Attention deficit and hyperactivity disorders最新文献

{"title":"Apparent lack of practice effects in the Test of Variables of Attention (TOVA) in adult ADHD.","authors":"Ann Rotem,&nbsp;Yaron Danieli,&nbsp;Joseph Ben-Sheetrit,&nbsp;Amit Bashari,&nbsp;Pavel Golubchik,&nbsp;Rachel Ben-Hayun,&nbsp;Abraham Weizman,&nbsp;Iris Manor","doi":"10.1007/s12402-018-0278-5","DOIUrl":"https://doi.org/10.1007/s12402-018-0278-5","url":null,"abstract":"<p><p>The test of variables of attention (TOVA) is a continuous performance test commonly used as an aid for diagnosis of ADHD and assessment of treatment response. It has been studied and standardized in both children and adults. As a repetitive measurement of treatment efficacy, used both in research and in the clinic, it's important to disprove a practice effect. A retrospective cohort analysis was done, using only the placebo-arm participants from two different randomized, multicenter, double-blind clinical trials on the efficacy of a non-stimulant (metadoxine-XR). In order to reveal the practice effects, only the participants that showed no placebo effect (< 25% improvement), in the Conners' Adult ADHD Rating Scale-investigator rated (CAARS-Inv), the gold standard, were included. Demographic data, CAARS-Inv baseline and TOVA results during each visit were recorded and analyzed. Ninety-one participants from two studies were pooled (2014 n = 24, 2016 n = 67). They did not differ significantly in any demographic parameter, most side effect frequencies, and CAARS-Inv baseline scores. The baseline TOVA performances demonstrated similarity in the degree of inattention, variability, impulsivity, and response time. The TOVA scores were not altered significantly between visits, as assessed by repeated-measures analysis of variance. No significant differences were detected between the TOVA baseline-to-endpoint scores as assessed by paired t test. No practice effects were detected, in both clinical trials, suggesting that the results of the TOVA are likely to represent genuine changes in attentional performance. Further studies are needed to replicate these findings.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"11 1","pages":"73-81"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-018-0278-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37103656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of disease-associated SLC9A9 mutations on protein-protein interaction networks: implications for molecular mechanisms for ADHD and autism.","authors":"Yanli Zhang-James,&nbsp;Marc Vaudel,&nbsp;Olav Mjaavatten,&nbsp;Frode S Berven,&nbsp;Jan Haavik,&nbsp;Stephen V Faraone","doi":"10.1007/s12402-018-0281-x","DOIUrl":"https://doi.org/10.1007/s12402-018-0281-x","url":null,"abstract":"<p><p>Na⁺/H⁺ Exchanger 9 (NHE9) is an endosomal membrane protein encoded by the Solute Carrier 9A, member 9 gene (SLC9A9). SLC9A9 has been implicated in attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), epilepsy, multiple sclerosis and cancers. To better understand the function of NHE9 and the effects of disease-associated variants on protein-protein interactions, we conducted a quantitative analysis of the NHE9 interactome using co-immunoprecipitation and isobaric labeling-based quantitative mass spectrometry. We identified 100 proteins that interact with NHE9. These proteins were enriched in known functional pathways for NHE9: the endocytosis, protein ubiquitination and phagosome pathways, as well as some novel pathways including oxidative stress, mitochondrial dysfunction, mTOR signaling, cell death and RNA processing pathways. An ADHD-associated mutation (A409P) significantly altered NHE9's interactions with a subset of proteins involved in caveolae-mediated endocytosis and MAP2K2-mediated downstream signaling. An ASD nonsense mutation in SLC9A9, R423X, produced no-detectable amount of NHE9, suggesting the overall loss of NHE9 functional networks. In addition, seven of the NHE9 interactors are products of known autism candidate genes (Simons Foundation Autism Research Initiative, SFARI Gene) and 90% of the NHE9 interactome overlap with SFARI protein interaction network PIN (p < 0.0001), supporting the role of NHE9 interactome in ASDs molecular mechanisms. Our results provide a detailed understanding of the functions of protein NHE9 and its disrupted interactions, possibly underlying ADHD and ASDs. Furthermore, our methodological framework proved useful for functional characterization of disease-associated genetic variants and suggestion of druggable targets.