Behavioral neuroscience最新文献_第10页

Effects of a cue associated with cocaine or food reinforcers on extinction and postextinction return of behavior. 与可卡因或食物强化物相关的线索对灭绝和灭绝后行为恢复的影响。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2022-08-01 DOI: 10.1037/bne0000519

David S Jacobs, Leah N Hitchcock, Rapheal G Williams, K Matthew Lattal

{"title":"Effects of a cue associated with cocaine or food reinforcers on extinction and postextinction return of behavior.","authors":"David S Jacobs, Leah N Hitchcock, Rapheal G Williams, K Matthew Lattal","doi":"10.1037/bne0000519","DOIUrl":"https://doi.org/10.1037/bne0000519","url":null,"abstract":"Studies of instrumental responding often include the delivery of a cue that is coincident with the delivery of the reinforcer. One purpose of this is for the cue to be removed during extinction and then presented later to assess whether responding returns (cue-induced reinstatement). In two experiments, we examined the effects of having a cue associated with reinforcement present or absent during extinction. In Experiment 1, the cue was associated with fixed ratio responding for intravenous cocaine or food pellets in one context (Context A), followed by extinction in another context (Context B), where responding produced the cue in one group but did not produce the cue in the other group. Afterward, contextual renewal was assessed with and without the cue in Context A. During extinction, a cue previously associated with cocaine reinforcement caused an increase in responding initially (an extinction burst) and throughout 16 2-hr extinction sessions, as well as weakened contextual renewal when animals were tested with the cue in Context A. In contrast, there were few detectable effects of the cue on extinction and contextual renewal when food pellets were the reinforcer. In Experiment 2, effects of a cue during extinction of progressive ratio responding were revealed with food pellets when animals showed weakened responding on the initial trials of postextinction reacquisition sessions. These experiments demonstrate that the presence of a cue associated with reinforcement during extinction may prolong responding in the short term while creating a more persistent form of extinction that resists relapse. (PsycInfo Database Record (c) 2022 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"136 4","pages":"307-317"},"PeriodicalIF":1.9,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477211/pdf/nihms-1826587.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9916707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Hormonal contraceptives alter amphetamine place preference and responsivity in the intact female rat. 激素避孕药改变安非他明在完整雌性大鼠的位置偏好和反应性。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2022-08-01 DOI: 10.1037/bne0000520

Emily N Hilz, Marcelle E Olvera, Dohyun Jun, Megha Chadha, Ross Gillette, Marie-H Monfils, Andrea C Gore, Hongjoo J Lee

{"title":"Hormonal contraceptives alter amphetamine place preference and responsivity in the intact female rat.","authors":"Emily N Hilz, Marcelle E Olvera, Dohyun Jun, Megha Chadha, Ross Gillette, Marie-H Monfils, Andrea C Gore, Hongjoo J Lee","doi":"10.1037/bne0000520","DOIUrl":"https://doi.org/10.1037/bne0000520","url":null,"abstract":"Hormonal contraceptives (HCs) containing synthetic ovarian hormones are commonly used among reproductive aged women; HCs alter the physiological state of the user by interfering with endogenous hormone concentrations and their actions on the reproductive tract. As ovarian hormones modulate the incidence of substance abuse disorders in women, this experiment explores how modulating female rat ovarian hormonal states with an HC containing the synthetic progestin levonorgestrel influences measures of drug preference and responsivity. First, rats underwent food-light Pavlovian conditioning to measure conditioned orienting, a known predictor of amphetamine (AMP) place preference. Then, rats were conditioned and tested for AMP place preference with either an HC implant or during estrous cycle stages associated with opposing ovarian hormone levels, that is, proestrus (P) or metestrus/diestrus (M/D), while recording ultrasonic vocalizations (USVs) as an index of he donic drug responsivity. Because of dopamine's (DA's) role in reward learning and memory, DA cell number and activity were examined using tyrosine hydroxylase and FOS immunohistochemistry after a final AMP challenge. Conditioned orienting did not differ between cycling and HC-implanted rats. HC rats emitted fewer USVs in response to AMP, showed marginally less AMP place preference, and had lower DA cell activity in the substantia nigra after AMP compared to P rats. M/D rats showed a similar behavioral profile and neural response as HC rats. This experiment suggests ovarian hormones affect drug preference and responsivity, while providing novel insight into how hormone-altering contraceptives may reduce these measures. (PsycInfo Database Record (c) 2022 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"136 4","pages":"318-329"},"PeriodicalIF":1.9,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9091683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Surprise-induced enhancements in the associability of Pavlovian cues facilitate learning across behavior systems. 惊喜引起的巴甫洛夫线索联想性的增强促进了跨行为系统的学习。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2022-08-01 DOI: 10.1037/bne0000505

