Biochemical Systematics and Ecology最新文献

{"title":"Use of infrared and mass spectrometry for the discrimination of metabolites from different stages of Schinus terebinthifolia Raddi leaves","authors":"Rodrigo Borges de Araujo Gomes ,&nbsp;Fabiana Gomes Ruas ,&nbsp;José Aires Ventura ,&nbsp;Paulo Roberto Filgueiras ,&nbsp;Ricardo Machado Kuster","doi":"10.1016/j.bse.2024.104918","DOIUrl":"10.1016/j.bse.2024.104918","url":null,"abstract":"<div><div>The Brazilian Peppertree (<em>Schinus terebinthifolia</em> Raddi) is a medicinal plant with several biological activities, the most important of which are anti-inflammatory, antimicrobial and antiproliferative. Therefore, scientific research and investigation of its bioactive compounds are required. Leaves at three development stages were collected from three different genotypes of <em>S. terebinthifolia</em>. Methanol extracts were prepared and analyzed by infrared and mass spectrometry. The data obtained were treated by principal component analysis (PCA). The PCA model applied to the mass spectrometry data proved to be efficient to discriminate the three stages of development, in addition to indicating a differentiated tendency in the production of secondary metabolites by the genotypes. Two principal components were needed to describe the variance of the infrared spectrometry data (81.96%), while for mass spectrometry data three principal components were needed (55.73%). Ten substances were the most influential in the separation of the groups (young, intermediate, and old leaves or differentiation between genotypes A, B, and C), with emphasis on methyl digallate, quinic acid hexoside, digallic acid, and methyl gallate. Infrared spectroscopy data allowed us to differentiate young leaves from intermediate ones and the spectral bands that most influenced this differentiation (related to the groups O–H, C–O, C<img>C, C–H and C<img>O) correlated with the substances indicated by mass spectrometry. These results showed a different distribution of compounds among the leaf development stages, providing valuable information for those aiming to isolate specific substances of biological interest.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142572547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of organic and mineral fertilizers and a foliar biostimulant on the yield and nutritional quality of strawberries (Fragaria ×ananassa Duch.) under field conditions","authors":"Idriss Djoko Kouam,&nbsp;Synthia Moungang,&nbsp;Honoré Issa Koulagna,&nbsp;Germain Pierre Ntsoli,&nbsp;Roland Wilfried Titti,&nbsp;Aoudou Yaouba","doi":"10.1016/j.bse.2024.104917","DOIUrl":"10.1016/j.bse.2024.104917","url":null,"abstract":"<div><div>The type of fertilization can affect the growth, yield, and nutritional quality of food products. The present study was carried out to determine the influence of organomineral fertilization and a biostimulant alone or in combination on the growth, yield and mineral composition of strawberry (<em>Fragaria</em>×<em>ananassa</em> Duch.). The experiment was conducted via a completely randomized block design arranged in a drawer with two factors, variety and fertilization. For this study, two cultivars, cvs. Charlotte and Camarosa were used. Nine treatments (including the control) resulting from the use of coffee pulp, poultry manure fertilizers, Bioval biostimulant, or chemical NPK fertilizer alone or in combination were used. The strawberry growth and yield parameters were collected. Fruits were analyzed to determine their protein, P, K, Na, Ca, and Mg contents; pH; and ash concentrations. The results demonstrated that fruit growth, yield, and mineral composition were influenced by fertilizer and variety. No differences in growth parameters were detected among the varieties. However, these factors influence fruit quality. Among the treatments, the combination of coffee pulp, chemical fertilizer, and Bioval (T8) yielded the most favorable results for all growth and yield variables. Compared with the Charlotte variety, the Camarosa variety presented higher levels of P, K, Ca, Mg, and Na. A positive correlation was observed between the levels of the nutrients K–Na, K–P, and P–Na and between pH and Mg. In contrast, significant antagonistic effects were obtained between the contents of Ca–Na, Ca–K, and Ca–P. This research has enabled the valorization of coffee pulp, which is currently underutilized for crop fertilization.