Attention deficit and hyperactivity disorders最新文献_第10页

A cost-effectiveness analysis of off-label atypical antipsychotic treatment in children and adolescents with ADHD who have failed stimulant therapy. 兴奋剂治疗失败的儿童和青少年ADHD非典型抗精神病药物治疗的成本-效果分析。

Attention deficit and hyperactivity disorders Pub Date : 2016-09-01 Epub Date: 2016-05-03 DOI: 10.1007/s12402-016-0198-1

Minji Sohn, Jeffery Talbert, Daniela C Moga, Karen Blumenschein

{"title":"A cost-effectiveness analysis of off-label atypical antipsychotic treatment in children and adolescents with ADHD who have failed stimulant therapy.","authors":"Minji Sohn, Jeffery Talbert, Daniela C Moga, Karen Blumenschein","doi":"10.1007/s12402-016-0198-1","DOIUrl":"https://doi.org/10.1007/s12402-016-0198-1","url":null,"abstract":"The objectives of this study are: (1) to estimate the expected health outcomes of atypical antipsychotics (AAPs) and other non-stimulant attention-deficit/hyperactivity disorder (ADHD) medications and (2) to evaluate the cost-effectiveness of AAPs compared to other non-stimulant ADHD medications. We used decision analysis to compare three alternatives for treating children and adolescents with ADHD who failed initial stimulant treatment: (1) AAPs, (2) a selective norepinephrine reuptake inhibitor (atomoxetine), and (3) selective α2-adrenergic agonists (clonidine and guanfacine). Probability estimates and quality-adjusted life year (QALY) weights were derived from a literature review. Cost-effectiveness was estimated using the expected health outcomes derived from the decision analysis and expected costs from the literature. The study was conducted from the third-party payer perspective, and the study period was 1 year. One-way deterministic sensitivity analysis and a Monte Carlo simulation were performed. Over the course of 1 year of ADHD pharmacotherapy, the highest QALY was for clonidine/guanfacine (expected QALY = 0.95) followed by atomoxetine (expected QALY = 0.94). Atypical antipsychotics yielded the lowest health outcome with an expected QALY of 0.84. In the cost-effectiveness analysis, the AAP strategy was dominated as it was less effective and more costly than other two strategies. Compared to clonidine/guanfacine, AAPs provided lower QALYs (0.11 QALY lost) at an additional cost of $2186 on average. Compared to atomoxetine, AAPs resulted in 0.10 QALYs lost at an additional cost of $2186. In this decision analysis model, AAPs provide lower expected health outcomes than other ADHD medications in children and adolescents who failed prior stimulant therapy. Furthermore, AAPs were not a cost-effective option. ","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"8 3","pages":"149-58"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-016-0198-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34452530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Skills training groups for men with ADHD in compulsory care due to substance use disorder: a feasibility study. 因物质使用障碍而接受强制护理的ADHD男性的技能训练组:可行性研究。

Attention deficit and hyperactivity disorders Pub Date : 2016-09-01 Epub Date: 2016-04-08 DOI: 10.1007/s12402-016-0195-4

B Bihlar Muld, J Jokinen, S Bölte, T Hirvikoski

{"title":"Skills training groups for men with ADHD in compulsory care due to substance use disorder: a feasibility study.","authors":"B Bihlar Muld, J Jokinen, S Bölte, T Hirvikoski","doi":"10.1007/s12402-016-0195-4","DOIUrl":"https://doi.org/10.1007/s12402-016-0195-4","url":null,"abstract":"Dialectical behavior therapy (DBT)-based skills training has been developed and previously evaluated for adults with ADHD in a psychiatric outpatient context. The aim of the present study was to evaluate the feasibility of DBT-based skills training as a voluntary intervention for men with ADHD in compulsory care due to severe substance abuse. Forty sufficiently detoxified men with ADHD in compulsory care due to life-threatening substance use disorder (SUD) were included in DBT-based skills training groups. Self- and staff-rating scales were administered before and after the treatment. The refusal rate was 42.9 %. Of those who started the DBT-based skills training, 70 % completed the treatment (attendance at ≥75 % of the sessions). The treatment acceptability was good. Both ADHD and psychiatric symptoms decreased from pre- to post-intervention in self-ratings, but not in staff ratings. The patients reported improved general well-being. The correlation between self- and staff ratings was poor. Motivation for voluntary nonpharmacological treatment was low in a compulsory care context. However, the results indicate that a DBT-based skills training program for adults with ADHD may be feasible for some patients with ADHD in combination with SUD in compulsory care, provided that considerable resources are allocated with adjustments to the target group and compulsory care context. ","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"8 3","pages":"159-72"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-016-0195-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34736332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Structured skills training for adults with ADHD in an outpatient psychiatric context: an open feasibility trial. 在门诊精神病学背景下对成人ADHD患者进行结构化技能培训:一项公开的可行性试验。

Attention deficit and hyperactivity disorders Pub Date : 2016-06-01 Epub Date: 2015-09-26 DOI: 10.1007/s12402-015-0182-1