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"11 1","pages":"91-105"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-018-0281-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37103658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parent-clinician agreement in rating the presence and severity of attention-deficit/hyperactivity disorder symptoms.","authors":"Ellen Nobel,&nbsp;J Agnes Brunnekreef,&nbsp;Russell J Schachar,&nbsp;Barbara J van den Hoofdakker,&nbsp;Pieter J Hoekstra","doi":"10.1007/s12402-018-0267-8","DOIUrl":"https://doi.org/10.1007/s12402-018-0267-8","url":null,"abstract":"<p><p>We determined the validity of a parent-report questionnaire as a research tool for rating attention-deficit/hyperactivity disorder (ADHD) symptoms in children. Using Cohen's kappa and Pearson correlation, we examined the agreement between parent reports of ADHD symptoms (using the Swanson, Nolan and Pelham Questionnaire-IV; SNAP-IV) and clinical judgment (using a semi-structured parent interview). Also, we explored factors that may be associated with the level of agreement, using regression analyses. We found moderate levels of agreement for severity of overall ADHD (r = 0.43) and for hyperactive-impulsive symptoms (r = 0.54), but no significant agreement for inattentive symptoms. On individual symptom level (range kappa = - 0.05-0.22) and for the presence/absence of ADHD (kappa = 0.14), agreement was poor. Therefore, we conclude that parent-report questionnaires may be acceptable to rate the overall severity of ADHD symptoms in treatment effect studies, but not to detect the presence of ADHD in epidemiological studies.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"11 1","pages":"21-29"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-018-0267-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37103267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family-based association study on functional α-synuclein polymorphisms in attention-deficit/hyperactivity disorder.","authors":"Manfred Gerlach,&nbsp;Manu Sharma,&nbsp;Marcel Romanos,&nbsp;Klaus-Peter Lesch,&nbsp;Susanne Walitza,&nbsp;H Annette Conzelmann,&nbsp;Rejko Krüger,&nbsp;Tobias J Renner","doi":"10.1007/s12402-019-00286-8","DOIUrl":"https://doi.org/10.1007/s12402-019-00286-8","url":null,"abstract":"<p><p>Studies have strongly suggested a disturbed regulation of dopaminergic neurotransmission in attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease (PD). A genetic and phenotypic overlap between both disorders is discussed. A well-studied risk gene for PD is the gene coding for α-synuclein (SNCA). α-Synuclein, a protein located primarily in the presynaptic vesicles, has been suggested to play a role in the modulation of dopamine transporter (DAT) function. DAT is the target of psychostimulants for the treatment of ADHD and plays a key role in regulating the dopamine concentrations in the synaptic cleft. In our sample consisting of German families with children affected by ADHD, we tested for association of allelic variants of two functionally relevant polymorphisms of the α-synuclein gene (NACP-Rep1: 156 families, 232 children; rs356219: 195 families, 284 children) with ADHD. Transmission disequilibrium test analysis revealed no over-transmission for NACP-Rep1 (OR 1, p_nom = 1 p_adj = 1) and rs356219 (OR 1.28; p_nom = 0288) in affected siblings. However, a subanalysis on trios with index children showed a nominal association of rs356219 with ADHD (OR 1.43, p_nom = 0.020), which survived Bonferroni correction (p_adj = 0.039); again, no association for NACP-Rep1 (OR 0.8, p = 0.317, p_adj = 0.634) was found. In conclusion, we found in our pilot study a trend for an association of the rs356219 genotype in SNCA that may affect α-synuclein function and contribute to the aetiology of ADHD. In light of the small sample size of our study, the link between PD and ADHD through dopamine-related neurobiology warrants further investigations. Future studies on SNCA in large ADHD samples should focus on specified symptoms and traits, e.g. attentional capacities or emotional dysregulation.