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of altitudinal gradients on chemical profiling and pesticidal activities of Hedychium spicatum Sm","authors":"Avneesh Rawat ,&nbsp;Om Prakash ,&nbsp;Ravendra Kumar ,&nbsp;Satya Kumar ,&nbsp;R.M. Srivastava ,&nbsp;Mamta Latwal ,&nbsp;Ganesh Pandey","doi":"10.1016/j.bse.2024.104914","DOIUrl":"10.1016/j.bse.2024.104914","url":null,"abstract":"<div><div><em>Hedychium spicatum</em> Sm. is an endangered herb which grows preferably in humid tropics and subtropics known for its distinct camphoraceous flavour and medicinal properties. The essential oils of <em>H. spicatum</em> rhizomes from six different natural habitats at different altitudes in Uttarakhand, India were analyzed. Twenty compounds were identified, accounting for 87.4–98.5% of the essential oils, with 1,8-cineole (33.4–41.9%), α-terpinene (39.6%), camphor (31.4%), and linalool (29.9%), being the prevalent major constituents of all accessions. HS-ALM (<em>H. spicatum</em> rhizomes Almora essential oil), HS-DDN (<em>H. spicatum</em> rhizomes Dehradun essential oil), HS-PAU (<em>H. spicatum</em> rhizomes Pauri essential oil), HS-TEH (<em>H. spicatum</em> rhizomes Tehri essential oil), and HS-USN (<em>H. spicatum</em> rhizomes Udham Singh Nagar essential oil) were dominated by oxygenated monoterpenes with 43.1–74.0%, respectively. In contrast, in HS-PIT (<em>H. spicatum</em> rhizomes Pithoragarh essential oil), hydrogenated monoterpenes dominated 57.8% of the total oil constituents. All accessions were assessed for significant nematicidal potential against <em>Meloidogyne incognita</em> and insecticidal potential against <em>Spodoptera litura</em>. The proteins/enzymes used for validation using docking studies were acetylcholinesterase (PBD ID: IC2O) and carboxylesterase (PDB ID: 1CI8). The study produced significant outcomes, showing the binding energy estimation of tested oil components to active sites supported the structure-activity relationship with bioinformatics tools.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical variability of selected medicinal plants from different agro-climatic zones in Kenya","authors":"Evans Omwango ,&nbsp;Justus Onguso ,&nbsp;John Ochora ,&nbsp;Peter Kirira ,&nbsp;Zipporah Kinyua ,&nbsp;Elias Mandela","doi":"10.1016/j.bse.2024.104915","DOIUrl":"10.1016/j.bse.2024.104915","url":null,"abstract":"<div><div>Medicinal properties of plants are a factor of their phytochemical content and profile. Agro-climatic factors such as temperature, sunlight, water availability, and soil composition can influence the profile of bioactive phytochemicals in plants and hence their medicinal potential. The study investigated the phytochemical variability in leaf extracts of selected medicinal plants, mango, guava, and avocado, from different agro-climatic zones in Kenya. Fresh healthy leaves were sampled from two hundred and twenty-seven mango (83), guava (85), and avocado (59) accessions in nine different geographical areas. Methanol extracts of the leaves were prepared and assayed for total phenol content (TPC), total flavonoid content (TFC), and antioxidant activity. The TPC and TFC distribution in the extracts did not correlate with the agro-climate zones. However, patterns were observed attributable to geographical and specific agro-climatic parameters. Further, correlation analyses showed that specific agro-climatic parameters significantly affected TPC and TFC. Specifically, guava TPC, avocado TPC, and mango TFC had a moderately negative correlation with rainfall and soil moisture. Mango TFC had a moderate correlation with altitude and temperature. However, none of the correlations was high (r ≥ 0.5), suggesting the effect of other confounding factors. No discernible trend was observed with the antioxidant properties. Though some geographical patterns and correlations with agro-climatic parameters were established in the study, TPC, TFC, and antioxidant activity and agro-climatic zones may not be conclusively used to characterize these medicinal plants. Future studies may narrow on specific bioactive molecules and specific agro-climatic parameters.