Behavioral neuroscience最新文献

Pigs as large-animal models for translational behavioral neuroscience. 猪作为转化行为神经科学的大型动物模型。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2026-10-01 DOI: 10.1037/bne0000665

Alcides P Lorenzo Gonzalez, Leila M Allen, Horatiu V Vinerean, Valentina Roldan, Deirdre A Murphy, Timothy A Allen

{"title":"Pigs as large-animal models for translational behavioral neuroscience.","authors":"Alcides P Lorenzo Gonzalez, Leila M Allen, Horatiu V Vinerean, Valentina Roldan, Deirdre A Murphy, Timothy A Allen","doi":"10.1037/bne0000665","DOIUrl":"https://doi.org/10.1037/bne0000665","url":null,"abstract":"Model choice in behavioral neuroscience is often driven by convenience and established research pipelines, contributing to a persistent reliance on murine species. Although rodents are essential for discovery, their limited alignment with human brain architecture and clinical technologies can constrain translational inference. Here, we argue that the pig (Sus scrofa) is an underutilized large-animal model with substantial translational value due to its gyrencephalic brain, human-relevant physiology, and compatibility with clinical imaging and neurotechnology. We review evidence that pigs can support rigorous cognitive and behavioral testing, including spatial learning, recognition memory, and executive function, and we frame pigs as a cross-species replication and scaling platform for testing the generality of canonical brain-behavior relationships. We also outline ethical challenges, practical barriers, and infrastructure considerations relevant to laboratories adopting porcine behavioral neuroscience, including housing, handling, monitoring, regulatory oversight, surgical support, and growth-related design constraints. (PsycInfo Database Record (c) 2026 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prefrontal cortex activity of adolescents with problematic smartphone use in response to gains and losses: A functional near-infrared spectroscopy study. 智能手机使用问题青少年前额叶皮层活动对得失的反应：一项功能近红外光谱研究。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2026-10-01 Epub Date: 2026-09-10 DOI: 10.1037/bne0000668

Irene Tauste-Garcia, Ana Nieto-Ruiz, Maria Moreno-Padilla, Ignacio Martin-Tamayo, Juan Verdejo-Roman, Maria Jose Fernandez-Serrano

{"title":"Prefrontal cortex activity of adolescents with problematic smartphone use in response to gains and losses: A functional near-infrared spectroscopy study.","authors":"Irene Tauste-Garcia, Ana Nieto-Ruiz, Maria Moreno-Padilla, Ignacio Martin-Tamayo, Juan Verdejo-Roman, Maria Jose Fernandez-Serrano","doi":"10.1037/bne0000668","DOIUrl":"10.1037/bne0000668","url":null,"abstract":"Problematic smartphone use (PSU) has become a widespread problem that is highly prevalent in adolescent population. Previous studies suggest that PSU is associated with impairment in reward processing system. Thus, increased sensitivity to rewards could make individuals more vulnerable to abusive behaviors, such as PSU. However, little is known about its underlying neural mechanisms. This study aimed to investigate the neural correlates of reward and punishment processing in adolescents with PSU by evaluating the hemodynamic responses to monetary gains and losses using functional near-infrared spectroscopy. Seventy adolescents (aged 13-18 years) participated in the present study. They were categorized into two groups based on their level of PSU: 36 problematic smartphone users and 34 nonproblematic smartphone users, who were matched for age and sex. Changes in oxygenated hemoglobin levels in the prefrontal cortex were measured using a 22-channel functional near-infrared spectroscopy system during the performance of the Iowa Gambling Task. Additionally, participants completed a Sensitivity to Punishment and Sensitivity to Reward Questionnaire. Our results showed that problematic smartphone users exhibited heightened sensitivity to reward than nonproblematic smartphone users, but no significant differences in oxygenated hemoglobin level changes between both groups were found. These results suggest that increased sensitivity to reward could make smartphone users more vulnerable to abusive behaviors related to these devices. However, PSU does not follow the same brain patterns as other addictions in processing monetary rewards. (PsycInfo Database Record (c) 2026 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"339-351"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148928918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel rat spatial inference task reveals rapid deduction of transitive relationships using schemas and deliberation. 一种新的大鼠空间推理任务揭示了使用图式和审议的传递关系的快速演绎。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2026-10-01 Epub Date: 2026-07-13 DOI: 10.1037/bne0000660

