Biopolymers最新文献_第2页

Structural Basis for Antagonist Binding to Vasopressin V1b Receptor Revealed by the Molecular Dynamics Simulations 分子动力学模拟揭示血管加压素 V1b 受体拮抗剂结合的结构基础

IF 2.9 4区生物学

Biopolymers Pub Date : 2024-09-17 DOI: 10.1002/bip.23627

Magdalena J. Ślusarz

{"title":"Structural Basis for Antagonist Binding to Vasopressin V1b Receptor Revealed by the Molecular Dynamics Simulations","authors":"Magdalena J. Ślusarz","doi":"10.1002/bip.23627","DOIUrl":"https://doi.org/10.1002/bip.23627","url":null,"abstract":"The human V1b receptor (V1bR) is primarily expressed in the corticotropic cells of the anterior pituitary where it is involved in the regulation of the hypothalamic–pituitary–adrenal (HPA) axis. The activation of V1bR induces the secretion of adrenocorticotropin hormone (ACTH) from the anterior pituitary cells which, in turn, stimulates the production of cortisol via the adrenal cortex. Clinical studies have demonstrated the chronic dysfunction of the HPA axis in patients with several psychiatric disorders. Thus, the inhibition of the V1b receptor and normalizing the HPA axis hyperactivity is a promising approach to the treatment of many stress-related disorders such as anxiety and depression. Nelivaptan is a selective V1bR antagonist that can be used for this purpose and an excellent molecule to study how antagonists interact with V1bR, especially since in recent years the experimental structures of vasopressin V2 and oxytocin receptors were solved, providing high-similarity templates for homology modeling of V1bR. Therefore, in this work, six independent molecular dynamics simulations of a V1bR-nelivaptan complex in a fully hydrated lipid bilayer, yielding a total simulation time of 6.0 μs, have been conducted. In the lowest-energy complexes obtained in this work and proposed to be the most probable structure of the V1bR-nelivaptan complex, the location of the ligand inside the receptor pocket is very similar to that of the other ligands observed in the experimental structures of the vasopressin/oxytocin receptor family. The receptor-ligand interaction has been analyzed and described, revealing the details of the molecular mechanism of this antagonist binding to V1bR and a probable contribution of L2005×40 and T2035×43 to binding selectivity.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142265068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autoclaved Starch: Structure and Functionality Relationship in a Matrix With the Same Contribution of Amylose and Amylopectin 高压灭菌淀粉：直链淀粉和支链淀粉含量相同的基质中的结构和功能关系

IF 2.9 4区生物学

Biopolymers Pub Date : 2024-09-11 DOI: 10.1002/bip.23624

Gonzalo Velazquez, Guadalupe Mendez‐Montealvo, Eduardo Morales‐Sanchez, Israel Sifuentes‐Nieves, Rodrigo Velazquez‐Castillo, Adrian Soler

{"title":"Autoclaved Starch: Structure and Functionality Relationship in a Matrix With the Same Contribution of Amylose and Amylopectin","authors":"Gonzalo Velazquez, Guadalupe Mendez‐Montealvo, Eduardo Morales‐Sanchez, Israel Sifuentes‐Nieves, Rodrigo Velazquez‐Castillo, Adrian Soler","doi":"10.1002/bip.23624","DOIUrl":"https://doi.org/10.1002/bip.23624","url":null,"abstract":"The rational use of autoclaved starches in food applications is difficult because there is a lack of information on their structure–functionality relationship. The novelty of this research relies on disclosing such an association. Hylon V starch was autoclaved at 105, 120, and 135°C to investigate its crystalline and double‐helical features and its relationship with functionality. In autoclaved Hylon V starch, interactions of amylopectin and amylose improved while the crystalline regions decreased. The degree of double helices (DD) decreased after autoclaving at 105°C and the degree of order (DO) increased after treatment at 120 and 135°C. The water solubility index (WSI) (4.63–6.38%) and swelling power (SP) (4.39–7.1 g/g) increased when the temperature increased. On the other hand, water (103.49–225.01%) and oil (61.91–94.53%) holding capacity (WHC and OHC, respectively) increased after autoclaving treatment, although the values decreased with the treatment intensity. The functional properties were affected when the structure changed as a function of the treatment temperatures. PCA analysis showed that WSI and SP of autoclaved Hylon V starch were associated with a high DD, with better compaction, and with stronger amylopectin–amylose interactions. WHC and OHC were associated with better crystallinity, stronger interactions of amylopectin and amylose, and heterogeneous double‐helical crystallites. These findings are useful for understanding the structure–functionality relationship of autoclaved Hylon V starch and pave the way for future research regarding the effects of its incorporation on the properties of food matrices such as bread, yogurt, cakes, and pudding.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Tetrapropylammonium Chloride Quaternary Ammonium Salt on Characterization, Cytotoxicity, and Antibacterial Properties of PLA/PEG Electrospun Mat 四丙基氯化铵季铵盐对聚乳酸/聚乙二醇电纺丝毡的特性、细胞毒性和抗菌性能的影响

