Biochemical Systematics and Ecology最新文献

{"title":"Seasonal variation in the chemical composition, antimicrobial and antioxidant potential of Aloysia gratissima leaves essential oil","authors":"Maryelen A. Souza ,&nbsp;Ketelin Kunh ,&nbsp;Otávio Sanaiotto ,&nbsp;Monica S.Z. Schindler ,&nbsp;Adriana Gasparetto ,&nbsp;Kanandra T. Bertoncello ,&nbsp;Renan de Souza Rezende ,&nbsp;J. Vladimir Oliveira ,&nbsp;Jaqueline Scapinello ,&nbsp;Jacir Dal Magro ,&nbsp;Liz G. Müller","doi":"10.1016/j.bse.2025.105006","DOIUrl":"10.1016/j.bse.2025.105006","url":null,"abstract":"<div><div>This study aimed to evaluate the effect of seasonality on the chemical composition and the antimicrobial and antioxidant activities of the essential oil from <em>Aloysia gratissima</em> leaves (AGO). The essential oils were extracted from dried and crushed <em>A. gratissima</em> leaves using hydrodistillation. The chemical composition of AGO was analyzed by gas chromatography-mass spectrometry (GC-MS). Antioxidant activity was assessed using the DPPH assay, while antimicrobial activity was determined by the minimum microbicidal concentration method. Across the four seasons, 33 to 45 chemical compounds were identified, accounting for 93.76 %–97.92 % of the oils. Among these, β-pinene, pinocamphone and <em>trans</em>-pinocarvyl acetate were predominant in three seasons, whereas guaiol was the major compound exclusively in autumn. The essential oils exhibited promising antimicrobial activity, particularly against <em>Staphylococcus aureus</em> and <em>Bacillus cereus</em>. This study represents the first seasonal characterization of the chemical composition and biological activities of AGO in Brazil.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":"121 ","pages":"Article 105006"},"PeriodicalIF":1.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new phenylpropanoid glycoside from the aerial parts of Saposhnikovia divaricata (Turcz.) Schischk. and its chemotaxonomic significance","authors":"Zhenqiang Liu ,&nbsp;Yan Pan ,&nbsp;Yan Sun ,&nbsp;Yuxuan Lin ,&nbsp;Shuang Liu ,&nbsp;Qian Zhang ,&nbsp;Juan Pan ,&nbsp;Wei Guan ,&nbsp;Haixue Kuang ,&nbsp;Anam Naseem ,&nbsp;Yan Liu ,&nbsp;Bingyou Yang","doi":"10.1016/j.bse.2025.105002","DOIUrl":"10.1016/j.bse.2025.105002","url":null,"abstract":"<div><div>A newly identified phenylpropanoid glycoside, calceolarioside F (<strong>1</strong>), together with twenty known compounds, including nine phenylpropanoids (<strong>2</strong>–<strong>10</strong>), eight flavonoids (<strong>11</strong>–<strong>18</strong>), and three chromones (<strong>19</strong>–<strong>21</strong>), were obtained and identified from the aerial parts of <em>Saposhnikovia divaricata</em> (Turcz.) Schischk. Calceolarioside F (<strong>1</strong>) was structurally identified through spectroscopic data analysis, including IR, UV, CD, ECD, HR-ESI-MS, and various NMR techniques such as (1D NMR and NOESY, HMBC, ¹H–¹H COSY, and HSQC), as well as by comparisons with literature data. According to the current research, this was the first instance of isolating compounds (<strong>2</strong>–<strong>18</strong>) from <em>Saposhnikovia</em>. In addition, the chemotaxonomic importance of the isolates was discussed.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":"121 ","pages":"Article 105002"},"PeriodicalIF":1.