Blake S Porter, Catherine Shi, Evgeniia Kozlova, Shantanu P Jadhav

{"title":"A novel rat spatial inference task reveals rapid deduction of transitive relationships using schemas and deliberation.","authors":"Blake S Porter, Catherine Shi, Evgeniia Kozlova, Shantanu P Jadhav","doi":"10.1037/bne0000660","DOIUrl":"10.1037/bne0000660","url":null,"abstract":"Inferential reasoning is a vital cognitive ability that enables animals to navigate novel situations by leveraging existing relational knowledge of memory schema, with hypothesized roles of prefrontal cortical-hippocampal circuits. Transitive inference (TI) tasks test the ability of subjects to infer relationships within a value hierarchy (e.g., A > B > C > D > E) after being trained only on adjacent premise pairs (e.g., A-B, B-C, etc.). In rodents, current TI paradigms are primarily based on odor-cues and have several limitations that preclude investigation of physiological mechanisms underlying schemas and inference-based choice. To address these challenges, we developed a novel, automated spatial TI task for rats using a radial maze with maze arms as premise elements and a dedicated deliberation zone. Most rats successfully learned the premise pairs over training. Further, animals demonstrated rapid, successful inference (test pair B > D and control pair A > E) within a single test session, with higher initial accuracy than comparable premise pairs, indicating the use of schema-based inference. We also investigated vicarious trial-and-error's (VTE), a behavioral correlate of spatial deliberation. VTE behavior was elevated on choice trajectories early in learning, when novel premise pairs were introduced, and generally for incorrect trials, corresponding to the hypothesized association of VTE's with uncertainty. Further, rats also exhibited elevated VTE behavior with high variability during inference testing, with individual variability suggestive of varying strengths of schema usage. Our findings demonstrate the feasibility of a rodent spatial TI task that provides new insights into the behavioral correlates of schemas and inference-based choices. (PsycInfo Database Record (c) 2026 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"279-295"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13367382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148435074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topiramate and anterior cingulate cortex high-frequency stimulation mitigate aggression and promote sociability in socially isolated male mice. 托吡酯和前扣带皮层高频刺激减轻了社会孤立雄性小鼠的攻击性并促进了社交性。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2026-10-01 Epub Date: 2026-08-10 DOI: 10.1037/bne0000663

Ilias Chaibi, Fatima-Zahra Lamghari Moubarrad, Mohamed Bennis, Saadia Ba-M'hamed

{"title":"Topiramate and anterior cingulate cortex high-frequency stimulation mitigate aggression and promote sociability in socially isolated male mice.","authors":"Ilias Chaibi, Fatima-Zahra Lamghari Moubarrad, Mohamed Bennis, Saadia Ba-M'hamed","doi":"10.1037/bne0000663","DOIUrl":"10.1037/bne0000663","url":null,"abstract":"Excessive aggression induced by social isolation (SI) has been closely linked to dysfunction in prefrontal circuits, particularly the anterior cingulate cortex (ACC). Topiramate, an antiepileptic drug known to enhance GABAergic and inhibit glutamatergic transmission, has demonstrated antiaggressive effects. In our previous work, we showed that topiramate's antiaggressive effects were associated with reduced neuronal death, improved neuronal morphology, and attenuated neuroinflammation in the ACC following SI. However, its impact on ACC neuronal activity remains poorly understood. In this study, we investigated the effects of topiramate on the spontaneous activity of ACC neurons in a mouse model of SI-induced aggression. Additionally, we explored whether direct restoration of ACC activity via high-frequency stimulation could similarly reduce excessive aggression. Systemic administration of topiramate (30 mg/kg, intraperitoneally) significantly increased attack latency, reduced attack frequency, and enhanced sociability. In vivo extracellular recording of spontaneous activity revealed a 50% reduction in ACC firing in isolated mice, which was partially restored (∼30%) by topiramate treatment. Moreover, high-frequency stimulation applied to the ACC markedly decreased aggressive behavior and robustly promoted social interaction. Together, these results provide convergent behavioral and electrophysiological evidence that SI-induced aggression is associated with ACC hypoactivity. The finding that both topiramate treatment and high-frequency stimulation of the ACC effectively reversed these deficits highlights the ACC as a key target for therapeutic interventions to treat aggression-related neuropsychiatric conditions. (PsycInfo Database Record (c) 2026 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"327-338"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is memory spared in monkeys with selective lesions of the hippocampus? 海马体选择性损伤的猴子能保留记忆吗？

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2026-10-01 Epub Date: 2026-08-03 DOI: 10.1037/bne0000658

Bo Zhang, Jeffrey M Long, Sania G Fong, Jennifer Young, Terrence Pleasant, Evelyn J Perez, Howard Eichenbaum, Cindy A Buckmaster, Elisabeth A Murray, Peter R Rapp