IF 2.9 4区生物学

Biopolymers Pub Date : 2024-09-11 DOI: 10.1002/bip.23626

Sena Özdil Şener, Sema Samatya Yilmaz, Merve Dandan Doganci, Erdinc Doganci

{"title":"Effect of Tetrapropylammonium Chloride Quaternary Ammonium Salt on Characterization, Cytotoxicity, and Antibacterial Properties of PLA/PEG Electrospun Mat","authors":"Sena Özdil Şener, Sema Samatya Yilmaz, Merve Dandan Doganci, Erdinc Doganci","doi":"10.1002/bip.23626","DOIUrl":"https://doi.org/10.1002/bip.23626","url":null,"abstract":"In this study, poly(lactic acid) (PLA)–tetrapropylammonium chloride (TCL)–poly(ethylene glycol) (PEG) nonwoven networks were produced using PLA, PEG with different concentrations (3, 5, 7, and 9 wt%), and TCL. PEG is included as a plasticizer in PLA polymer, which has high biocompatibility but a brittle structure. The importance of this study is to investigate the effect of TCL salt on the characterization of PLA–PEG nanofibers. For this research, the cytotoxicity test system responsible for the fibroblast cell line (L929) was evaluated with the liquid absorption capacity (LAC) and drying time tests for its use in wound dressings. The addition of TCL salt reduced bead formation in PLA–PEG nanofibers and increased the homogeneity of fiber dispersion. The smoothest and most homogeneous nonwoven networks were obtained as PLA–5TCL–PEG. It was also reported that this nonwoven network exhibited liquid absorption behavior with a maximum increase of 150% compared to the PLA–PEG nonwoven network and had the highest Young's modulus value of 12.97 MPa. In addition to these tests, evaluations were made with Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), drying time test, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and mechanical tests. In addition, high cell viability was observed in L292 mouse fibroblast cells at the end of the 24th hour, again with the effect of TCL salt. In addition, antibacterial activity was tested against gram‐negative E. coli and gram‐positive S. aureus bacteria, and it was observed that there was no antibacterial activity. Since PLA–TCL–PEG nonwoven webs have a maximum cell viability of 133.27%, they are recommended as a potential dermal wound dressing.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Patch/Film for Drug Delivery-Current Status and Future Prospects. 用于给药的口腔贴片/薄膜--现状与前景。

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-09-04 DOI: 10.1002/bip.23625

Yujie Yan, Wenjie Yan, Sihua Wu, Hang Zhao, Qianming Chen, Jiongke Wang

引用次数: 0

Imparting of Nearly Superparamagnetic Properties to Cryogel Scaffolds With Mesoporous MNPs for Magneto-Sensitive Tissue Engineering Strategies. 用介孔 MNPs 为冷凝胶支架赋予近超顺磁性能，以实现磁敏感组织工程策略。

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-08-19 DOI: 10.1002/bip.23623

Didem Demir, Fatma Ulusal, Hasan Ulusal, Seda Ceylan, Sibel Dağlı, Nalan Özdemir, Mehmet Tarakçıoğlu

