Biopolymers最新文献_第3页

Gallic Acid Loaded Alginate-Gelatin Beads for Potential Bone Tissue Engineering Applications 没食子酸负载海藻酸凝胶珠潜在的骨组织工程应用

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-06-04 DOI: 10.1002/bip.70033

Mehmet Ali Karaca, Ali Reza Kamali, Bita Erin Kamali, Bilge Temiz, Furkan Özben, Duygu Ege, Hale Saybaşılı

{"title":"Gallic Acid Loaded Alginate-Gelatin Beads for Potential Bone Tissue Engineering Applications","authors":"Mehmet Ali Karaca, Ali Reza Kamali, Bita Erin Kamali, Bilge Temiz, Furkan Özben, Duygu Ege, Hale Saybaşılı","doi":"10.1002/bip.70033","DOIUrl":"https://doi.org/10.1002/bip.70033","url":null,"abstract":"<p>In this study, alginate/gelatin (AL/GEL) spherical beads are prepared and encapsulated with 1 wt % of needle-shaped gallic acid (GA) crystals to develop a drug delivery system. The % encapsulation efficiency of GA into AL/GEL beads, its release rate, and the stability of the beads are evaluated, followed by cytocompatibility studies. The interactions between GA, AL, and GEL are examined by using FTIR. Morphological observations reveal that increasing the GEL concentration above 0.4 wt.% possibly hinders the binding of calcium ions with the carboxylate groups of AL, resulting in the formation of beads with larger diameters. In contrast, the bead diameter decreases with the incorporation of GA due to hydrogen bonding. EDX analysis of GA-loaded AL/GEL beads indicated that GA binds to the GEL-rich region. Furthermore, EDX analysis of mineralized beads demonstrated that GA enhanced calcium deposition near the alginate-rich region. In vitro studies demonstrate that AL/GEL beads loaded with ≤ 0.5 (wt.) % GA are cytocompatible and MC3T3-E1 murine pre-osteoblast cells proliferated over a 5-day period. Overall, the prepared beads show potential as a drug delivery system for bone regeneration applications.</p>","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":"116 4","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bip.70033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid Quantitative Assessment of Residual Stress States in PLA Components Enabled by the Combination of Photoelasticity and the Hole Drilling Method 光弹性与钻孔法结合对聚乳酸构件残余应力状态的快速定量评估

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-05-31 DOI: 10.1002/bip.70026

Olzhas Tlegenov, Margarita Reit, Jan-Christoph Zarges, Alexander Liehr, Thomas Niendorf, Hans-Peter Heim

{"title":"Rapid Quantitative Assessment of Residual Stress States in PLA Components Enabled by the Combination of Photoelasticity and the Hole Drilling Method","authors":"Olzhas Tlegenov, Margarita Reit, Jan-Christoph Zarges, Alexander Liehr, Thomas Niendorf, Hans-Peter Heim","doi":"10.1002/bip.70026","DOIUrl":"https://doi.org/10.1002/bip.70026","url":null,"abstract":"<p>Poly(lactic acid) (PLA) is one of the most prominent biopolymers and is considered a viable alternative to petroleum-based polymers. While it exhibits comparable properties to conventional polymers like PET, in certain applications, particularly those involving elevated temperatures, PLA has performance limitations. In addition, the properties of PLA are dependent on the processing parameters in injection molding. Non-optimal process parameters can lead to defects or undesirable effects that cannot be detected immediately after injection molding. This includes orientation and residual stresses, which significantly influence the material and failure properties. The present study investigates the influence of injection molding machine settings on the residual stress state in PLA components. Test specimens were produced using two different mold tools: an ejector pin and a full-surface ejector, while varying key machine settings. Residual stress was assessed using a polariscope and the hole drilling method. The polariscope identified distinct isochromatic fringe patterns, particularly near the sprue, indicating regions of elevated residual stress. The hole drilling method confirmed the presence of high residual stress at the specimen edges, extending to a depth of 600 μm, with a peak stress value of 47 MPa. Results revealed that the ejector pin mold induced both tensile and compressive stress states, whereas the full-surface ejector mold predominantly caused high compressive stresses at the edges. These findings highlight the importance of optimizing injection molding parameters to minimize residual stress and improve the mechanical performance of PLA components.</p>","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":"116 4","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bip.70026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioresorbable Composite Polymeric Stents: Alleviating Deployment Damage and Maintaining Significant Mechanical Properties 生物可吸收复合聚合物支架：减轻部署损伤和保持显著的机械性能