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal variation on chemical composition and in vitro cytotoxic and anti-inflammatory activities of Myrciaria dubia (Kunth) McVaugh essential oil from Amazon","authors":"Jennifer de A. Nunes ,&nbsp;Leonan L. Teixeira ,&nbsp;Wanilce Maria O. Nascimento ,&nbsp;Dielly C.F. Lopes ,&nbsp;Joyce Kelly R. da Silva ,&nbsp;Laine C. Pinto ,&nbsp;Paulo Vinicius L. Santos ,&nbsp;Pablo Luis B. Figueiredo","doi":"10.1016/j.bse.2025.105001","DOIUrl":"10.1016/j.bse.2025.105001","url":null,"abstract":"<div><div><em>Myrciaria dubia</em> (Kunth) McVaugh is a fruit tree native to the Amazon, commonly known as camu-camu. This species has applications in traditional medicine, pharmaceuticals, and cosmetics due to its high content of phenolic compounds, such as anthocyanins and tannins in its fruits, which have antioxidant and anti-inflammatory properties. This work aims to evaluate the influence of seasonality on chemical composition, and in vitro cytotoxicity and anti-inflammatory activities of <em>M. dubia</em> essential oil. Botanical material was collected monthly, the leaf essential oils were extracted by hydrodistillation, and the fruits were subjected to simultaneous distillation-extraction. GC and GC-MS performed chemical analyses of the essential oils and volatile concentrates. The local climatic parameters insolation, temperature, relative humidity, and precipitation were monitored. The MTT assay was performed to evaluate cell viability. Subsequently, a nitrite standard curve was performed to determine the nitrite concentration in the samples. The oils were tested for cytotoxic activity against gastric ascites (AGP01), glioblastoma (AHOL), and lung cancer (A549) cell lines, as well as against non-malignant murine macrophages (RAW 264.7). The essential oil yield ranged from 0.4% (April/2024) to 0.9% (October/2023), with an annual average of 0.7 ± 0.1%. There were no significant differences in the yields of the dry and rainy periods. The leaf essential oils constituents were characterized by α-pinene (0.28–49.13%), (<em>E</em>)-caryophyllene (12.1–34.31%), caryophyllene oxide (4.03–17.08%), leptospermone (3.88–7.92%), and δ-cadinene (1.78–6.67%). The main compounds of fruit volatile concentrates were α-pinene (25.1–55.5%), α-terpineol (7.88–21.08%), limonene (6.43–16.79%), and (<em>E</em>)-caryophyllene (3.44–8.67%). The essential oils treatment of <em>M. dubia</em> seasonal study showed significant variations in the nitrite concentration, highlighting the oil's anti-inflammatory effect. The cytotoxic activity showed antiproliferative activity against cancer cell lines AGP01, AHOL, and A549, as well as non-malignant RAW 264.7. These results reinforce the value of <em>M. dubia</em> as a promising source for developing pharmaceutical ingredients, especially in combating inflammatory processes and cell therapy of tumor cell lines.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":"121 ","pages":"Article 105001"},"PeriodicalIF":1.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A survey of tryptamines in southern African Senegalia and Vachellia reveals N,N-dimethyltryptamine in Senegalia ataxacantha","authors":"Nicholas Sadgrove,&nbsp;Ben-Erik Van Wyk","doi":"10.1016/j.bse.2025.104993","DOIUrl":"10.1016/j.bse.2025.104993","url":null,"abstract":"<div><div>As part of a preliminary chemophenetic study of the two genera of African ex. <em>Acacia</em> Mill. <em>sensu lato</em> (<em>Senegalia</em> Raf. and <em>Vachellia</em> Wight &amp; Arn.), the distribution of alkaloids and amines was investigated with a focus on resolving unsubstantiated claims surrounding the existence of psychedelics in these genera. Nineteen of the 44 southern African taxa were screened, including eleven from <em>Senegalia</em> and eight from <em>Vachellia</em>. Lipophilic amine-specific extracts were produced from leaves, including other organs if available, then the extracts were studied by high performance liquid chromatography. The identities of four compounds