Inmaculada Márquez, Gabriel Loewinger, Juan Pedro Vargas, Juan Carlos López, Estrella Díaz, Guillem R Esber

{"title":"Surprise-induced enhancements in the associability of Pavlovian cues facilitate learning across behavior systems.","authors":"Inmaculada Márquez, Gabriel Loewinger, Juan Pedro Vargas, Juan Carlos López, Estrella Díaz, Guillem R Esber","doi":"10.1037/bne0000505","DOIUrl":"https://doi.org/10.1037/bne0000505","url":null,"abstract":"Surprising violations of outcome expectancies have long been known to enhance the associability of Pavlovian cues; that is, the rate at which the cue enters into further associations. The adaptive value of such enhancements resides in promoting new learning in the face of uncertainty. However, it is unclear whether associability enhancements reflect increased associative plasticity within a particular behavior system, or whether they can facilitate learning between a cue and any arbitrary outcome, as suggested by attentional models of conditioning. Here, we show evidence consistent with the latter hypothesis. Violating the outcome expectancies generated by a cue in an appetitive setting (feeding behavior system) facilitated subsequent learning about the cue in an aversive setting (defense behavior system). In addition to shedding light on the nature of associability enhancements, our findings offer the neuroscientist a behavioral tool to dissociate their neural substrates from those of other, behavior system- or valence-specific changes. Moreover, our results present an opportunity to utilize associability enhancements to the advantage of counterconditioning procedures in therapeutic contexts. (PsycInfo Database Record (c) 2022 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"136 4","pages":"285-292"},"PeriodicalIF":1.9,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396881/pdf/nihms-1825158.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9915692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time to contrast models of timing: The structure of temporal memory. 时间与时间模型的对比:时间记忆的结构。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2022-06-02 DOI: 10.1037/bne0000521

A. Machado, Marilia Pinheiro de Carvalho, Marco Vasconcelos

引用次数: 1

Delayed but not immediate effects of estrogen curtail gamma-aminobutyric acid-mediated feeding responses elicited from the nucleus accumbens shell. 雌激素延迟但不是立即的影响减少-氨基丁酸介导的喂养反应引起的伏隔核壳。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2022-06-01 DOI: 10.1037/bne0000511

Julio C Diaz, Kate Dunaway, Elizabeth Sheil, Ken Sadeghian, Anthony Auger, Brian A Baldo

{"title":"Delayed but not immediate effects of estrogen curtail gamma-aminobutyric acid-mediated feeding responses elicited from the nucleus accumbens shell.","authors":"Julio C Diaz, Kate Dunaway, Elizabeth Sheil, Ken Sadeghian, Anthony Auger, Brian A Baldo","doi":"10.1037/bne0000511","DOIUrl":"https://doi.org/10.1037/bne0000511","url":null,"abstract":"The present study investigated immediate versus delayed effects of estrogen replacement in ovariectomized (OVX) rats on hyperphagia elicited by gamma-aminobutyric acid (GABA)-A-agonist (muscimol) infusions into the nucleus accumbens shell (AcbSh). First, because intra-AcbSh muscimol-induced feeding has never been explored in OVX rats, a dose-effect curve was generated and compared to sham-operated males, the current point of reference in the literature. Muscimol (5, 10, 25, and 50 ng) increased food intake in both sexes, and both sexes reached the same asymptotic level of intake. Nevertheless, slopes of the linearized dose-effect functions for males and OVX females differed significantly, with females starting at a lower baseline and exhibiting a steeper slope. Next, the behavioral profiles of a behaviorally active, but nonmaximal intra-AcbSh muscimol dose (25 ng), were examined in a separate group of OVX females at two time-points: immediately after injecting 17β-estradiol 3-benzoate (EB) subcutaneously (5 μg), and 24 hr post-EB. Delayed, but not immediate, EB pretreatment suppressed, but did not eliminate, muscimol-driven food intake. However, EB did not change nonfood-directed behaviors such as locomotion or rearing. These results demonstrate that feeding mediated by intra-AcbSh GABA-A receptors is delimited by delayed, but not rapid, effects of estradiol. (PsycInfo Database Record (c) 2022 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"136 3","pages":"219-229"},"PeriodicalIF":1.9,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450853/pdf/nihms-1825171.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9554446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Chronic cocaine causes age-dependent increases in risky choice in both males and females. 慢性可卡因导致男性和女性的风险选择随年龄增长而增加。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2022-06-01 DOI: 10.1037/bne0000509