E Morgensterns, J Alfredsson, T Hirvikoski

{"title":"Structured skills training for adults with ADHD in an outpatient psychiatric context: an open feasibility trial.","authors":"E Morgensterns, J Alfredsson, T Hirvikoski","doi":"10.1007/s12402-015-0182-1","DOIUrl":"https://doi.org/10.1007/s12402-015-0182-1","url":null,"abstract":"The aim of the current study was to evaluate the feasibility, acceptability, and effectiveness of Dialectical Behavioral Therapy-based skills training groups for adults with ADHD in an outpatient psychiatric context. Furthermore, the purpose was to analyze the impact of clinical characteristics on the effect and attrition. Ninety-eight adults (out of 102) with ADHD were allocated to the treatment. Self-rating scales were administered as baseline before the first session (T1), post-treatment (T2), and at 3-month follow-up (T3). Approximately 80 % (74 individuals) attended at least two-thirds of the sessions. Treatment satisfaction was good. ADHD symptoms and ADHD-related functional impairment in every-day life were reduced. Well-being, ability to be mindful, acceptance of emotions and quality of life were increased. The results were stable at 3-month follow-up. None of the predictors, i.e., age, comorbidity, ADHD medication status, IQ-level, treatment credibility, or functional impairment at the beginning of treatment, significantly predicted treatment outcome (change in ADHD symptoms from T1 to T2). Likewise, none of the predictors, i.e., irritability/aggression, comorbidity, and functional impairment, were significantly associated with attrition. Due to the difficulties in predicting treatment outcome, as well as attrition, based on clinical characteristics, broad inclusion criteria should be applied. ","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"8 2","pages":"101-11"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-015-0182-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34208206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

The impact of sleep restriction on daytime movement in typically developing children. 睡眠限制对正常发育儿童日间活动的影响。

Attention deficit and hyperactivity disorders Pub Date : 2016-03-01 Epub Date: 2015-07-10 DOI: 10.1007/s12402-015-0180-3

Abbey Poirier, Melissa Gendron, Jennifer Vriend, Fiona Davidson, Penny Corkum

引用次数: 5

Lifetime stability of ADHD symptoms in older adults. 老年人ADHD症状的终生稳定性

Attention deficit and hyperactivity disorders Pub Date : 2016-03-01 Epub Date: 2015-06-12 DOI: 10.1007/s12402-015-0178-x

E J Semeijn, H C Comijs, H C W de Vet, J J S Kooij, M Michielsen, A T F Beekman, D J H Deeg

{"title":"Lifetime stability of ADHD symptoms in older adults.","authors":"E J Semeijn, H C Comijs, H C W de Vet, J J S Kooij, M Michielsen, A T F Beekman, D J H Deeg","doi":"10.1007/s12402-015-0178-x","DOIUrl":"https://doi.org/10.1007/s12402-015-0178-x","url":null,"abstract":"Attention-deficit/hyperactivity disorder (ADHD) has been shown to continue into old age. Studies in children and younger adults show a reduction in hyperactive-impulsive symptoms, whereas the number of inattentive symptoms stays stable. The current study examined the lifetime stability of ADHD symptoms up to old age. Data on ADHD diagnosis and symptoms were collected in a two-phase side-study (N = 231) of the Longitudinal Aging Study Amsterdam. Paired t tests and ANCOVAs were used to analyze the data. Paired t test suggests continuity of the number of reported ADHD symptoms currently present and present in childhood. The change in the balance of inattentive/hyperactive-impulsive symptoms at present and in childhood is also the same in persons with ADHD. Finally, the difference in the change in the balance of inattentive/hyperactive-impulsive symptoms in those with and without ADHD suggests continuity throughout the life span. Our results suggest that diagnostic criteria developed for younger adults may be used among older adults. However, we collected our data retrospectively, which may have biased our results. Future research should follow larger cohorts of patients with ADHD prospectively over the life span.","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"8 1","pages":"13-20"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-015-0178-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33383251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Successful treatment of an adult with symptomatic attention deficit, hyperactivity, and impulsivity after temporal lobe resection: case report. 成功治疗一例颞叶切除后出现症状性注意缺陷、多动和冲动的成人:病例报告。

Attention deficit and hyperactivity disorders Pub Date : 2016-03-01 Epub Date: 2015-10-29 DOI: 10.1007/s12402-015-0184-z

Robert Untucht, Andreas Reif

引用次数: 2

Emotional symptoms and their contribution to functional impairment in adults with attention-deficit/hyperactivity disorder. 成人注意力缺陷/多动障碍患者的情绪症状及其对功能损害的影响

Attention deficit and hyperactivity disorders Pub Date : 2016-03-01 Epub Date: 2015-08-09 DOI: 10.1007/s12402-015-0181-2