were determined by nuclear magnetic resonance spectroscopy, i.e., tryptamine, <em>N</em>-methyltryptamine (NMT), <em>N,N</em>-dimethyltryptamine (DMT) and hordenine. With repeated sampling of select species (<em>Senegalia ataxacantha</em> (DC.) Kyal. &amp; Boatwr., <em>Senegalia caffra</em> (Thunb.) P.J.H.Hurter &amp; Mabb., and <em>Senegalia polyacantha</em> (Willd.) Seigler &amp; Ebinger.) it was demonstrated that the chemistry varies intraspecifically, and potentially according to season or organ (flowers, bark, or leaves). It was observed that in South African biota from Gauteng province, tryptamines are detected in species from <em>Senegalia</em>, but not from <em>Vachellia</em> so far, representing a potential chemosystematic marker requiring further research. Only <em>S. ataxacantha</em> had quantifiable levels of the psychedelic amine DMT, occurring in the leaves and flowers at concentrations ranging from 0.01 to 0.05% (mass/mass, wet leaf weight). Quantifiable levels of DMT were detected in just one specimen from a single population, but not in others, or other populations sampled (aside from trace amounts). We conclude that further research is required to identify southern African genotypes of <em>Senegalia</em> and <em>Vachellia</em> with levels of small lipophilic amines and alkaloids high enough to be compared to the species used for psychedelic purposes in South America (1.0 &gt; 0.2% of mass, wet leaf weight) and to identify quantifiable levels of tryptamines (&gt;0.01% of mass, wet leaf weight) in species of <em>Vachellia</em>. We also emphasize that due to geographical chemical variation, our data cannot be compared to other parts of Africa, such as Egypt or other countries in eastern Africa.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":"121 ","pages":"Article 104993"},"PeriodicalIF":1.4,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new ceramide and other constituents from Crinum ornatum (L.f.) Herb. (Amaryllidaceae) and their chemophenetic significance","authors":"Kedeu Kouvourbe ,&nbsp;Christine Claire Waleguele ,&nbsp;Yves Martial Mba Nguekeu ,&nbsp;Elise Vanessa Ngouadjio Temgoua ,&nbsp;Elodie Gaële Matheuda ,&nbsp;Marie Germaine Tsepeupon Matchide ,&nbsp;Marthe Aimée Tchuente Tchuenmogne ,&nbsp;Arno Rusel Donfack Nanfack ,&nbsp;Takeshi Kodama ,&nbsp;Stijn Anthonissen ,&nbsp;Wim Dehaen ,&nbsp;Silvère Augustin Ngouela ,&nbsp;Mathieu Tene ,&nbsp;Morita Hiroyuki ,&nbsp;Maurice Ducret Awouafack","doi":"10.1016/j.bse.2025.104991","DOIUrl":"10.1016/j.bse.2025.104991","url":null,"abstract":"<div><div>A previously undescribed ceramide, crinceramide (<strong>1</strong>), along with nineteen known compounds (<strong>2</strong>–<strong>20</strong>) were isolated from <em>Crinum ornatum</em> (L.f.) Herb. using column chromatography techniques over silica gel and Sephadex LH-20. The structure of the new compound was established by different spectroscopic methods including 1D and 2D-NMR, HRESI-MS and chemical conversions. The extract and fractions had strong activities on three human cancer cells (lung A549, breast MCF7, and cervical HeLa) with IC₅₀ from &lt;0.63 to 9.76 μg/mL whereas compounds displayed IC₅₀ ranging from 39.79 to &gt; 100 μM. Moupinamide (<strong>2</strong>) was the most active with IC₅₀ 39.79 ± 0.47 μM on A549 cell and <strong>1</strong> had IC₅₀ &gt; 100 μM against all cells used. The antibacterial activity was also assayed and moupinamide (<strong>2</strong>) had significant activity against <em>Mycobacterium smegmatis</em> (MIC = 9.7 μg/mL) while other samples possessed mostly weak and moderate activities. To the best of our knowledge, this study is the first isolation of ceramide from the <em>Crinum</em> genus, providing new insights into the chemodiversity of this genus. Moreover, new data concerning the pharmacological properties of <em>C. ornatum</em> (L.f.) Herb. and its chemophenetic significance in the genus <em>Crinum</em> and the Amaryllidaceae family were revealed.