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"11 1","pages":"107-111"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-019-00286-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37103659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective memory (partially) mediates the link between ADHD symptoms and procrastination.","authors":"Mareike Altgassen,&nbsp;Anouk Scheres,&nbsp;Marc-Andreas Edel","doi":"10.1007/s12402-018-0273-x","DOIUrl":"https://doi.org/10.1007/s12402-018-0273-x","url":null,"abstract":"<p><p>Individuals with attention deficit hyperactivity disorder (ADHD) often show poor planning and poor organization of tasks and activities which has been related to reduced memory for delayed intentions (prospective memory) and procrastination-in addition to other cognitive or motivational factors. This study set out to bring the fields of prospective memory and procrastination research together and to explore possible relations between the two constructs in ADHD. Twenty-nine adults with ADHD and 24 healthy controls performed several laboratory-based and real-life prospective memory tasks and filled in questionnaires measuring their symptom severity and procrastination behaviour. Overall, individuals' with ADHD showed clear deficits in everyday prospective memory performance. Individuals with ADHD recalled and executed less of their own real-life intentions. Moreover, there were clear links between everyday prospective memory performance and reported procrastination behaviour, and everyday prospective memory performance mediated the link between ADHD symptoms and procrastination behaviour.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"11 1","pages":"59-71"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-018-0273-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37103655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of successful learning of self-regulation on reward processing in children with ADHD using fMRI.","authors":"Sarah Baumeister,&nbsp;Isabella Wolf,&nbsp;Sarah Hohmann,&nbsp;Nathalie Holz,&nbsp;Regina Boecker-Schlier,&nbsp;Tobias Banaschewski,&nbsp;Daniel Brandeis","doi":"10.1007/s12402-018-0269-6","DOIUrl":"https://doi.org/10.1007/s12402-018-0269-6","url":null,"abstract":"<p><p>Neurofeedback (NF) is a non-pharmacological treatment for attention-deficit/hyperactivity disorder (ADHD) that is targeting self-regulation, is efficacious when standard protocols are used and induces partly specific neurophysiological changes in the inhibitory network. However, its effects on reward processing, which is also considered an important aspect of ADHD and has been linked to neurophysiological deficits, remain unknown. Children with ADHD (N = 15, mean age 11.8, SD 1.52) were randomly assigned to either slow cortical potential NF (n = 8) or EMG biofeedback control training (n = 7) and received 20 sessions of training under comparable conditions. Learning was defined as the slope of successful training runs across all transfer sessions. Whole brain analysis, region-of-interest analysis of anticipatory ventral striatal (VS) activation, and analysis of behavioral data were performed. Clinically, the NF group improved more than the EMG group. Whole brain analysis indicated increased activation in the left superior frontal gyrus in the control group only, and in medial prefrontal cortex and dorsolateral prefrontal gyrus (DLPFC) after treatment across all groups. Only successful learners of self-regulation (n = 8) showed increased left inferior frontal gyrus and DLPFC activation after treatment. Left VS activation was increased after treatment and showed a significant time*medication-status interaction. Specific treatment effects were found in left frontal regions for the control treatment and successful learners. Also, unmedicated participants, irrespective of treatment type or successful learning, showed treatment-induced improvement in reward processing. The results suggest no prominent specific effect of NF on reward processing. However, cautious interpretation is warranted due to the small sample.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"11 1","pages":"31-45"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-018-0269-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36496228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How do children with and without ADHD talk about frustration?: Use of a novel emotion narrative recall task.","authors":"Nicholas D Fogleman,&nbsp;Kirsten D Leaberry,&nbsp;Paul J Rosen,&nbsp;Danielle M Walerius,&nbsp;Kelly Slaughter","doi":"10.1007/s12402-018-0255-z","DOIUrl":"https://doi.org/10.1007/s12402-018-0255-z","url":null,"abstract":"<p><p>Children with attention-deficit/hyperactivity disorder (ADHD) experience difficulties related to emotional reactivity and regulation. The current study examines differences in the emotional reactivity and regulation of children with and without ADHD in the context of their real-life experiences of negative emotion using a novel ecologically valid methodology. Eighty-three 8-12-year-old