中国脚草的化学成分及其化学分类意义

IF 2 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Systematics and Ecology Pub Date : 2025-08-30 DOI:10.1016/j.bse.2025.105119

Li Yan, Wan-Bai Su, Zhi-Yang Tang, Yang Yu, Jin-Song Liu, Yun-Peng Sun, Guo-Kai Wang

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引用次数: 0

摘要

从羊角草（Clinopodium chinense, Benth.）的地上部分中分离到25个化合物。包括8种三萜（1-8）、9种黄酮类化合物（9-17）、3种巨藤甲烷（18-20）、4种苯丙素（21-24）和1种酚类化合物（25）。用核磁共振光谱对其结构进行了分析，并与文献资料进行了对比验证。其中化合物3、4为首次从该植物中分离得到。其中化合物23为首次从该属植物中分离得到。其中化合物18、19、24和25为首次从该科中分离得到。3、7、23和25表现出显著的抗炎活性，其中7表现出最强的抑制作用（IC50 = 3.33±0.52 μM）。此外，还对分离化合物的化学分类意义进行了详细的讨论。这些发现不仅为评价兰科植物与其他植物科之间的系统发育关系提供了化学分类证据，而且大大扩展了兰科植物中已知的特化代谢物的结构多样性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Chemical constituents from Clinopodium chinense and their chemotaxonomic significance

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Chemical constituents from Clinopodium chinense and their chemotaxonomic significance

Twenty-five compounds were isolated from the aerial parts of Clinopodium chinense (Benth.) O. Kuntze, including eight triterpenoids (1–8), nine flavonoids (9–17), three megastigmanes (18–20), four phenylpropanoids (21–24), and one phenolic compound (25). Their structures were elucidated using NMR spectroscopy and verified by comparison with literature data. Among them, compounds 3 and 4 were obtained from this plant for the first time. Compounds 23 was isolated for the first time from the genus Clinopodium. Compounds 18, 19, 24, and 25 were reported for the first time in the family Lamiaceae. Additionally, 3, 7, 23, and 25 exhibited notable anti-inflammatory activity, with 7 displaying the most potent inhibitory effect (IC₅₀ = 3.33 ± 0.52 μM). Furthermore, a detailed discussion was provided regarding the chemotaxonomic significance of the isolated compounds. These findings not only offer chemotaxonomic evidence for evaluating the phylogenetic relationships between Lamiaceae and other plant families, but also substantially expand the known structural diversity of specialized metabolites within this family.

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来源期刊

Biochemical Systematics and Ecology 生物-进化生物学

CiteScore

3.00

自引率

12.50%

发文量

147

审稿时长

43 days

期刊介绍： Biochemical Systematics and Ecology is devoted to the publication of original papers and reviews, both submitted and invited, in two subject areas: I) the application of biochemistry to problems relating to systematic biology of organisms (biochemical systematics); II) the role of biochemistry in interactions between organisms or between an organism and its environment (biochemical ecology). In the Biochemical Systematics subject area, comparative studies of the distribution of (secondary) metabolites within a wider taxon (e.g. genus or family) are welcome. Comparative studies, encompassing multiple accessions of each of the taxa within their distribution are particularly encouraged. Welcome are also studies combining classical chemosystematic studies (such as comparative HPLC-MS or GC-MS investigations) with (macro-) molecular phylogenetic studies. Studies that involve the comparative use of compounds to help differentiate among species such as adulterants or substitutes that illustrate the applied use of chemosystematics are welcome. In contrast, studies solely employing macromolecular phylogenetic techniques (gene sequences, RAPD studies etc.) will be considered out of scope. Discouraged are manuscripts that report known or new compounds from a single source taxon without addressing a systematic hypothesis. Also considered out of scope are studies using outdated and hard to reproduce macromolecular techniques such as RAPDs in combination with standard chemosystematic techniques such as GC-FID and GC-MS.