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":"121 ","pages":"Article 104991"},"PeriodicalIF":1.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143528621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mulberry Diels-Alder-type adducts and other phenolic compounds with ATP-citrate lyase inhibitory effects from Morus alba and their chemotaxonomic significance","authors":"Qi Zhou,&nbsp;Ying-Peng Tong,&nbsp;Jiang Wan,&nbsp;Li-Hong Yan,&nbsp;Chun-Xiao Jiang,&nbsp;Jin-Feng Hu","doi":"10.1016/j.bse.2025.104992","DOIUrl":"10.1016/j.bse.2025.104992","url":null,"abstract":"<div><div>A phytochemical investigation on the twigs of <em>Morus alba</em> L. (family Moraceae) resulted in the isolation of 13 compounds (<strong>1</strong>−<strong>13</strong>), including five mulberry Diels-Alder-type adducts (MDAAs, <strong>1</strong>−<strong>5</strong>), two 2-arylbenzofurans (<strong>6</strong>, <strong>7</strong>), two flavonoids (<strong>8</strong>, <strong>9</strong>), one biphenyl (<strong>10</strong>), one lignan (<strong>11</strong>), and two coumarins (<strong>12</strong>, <strong>13</strong>). Among them, lyoniresinol (<strong>11</strong>) was obtained from the genus <em>Morus</em> for the first time. The structures of these compounds were determined by comparison of their physical and spectroscopic data with those reported in the literature. Kuwanon J (<strong>1</strong>), mulberrofuran J (<strong>2</strong>), kuwanon G (<strong>3</strong>), albafuran C (<strong>4</strong>), mulberrofuran G (<strong>5</strong>), mulberroside C (<strong>6</strong>), and oxyresveratrol (<strong>10</strong>) exhibited remarkable inhibitory effects against ATP-citrate lyase, with IC₅₀ values ranging from 0.3 to 14.9 μM. The chemotaxonomic significance of the isolated MDAAs and other phenolic compounds within the <em>Morus</em> species was discussed through a compound-species network analysis.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":"121 ","pages":"Article 104992"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two new aggreceride derivatives and other chemical constituents from the stems of Tarenna conferta Benth and their potential antileishmanial activity against Leishmania donovani promastigotes: Insight from molecular docking analysis","authors":"Raïssa Carelle Dzukoug ,&nbsp;Angelique Nicolas Messi ,&nbsp;Rostanie Dongmo Zeukang ,&nbsp;Susan Lucia Bonnet ,&nbsp;Anke Wilhelm ,&nbsp;Denis-Gregoire Tene ,&nbsp;Xavier Siwe-Noundou ,&nbsp;Abderaman Bintou Souham ,&nbsp;Karel Grobler von Eschwege ,&nbsp;Alex de Theodore Atchade ,&nbsp;Joséphine Ngo Mbing ,&nbsp;Dieudonné Emmanuel Pegnyemb ,&nbsp;Anastasie Ewola Tih ,&nbsp;Raphaël Tih Ghogomu ,&nbsp;Muhammad Iqbal Choudhary","doi":"10.1016/j.bse.2025.104990","DOIUrl":"10.1016/j.bse.2025.104990","url":null,"abstract":"<div><div><em>Tarenna conferta</em> Benth is traditionally used to treat fever, headaches, parasitic and skin diseases. The aim of this study was to identify potential antileishmanial bioactive compounds from <em>T. conferta</em> and <em>in silico</em> studies against target receptors (2JK6 and 2W0H). The performance of successive chromatographic techniques followed by characterization using NMR (1D and 2D) as well as HR-ESIMS analyses, of methylene choride fraction of the stems of <em>T. conferta</em>, led to the identification of two unprecedented derivatives