Shelby L Blaes, Kristy G Shimp, Sara M Betzhold, Barry Setlow, Caitlin A Orsini

{"title":"Chronic cocaine causes age-dependent increases in risky choice in both males and females.","authors":"Shelby L Blaes, Kristy G Shimp, Sara M Betzhold, Barry Setlow, Caitlin A Orsini","doi":"10.1037/bne0000509","DOIUrl":"https://doi.org/10.1037/bne0000509","url":null,"abstract":"Individuals who use cocaine exhibit maladaptive decision-making, overweighting rewards, and underweighting potential risks. We previously showed that chronic cocaine self-administration in young adult male rats causes long-lasting increases in risk taking. The present study expanded upon these findings to determine whether effects of cocaine on risk taking depend on the route of cocaine administration and extend to females. To address the former question, rats in Experiment 1 were trained on the Risky Decision-making Task (RDT), received passively administered cocaine, and were retested in the RDT. Surprisingly, passive cocaine had no effect on risk taking. Experiment 2 determined whether cocaine self-administration increases risk taking in females in a manner comparable to males. Males and females were trained in the RDT, underwent cocaine self-administration, and were retested in the RDT. Unexpectedly, cocaine self-administration had no effect on risk taking in either sex. Because Experiments 1 and 2 involved cocaine exposure at a considerably older age than in previous work, Experiments 3 and 4 determined if cocaine effects on risk taking depend on the age of exposure. Rats began cocaine self-administration at postnatal (PN) day 77 (Experiment 3) or passive cocaine injections starting on PN day 63 (Experiment 4) and were tested in the RDT 3 weeks after cocaine cessation. In these experiments, cocaine increased risk taking in both sexes. These results reveal a limited time window during young adulthood of vulnerability to the effects of chronic cocaine on risk taking. (PsycInfo Database Record (c) 2022 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"136 3","pages":"243-263"},"PeriodicalIF":1.9,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346435/pdf/nihms-1825631.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9553995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Are observed effects of movement simulated during motor imagery performance? 在运动图像表现过程中，观察到的运动效果是否模拟？

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2022-06-01 DOI: 10.1037/bne0000517

Jack P. Solomon, A. Hurst, JungWoo Lee, S. Boe

{"title":"Are observed effects of movement simulated during motor imagery performance?","authors":"Jack P. Solomon, A. Hurst, JungWoo Lee, S. Boe","doi":"10.1037/bne0000517","DOIUrl":"https://doi.org/10.1037/bne0000517","url":null,"abstract":"Motor learning relies on adjusting the performance of movements via error detection and correction. How motor learning proceeds via motor imagery, the imagination of movement, is not understood. Motor imagery-based learning is thought to rely on comparing the predicted effect of movement, resulting from the forward model, against its intended effect. Whether motor imagery-based learning uses the observed effect of movement, simulated in motor imagery, to make comparisons to the intended effect to permit error detection and correction, is an open question. To address this, transcranial magnetic stimulation was used to inhibit the left inferior parietal lobe (L_IPL) after each trial of a task requiring participants to reproduce complex trajectories via motor imagery. From past work, we speculated the L_IPL was a candidate for integrating simulated feedback about task performance (simulated observed effects), hypothesizing inhibition of the L_IPL would impair learning, suggesting simulated observed effects of movement are used in motor imagery-based learning. Participants received stimulation to the L_IPL or over the vertex of the head after each trial. Learning was defined as reduced error on a repeated trajectory in comparison to randomly generated trajectories. Regardless of group participants learned, a finding countering our hypothesis, suggesting (a) observed effects of movement are not simulated in motor imagery; (b) the L_IPL is not involved in integrating simulated observed effects of movement; or (c) the timing of the stimulation did not align with the speculated role of the L_IPL. Results encourage further research probing simulated feedback in motor imagery and its neural correlates. (PsycInfo Database Record (c) 2022 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"136 3 1","pages":"264-275"},"PeriodicalIF":1.9,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49077622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Delay discounting in aging: The influence of cognitive and psychological variables. 衰老中的延迟贴现:认知和心理变量的影响。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2022-05-23 DOI: 10.1037/bne0000518

