Behavioral neuroscience最新文献_第5页

Emerging role of the lateral habenula in conditioned inhibition and depression. 外侧哈文脑在条件性抑制和抑郁中的新作用

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2024-04-18 DOI: 10.1037/bne0000586

In-Beom Jin, Nam-Heon Kim, Jung-Soo Han

{"title":"Emerging role of the lateral habenula in conditioned inhibition and depression.","authors":"In-Beom Jin, Nam-Heon Kim, Jung-Soo Han","doi":"10.1037/bne0000586","DOIUrl":"https://doi.org/10.1037/bne0000586","url":null,"abstract":"Associating a neutral conditioned stimulus (CS) with the absence of a biologically significant unconditioned stimulus (US) confers conditioned inhibitory properties upon the CS, referred to as conditioned inhibition. Conditioned inhibition and conditioned excitation, an association of a CS with the presence of the US, are fundamental components of associative learning. While the neural substrates of conditioned excitation are well established, those of conditioned inhibition remain poorly understood. Recent research has shed light on the lateral habenula (LHb) engagement in conditioned inhibition, along with the midbrain dopaminergic neurons. This article reviews behavioral tasks conducted to assess conditioned inhibition and how experimental LHb manipulations affect performance in these tasks. These results underscore the critical role of the LHb in conditioned inhibition. Intriguingly, stress increases LHb reactivity and impairs performances in tasks consisting of a component of conditioned inhibition in animals. Dysfunction of the LHb is observed in patients with depression. The ability of an organism to perform conditioned inhibition is closely linked to altered neuronal activity in the LHb, which has implications for mental disorders. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"3 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140630767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naturalistic housing condition promotes behavioral flexibility and increases resilience to stress in rats. 自然的饲养条件可促进大鼠行为的灵活性，并增强其对压力的适应能力。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2024-04-18 DOI: 10.1037/bne0000597

Nicoli Caratti, Ana Paula Crestani, Jordana Griebler Luft, Lucas de Oliveira Alvares

引用次数: 0

Translational research in punishment learning. 惩罚性学习的转化研究。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2024-04-18 DOI: 10.1037/bne0000587

Philip Jean-Richard-Dit-Bressel, Kelly Gaetani, Lilith Zeng, Gabrielle Weidemann, Gavan P McNally

引用次数: 0

Mediated learning: A computational rendering of ketamine-induced symptoms. 中介学习：氯胺酮诱发症状的计算呈现。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2024-04-18 DOI: 10.1037/bne0000591

Esther Mondragón

引用次数: 0

Variability in odor hedonic perception: A challenge for neurosensory and behavioral research. 气味享乐感的可变性：神经感觉和行为研究面临的挑战。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2024-04-18 DOI: 10.1037/bne0000595

Charlotte Bontempi, Gérard Brand, Laurence Jacquot

{"title":"Variability in odor hedonic perception: A challenge for neurosensory and behavioral research.","authors":"Charlotte Bontempi, Gérard Brand, Laurence Jacquot","doi":"10.1037/bne0000595","DOIUrl":"https://doi.org/10.1037/bne0000595","url":null,"abstract":"Odor hedonic perception (pleasant/unpleasant character) is considered to be the first and one of the most important dimensions in olfaction and is known to be highly variable and dependent on several factors related to the stimulus, individual characteristics, and context. Although numerous experimental studies have been published on this topic, there is no comprehensive general review on the variability in odor hedonic perception. Therefore, the aim of this article was to describe and detail all the factors involved in the variability in odor hedonic perception. Stimulus properties-related variability includes the concentration/intensity and the physicochemical properties. Individual-related variability includes sex, age, and physiological state characteristics, while context-related variability involves factors associated with the stimulation context, such as stimulation pathway, exposure frequency, verbal influences, cross-modal associations, hedonic contrast, and cultural background. Subsequently, a section is devoted to the brain processing of odor hedonicity, although its role in odor hedonic variability is largely unknown. Finally, the article discusses the relationship between the hedonic qualities of odors and the resulting behavioral responses in both animals and humans. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"15 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140630837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psilocybe cubensis extract potently prevents fear memory recall and freezing behavior in short- but not long-term in a rat model of posttraumatic stress disorder. 在创伤后应激障碍大鼠模型中，西洛贝提取物能有效防止恐惧记忆回忆和冻结行为的短期而非长期发生。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2024-04-01 Epub Date: 2024-01-18 DOI: 10.1037/bne0000579

Zahra Ghofrani-Jahromi, Sarah Nouri-Darehno, Mehrsa Rahimi-Danesh, Nastaran Talaee, Eghbal Jasemi, Ali Razmi, Salar Vaseghi