i.e. a new derivative of a dicarboxylic acid (<strong>1</strong>) and a new hydroxy ester derivative (<strong>2</strong>), with seven known compounds <strong>3</strong>, <strong>4</strong>, <strong>5</strong>, <strong>6</strong>, <strong>7</strong>, <strong>8</strong> and <strong>9</strong>. Compounds <strong>1, 3</strong> and <strong>4</strong> displayed highly potent antileishmanial activity against <em>Leishmania donovani</em> promastigotes with IC₅₀ values of 3.586 ± 0.554 μg/mL, 0.154 ± 0.8123 μg/mL and 0.789 ± 0.105 μg/mL respectively, compared to amphotericine B (IC₅₀ = 0.198 ± 0.704 μM), used as positive control. However crude extract exhibited significant antileishmanial activity against <em>L. donovani</em> (MHOM/SD/62/1S) promastigotes (IC₅₀ 56.860 ± 1.755 μg/mL) and showed no cytotoxicity on RAW 264.7 macrophage cells. The molecular docking provides a captivating glimpse into the intricate interactions between compounds <strong>1</strong>, <strong>2</strong>, <strong>3</strong>, and <strong>4</strong> and the target receptors (2JK6 and 2W0H). The results revealed that, compounds <strong>1</strong>, <strong>3</strong>, and <strong>4</strong> consistently displayed strong binding affinities and hydrogen bond interactions, showcasing their potential for effective therapeutic interventions. Compounds <strong>2</strong> and <strong>3</strong> exhibit moderate binding affinities with essential amino acids. In terms of potential drug development, compound <strong>4</strong> emerges as a standout candidate due to its exceptionally high binding affinities and specific interactions.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":"121 ","pages":"Article 104990"},"PeriodicalIF":1.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical composition and chemotaxonomic studies on the roots of Angelica acutiloba","authors":"Zhi-Xia Sun ,&nbsp;Fei-Fei Geng ,&nbsp;Han-Yu Zhang ,&nbsp;Yong-Hu Chen ,&nbsp;Zhe Jiang ,&nbsp;Xue-Zheng Li","doi":"10.1016/j.bse.2025.104985","DOIUrl":"10.1016/j.bse.2025.104985","url":null,"abstract":"<div><div>A chemical study of <em>Angelica acutiloba</em> resulted in the isolation of 27 distinct compounds: six phthalides (<strong>1</strong>–<strong>6</strong>), four coumarins (<strong>7</strong>–<strong>10</strong>), one benzofuran (<strong>11</strong>), five esters (<strong>12–16</strong>), one saturated fatty acid (<strong>17</strong>)<strong>,</strong> five phenols (<strong>18–22</strong>), one sterol (<strong>23</strong>), one amide (<strong>24</strong>), one hydroxy acid (<strong>25</strong>), two glycosides (<strong>26, 27</strong>). Among these, several compounds were isolated from various sources for the first time. Specifically, compounds <strong>4</strong>, <strong>13</strong>, <strong>16</strong>, <strong>20</strong>, and <strong>25</strong> were isolated for the first time from the family Apiaceae; compounds <strong>2</strong>, <strong>3</strong>, <strong>5</strong>, <strong>7</strong>, <strong>10</strong>, <strong>12</strong>, <strong>21</strong>, <strong>22</strong>, and <strong>26</strong> were isolated for the first time from the genus <em>Angelica</em> L.; and compounds <strong>6</strong>, <strong>8</strong>, <strong>9</strong>, <strong>11</strong>, <strong>14</strong>, <strong>18</strong>, <strong>19</strong>, <strong>24</strong>, and <strong>27</strong> were isolated for the first time from <em>A. acutiloba</em>. In addition, the chemotaxonomic importance of the compounds isolated from <em>A. acutiloba</em> were addressed. The results demonstrated that <em>A. acutiloba</em> comprises a range of typical components observed in the family Apiaceae and exhibits a close genetic relationship with <em>A. sinensis</em>.