structures, which are useful in biomedical applications. Unlike metallic implants that can cause stress shielding, polymeric scaffolds offer a safer alternative. This study is focused on enhancing the compressive strength of additive-manufactured polylactic acid (PLA) scaffolds with a diamond structure. The response surface methodology (RSM)-based experimental design was developed to study the influence of printing parameters. The fused deposition modeling (FDM) process parameters were optimized, achieving a compressive strength of 56.2 MPa. Subsequently, the scaffolds were fabricated at optimized parameters and underwent ultrasonic-assisted polydopamine coating. With the utilization of the RSM approach, the study examined the effects of ultrasonic vibration power, coating solution concentration, and submersion time on compressive strength. The optimal coating conditions led to a maximum compressive strength of 92.77 MPa-a 65.1% improvement over the uncoated scaffold. This enhancement is attributed to the scaffold's porous structure, which enables uniform coating deposition. Energy-dispersive x-ray spectroscopy confirmed the successful polydopamine coating, with 10.64 wt% nitrogen content. These findings demonstrate the potential of ultrasonic-assisted coating in improving the mechanical properties of PLA scaffolds, making them suitable for biomedical applications.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":" ","pages":"e23629"},"PeriodicalIF":3.2,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biopolymers最新文献