Biochemical Systematics and Ecology最新文献

{"title":"Micromeria graeca L., essential Oils: In vitro and In silico evaluation","authors":"Mustapha Laghmari ,&nbsp;Jihane Touhtouh ,&nbsp;Tarik Aanniz ,&nbsp;Gökhan Zengin ,&nbsp;Abdelhakim Bouyahya ,&nbsp;Riaz Ullah ,&nbsp;Amal Alotaibi ,&nbsp;Mohamed Akhazzane ,&nbsp;Taoufiq Benali ,&nbsp;Khalil Hammani","doi":"10.1016/j.bse.2025.105071","DOIUrl":"10.1016/j.bse.2025.105071","url":null,"abstract":"<div><div>The discovery of new natural molecules with therapeutic and/or cosmetic properties is a major concern of the pharmaceutical industry. In this sense, volatile compounds from plants have recently attracted significant interest as candidate natural substances. The aims of this research were to identify the volatile compounds of <em>Micromeria graeca</em> essential oil (MGEO) and to study its antimicrobial, antioxidant, and anti-enzymatic effects using <em>in vitro</em> and computational approaches, including molecular docking and molecular dynamics interaction studies. Gas chromatography coupled with mass spectrometry (GC-MS-MS) analysis revealed that MGEO contain 17 chemical compounds which were dominated by citral (29.3 %), neral (16.3 %), and caryophyllene oxide (10.4 %). The disc diffusion method and the broth microdilution techniques demonstrated that MGEO significantly inhibits the growth of <em>Bacillus subtilis</em>, <em>Proteus mirabilis</em>, <em>Staphyloccocus aureus</em>, and <em>Candida albicans</em> which the inhibition zone diameters ranged between 51 and 71 mm and MIC values ranged from 1.56 to superior to 50 mg/mL. The antioxidant effects indicate that MGEO exerts an important activity in 2,2′-diphenyl-1-picrylhydrazyl (DPPH), 2,2- azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), ferric reducing antioxidant power (FRAP), cupric ion reducing activity (CUPRAC), ferrous chelating, and phosphomolybdenum models. Indeed, MGEO exerted significant antioxidant activity in several assays, demonstrating antioxidant powers with inhibitory values of 84.02 ± 3.25 mg TE/g of EO (Cuprac), 47.67 ± 0.22 mg TE/g of EO (ABTS), 45.45 ± 0.26 mg TE/g of EO (FRAP), 28.90 ± 1.19 mmol TE/g (Phosphomolybdenum), 22.41 ± 3.00 mg EDTAE/g of EO (Chelating), and 9.04 ± 0.67 mg TE/g of EO (DPPH). Remarkably, MGEO shows good potential to inhibit tyrosinase (41.05 mg KAE/g), butyrylcholinesterase and acetylcholinesterase (2.06 and 1.68 mg GALAE/g, respectively), and α-amylase (0.87 mmol ACAE/g) enzymes. Additionally, the molecular docking study demonstrated that each chemical interacted differently with the active regions of the five different enzymes. Collectively, our findings provides valuable information qualifying the studied plant as an interesting source of bioactive compounds.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":"123 ","pages":"Article 105071"},"PeriodicalIF":1.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical investigation of Pteris fauriei Hieron","authors":"Yan Luo ,&nbsp;Lu Zhang ,&nbsp;Chenliang Zhao ,&nbsp;Yaxin Yang ,&nbsp;Jianghai Ye ,&nbsp;Kang He ,&nbsp;Chunhua Lai ,&nbsp;Juan Zou","doi":"10.1016/j.bse.2025.105072","DOIUrl":"10.1016/j.bse.2025.105072","url":null,"abstract":"<div><div><em>Pteris fauriei</em> Hieron., a terrestrial fern species belonging to the Pteridaceae family, is typically found in shaded understories of forests at elevations ranging from 300 to 800 m. This species preferentially colonizes acidic soils, particularly in moist environments adjacent to drainage ditches or other similar habitats. The phytochemical investigation of <em>P. fauriei</em> collected from Guizhou province was carried out and seven secondary metabolites were identified. They were characterized as: <em>ent</em>-11<em>α</em>-hydroxy-15-oxo-kaur-16-en-19-oic acid-<em>O</em>-<em>β</em>-<em>D</em>-glucoside (<strong>1</strong>), 16<em>β</em>-hydroxy-15-oxo-<em>ent</em>-kaur-19-oly-glucoside (<strong>2</strong>), 11<em>β</em>-hydroxy-15-oxo-<em>ent</em>-kaur-16-en-19-oic acid (<strong>3</strong>), <em>ent</em>-11<em>α</em>-hydroxy-15-oxo-kaur-19-oic acid (<strong>4</strong>), apigenin-7-<em>O</em>-<em>β</em>-D-glucoside (<strong>5</strong>), luteolin-7-<em>O</em>-<em>β</em>-D-glucoside (<strong>6</strong>), <em>β</em>-sitosterol (<strong>7</strong>). The structures of the obtained monomeric compounds were established based on their physicochemical properties, analysis of their NMR data and by comparing their spectroscopic data with those reported in the literature. Notably, compounds (<strong>1</strong>–<strong>5</strong>) were firstly isolated from this species and represented novel chemical records for <em>P. fauriei</em>, expanding the documented phytochemical profile of this species and offering a scientific foundation for the development and utilization of <em>P. fauriei</em>. The chemotaxonomic implications of these findings are discussed, particularly regarding the biosynthetic relationship between <em>ent</em>-kaurane diterpenoids and their ecological roles in Pteridaceae.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":"123 ","pages":"Article 105072"},"PeriodicalIF":1.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical constituents from the roots of Berberis aetnensis C. Presl. and their chemotaxonomic significance","authors":"Thomas Maroselli,&nbsp;Ange Bighelli,&nbsp;Joseph Casanova,&nbsp;Mathieu Paoli","doi":"10.1016/j.bse.2025.105070","DOIUrl":"10.1016/j.bse.2025.105070","url":null,"abstract":"<div><div>This study focused on the phytochemical constituents of <em>Berberis aetnensis</em> C. Presl. roots, scarcely reported up to now. Two root extracts (DCM and EtOAc) were investigated, after column chromatography steps, by ¹³C NMR dereplication following a procedure developed in our laboratory. Twenty-one known compounds were identified, including six phenylpropanoids (<strong>1</strong>–<strong>4</strong> and <strong>9</strong>,<strong>10</strong>), one benzaldehyde derivative (<strong>5</strong>), three benzoic acid derivatives (<strong>6</strong>–<strong>8</strong>), six lignans (<strong>11</strong>–<strong>16</strong>), three steroids (<strong>17</strong>–<strong>19</strong>) and two alkaloids (<strong>20</strong>,<strong>21</strong>). Compounds <strong>1</strong>–<strong>18</strong> were reported for the first time in <em>B. aetnensis</em> extracts, while compounds <strong>9</strong>, <strong>10</strong> and <strong>15</strong> were identified for the first time in the genus <em>Berberis</em>.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":"123 ","pages":"Article 105070"},"PeriodicalIF":1.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into Genotype × environment interactions affecting essential oil yield and quality stability in Cymbopogon species and genotypes","authors":"R.K. Lal ,&nbsp;C.S. Chanotiya ,&nbsp;Rashami Lahiri","doi":"10.1016/j.bse.2025.105068","DOIUrl":"10.1016/j.bse.2025.105068","url":null,"abstract":"<div><div>To explore the stability and chemical composition of essential oil yield in diverse <em>Cymbopogon</em> genotypes, a genotype × environment interaction (GEI) study was conducted using germplasm from the CSIR-CIMAP Lucknow National Gene Bank. Essential oil profiles varied across species: lemongrass (<em>C. citratus</em>) predominantly contained citral (geranial and neral), while Java citronella (<em>C. winterianus</em>) was rich in citronellal, citronellol, and geraniol. Chemotypes such as methyl eugenol, geranyl acetate, and myrcene were also detected. Pooled ANOVA revealed significant effects of genotype (G), environment, and GEI for all traits except X7. IPCA1 was significant for every attribute, indicating the relevance of GEI in trait expression. Correlation analysis showed positive associations between oil content and compounds such as limonene, citronellal, geraniol, and geranyl acetate, while geranial and neral were negatively correlated with essential oil yield. Notably, neral and geranial were positively correlated with each other. For herbage yield, genotypes GEN 12, 1, 7, and 6 performed best; for essential oil content, GEN 12, 1, 7, and 13 were superior. Stability analysis across environments identified GEN 12 and 1 as the most consistent yield traits. GEN 5, 11, 14, and 8 were stable for neral content, and GEN 9, 15, 4, and 5 for geranial. These findings highlight the genetic diversity and stability of select <em>Cymbopogon</em> genotypes, supporting their use in breeding programs and recommending them for pilot-scale cultivation and varietal release aimed at enhanced and stable essential oil production.