{"title":"Psilocybe cubensis extract potently prevents fear memory recall and freezing behavior in short- but not long-term in a rat model of posttraumatic stress disorder.","authors":"Zahra Ghofrani-Jahromi, Sarah Nouri-Darehno, Mehrsa Rahimi-Danesh, Nastaran Talaee, Eghbal Jasemi, Ali Razmi, Salar Vaseghi","doi":"10.1037/bne0000579","DOIUrl":"10.1037/bne0000579","url":null,"abstract":"Psilocybe cubensis is a species of psilocybin mushroom (magic mushroom) of moderate potency whose principal active compounds are psilocybin and psilocin. Recent studies have shown the significant procognitive and mood-enhancer effects of Psilocybe cubensis. However, evidence is so limited, especially in preclinical studies. We aimed to investigate the effect of Psilocybe cubensis extract on posttraumatic stress disorder (PTSD)-like behavior, pain perception, locomotor activity, and anxiety in a rat model of PTSD. Male rats were exposed to three consecutive shocks (0.8 mA, 3 s interval) paired with three sounds broadcasted 3 s before delivering shocks (75 dB, 3 s). After 1, 3, or 21 days, freezing rate was measured in the fear-conditioning apparatus. Open filed test and hot plate were used to assess locomotor activity and anxiety, and pain subthreshold, respectively. Psilocybe cubensis was injected intraperitoneal at the dose of 25 mg/kg (single administration) before (pretrain) or after (posttrain) shocks, or before the test (pretest). Results showed psilocybin potently alleviated PTSD symptom is short- but not long-term after the induction of PTSD. Psilocybe cubensis decreased locomotor activity only in a short period after administration. Psilocybe cubensis also increased pain subthreshold and decreased anxiety. In conclusion, Psilocybe cubensis effects on PTSD-like behavior and locomotor activity seem to be remained in short-term, while Psilocybe cubensis effects on pain subthreshold and anxiety remained long-term. This is the first study evaluating the effect of Psilocybe cubensis on PTSD-like behavior in rats in three different time protocols (1, 3, and 21 days after fear conditioning). (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"73-84"},"PeriodicalIF":1.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139485082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kamin blocking is disrupted by low-dose ketamine in mice: Further implications for aberrant stimulus processing in schizophrenia. 小鼠体内低剂量氯胺酮破坏Kamin阻断：对精神分裂症异常刺激处理的进一步启示。

IF 1.6 4区医学

Behavioral neuroscience Pub Date : 2024-02-01 Epub Date: 2023-09-28 DOI: 10.1037/bne0000572

Riria Suzuki, Kenji Yamaguchi, Yutaka Kosaki

{"title":"Kamin blocking is disrupted by low-dose ketamine in mice: Further implications for aberrant stimulus processing in schizophrenia.","authors":"Riria Suzuki, Kenji Yamaguchi, Yutaka Kosaki","doi":"10.1037/bne0000572","DOIUrl":"10.1037/bne0000572","url":null,"abstract":"Previous studies have shown that low doses of ketamine, an N-methyl-D-aspartate receptor antagonist, produce aberrantly strong internal representations of associatively activated but absent stimuli in humans and nonhuman animals, suggesting the validity of ketamine treatment as a preclinical model of the positive symptoms of schizophrenia, including hallucinations and delusions. However, whether acute ketamine treatment also impairs the ability to ignore present but informationally redundant stimuli, which is another hallmark of schizophrenia, remains unclear. Accordingly, the present study investigated whether injections of low-dose ketamine attenuate Kamin blocking in an appetitive conditioning preparation in mice. Mice in the blocking group were initially trained with A+ conditioning (i.e., conditioned stimulus A paired with a sucrose solution), followed by compound AX+ training, before the conditioned responses to the cue X were tested in extinction. The animals in the control group received B+ training before the AX+ training. Half of the mice in each group received an injection of 16 mg/kg ketamine before each compound conditioning session and the extinction test, whereas the other half received saline. The results showed a reliable blocking effect in the saline-treated mice, whereas the blocking effect was absent in the ketamine-treated mice. Specifically, the absence of blocking was due to the ketamine-treated mice learning about the blocked cues. This finding further validates the use of low-dose ketamine as a preclinical model of schizophrenia. It also suggests a possible link between hallucination-like aberrant processing of absent events and a reduced ability to suppress attentional processing of task-irrelevant stimuli. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"30-42"},"PeriodicalIF":1.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41116040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictions about reward outcomes in rhesus monkeys. 对恒河猴奖励结果的预测。

IF 1.6 4区医学

Behavioral neuroscience Pub Date : 2024-02-01 Epub Date: 2023-12-07 DOI: 10.1037/bne0000573