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical constituents from noni (Morinda citrifolia L.) fruit juice and their chemotaxonomic significance","authors":"Yu-Qin Meng ,&nbsp;Bin Zhang ,&nbsp;Dong-Hui Zhang ,&nbsp;Zhang-Xin Yu ,&nbsp;Chun-Hua Long ,&nbsp;Si-Rong Li ,&nbsp;Xue-Na Zhang ,&nbsp;Xiao-Bao Li ,&nbsp;Guang-Ying Chen","doi":"10.1016/j.bse.2024.104910","DOIUrl":"10.1016/j.bse.2024.104910","url":null,"abstract":"<div><div>Extensive phytochemical investigation on the noni juice, a globally renowned health beverage derived from the fermentation of noni (<em>Morinda citrifolia</em> L.) fruit in tropical regions, led to the discovery of a new coumarin glycoside, esculetin-7-<em>O</em>-<em>β</em>-<span>d</span>-glycopyranosyl-(1 → 6)-<em>β</em>-<span>d</span>-glucopyranoside (<strong>1</strong>), along with a new natural product (<strong>8</strong>), and eighteen known compounds: six coumarin derivatives (<strong>2</strong>–<strong>7</strong>), two alkaloids (<strong>9</strong> and <strong>16</strong>), six diketopiperazines (<strong>10</strong>–<strong>15</strong>), a furan derivative (<strong>17</strong>), and three lignans (<strong>18</strong>–<strong>20</strong>). The structures of these compounds were elucidated through extensive NMR and HRESIMS analysis. The NMR data of compounds <strong>2</strong> and <strong>8</strong> are reported comprehensively for the first time. The chemotaxonomic significance of the isolated compounds was also examined, highlighting their significance. Notably, compounds <strong>1</strong>–<strong>4</strong>, <strong>8</strong>–<strong>16</strong>, and <strong>18</strong> were being reported from the genus <em>Morinda</em> for the first time. These findings contribute to the growing understanding of the chemical diversity of noni juice.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NMR metabolic profiling and biological activities of different extracts from a Turkish herbal tea-Clinopodium nepeta subsp. glandulosum","authors":"Francesca Guzzo ,&nbsp;Carlo Raucci ,&nbsp;Gokhan Zengin ,&nbsp;Gizem Emre ,&nbsp;Asaad Khalid ,&nbsp;Mohamad Fawzi Mahomoodally ,&nbsp;Brigida D'Abrosca","doi":"10.1016/j.bse.2024.104908","DOIUrl":"10.1016/j.bse.2024.104908","url":null,"abstract":"<div><div><em>Clinopodium nepeta</em> subsp. <em>glandulosum</em> (Req.) Govaerts (Lamiaceae), is traditionally used as antispasmodic, diaphoretic, stimulant, and tonic medicinal herbs and as mint-like spice used in various culinary recipes. Nonetheless, there is still a dearth of studies to validate its biological properties. The total phenolic and flavonoid contents, scavenging activity of DPPH and ABTS radicals, ferric reducing antioxidant power (FRAP), total antioxidant via phosphomolybdenum assay, metal ion chelating capacity of different extracts (<em>n-</em>hexane, dichloromethane, ethyl acetate, ethanol, ethanol/water and water) of <em>C. nepeta</em> were determined. The water extract contained the highest phenolic contents (51.47 ± 0.62 mg GAE/g) and ethanol/water extract yielded largest amount of flavonoid contents (43.86 ± 0.63 mg RE/g). The DPPH free radical scavenging activity of the extracts was in the order of ethanol/water &gt; water &gt; ethanol &gt; ethyl acetate &gt; dichloromethane &gt; n-hexane. The enzyme inhibition of the different extracts was also investigated. Ethanol/Water extract demonstrated the highest AChE inhibitory capacity (2.66 mg GALAE/g) while ethyl acetate extract revealed high BChE inhibitory activity (3.29 mg GALAE/g). Exhaustive 2D-NMR investigation has revealed the presence of acacetin derivatives, ursolic acid along with and 2,4-di-<em>t</em>-butylphenol. These findings revealed that extracts of <em>C. nepeta</em> could be used as a promising therapeutic agent against free radicals, brain enzymes including AChE and BChE and in the treatment of hyperpigmentation as a skin whitening ingredient as well as in the treatment and management of diabetes. However, further studies are required to determine the safety profiles of these extracts.