Formulation and Characterization of Cerium Ion Cross-Linked Alginate/PVA Films for Wound Dressing Applications

IF 3.2 4区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biopolymers Pub Date : 2025-08-13 DOI:10.1002/bip.70043

Nilay Kahya, Nevin Öztekin, Alper Gürarslan

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Abstract

Herein, alginate films doped with cerium(III) carbonate were prepared via the casting method. An acid treatment process was applied to the films for cross-linking by free Ce³⁺ ions. The incorporation of poly(vinyl) alcohol into the alginate matrix enhanced the film properties. Fourier transform infrared spectroscopy and differential scanning calorimetry analyses confirmed that PVA did not alter the chemical structure of the Ce/Alg films. Analysis of the morphological characteristics of Ce/Alg films using a scanning electron microscope revealed that porosity existed in the films. Cerium-alginate films rapidly swell in PBS (pH = 7.4) and water within 10 min, demonstrating their potential for effective fluid absorption in wound environments. The water vapor permeability test exhibited that the films have the ability to transmit moisture. This present work reports the formulation of cerium(III) cross-linked alginate films and characterization studies of the films. The films are regarded as subject to efficient wound coverage dressings in future studies with their favorable biomaterial properties.

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伤口敷料用铈离子交联海藻酸盐/聚乙烯醇膜的配方和性能

本文采用浇铸法制备了掺杂碳酸铈的海藻酸盐薄膜。采用酸处理工艺对薄膜进行了自由Ce3+交联。在海藻酸盐基质中加入聚乙烯醇增强了膜的性能。傅里叶变换红外光谱和差示扫描量热分析证实，PVA没有改变Ce/Alg薄膜的化学结构。扫描电镜分析了Ce/Alg膜的形态特征，发现膜中存在孔隙。海藻酸铈薄膜在PBS （pH = 7.4）和水中10分钟内迅速膨胀，表明它们在伤口环境中有效吸收液体的潜力。透湿性试验表明，薄膜具有透湿性。本文报道了铈（III）交联藻酸盐薄膜的制备及其表征研究。该膜具有良好的生物材料性能，在未来的研究中被认为是有效的伤口覆盖敷料。

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来源期刊

Biopolymers 生物-生化与分子生物学

CiteScore

5.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Founded in 1963, Biopolymers publishes strictly peer-reviewed papers examining naturally occurring and synthetic biological macromolecules. By including experimental and theoretical studies on the fundamental behaviour as well as applications of biopolymers, the journal serves the interdisciplinary biochemical, biophysical, biomaterials and biomedical research communities.