Beatrice Mörstedt, Salvatore Corbisiero, Hannes Bitto, Rolf-Dieter Stieglitz

{"title":"Emotional symptoms and their contribution to functional impairment in adults with attention-deficit/hyperactivity disorder.","authors":"Beatrice Mörstedt, Salvatore Corbisiero, Hannes Bitto, Rolf-Dieter Stieglitz","doi":"10.1007/s12402-015-0181-2","DOIUrl":"https://doi.org/10.1007/s12402-015-0181-2","url":null,"abstract":"Attention-deficit/hyperactivity disorder (ADHD) is a severe neurodevelopmental disorder beginning in childhood and consisting of the core symptoms of inattention, hyperactivity, and impulsivity. The disorder is often accompanied by functional impairment in daily life. Research showed that severe impairment cannot be fully explained by the core symptoms of ADHD. Accordingly, emotional symptoms in ADHD and their influence on functional impairment have increasingly become the focus of research in recent years. The aim of the current study was to investigate the relationship between ADHD core symptoms, emotional symptoms, and functional impairment. We assumed that emotional symptoms might form part of adult ADHD and that the connection between ADHD core symptoms and functional impairment may be partly mediated by emotional symptoms. Data of 176 participants from an ADHD Special Consultations Unit were included. Of these participants, 146 were diagnosed with ADHD, while 30 received no such diagnosis. We developed a structural equation model which included core symptoms, emotional symptoms, and four domains of daily impairment (family life, social life, work, and organization). As predicted, results indicate that emotional symptoms are directly linked to adult ADHD and bear a strong negative influence on different domains of daily life. The results of different analyses showed a mediation of the relationship between ADHD core symptoms and impairment through emotional symptoms: While the connection between inattention and work and organization was partly mediated, the connections between impulsivity and family life and between inattention and social life were shown to be fully mediated through emotional symptoms. ","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"8 1","pages":"21-33"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-015-0181-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33905765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Demographic, developmental and psychosocial predictors of the development of anxiety in adults with ADHD. 成人ADHD患者焦虑发展的人口学、发育和社会心理预测因素。

Attention deficit and hyperactivity disorders Pub Date : 2016-03-01 Epub Date: 2015-10-20 DOI: 10.1007/s12402-015-0183-0

Katie Grogan, Jessica Bramham

{"title":"Demographic, developmental and psychosocial predictors of the development of anxiety in adults with ADHD.","authors":"Katie Grogan, Jessica Bramham","doi":"10.1007/s12402-015-0183-0","DOIUrl":"https://doi.org/10.1007/s12402-015-0183-0","url":null,"abstract":"The purpose of this research was to investigate potential demographic, developmental and psychosocial predictors of anxiety in the context of ADHD. Participants included 267 adults with a diagnosis of ADHD (168 males:99 females) and an age range of 18-70 years (M = 31 years; SD = 10.03 years). A background interview, parent questionnaire and rating scales were used to gather participant information. Correlations, independent t tests and one-way analysis of variances were used to identify variables associated with anxiety, and a stepwise multiple regression was used to identify potential predictors of anxiety. Variables associated with anxiety included childhood aggression, employment status, difficulties making friends, number of children and caffeine intake. Childhood aggression and caffeine intake were the potential predictors. Clinicians should be aware of these potential predictors of anxiety in the context of ADHD in order to minimise the likelihood of the development or maintenance of comorbid anxiety. Future research is needed in order to draw any conclusions on cause and effect.","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"8 1","pages":"35-44"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-015-0183-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34172422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

ADHD stigma among college students. 大学生对多动症的耻辱感。

Attention deficit and hyperactivity disorders Pub Date : 2016-03-01 Epub Date: 2015-07-02 DOI: 10.1007/s12402-015-0179-9

Amanda Chi Thompson, Elizabeth K Lefler

引用次数: 15

Oxidative and nitrosative stress in ADHD: possible causes and the potential of antioxidant-targeted therapies. 多动症的氧化应激和亚硝化应激:可能的原因和抗氧化剂靶向治疗的潜力。

Attention deficit and hyperactivity disorders Pub Date : 2015-12-01 Epub Date: 2015-04-19 DOI: 10.1007/s12402-015-0170-5

Adrian L Lopresti

{"title":"Oxidative and nitrosative stress in ADHD: possible causes and the potential of antioxidant-targeted therapies.","authors":"Adrian L Lopresti","doi":"10.1007/s12402-015-0170-5","DOIUrl":"https://doi.org/10.1007/s12402-015-0170-5","url":null,"abstract":"Attention deficit hyperactivity disorder (ADHD) has a complex aetiology although theories associated with disturbances in dopaminergic and noradrenergic activity are most commonly cited. The importance of these catecholamines in ADHD is supported by its effective treatment utilising stimulant and non-stimulant medications that modify their activity. Recently, there has been interest in oxidative and nitrosative stress (O&NS) in ADHD and its potential to contribute to this condition. In this article, research investigating O&NS in ADHD is reviewed and its impact on catecholaminergic activity and neurological structure is discussed. Lifestyle, environmental, psychological and nutritional influences on O&NS in people with ADHD are reviewed, and evidence for the therapeutic efficacy of antioxidant-related therapies is assessed. A selection of interventions with antioxidant mechanisms is presented as potential options for the treatment of ADHD. However, further research is required to help elucidate the role of O&NS and antioxidants for the prevention and management of ADHD. ","PeriodicalId":88387,"journal":{"name":"Attention deficit and hyperactivity disorders","volume":"7 4","pages":"237-47"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12402-015-0170-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33234509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36