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The oleochemical potential of some wild nutmegs from North East India","authors":"Rubi Barman ,&nbsp;Jadumoni Saikia ,&nbsp;Prasanna Sarmah ,&nbsp;Parthapratim Konwar ,&nbsp;Siddhartha Proteem Saikia ,&nbsp;Saikat Haldar ,&nbsp;Dipanwita Banik","doi":"10.1016/j.bse.2024.104904","DOIUrl":"10.1016/j.bse.2024.104904","url":null,"abstract":"<div><div>The essential and fixed oils cover a vast arena of industrial usage, including flavour-fragrances, cosmetics, health-body care, biofuel and bioenergy. The species of Myristicaceae were traditionally used to prepare soaps and candles. The research focused on extracting and characterising the essential and fixed oils of Myristicaceae from Assam and adjoining region. The study found essential oil for the first time from vegetative parts of <em>Horsfieldia kingii</em> and <em>H. amygdalina</em> from NE India<em>.</em> GC-MS analysis exhibited nearly 47 compounds among <em>Horsfieldia kingii, H. amygdalina</em> and <em>Knema angustifolia</em>, having compositional similarity among the latter two. About 11 common and significant compounds identified were copaene (1.34–22.22%), β-caryophyllene (0.34–4.36%), caryophyllene oxide (0.82–50.43%), humulene epoxide II (1.21–5.67%), δ-cadinol (1.10–7.92%), epi-γ-eudesmol (3.03–10.83%), globulol (0.82–42.28%), viridiflorol (2.34–39.14%), β-elemene (0.47–18.62%), shyobunol (1.37–7.5%) and t-cadinol (1.29–4.46%). The volatiles with high area coverage were juniper camphor (70.85%), caryophyllene oxide (50.43%), globulol (42.28%), viridiflorol (39.14%), α-pinene (36.56%), and β-selinene (20.53%). The physicochemical parameters of fixed oils of kernel and mace of <em>H. amygdalina</em>, <em>H. kingii</em>, <em>K. angustifolia, K. linifolia</em> and <em>K. tenuinervia</em> for the first time showed the yield 6.10–44.35% with compositional abundance of myristic acid, methyl ester (20.87–86.1%), lauric acid, methyl ester (35.81–40.02%), oleic acid, methyl ester (30.2–47.45%), palmitic acid, methyl ester (19.16–37.9%), mostly the saturated fatty acids. Both essential and fixed oils of wild nutmegs depicted the commercial potential of wild biowaste for novel renewable source of biomarkers.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical profiling and bioactivity analysis of shoots and roots essential oil of Indian Blumea mollis D. Don (Merr.)","authors":"Sushma Kholiya ,&nbsp;Mahipal Singh ,&nbsp;Amit Chauhan ,&nbsp;Rajendra Chandra Padalia ,&nbsp;Ameeta Tiwari","doi":"10.1016/j.bse.2024.104913","DOIUrl":"10.1016/j.bse.2024.104913","url":null,"abstract":"<div><div>Aromatic plants contain essential oils, potent extracts renowned for therapeutic benefits. Essential oils are commonly utilized due to their diverse range of phytochemicals that possess therapeutic properties. The present study analyses the chemical composition of the essential oil obtained from shoots and roots of <em>Blumea mollis</em> (Family: Asteraceae), using GC-FID and GC-MS techniques. A total of 49 and 46 compounds were identified from shoots and roots accounting for 95.6 % and 88.4 % respectively. β-caryophyllene is reported as major compound 36.2 ± 0.50 % in essential oil of the shoots and 33.8 ± 0.55 % in essential oil of the roots. Both essential oils of shoots and roots were dominated by sesquiterpene hydrocarbons (59.2–76.4%), followed by oxygenated sesquiterpene (14.9–20.3%). The <em>in vitro</em> antioxidant activity was determined using DPPH radical scavenging activity, H₂O₂ radical scavenging activity, and Iron(II) complexing activity. The highest antioxidant activity was observed in root essential oil of <em>B. mollis.</em> The oils also inhibited the activity of α-amylase with IC₅₀ of 3.53 ± 0.04 μg/ml (shoot), 3.45 ± 0.04 μg/ml (root). Root oil also showed good activity for protein denaturation with IC₅₀ of 3.02 ± 0.03 g/ml as compared to shoot essential oil. This is first time that essential oil constituent and biological activity of <em>B. mollis</em> roots and shoots have been characterized from India.