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":"123 ","pages":"Article 105068"},"PeriodicalIF":1.4,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oleanane-type bidesmosides from Agrostemma githago L. roots and aerial parts","authors":"Reneta Gevrenova ,&nbsp;Izabela Nawrot-Hadzik ,&nbsp;Adam Matkowski","doi":"10.1016/j.bse.2025.105069","DOIUrl":"10.1016/j.bse.2025.105069","url":null,"abstract":"<div><div>A comprehensive analysis of triterpenoid saponins in <em>Agrostemma githago</em> L. (Caryophyllaceae) by liquid chromatography – quadrupol-Orbitrap mass spectrometry allowed for annotation of 49 gypsogenin-, quillaic acid- and oleanolic acid-bidesmosides in the roots and aerial parts. Generally, the detected saponins belong to <strong>G</strong>lucuronide <strong>O</strong>leanane-type <strong>T</strong>riterpenoid <strong>C</strong>arboxylic <strong>A</strong>cids 3,28-<strong>B</strong>idesmosides (GOTCABs) including a variety of acetylated derivatives of 34 core structures forming isobaric isomers. For the first time, forty five saponins were annotated in the <em>A. githago</em>, being present particularly in the roots<em>.</em> The branched trisaccharide (HexA, Pent, Hex/HexA, 2Hex) is linked at C-3 of the sapogenin <em>via</em> glycosidic bond. C-28 ester chain consists mainly of mono-, di- and triacetyl tetra- and pentasaccharides. The chemophenetic significance of GOTCAB saponins in this species is discussed.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":"123 ","pages":"Article 105069"},"PeriodicalIF":1.4,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seaweed sap from Solieria chordalis enhances growth, yield and essential oil quality in rose-scented geranium (Pelargonium graveolens L’Hér.) varieties","authors":"K.M. Prakhyath ,&nbsp;N.D. Yogendra ,&nbsp;T. Arul Prakash ,&nbsp;R.C. Padalia ,&nbsp;V. Veeragurunathan ,&nbsp;Vijay Anand K. Gopalakrishnan ,&nbsp;Arup Ghosh","doi":"10.1016/j.bse.2025.105062","DOIUrl":"10.1016/j.bse.2025.105062","url":null,"abstract":"<div><div>Geranium (<em>Pelargonium graveolens</em> L'Hér) is a valuable aromatic crop in the industrial sector, and its essential oil is highly prized for its many medicinal and aromatic properties. Nevertheless, there is a paucity of scholarly literature on the efficacy of geranium when subjected to the application of seaweed extract as a source of nutrients. In this context, an investigation was undertaken under controlled playhouse conditions to evaluate the effect of different concentrations of <em>Solieria chordalis</em> extract on the growth and yield attributes of two geranium varieties: Bio-G-171 and CIM-Bharath. The foliar application of SCLE with the recommended dose of fertilizer (RDF) significantly enhanced plant height, number of leaves, branches, internode length, and L:S ratio of geranium. The most pronounced effects in these parameters were particularly evident in the cultivar Bio-G-171 when treated with RDF +10 % SCLE, as well as in CIM-Bharath with RDF +7.5 % SCLE. Furthermore, notable herbage yields of 660.50 g per plant and 653.33 g per plant were documented in CIM-Bharath and Bio-G-171, respectively, corresponding to 10 % and 7.5 % SCLE concentrations. Essential oil content also showed a significant disparity between the two varieties, with CIM-Bharath recording higher percentages (0.36 %) than Bio-G-171 (0.29 %). Nonetheless, essential oil recovery in both varieties was not affected by SCLE application. The analysis of the chemical composition revealed the presence of 23 distinct compounds, with citronellol (C) and geraniol (G) serving as the principal constituents, exhibiting varying concentrations across different varieties. Notably, a higher C: G ratio was observed in CIM-Bharath (8.88) compared to Bio-G-171 (2.45). The study concludes that SCLE treatments, particularly within the range of 7.50–10.0 %, exerted a positive influence on growth, yield, and the composition of essential oils in both varieties of geranium.