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-05-31 DOI: 10.1002/bip.70034

Jian Lv, Yi Zhang, Renhua Sun, Xue Hu, Rixin Hua, Yuan Tian, Jie Cheng, Ji Lang, Ziyu Wu, Yazhou Li, Jiaqi Zeng, Min Zhou, Zhonghua Ni, Gutian Zhao

{"title":"Bioresorbable Composite Polymeric Stents: Alleviating Deployment Damage and Maintaining Significant Mechanical Properties","authors":"Jian Lv, Yi Zhang, Renhua Sun, Xue Hu, Rixin Hua, Yuan Tian, Jie Cheng, Ji Lang, Ziyu Wu, Yazhou Li, Jiaqi Zeng, Min Zhou, Zhonghua Ni, Gutian Zhao","doi":"10.1002/bip.70034","DOIUrl":"https://doi.org/10.1002/bip.70034","url":null,"abstract":"<div>\u0000 \u0000 <p>The latest-generation Poly(L-lactic acid) (PLLA) based fully bioresorbable stents (BRS) are facing a grave challenge due to their higher clinical risk of post-implantation. There is consensus that the strut thickness of BRS far exceeds that of metal stents; this is the main reason for the poor clinical outcomes. Therefore, overcoming the gap in mechanical properties between PLLA and metal, and effectively reducing the strut thickness of BRS without sacrificing mechanical properties, is a research priority. In this paper, the vital structural weakness of BRS causing the poor mechanical properties was discovered from the preparation process. We proposed the use of an elastomeric coating to alleviate the damage in weakness during deployment. Experiments and numerical simulations conducted on PLLA stents with and without poly(L-lactide-co-ε-caprolactone) (PLCL) coating have confirmed that they can reduce stress concentration during deployment. The composite stents exhibit higher radial supporting capability after deployment. Significantly, the radial strength of the 100 μm thin-strut stent increased by 31%, up to 1061.8 mmHg. Moreover, in vivo animal experiments conducted on rabbits show encouraging biocompatibility and effectiveness of the composite stents. Our work provided a pure thin-strut PLLA stent with superior mechanical properties and biocompatibility, which can become a reliable platform for future research and clinical applications of BRS.</p>\u0000 </div>","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":"116 4","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cationic Cyclodextrin Loaded Photosensitizer Ce6 for the Treatment of Periodontitis 阳离子环糊精负载光敏剂Ce6治疗牙周炎

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-05-30 DOI: 10.1002/bip.70030

Zhe Sun, Jie Mou, Yawen Cui, Yifan Xuan, Jinxin Yang, Zongxiang Liu

{"title":"Cationic Cyclodextrin Loaded Photosensitizer Ce6 for the Treatment of Periodontitis","authors":"Zhe Sun, Jie Mou, Yawen Cui, Yifan Xuan, Jinxin Yang, Zongxiang Liu","doi":"10.1002/bip.70030","DOIUrl":"https://doi.org/10.1002/bip.70030","url":null,"abstract":"<div>\u0000 \u0000 <p>Periodontitis is a bacterial infectious disease. Photodynamic therapy (PDT) offers high selectivity, drug-resistance-free treatment, and immune regulation. The second-generation porphyrin photosensitizer Ce6 excels in reactive oxygen species (ROS) production. However, periodontitis pathogens' negative charge limits Ce6's interaction with them. This study prepared a modified cationic cyclodextrin (sPAM) and encapsulated Ce6 in an aqueous medium to create a nano-photodynamic system (Ce6@sPAM), which was characterized. In vitro evaluations assessed Ce6@sPAM's photodynamic performance, safety, antibacterial properties, and effects on immunoregulation. TEM images revealed Ce6@sPAM's irregular spherical shape, with a size of 236 nm by DLS and a Zeta potential of +16.4 mV. Ce6@sPAM exhibits a notably brief light half-life of merely 13 min, facilitating its swift in vivo clearance. SOSG and DCFH-DA fluorescence experiments showed Ce6@sPAM had stronger ROS generation (<i>p</i> < 0.05) and better bacterial penetration (<i>p</i> > 0.05) than Ce6. Co-incubation with Ce6@sPAM reversed bacterial surface potential from negative to positive. Bio-safety tests confirmed its excellent biocompatibility. In antibacterial tests, sPAM showed antibacterial properties, and Ce6@sPAM had a stronger effect than Ce6 under light (<i>p</i> < 0.001). Ce6@sPAM also exhibited high macrophage killing rates (> 90%) without specificity (<i>p</i> > 0.05) and can induce M1 macrophages to M2 polarization. Ce6-loaded modified cyclodextrin nanoparticles hold great promise for synergistic PDT in periodontitis treatment, especially in early stages for optimal immunomodulation.</p>\u0000 </div>","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":"116 4","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Interaction Between Starch-Polyvinyl Alcohol Matrix With Barley Microfibers: Structural, Barrier, and Viscoelastic Performance in Extruded Films 淀粉-聚乙烯醇基质与大麦微纤维之间的化学相互作用：挤压膜的结构、屏障和粘弹性性能