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison and diversity of phytochemical profiles of Spondias mombin and S. tuberosa using LC-MS and multivariate statistical analysis","authors":"Marina Dantas Corradin ,&nbsp;Alvaro Luis Lamas Cassago ,&nbsp;Maria Auxiliadora Coelho de Lima ,&nbsp;Viseldo Ribeiro de Oliveira ,&nbsp;Christiane Mendes Cassimiro Ramires ,&nbsp;Ricardo Elesbão Alves ,&nbsp;Guilherme Julião Zocolo ,&nbsp;Fernando Batista Da Costa","doi":"10.1016/j.bse.2024.104912","DOIUrl":"10.1016/j.bse.2024.104912","url":null,"abstract":"<div><div>The species <em>Spondias mombin</em> and <em>Spondias tuberosa</em> are fruit plants from the family Anacardiaceae, and the fruits of these plants are popularly known as “cajá” and “umbu”, respectively, and are marketed as exotic fruits in Brazil. The promoted marketing of these species in the market is hampered by their genetic variability and a lack of knowledge of techniques for reproduction, harvesting, and conservation. Therefore, active germplasm banks (AGBs) were created by The Brazilian Agricultural Research Corporation (EMBRAPA) to conserve genetic resources and optimize the use of these species. One of the approaches to the selection of species is metabolomics studies. In this work, using liquid chromatography‒mass spectrometry-based metabolomics, multivariate statistical analysis was used to correlate the metabolomic profiles of the bark, branches, and leaves of <em>S. mombin</em> and <em>S. tuberosa</em>. Thus, the compounds that most influenced the observed groups were identified and indicated as chemical markers of these species. To carry out the dereplication of the metabolomic profiles, a library of chemical structures of the Anacardiaceae family was constructed, which enabled the identification of 40 compounds, 10 of which were at level 1 using the library and reference standards and 30 at level 2 using only the library. The results of the present study showed that the branches and bark contain gallic acid and citric acid as chemical markers, and their profiles are similar between species. In the case of the leaves of <em>S. mombin</em>, the anacardic acid C17:3 and quercetin derivatives were identified as chemical markers, while the leaves of <em>S. tuberosa</em> contained the anacardic acids C17:1, C17:2, and C13 as chemical markers. Meteorological factors had a greater influence on the metabolic profile of the leaves than did genetic variability. In the case of <em>S. mombin</em> leaves, flavonoids are inversely correlated with cloudiness and directly correlated with the temperature at the collection site.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chloranthus japonicus Sieb. (Chloranthaceae): A review of metabolite structural diversity and pharmacology","authors":"Nguyen Thi Thoa ,&nbsp;Nguyen Quang Hop ,&nbsp;Ninh The Son","doi":"10.1016/j.bse.2024.104911","DOIUrl":"10.1016/j.bse.2024.104911","url":null,"abstract":"<div><div><em>Chloranthus japonicus</em> Sieb. (the family Chloranthaceae) is a medicinal Asian plant with interesting phytochemicals. The current study aims to comprehensively provide an in-depth review of phytochemistry, and the role of <em>C. japonicus</em> secondary metabolites in pharmacology. Using chromatographic columns, 207 compounds have been isolated and structurally elucidated with a diversity of sesquiterpenoids. Several compounds, such as chlojaponilide M, cycloshizukaol A, chlojapolactone A, hitorins A-H, japonicones A-C, and trishizukaol A were characteristic metabolites of <em>C. japonicus</em>. It also brings benefits in the use of <em>C. japonicus</em> constituents for drug development, in which they possess various biological values, such as anticancer, anti-microbial, anti-virus, anti-inflammation, anti-obesity, and metabolic activities. Some isolated agents themselves have potential since they are better than the positive controls. The NF-κB (nuclear factor kappa B) is one of the underlying molecular mechanisms for pharmacological exploration. Collectively, extensive <em>in vitro</em> and <em>in vivo</em> biomedical studies on <em>C. japonicus</em> constituents, especially lindenane-type sesquiterpenoids, are necessary.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}