{"title":"Imparting of Nearly Superparamagnetic Properties to Cryogel Scaffolds With Mesoporous MNPs for Magneto-Sensitive Tissue Engineering Strategies.","authors":"Didem Demir, Fatma Ulusal, Hasan Ulusal, Seda Ceylan, Sibel Dağlı, Nalan Özdemir, Mehmet Tarakçıoğlu","doi":"10.1002/bip.23623","DOIUrl":"https://doi.org/10.1002/bip.23623","url":null,"abstract":"This work reports the assembly of mesoporous iron oxide nanoparticles (meso-MNPs) with cryogel scaffolds composed of chitosan and gelatin. Meso-MNPs with a particle size ranging from 2 and 50 nm, a surface area of 140.52 m2 g-1, and a pore volume of 0.27 cm3 g-1 were synthesized on a porous SiO2 template in the presence of PEG 6000 followed by leaching of SiO2. Different ratios of meso-MNPs were successfully incorporated into chitosan:gelatin cryogels up to an amount equivalent to the entire amount of polymer. The morphological structure and physicochemical properties of the cryogels were directly affected by the amount of MNPs. VSM curves showed that all composite cryogels could be magnetized by applying a magnetic field. In the context of the safety of magnetic cryogel scaffolds for use in biomedicine, it is important to note that all values are below the exposure limit for static magnetic fields, and according to cytotoxicity data, scaffolds containing meso-MNPs showed nontoxicity with cell viability ranging from 150% to 275%. In addition, microbial analysis with gram-negative and gram-positive bacteria showed that the scaffolds exhibited activity against these bacteria.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship Between Cryoprotectant Potential and Protein Hydration in Aqueous Zwitterionic Solutions. 水性齐聚物溶液中的低温保护电位与蛋白质水合作用之间的关系

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-08-17 DOI: 10.1002/bip.23622

Takahiro Takekiyo, Shuto Yamada, Tetsuya Hirata, Takeru Ishizaki, Kosuke Kuroda, Yukihiro Yoshimura

{"title":"Relationship Between Cryoprotectant Potential and Protein Hydration in Aqueous Zwitterionic Solutions.","authors":"Takahiro Takekiyo, Shuto Yamada, Tetsuya Hirata, Takeru Ishizaki, Kosuke Kuroda, Yukihiro Yoshimura","doi":"10.1002/bip.23622","DOIUrl":"https://doi.org/10.1002/bip.23622","url":null,"abstract":"The cryoprotectant potential of 3-(1-(2-(2-methoxyethoxy)ethyl)imidazol-3-io)butane-1-carboxylate (OE2imC3C) for proteins necessitates assessment to elucidate its relationship with protein hydration. To reveal this relationship, we assessed the protein stability (pre-freezing and post-thawing) and melting behavior in dilute aqueous protein-OE2imC3C solutions containing varying mole fractions (x) of OE2imC3C (x = 0, 7.7 × 10-3, and 1.7 × 10-2) using Fourier-transform infrared (FTIR) and near-UV circular dichroism (near-UV CD) spectroscopy and differential scanning calorimetry (DSC) techniques. Following freezing/thawing using a deep freezer, protein stability in aqueous OE2imC3C solutions (x = 1.7 × 10-2) preserved the folded state owing to the protein-OE2imC3C interaction, whereas stability at x = 7.7 × 10-3 was reduced. These results indicate that the protein cryoprotectant potential in aqueous OE2imC3C solutions at x = 1.7 × 10-2 is higher than that at x = 7.7 × 10-3, owing to the preferential binding of OE2imC3C with proteins.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of Alkali Treatment Conditions of Ramie Fabrics Using Box–Behnken Method. 使用箱式贝肯法优化苎麻织物的碱处理条件

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-08-12 DOI: 10.1002/bip.23621