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":"123 ","pages":"Article 105062"},"PeriodicalIF":1.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolite profiling and cytotoxicity of Tragopogon dubius fractions against MCF-7 cells","authors":"Sheikh Showkat Ahmad,&nbsp;Chandnig Garg,&nbsp;Satwinderjeet Kaur","doi":"10.1016/j.bse.2025.105065","DOIUrl":"10.1016/j.bse.2025.105065","url":null,"abstract":"<div><div><em>Tragopogon dubius</em> is a biennial herbaceous plant with multiple uses in ethnomedicine. Traditionally consumed as a vegetable, it has been reported to treat various conditions, including wounds, liver dysfunction, kidney disorders, and certain skin diseases. Despite its traditional use, it remains one of the least explored species in terms of biological activity. This study aimed to evaluate the antigenotoxic, antioxidant, and antiproliferative properties of the ethyl acetate extract obtained from the stem and leaves of <em>T. dubius</em> (TrDE), along with eleven fractions (F-1 to F-11) isolated via preparative thin-layer chromatography. Phytochemical profiling was performed using High-Resolution Liquid Chromatography-Mass Spectrometry (HRLC-MS/QTOF/Orbitrap) and Gas Chromatography-Mass Spectrometry (GC-MS). Among the isolated fractions, F-9, F-10, and F-11 showed the highest antioxidant activity at a concentration of 800 μg/mL, as determined by DPPH (IC₅₀ 44.70, 19.90, and 25.35 μg/mL), ABTS (IC₅₀ 64.53, 22.64, and 34.28 μg/mL), and FRAP (IC₅₀ 37.92, 23.85, and 57.96 μg/mL) assays. The F-11 fraction also exhibited the highest total phenolic content (70.00 ± 1.10 mg GAE/g dw), followed by F-10 and F-9, all exceeding the crude extract (33.04 ± 1.10 mg GAE/g dw). Additionally, the TrDE extract displayed genoprotective effects against hydrogen peroxide (H₂O₂)-induced DNA damage in human lymphocytes. In antiproliferative assays, the fractions demonstrated significant cytotoxicity against MCF-7 breast cancer cells in a dose-dependent manner. Notably, fractions F-7, F-10, and F-11 exhibited the highest cytotoxic effects, with GI₅₀ values of 20.14, 35.37, and 33.58 μg/mL, respectively. These findings suggest that <em>T. dubius</em> fractions possess promising therapeutic potential against human breast cancer (MCF-7), warranting further in vivo investigation.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":"123 ","pages":"Article 105065"},"PeriodicalIF":1.4,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical constituents of Tinospora hainanensis and their chemotaxonomic significance","authors":"Ming-Hua Wang,&nbsp;Rui Ao,&nbsp;Bao-Qiang Liu,&nbsp;Juan Zhang,&nbsp;Jun-Sheng Zhang","doi":"10.1016/j.bse.2025.105061","DOIUrl":"10.1016/j.bse.2025.105061","url":null,"abstract":"<div><div>A phytochemical investigation on the vines of <em>Tinospora hainanensis</em> led to the isolation and characterization of a novel lignan (<strong>1</strong>), nine previously identified lignans (<strong>2</strong>−<strong>10</strong>), four known alkaloids (<strong>11</strong>−<strong>14</strong>), one cinnamic acid derivative (<strong>15</strong>), one catechol derivative (<strong>16</strong>) and one triterpenoid (<strong>17</strong>). The molecular structures of these constituents were elucidated through the application of an extensive array of spectroscopic methods, and the absolute configuration of <strong>1</strong> was determined by CD method. Notably, compounds <strong>1</strong>−<strong>7</strong>, <strong>9</strong>, <strong>14</strong> and <strong>16</strong>−<strong>17</strong> are identified as new contributions to the Menispermaceae family. Moreover, the current research extends to explore the chemotaxonomic significance of these isolates.