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":"121 ","pages":"Article 104985"},"PeriodicalIF":1.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal variation in chemical composition and bioactivity of Eucalyptus tereticornis leaf essential oil","authors":"Mamta Khaiper ,&nbsp;Pawan Kumar Poonia ,&nbsp;Sunil Kumar Dhanda ,&nbsp;Ravi Beniwal ,&nbsp;Preety Verma ,&nbsp;Mohammed Nasir","doi":"10.1016/j.bse.2025.104988","DOIUrl":"10.1016/j.bse.2025.104988","url":null,"abstract":"<div><div><em>Eucalyptus</em> is recognized worldwide for its medicinal properties. This study aimed to evaluate the chemical composition, antifungal and antioxidant properties of essential oils (EOs) from <em>Eucalyptus tereticornis</em> clone C-7 during different seasons: winter, summer and rainy. EOs were obtained from leaves via hydrodistillation and their chemical composition was analyzed using gas chromatography-mass spectrometry (GC-MS). The analysis identified 77, 57 and 82 compounds in the EOs obtained during winter, summer and rainy season, respectively. The key constituents identified included isopulegol, eucalyptol, <em>cis</em>-sabinene hydrate, camphene, 3-carene, bicyclogermacrene and (−)globulol. Summer season EOs showed the most potent antifungal activity against the four fungal species tested: Magnaporthe grisea, Rhizoctonia solani, Rhizoctonia bataticola and Fusarium oxysporum. Furthermore, the antiradical activity by DPPH test was highest in summer season EOs, followed by rainy season EOs. The seasonal variation in the chemical composition of <em>Eucalyptus tereticornis</em> EOs highlights that its potential use should consider its harvesting for medicinal and nutraceutical applications.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":"121 ","pages":"Article 104988"},"PeriodicalIF":1.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urease inhibitory compounds from the stem bark of Parinari excelsa sabine and their chemophenetic significance","authors":"Alain W. Ngouonpe ,&nbsp;Joseph Tchamgoue ,&nbsp;Alain Tadjong Tcho ,&nbsp;Bruno Dupon A. Ambamba ,&nbsp;Muhammad S. Ali ,&nbsp;Mehreen Lateef ,&nbsp;Simeon F. Kouam","doi":"10.1016/j.bse.2025.104989","DOIUrl":"10.1016/j.bse.2025.104989","url":null,"abstract":"<div><div>The chemical study of <em>n</em>-hexane and ethyl acetate soluble fractions from the stem bark of <em>Parinari excelsa</em> led to the isolation of eleven secondary metabolites, including lupane (<strong>1</strong>, <strong>6</strong>, <strong>9</strong> and <strong>10</strong>), taraxarane (<strong>7</strong> and <strong>11</strong>), and fridelane (<strong>5</strong>) triterpenes, a steroidal glycoside (<strong>4</strong>) and three phenolic compounds (<strong>2</strong>, <strong>3</strong> and <strong>8</strong>). Their structures were established by spectroscopic techniques (especially 1D and 2D NMR) and high-resolution mass spectrometry, as well as by comparison with literature data. Apart from 3-<em>O</em>-β-<span>d</span>-glucopyranosyl-stigmasta-5,11(12)-diene (<strong>4</strong>), all these compounds are reported for the first time in the genus <em>Parinari</em>. Compounds <strong>3</strong>, <strong>4</strong> and <strong>10</strong> were found to be urease inhibitors with IC₅₀ values ranging from 10.8 to 22.4, while compounds <strong>1</strong> and <strong>5−8</strong> showed moderate activity with IC₅₀ ranging from 49.4 to 62.9 μM. The chemophenetic relevance of the isolates is discussed.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":"121 ","pages":"Article 104989"},"PeriodicalIF":1.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}