I. Macedo, C. Fernandes, F. Barbosa, J. Marques-Teixeira

{"title":"Delay discounting in aging: The influence of cognitive and psychological variables.","authors":"I. Macedo, C. Fernandes, F. Barbosa, J. Marques-Teixeira","doi":"10.1037/bne0000518","DOIUrl":"https://doi.org/10.1037/bne0000518","url":null,"abstract":"Delay discounting (or temporal discounting) refers to the decrease of the subjective value of a reward as the time interval for receiving that reward increases. A recent meta-analysis showed that delay discounting appears to be similar across the lifespan as younger, middle-aged, and older adults prefer sooner rewards, despite smaller, over later rewards, even if larger. However further investigation is needed to understand the potential role of individual factors in delay discounting across the lifespan. The present study aimed to contribute to this debate, by investigating the influence of sociodemographic, neurocognitive, and psychological variables on delay discounting. For this purpose, 88 participants (30 younger, 30 middle-aged, and 28 older adults) aged between 19 and 73 years old completed the Monetary Choice Questionnaire (MCQ), a comprehensive battery of neurocognitive tests, and self-report measures of psychopathology. Results revealed no group differences in the rate of discounting. A well-established effect of the amount of the delayed reward was replicated, showing that medium rewards were less discounted than smaller rewards, and larger rewards had lower discounting rates than smaller and medium rewards-the magnitude effect. Regarding the influence of neurocognitive and psychological factors on delay discounting, better working memory, as assessed by the Corsi block-tapping task, significantly predicted larger magnitude effects. The findings of the current work are consistent with the results of previous studies, suggesting that temporal discounting is a stable function across the adult life span. (PsycInfo Database Record (c) 2022 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44738410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Supplemental Material for Delay Discounting in Aging: The Influence of Cognitive and Psychological Variables 衰老延迟折扣的补充材料：认知和心理变量的影响

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2022-05-05 DOI: 10.1037/bne0000518.supp

引用次数: 0

Quantifying the inverted U: A meta-analysis of prefrontal dopamine, D1 receptors, and working memory. 量化倒U:前额叶多巴胺、D1受体和工作记忆的荟萃分析。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2022-04-07 DOI: 10.1037/bne0000512

Matthew A Weber, Mackenzie M Conlon, Hannah R Stutt, Linder Wendt, Patrick Ten Eyck, Nandakumar S Narayanan

{"title":"Quantifying the inverted U: A meta-analysis of prefrontal dopamine, D1 receptors, and working memory.","authors":"Matthew A Weber, Mackenzie M Conlon, Hannah R Stutt, Linder Wendt, Patrick Ten Eyck, Nandakumar S Narayanan","doi":"10.1037/bne0000512","DOIUrl":"https://doi.org/10.1037/bne0000512","url":null,"abstract":"Dopamine in the prefrontal cortex can be disrupted in human disorders that affect cognitive function such as Parkinson's disease (PD), attention-deficit hyperactivity disorder (ADHD), and schizophrenia. Dopamine has a powerful effect on prefrontal circuits via the D1-type dopamine receptor (D1DR). It has been proposed that prefrontal dopamine has \"inverted U-shaped\" dynamics, with optimal dopamine and D1DR signaling required for peak cognitive function. However, the quantitative relationship between prefrontal dopamine and cognitive function is not clear. Here, we conducted a meta-analysis of published manipulations of prefrontal dopamine and the effects on working memory, a high-level executive function in humans, primates, and rodents that involves maintaining and manipulating information over seconds to minutes. We reviewed 646 articles and found that 75 studies met criteria for inclusion. Our quantification of effect sizes for dopamine, D1DRs, and behavior revealed a negative quadratic slope. This is consistent with the proposed inverted U-shape of prefrontal dopamine and D1DRs and working memory performance, explaining 10% of the variance. Of note, the inverted quadratic fit was much stronger for prefrontal D1DRs alone, explaining 26% of the variance, compared to prefrontal dopamine alone, explaining 10% of the variance. Taken together, these data, derived from a variety of manipulations and systems, demonstrate that optimal prefrontal dopamine signaling is linked with higher cognitive function. Our results provide insight into the fundamental dynamics of prefrontal dopamine, which could be useful for pharmacological interventions targeting prefrontal dopaminergic circuits, and into the pathophysiology of human brain disease. (PsycInfo Database Record (c) 2022 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"2 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138538649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0