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-05-30 DOI: 10.1002/bip.70031

Guadalupe P. Radilla-Serrano, Otilo A. Acevedo-Sandoval, Carlos A. Gomez-Aldapa, Javier Castro-Rosas, Ernesto Hernandez-Hernandez, Pablo Gonzalez-Morones, Beatriz L. España-Sanchez, Francisco Hernandez-Gamez, Israel Sifuentes-Nieves

{"title":"Chemical Interaction Between Starch-Polyvinyl Alcohol Matrix With Barley Microfibers: Structural, Barrier, and Viscoelastic Performance in Extruded Films","authors":"Guadalupe P. Radilla-Serrano, Otilo A. Acevedo-Sandoval, Carlos A. Gomez-Aldapa, Javier Castro-Rosas, Ernesto Hernandez-Hernandez, Pablo Gonzalez-Morones, Beatriz L. España-Sanchez, Francisco Hernandez-Gamez, Israel Sifuentes-Nieves","doi":"10.1002/bip.70031","DOIUrl":"https://doi.org/10.1002/bip.70031","url":null,"abstract":"<div>\u0000 \u0000 <p>In this study, the effect of microwave (MW) treatment on obtaining barley microfibers and their effect on the chemical, structural, and viscoelastic properties of films based on starch (S) and polyvinyl alcohol (P) was inspected. SEM, FTIR, and TGA analysis revealed that MW treatment effectively achieves the defibrillation and the destabilization of hydrogen bonds of the hemicellulose and lignin molecules, resulting in the obtention of barley microfibers (BM). XPS analysis allowed identification of the oxidation and crosslinking mechanism of S, P, and S/P films containing BM during the extrusion process. PBM and SPBM films showed an increase in C<span></span>C proportions linked to the crosslinking phenomena and promoted stronger O<span></span>CO interactions, which increased the storage modulus from 195.5 to 380.8 MPa and from 78.0 to 134 MPa, respectively. Conversely, SBM showed lower interactions C<span></span>C and high C<span></span>OH bonds that reduced the component adhesion. Thus, the matrix type and extrusion process determined the chemical interaction with BM, resulting in films with different rigidity that can be useful in different sustainable packaging solutions.</p>\u0000 </div>","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":"116 4","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Metal-Modified Nanocellulose as a Biofilm Analogue for Biofilm Mimicry in Biomedical and Environmental Applications 金属修饰纳米纤维素作为生物膜模拟物的合成及其在生物医学和环境中的应用

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-05-30 DOI: 10.1002/bip.70029

Darryl W. Taylor, A-Andrew D. Jones III

{"title":"Synthesis of Metal-Modified Nanocellulose as a Biofilm Analogue for Biofilm Mimicry in Biomedical and Environmental Applications","authors":"Darryl W. Taylor, A-Andrew D. Jones III","doi":"10.1002/bip.70029","DOIUrl":"https://doi.org/10.1002/bip.70029","url":null,"abstract":"<div>\u0000 \u0000 <p>Bacterial biofilms are complex, multi-component structures consisting primarily of four key elements: polysaccharides, metal ions, proteins, and extracellular DNA. In our research, we specifically focus on the polysaccharide and metal ion components, which play a crucial role in determining the biofilm's mechanical properties. Polysaccharides provide the structural matrix, although metal ions, particularly divalent cations like calcium and cobalt, cross-link with the polysaccharides, thereby modulating the biofilm's rigidity and viscoelastic behavior. By introducing divalent cations into nanocellulose, we can replicate this natural cross-linking process, allowing us to finely tune the material's mechanical properties to more closely resemble those of bacterial biofilms. This approach not only enhances the accuracy of synthetic biofilm models over alginate hydrogels but also provides valuable insights into how biofilms maintain their structural integrity in various environments. Our findings indicate that nanocellulose exhibits mechanical properties closer to biofilms than alginate analogs, making it a suitable non-living control for biofilm studies. Furthermore, divalent nickel, followed by calcium and magnesium, demonstrate a closer mechanical mimicry to biofilms. In conclusion, this research shows the potential of nanocellulose as a versatile material for bacterial biofilm mimicry.</p>\u0000 </div>","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":"116 4","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green Agarose Hydrogel Implants With High Biocompatibility for Skin Repair and Regeneration in Photoaged Skin 具有高生物相容性的绿色琼脂糖水凝胶植入物用于光老化皮肤修复和再生