Yiyun Huang, Hayoung Chang, Laurie R Santos, Alexandra G Rosati

{"title":"Predictions about reward outcomes in rhesus monkeys.","authors":"Yiyun Huang, Hayoung Chang, Laurie R Santos, Alexandra G Rosati","doi":"10.1037/bne0000573","DOIUrl":"10.1037/bne0000573","url":null,"abstract":"Human infants and nonhuman animals respond to surprising events by looking longer at unexpected than expected situations. These looking responses provide core cognitive evidence that nonverbal minds make predictions about possible outcomes and detect when these predictions fail to match reality. We propose that this phenomenon has crucial parallels with the processes of reward prediction error, indexing the difference between expected and actual reward outcomes. Most work on reward prediction errors to date involves neurobiological techniques that cannot be implemented in many relevant populations, so we developed a novel behavioral task to assess monkeys' predictions about reward outcomes using looking time responses. In Study 1, we tested how semi-free-ranging monkeys (n = 210) responded to positive error (more rewards than expected), negative error (less rewards than expected), and a number control. We found that monkeys looked longer at a given reward when it was unexpectedly large or small, compared to when the same quantity was expected. In Study 2, we compared responses in the positive error condition in monkeys ranging from infancy to old age (n = 363), to assess lifespan changes in sensitivity to reward predictions. We found that adolescent monkeys showed heightened responses to unexpected rewards, similar to patterns seen in humans, but showed no changes during aging. These results suggest that monkeys' looking responses can be used to track their predictions about rewards, and that monkeys share some developmental signatures of reward sensitivity with humans, providing a new approach to access cognitive processes underlying reward-based decision making. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"43-58"},"PeriodicalIF":1.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138497714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can the resting state peak alpha frequency explain the relationship between temporal resolution power and psychometric intelligence? 静息状态的峰值阿尔法频率能解释时间分辨能力和心理智力之间的关系吗？

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2024-02-01 Epub Date: 2023-10-05 DOI: 10.1037/bne0000571

Lisa M Makowski, Stefan J Troche

{"title":"Can the resting state peak alpha frequency explain the relationship between temporal resolution power and psychometric intelligence?","authors":"Lisa M Makowski, Stefan J Troche","doi":"10.1037/bne0000571","DOIUrl":"10.1037/bne0000571","url":null,"abstract":"The temporal resolution power (TRP) hypothesis states that individuals with higher TRP, as reflected by a higher performance on several psychophysical timing tasks, perform better on intelligence tests due to their ability to process information faster and coordinate their mental operations more effectively. It is proposed that these differences in TRP are related to the rate of a master clock based on neural oscillations. The present study aimed to investigate whether the peak alpha frequency (PAF) measured via electroencephalography (EEG) reflects a psychophysiological measure of this rate and its potential role in explaining the relationship between TRP and psychometric intelligence. A sample of 129 young adults (M = 23.0, SD = 3.1) completed a short version of Raven's Advanced Progressives Matrices and three timing tasks. PAF was measured using EEG before each timing task during two resting states with eyes closed (EC) and eyes open (EO), respectively. From these PAF measurements, four latent PAF variables were extracted, differing in resting state (EC, EO) and electrode cluster (frontal/central, parietal/occipital). The results confirmed a strong association between TRP and psychometric intelligence (r = .56, p < .01), as previously reported in other studies. Additionally, we found a positive association between intelligence and a latent PAF variable extracted from frontal/central electrodes in the EO resting state conditions (r = .27, p < .05). However, there was no association between TRP and PAF. This indicates that PAF does not reflect the underlying psychophysiological mechanism that links TRP to intelligence. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"15-29"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41099759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphine exposure during adolescence induces enduring social changes dependent on adolescent stage of exposure, sex, and social test. 青少年时期接触吗啡会诱发持久的社会变化，这取决于接触吗啡的青少年阶段、性别和社会测试。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2024-02-01 Epub Date: 2023-12-21 DOI: 10.1037/bne0000567

David N King'uyu, Erin L Edgar, Christopher Figueroa, J M Kirkland, Ashley M Kopec

{"title":"Morphine exposure during adolescence induces enduring social changes dependent on adolescent stage of exposure, sex, and social test.","authors":"David N King'uyu, Erin L Edgar, Christopher Figueroa, J M Kirkland, Ashley M Kopec","doi":"10.1037/bne0000567","DOIUrl":"10.1037/bne0000567","url":null,"abstract":"Drug exposure during adolescence, when the \"reward\" circuitry of the brain is developing, can permanently impact reward-related behavior into adulthood. Epidemiological studies show that opioid treatment during adolescence, such as pain management for a dental procedure or surgery, increases the incidence of psychiatric illness including substance use disorders. Moreover, the opioid epidemic currently in the United States is affecting younger individuals raising the impetus to understand the pathogenesis of the negative effects of opioids. One reward-related behavior that develops during adolescence is social behavior. We previously demonstrated that developmental changes in the nucleus accumbens reward region regulate social development in rats during sex-specific adolescent periods: early to mid-adolescence in males (postnatal day, P30-40) and preearly adolescence in females (P20-30). We thus hypothesized that the developmental stage of morphine exposure will differentially impact social behavior development such that drug administered during the female critical period would result in adult sociability deficits in females, but not males, and morphine administered during the male critical period would result in adult sociability deficits in males, but not females. We found that morphine exposure during the female critical period primarily resulted in deficits in sociability in females, while morphine exposure during the male critical period primarily resulted in deficits in sociability primarily in males. However, depending on the test performed and the social parameter measured, social alterations could be found in both sexes that received morphine exposure at either adolescent stage. These data indicate that when drug exposure occurs during adolescence, and how the endpoint data are measured, will play a large role in determining the effects of drug exposures on social development. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"59-71"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0