Megastigmanes and indoles from Culcasia parviflora (Araceae)

IF 2 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Systematics and Ecology Pub Date : 2025-09-20 DOI:10.1016/j.bse.2025.105138

Onome M. Adeboye , Fazila Zulfiqar , Abimbola Sowemimo , Margaret Sofidiya , Ikhlas A. Khan , Zulfiqar Ali

引用次数: 0

Abstract

Plants of the Culcasia genus have long been used by traditional healers to treat various ailments since ancient times. Ethnomedicinal studies highlight their application in alleviating pain and inflammation, combating cancer, and even in pregnancy detection. Among them, Culcasia parviflora N.E.Br. (family Araceae) is traditionally used in Africa for pain and inflammation relief, although its chemical constituents remain largely unexplored. In this study, eight compounds, including megastigmanes and indoles, were isolated from a 95 % ethanol extract of C. parviflora leaves. Structural elucidation was carried out using one- and two-dimensional NMR spectroscopy, with the results compared against previously reported data. This work details the isolation and structural characterization of these compounds and discusses their chemotaxonomic relevance.

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天南星科细花莲的巨藤甾类和吲哚类化合物

自古以来，Culcasia属植物就一直被传统治疗师用来治疗各种疾病。民族医学研究强调了它们在减轻疼痛和炎症，对抗癌症，甚至怀孕检测方面的应用。其中，parviflora Culcasia N.E.Br。（天南星科）在非洲传统上用于缓解疼痛和炎症，尽管其化学成分在很大程度上仍未被探索。本研究从parviflora叶片的95%乙醇提取物中分离得到了8个化合物，包括巨藤草碱和吲哚。结构解析使用一维和二维核磁共振波谱进行，结果与先前报道的数据进行比较。这项工作详细介绍了这些化合物的分离和结构特征，并讨论了它们的化学分类相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemical Systematics and Ecology 生物-进化生物学

CiteScore

3.00

自引率

12.50%

发文量

147

审稿时长

43 days

期刊介绍： Biochemical Systematics and Ecology is devoted to the publication of original papers and reviews, both submitted and invited, in two subject areas: I) the application of biochemistry to problems relating to systematic biology of organisms (biochemical systematics); II) the role of biochemistry in interactions between organisms or between an organism and its environment (biochemical ecology). In the Biochemical Systematics subject area, comparative studies of the distribution of (secondary) metabolites within a wider taxon (e.g. genus or family) are welcome. Comparative studies, encompassing multiple accessions of each of the taxa within their distribution are particularly encouraged. Welcome are also studies combining classical chemosystematic studies (such as comparative HPLC-MS or GC-MS investigations) with (macro-) molecular phylogenetic studies. Studies that involve the comparative use of compounds to help differentiate among species such as adulterants or substitutes that illustrate the applied use of chemosystematics are welcome. In contrast, studies solely employing macromolecular phylogenetic techniques (gene sequences, RAPD studies etc.) will be considered out of scope. Discouraged are manuscripts that report known or new compounds from a single source taxon without addressing a systematic hypothesis. Also considered out of scope are studies using outdated and hard to reproduce macromolecular techniques such as RAPDs in combination with standard chemosystematic techniques such as GC-FID and GC-MS.