Bewuket Teshome Wagaye, Jiansheng Guo

{"title":"Optimization of Alkali Treatment Conditions of Ramie Fabrics Using Box–Behnken Method.","authors":"Bewuket Teshome Wagaye, Jiansheng Guo","doi":"10.1002/bip.23621","DOIUrl":"https://doi.org/10.1002/bip.23621","url":null,"abstract":"Ramie is a widely used plant fiber for making textiles and reinforcement in biodegradable composites. Pretreating cellulosic fibers with alkali before producing composites is increasingly used to enhance adhesion with polymeric resin. In this work, response surface methodology (RSM) based on the Box-Behnken technique was utilized to investigate the impact of independent variables on ramie fabric characteristics and determine the optimal treatment condition. The impact of alkali concentration, treatment time, and temperature on the breaking load and elongation at break of woven ramie fabrics were evaluated using Design-Expert software, which established the design matrix and analyzed the experimental data employing numerical and graphical optimization methods. Moreover, the impact of alkali treatment conditions on the surface morphology, structural change of ramie fabrics, and thermal properties was investigated. Based on the analysis of variance (ANOVA) results, the suggested quadratic models can adequately predict the breaking load and elongation at break of the ramie woven fabrics within the range of conditions applied in this investigation. The RSM revealed that an alkali concentration of 6.12%, a treatment time of 30 min, and a temperature of 39.13°C resulted in an optimum treatment condition with a breaking load of 518.28 N and elongation at break of 23.36%.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosynthesis of High Toughness Poly(3‐Hydroxypropionate)‐Based Block Copolymers With Poly(D‐2‐Hydroxybutyrate) and Poly(D‐Lactate) Segments Using Evolved Monomer Sequence‐Regulating Polyester Synthase 利用进化单体序列调节聚酯合成酶生物合成具有聚（D-2-羟基丁酸酯）和聚（D-乳酸酯）段的高韧性聚（3-羟基丙酸酯）基嵌段共聚物

IF 2.9 4区生物学

Biopolymers Pub Date : 2024-08-08 DOI: 10.1002/bip.23618

Tomoya Kawakami, Hiroya Tomita, Phan Thi Hien, Ken'ichiro Matsumoto

{"title":"Biosynthesis of High Toughness Poly(3‐Hydroxypropionate)‐Based Block Copolymers With Poly(D‐2‐Hydroxybutyrate) and Poly(D‐Lactate) Segments Using Evolved Monomer Sequence‐Regulating Polyester Synthase","authors":"Tomoya Kawakami, Hiroya Tomita, Phan Thi Hien, Ken'ichiro Matsumoto","doi":"10.1002/bip.23618","DOIUrl":"https://doi.org/10.1002/bip.23618","url":null,"abstract":"This study synthesized poly(3‐hydroxypropionate) [P(3HP)]‐containing polyhydroxyalkanoate (PHA) block copolymers, P(3HP)‐b‐P[2‐hydroxybutyrate (2HB)] and P(3HP)‐b‐P(D‐lactate) (PDLA), using Escherichia coli. The cells expressing an evolved sequence‐regulating PHA synthase, PhaCARNDFH, and propionyl‐CoA transferase were cultured with the supplementation of the corresponding monomer precursors in the medium. The block structure of P(3HP)‐b‐PDLA was confirmed by proton nuclear magnetic resonance analysis and solvent fractionation. The molecular weights of the polymers were in the range of 0.8–2.8 × 105. The solvent‐cast polymer films were subjected to isothermal treatment to promote phase separation and crystallization and were subsequently melt‐quenched to produce an amorphous phase. The melt‐quenched P(3HP)‐b‐P(2HB) film exhibited a high elongation at break (1153%), resulting in a toughness of 181 MJ/m3. The solvent‐cast film of P(3HP)‐b‐65 mol% PDLA exhibited partial elastic deformation, in which the P(3HP) phase functioned as a soft segment. The melt‐quenching of the polymer resulted in embrittlement presumably due to the high lactate fraction. Overall, the P(3HP)‐based block copolymers exhibited several mechanical properties depending on the higher‐order structure of the polymer and the properties of the P(2‐hydroxyalkanoate) segments. This study findings show that P(3HP)‐b‐P(2HB) and P(3HP)‐b‐PDLA can function excellently if their microstructures are properly controlled.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141938921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and Characterization of Durian Husk-Based Biocomposite Films Reinforced With Nanocellulose From Corn Husk and Pineapple Leaf. 以玉米皮和菠萝叶纳米纤维素为增强材料的榴莲壳基生物复合薄膜的制备与表征