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-05-29 DOI: 10.1002/bip.70032

Ying Guo, Bei Tian, Yi Xie, Xiuxia Sun, Jianxi Xiao

{"title":"Green Agarose Hydrogel Implants With High Biocompatibility for Skin Repair and Regeneration in Photoaged Skin","authors":"Ying Guo, Bei Tian, Yi Xie, Xiuxia Sun, Jianxi Xiao","doi":"10.1002/bip.70032","DOIUrl":"https://doi.org/10.1002/bip.70032","url":null,"abstract":"<div>\u0000 \u0000 <p>Skin aging is a multifaceted process marked by the destruction of skin structure and the diminishment of skin function, significantly impacting both physical and mental health. Injectable hydrogels are promising for skin repair, but chemical crosslinking in most hydrogels can cause cytotoxicity, whereas agarose hydrogels avoid crosslinking yet face injectability challenges. We have herein developed green agarose hydrogel implants with high biocompatibility for skin repair and regeneration in photoaged skin. The hydrogel is prepared by utilizing agarose's ability to dissolve at high temperatures and gel at low temperatures. This process yields implants with particle sizes predominantly ranging from 100 to 150 μm. The agarose hydrogel implant exhibits excellent injectability, with a steady injection force curve consistently around 4 N. The agarose hydrogel implant promotes the proliferation of human dermal fibroblasts and does not induce hemolysis or pyrogenic reactions. In a photoaging mouse model, the agarose hydrogel implant improves skin density and hydration, reduces transepidermal water loss, and stimulates collagen regeneration. This agarose hydrogel implant provides a novel approach to repairing aged skin and holds significant potential in the fields of skin health and tissue regeneration.</p>\u0000 </div>","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":"116 4","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central Composite Design Based Optimization of Carbohydrate Coated Albumin Nanoparticles for HCC: Synthesis, Extensive Characterization and In Vivo Pharmacokinetic Evaluation 肝细胞癌碳水化合物包被白蛋白纳米颗粒的中心复合设计优化：合成、广泛表征和体内药代动力学评价

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-05-29 DOI: 10.1002/bip.70028

Sanya Batheja, Rakesh K. Sahoo, Sarita Rani, Shruti Gupta, Kiran K. Tejavath, Sonal Sinha, Ajazuddin, Awesh K. Yadav, Amit Kumar Goyal, Umesh Gupta

{"title":"Central Composite Design Based Optimization of Carbohydrate Coated Albumin Nanoparticles for HCC: Synthesis, Extensive Characterization and In Vivo Pharmacokinetic Evaluation","authors":"Sanya Batheja, Rakesh K. Sahoo, Sarita Rani, Shruti Gupta, Kiran K. Tejavath, Sonal Sinha,  Ajazuddin, Awesh K. Yadav, Amit Kumar Goyal, Umesh Gupta","doi":"10.1002/bip.70028","DOIUrl":"https://doi.org/10.1002/bip.70028","url":null,"abstract":"<div>\u0000 \u0000 <p>Hepatocellular carcinoma (HCC) is one serious cause of cancer-associated deaths worldwide. Poor bioavailability and non-specific targeting of drugs is a challenge. Gemcitabine (GEM) is broad-spectrum anticancer drug for liver and other cancers. In this study, an attempt to formulate drug-loaded galactosylated albumin-based nanoparticles (GEM-LA-BSA NPs) was made to increase the bioavailability and targetability of hydrophilic drugs. The formulation was optimized using central composite design for further evaluation and developed a pilot-scale approach for commercialization. LA-BSA conjugate was synthesized, characterized, and formulated into a nanoformulation. The particle size of the optimal formulation was 40.19 ± 7.98 nm with reduced drug release (57.78% ± 4.10%) in 48 h and aggregates-like structure by HR-TEM. In vitro studies in HepG2 cells indicated better cytotoxicity of GEM-LA-BSA NPs than GEM (IC<sub>50</sub> values 226.42 ± 11.32 and 366.03 ± 11.93 μg/mL, respectively), while in vivo studies in SD rats exhibited almost two-fold bioavailability, better pharmacokinetics, and reduced IC50 portraying immense potential as an effective drug delivery system.</p>\u0000 </div>","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":"116 4","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Mechanistic Understanding of Reactive Oxygen Species (ROS)-Responsive Bio-Polymeric Nanoparticles: Current State, Challenges and Future Toward Precision Therapeutics 对活性氧（ROS）反应的生物聚合物纳米颗粒的机制理解：精密治疗的现状、挑战和未来