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":"123 ","pages":"Article 105061"},"PeriodicalIF":1.4,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biocontrol potential of metabolites from Streptomyces sp., non-toxic Aspergillus fumigatus, and their co-cultures against tomato anthracnose","authors":"Tavga Sulaiman Rashid ,&nbsp;Hayman Kakakhan Awla ,&nbsp;Rouhallah Sharifi","doi":"10.1016/j.bse.2025.105067","DOIUrl":"10.1016/j.bse.2025.105067","url":null,"abstract":"<div><div>The biological activity of <em>Streptomyces</em> sp. and <strong>non-toxic</strong> <em>Aspergillus fumigatus</em>, along with their metabolites in mono and co-culture, was tested against <em>Colletotrichum acutatum</em>. Additionally, the presence of volatile metabolites was observed using gas chromatography-mass spectrometry (GC-MS). The tomato plants were treated with both <em>Streptomyces</em> sp. and <em>A. fumigatus</em> separately and in combination for <em>in vivo</em> test. Both <em>Streptomyces</em> sp. and <em>A. fumigatus</em> exhibited antifungal activity against <em>C. acutatum</em>. In co-cultivation, metabolites demonstrated 100 % inhibition of the pathogenic fungus. According to GC-MS analysis, 35 compounds were identified from <em>A. fumigatus</em>, and 21 from <em>Streptomyces</em> sp. Co-cultivation of <em>A. fumigatus</em> and <em>Streptomyces</em> sp. induced the biosynthesis of 21 compounds. Most of volatile compounds present at high percentages in co-culture were not detected in the monoculture of each microorganism. The top volatiles in co-culture included acetic acid (25.58 %), furfural (9.89 %), Levulinic acid, methyl ester (7.22 %), dimethadione (6.50 %), benzene acetic acid (6.03 %), and levulinic acid (5.93 %). Significant improvements in shoot height, root length, shoot and root dry weight and the anthracnose disease reduction were observed mainly with the combination of <em>Streptomyces</em> sp. and <em>A. fumigatus</em>. These outcomes support the use of the co-cultivation technique as a viable approach for acquiring beneficial metabolites from microorganisms.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":"123 ","pages":"Article 105067"},"PeriodicalIF":1.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new antibacterial diarylpropanoid and other constituents from Lannea velutina A. Rich (Anacardiaceae) and their chemotaxonomic significance","authors":"Ervira Keubou Djoukam ,&nbsp;Roukayatou Mbouangouere ,&nbsp;Jean-De-Dieu Tamokou ,&nbsp;Arno R. Donfack Nanfack ,&nbsp;Germaine Matsuete-Takongmo ,&nbsp;Apollinaire Tsopmo ,&nbsp;Mathieu Tene","doi":"10.1016/j.bse.2025.105063","DOIUrl":"10.1016/j.bse.2025.105063","url":null,"abstract":"<div><div>Phytochemical investigation of the methanol extracts from the stem bark and leaves of <em>Lannea velutina</em> afforded a new diarylpropanoid (<strong>1</strong>) and eighteen previously described compounds from other plants. They included eleven flavonoids (<strong>2</strong>–<strong>12</strong>), three triterpenoids (<strong>13</strong>–<strong>15</strong>), three steroids (<strong>16</strong>–<strong>18</strong>) and one sugar (<strong>19</strong>). The structure of compound <strong>1</strong> was established by analysis of its spectroscopic and spectrometric data. All the isolated compounds are here reported for the first time from <em>L. velutina</em> species while only compounds <strong>3</strong>, <strong>6</strong>, <strong>8</strong>, <strong>10</strong>, <strong>13</strong>–<strong>16</strong> and <strong>18</strong> were previously reported from the genus <em>Lannea</em>. The extracts, fractions, and compounds were subjected to <em>in vitro</em> antibacterial assays against one Gram-positive (<em>Enterococcus faecalis</em> ATCC 29212) and three Gram-negative (<em>Escherichia coli</em> ATCC 8739, <em>Salmonella</em> Typhi ATCC 6539 and <em>Pseudomonas aeruginosa</em> 4C 76110) bacteria. The MeOH extract from the stem bark, its chromatographic fraction C and the EtOAc partitioned leaves extract showed significant activity against the growth of <em>E. faecalis</em>, <em>E. coli</em> and <em>P. aeruginosa</em> (16 ≤ MIC ≤64 μg/mL). Lannepoxide (<strong>1</strong>) inhibition activities were 16 ≤ MIC ≤128 μg/mL against the four bacterial strains. The findings demonstrated the chemotaxonomic significance of the isolated compounds and their potential as antimicrobial agents.</div></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":"123 ","pages":"Article 105063"},"PeriodicalIF":1.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}