children (46 ADHD, 38 non-ADHD) participated in the study. Children completed the negative emotion narrative recall task, a novel task whereby children provided a narrative recall of a real-life event where they experienced negative emotion. ANCOVA indicated children with ADHD recalled significantly more overall frustration and intense frustration than children without ADHD. Children with ADHD exhibiting more negative emotional reactivity while recalling negative emotions than children without ADHD. The current study suggests that children with ADHD are uniquely impacted by negative emotional experiences and represents an important step in understanding the emotional reactivity and regulation of children with ADHD.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"10 4","pages":"297-307"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-018-0255-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35958850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editors must be vigilant to guarantee the quality and credibility of published scientific work.","authors":"Manfred Gerlach","doi":"10.1007/s12402-018-0275-8","DOIUrl":"https://doi.org/10.1007/s12402-018-0275-8","url":null,"abstract":"<p><p></p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"10 4","pages":"245-246"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-018-0275-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35479998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating attention-deficit/hyperactivity disorder using ecological momentary assessment: a systematic review.","authors":"Carolina Miguelez-Fernandez,&nbsp;Santiago J de Leon,&nbsp;Itziar Baltasar-Tello,&nbsp;Inmaculada Peñuelas-Calvo,&nbsp;María Luisa Barrigon,&nbsp;Alba Sedano Capdevila,&nbsp;David Delgado-Gómez,&nbsp;Enrique Baca-García,&nbsp;Juan J Carballo","doi":"10.1007/s12402-018-0261-1","DOIUrl":"https://doi.org/10.1007/s12402-018-0261-1","url":null,"abstract":"<p><p>Ecological momentary assessment is an excellent tool for the measurement of different day-to-day domains in patients and capturing real-world and real-time data. The purpose of this review is to evaluate feasibility in current ecological momentary assessment studies on emotional and behavioral functioning, functional impairments, and quality of life patients with an attention-deficit/hyperactivity disorder diagnosis. This systematic review follows the recommendation of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines selecting articles published from January 1, 1990, up to the latest access on May 2018, identifying a pool of 23 eligible studies. Twenty-three studies demonstrate the validity of ecological momentary assessment methodology in evaluating different aspects of patients with attention-deficit/hyperactivity disorder. Fifteen studies focus on the child's or adolescent's daily behavior, while eight studies only focus on adults. The studies presented in this review monitored patients and their families over a maximum period of 28 days. We can conclude that ecological momentary assessment can be successfully implemented with attention-deficit/hyperactivity disorder patients to evaluate diverse backgrounds. However, more studies are needed with a longer monitoring period, especially in adolescents, to determine the effectiveness of ecological momentary assessment on patients with attention-deficit/hyperactivity disorder.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"10 4","pages":"247-265"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-018-0261-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36416417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADHD symptoms in a young patient with central diabetes insipidus.","authors":"Irene Dupong,&nbsp;Sophie Guilmin-Crepon,&nbsp;Peyre Hugo","doi":"10.1007/s12402-018-0264-y","DOIUrl":"https://doi.org/10.1007/s12402-018-0264-y","url":null,"abstract":"<p><p>Diabetes insipidus is known to be associated with neurodevelopmental disorders. In this case report, we present a child suffering from a central diabetes insipidus (DI) and an attention-deficit/hyperactivity disorder (ADHD). The DI was due to a mutation on the vasopressin gene, impairing its secretion. We discuss the effects of this impairment on the central nervous system and how it might be linked to ADHD symptoms.</p>","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"10 4","pages":"317-320"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-018-0264-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36443507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}