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-08-08 DOI: 10.1002/bip.23619

Nattapron Siribanluehan, Piyachat Wattanachai

{"title":"Preparation and Characterization of Durian Husk-Based Biocomposite Films Reinforced With Nanocellulose From Corn Husk and Pineapple Leaf.","authors":"Nattapron Siribanluehan, Piyachat Wattanachai","doi":"10.1002/bip.23619","DOIUrl":"https://doi.org/10.1002/bip.23619","url":null,"abstract":"This research explores the integration of corn husk nanocellulose (CHNc) and pineapple leaf nanocellulose (PLNc) as reinforcing agents in a carboxymethyl cellulose-based film derived from durian husk (CMCDH). Through a solvent-casting method, composite films were fabricated with varying nanocellulose contents (15, 30, and 45 wt%). Analysis using Fourier transform infrared spectroscopy and x-ray diffraction confirmed the effectiveness of alkaline and bleaching treatments in eliminating noncellulosic components. Transmission electron microscopy image revealed the rod-like morphology of CHNc and PLNc, with dimensions approximately 206.5 × 7.2 nm and 150.7 × 6.5 nm, respectively. The inclusion of nanocellulose decreased the transparency of CMCDH films while enhancing their tensile strength, thermal stability, and water vapor transmission rate. Notably, CMCDH/PLNc(30%) exhibited the highest tensile strength at 5.06 ± 0.83 MPa, representing a remarkable 220% increase compared to CMCDH biofilm. Thermogravimetric analysis and differential scanning calorimeter results indicated that nanocellulose incorporation delayed the film's decomposition temperature by approximately 10°C. Moreover, CMCDH/PLNc(30%) demonstrated the lowest water vapor transmission rate, marking a 20% improvement. However, the film's properties were compromised at the highest nanocellulose content (45 wt%) due to observed fiber aggregation, as revealed by scanning electron microscopy analysis.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141900849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Customized Modification of Welan Gum Properties Through Controllable Grafting of Acrylamide. 通过丙烯酰胺的可控接枝定制改良韦兰胶性能。

IF 3.2 4区生物学

Biopolymers Pub Date : 2024-08-07 DOI: 10.1002/bip.23620

Guorui Xu, Jianye Li, Xiang Li, Yongkang Jia, Yajie Song, Jiming Wang, Lei Wang, Haibo Zhang

{"title":"Customized Modification of Welan Gum Properties Through Controllable Grafting of Acrylamide.","authors":"Guorui Xu, Jianye Li, Xiang Li, Yongkang Jia, Yajie Song, Jiming Wang, Lei Wang, Haibo Zhang","doi":"10.1002/bip.23620","DOIUrl":"https://doi.org/10.1002/bip.23620","url":null,"abstract":"Welan gum (WG) has a wide range of applications, but it is not yet suitable for applications such as oil recovery profile control that have complex requirements for viscosity, gelation properties, and so forth. Grafting modification is an important strategy for improving the property of WG, but there are few reports on controllable modification of WG to customize it for specific application. Acrylamide (AM) dosage was identified as the key factor affecting the grafting ratio of AM onto WG by a uniform experimental design. The grafting ratio can be directly adjusted between 99% and 378% based on the positive correlation with dosage of AM, and viscosity can be adjusted between 206 and 327 mPa s based on the negative correlation with grafting ratio. The 50% weight loss temperature of W11 with a grafting ratio of 110% raised from 314 to 336°C after grafting. The viscosity of the hydrogel formed with WG11 reached 15,654 mPa s, nearly nine times higher than that of unmodified WG. In addition, the gelation time can be controlled within 5 days, so that it can be injected to the optimal area in oilfield profile, avoiding pipeline blockage. This study enables adjusting viscosity of WG grafted with AM by controlling the grafting rate, and enhances gelation performance and thermal stability of WG, which will expand the application of WG in oil recovery and other fields.","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0