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-05-15 DOI: 10.1002/bip.70027

Vivek Pandey, Tejasvi Pandey

{"title":"A Mechanistic Understanding of Reactive Oxygen Species (ROS)-Responsive Bio-Polymeric Nanoparticles: Current State, Challenges and Future Toward Precision Therapeutics","authors":"Vivek Pandey, Tejasvi Pandey","doi":"10.1002/bip.70027","DOIUrl":"https://doi.org/10.1002/bip.70027","url":null,"abstract":"<div>\u0000 \u0000 <p>Inflammation is a hallmark of various pathological conditions, including cancer, cardiovascular diseases, neurodegenerative disorders, and autoimmune diseases. Reactive oxygen species (ROS) are crucial mediators in the inflammatory microenvironment, playing a pivotal role in both normal cellular processes and disease progression. Targeting ROS overproduction in inflamed tissues has emerged as a promising therapeutic strategy. Polymeric nanoparticles (NPs) responsive to ROS levels in pathological tissues have gained substantial attention as precision drug delivery systems, capable of ensuring controlled, site-specific drug release. This review provides a comprehensive mechanistic insight into ROS-responsive polymeric nanoparticles, examining their structural design, functionalization strategies, drug release mechanisms, and potential for targeted therapies in inflammatory conditions. Furthermore, we discuss recent advancements, challenges, and future directions in utilizing ROS-responsive polymeric nanoparticles for precision therapeutics, highlighting their transformative potential in clinical applications.</p>\u0000 </div>","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":"116 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studies on Gelatin-Keratin-Chitosan Functionalized Silver Nanoparticles Based Bionanocomposite Films With Improved Antimicrobial and UV-Blocking Properties 明胶-角蛋白-壳聚糖功能化纳米银生物纳米复合膜的抗微生物和抗紫外线性能研究

IF 3.2 4区生物学

Biopolymers Pub Date : 2025-05-07 DOI: 10.1002/bip.70023

S. P. Naseem Banu, Kannapiran Rajendrakumar

{"title":"Studies on Gelatin-Keratin-Chitosan Functionalized Silver Nanoparticles Based Bionanocomposite Films With Improved Antimicrobial and UV-Blocking Properties","authors":"S. P. Naseem Banu, Kannapiran Rajendrakumar","doi":"10.1002/bip.70023","DOIUrl":"https://doi.org/10.1002/bip.70023","url":null,"abstract":"<div>\u0000 \u0000 <p>This study investigates the properties of a biocomposite film made from gelatin and sustainably sourced keratin incorporating chitosan-functionalized silver nanoparticles. Varied concentrations of chitosan solution (i.e., 0.4%, 0.6%, 0.8%, and 1% w/v) were used in the synthesis of silver nanoparticles, and their particle size, distribution, and antibacterial and antifungal activities were evaluated against foodborne pathogens (<i>Escherichia coli</i>, <i>Staphylococcus aureus</i>, <i>Rhizopus stolonifer</i>, and <i>Aspergillus niger</i>). The addition of keratin enhanced the film's tensile strength to 16.64 MPa, a 403% increase compared to the gelatin film. However, incorporating 2% chitosan functionalized silver nanoparticles reduced the tensile strength to 9.07 MPa compared to the Gelatin-Keratin film. The distribution of nanoparticles and the interaction between the polymer chains were analyzed using scanning electron microscopy and Fourier transform infrared spectroscopy. The composite films also exhibited significant UV blocking efficiency, achieving 99% blockage of ultraviolet A and 100% blockage of ultraviolet B. The biocompatibility of the films was tested with MG63 cell lines, showing that silver nanoparticle concentrations (0.3%–2%) improved cell viability to 87% after 96 h of incubation. These findings reveal that the bionanocomposite films exhibit strong antibacterial and antifungal properties, along with excellent biocompatibility, making them ideal materials for wound healing and tissue engineering applications.</p>\u0000 </div>","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":"116 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0