{"title":"Is memory spared in monkeys with selective lesions of the hippocampus?","authors":"Bo Zhang, Jeffrey M Long, Sania G Fong, Jennifer Young, Terrence Pleasant, Evelyn J Perez, Howard Eichenbaum, Cindy A Buckmaster, Elisabeth A Murray, Peter R Rapp","doi":"10.1037/bne0000658","DOIUrl":"10.1037/bne0000658","url":null,"abstract":"Normal explicit/declarative memory requires a system of anatomically related structures in the medial temporal lobe that includes the hippocampus and the entorhinal, perirhinal, and parahippocampal cortex. Although extensive medial temporal lobe damage in primates causes robust anterograde amnesia, defining the contribution of the hippocampus proper has proved challenging. We revisited that enduring puzzle here, directly addressing a number of factors suspected to contribute to conflicting results across earlier studies. Among them, we explored the effects of selective hippocampus lesions produced by two common excitotoxin methods, ibotenic acid and N-methyl-D-aspartic acid. Sample sizes were substantial, and all behavioral testing was conducted postoperatively. Performance was assessed on several standard procedures designed for monkeys, including multiple variants of the delayed nonmatching-to-sample test of visual object recognition, a series of rapidly acquired two-choice object discriminations, and a delayed response test of spatiotemporal memory. We used task-specific parametric manipulations (e.g., increasing retention intervals and reduced stimulus set size) to systematically vary demands on memory and test/retest analyses to enhance sensitivity for detecting impairment. Although both lesion groups sustained substantial hippocampal damage, their performance failed to differ from that of intact controls on any task, under any key test condition, regardless of data analytic strategy. The findings constrain plausible accounts of extant discrepancies in the literature and, moreover, highlight the need for fresh perspectives on the core operating characteristics of memory mediated by the primate hippocampus. (PsycInfo Database Record (c) 2026 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"310-326"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13437031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distal pup cues attenuate defensive reactivity and fear-potentiated startle magnitude in postpartum rats without altering sensorimotor gating. 幼崽远端提示在不改变感觉运动门控的情况下减弱产后大鼠的防御反应和恐惧增强的惊吓强度。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2026-10-01 Epub Date: 2026-07-09 DOI: 10.1037/bne0000661

Mengjiao Zhang, Ming Li

{"title":"Distal pup cues attenuate defensive reactivity and fear-potentiated startle magnitude in postpartum rats without altering sensorimotor gating.","authors":"Mengjiao Zhang, Ming Li","doi":"10.1037/bne0000661","DOIUrl":"10.1037/bne0000661","url":null,"abstract":"Using a novel behavioral paradigm that integrates fear-potentiated startle (FPS) and prepulse inhibition testing, this study examined how motherhood and infant cues impact innate defensive reactivity (as measured by the magnitude of basal startle reflex), attentional processing (as measured by prepulse inhibition), acquisition, and expression of conditioned fear (as measured by the FPS) in postpartum female rats. Sprague-Dawley mother rats from Postpartum Day 3-9 were tested in this paradigm either in the presence or absence of their own two pups (Experiments 1 and 2), and their performance was compared to virgin female rats and males (Experiment 3). Compared to mother rats tested alone, those tested with their pups being placed inside the apparatus (with no physical contact) showed significantly reduced baseline startle response and reduced overall startle magnitude under the FPS testing procedure. Importantly, this pup-induced reduction of baseline startle and fear startle was only observed in mother rats, not in virgin females or male rats. Notably, pup presence did not alter prepulse inhibition under various testing conditions nor did it affect the acquisition and expression of FPS. Also, postpartum females did not differ from virgin females and males in the acquisition and expression of conditioned fear. Together, these results suggest that distal pup cues may powerfully inhibit defensive reactivity in mother rats, without altering aversive learning or sensorimotor gating ability. The possible behavioral mechanisms involved in this pup effect are discussed. (PsycInfo Database Record (c) 2026 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"296-309"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13353198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2026-09-28 DOI: 10.1037/bne0000670

Leonard Faul, Samantha E Williams, R Gerald Monkman, Brianna D Lenza, Cortney L Flory, Sandry M Garcia, Elizabeth A Kensinger, Jaclyn H Ford

{"title":"Age-related reversals in the neural support of emotional memory vividness: New evidence for preparatory prefrontal activity during memory search.","authors":"Leonard Faul, Samantha E Williams, R Gerald Monkman, Brianna D Lenza, Cortney L Flory, Sandry M Garcia, Elizabeth A Kensinger, Jaclyn H Ford","doi":"10.1037/bne0000670","DOIUrl":"10.1037/bne0000670","url":null,"abstract":"Previous research identified age-related changes in the parametric modulation of neural activity by emotional memory vividness. Within the dorsomedial prefrontal cortex (PFC), older adults showed a stronger relationship between neural recruitment and positive memory vividness, whereas younger adults showed a stronger relationship for negative memories. More work is needed to corroborate these Age × Valence interactions while clarifying if they are uniquely sensitive to vividness ratings made after an instructed elaboration period or predictive of how vividness ratings might change from initial recognition to postelaboration. The present study assessed a new sample of participants (n = 60, ages 18-87) who completed a nearly identical paradigm as in previous work. Participants encoded emotional images paired with neutral titles and, during scanned retrieval, were presented with only the neutral titles in an old/new recognition task. Remembered titles were rated on the initial vividness of recollection for the paired image and a second rating of vividness after instructed elaboration. Results confirmed prefrontally mediated alterations to emotional memory phenomenology across the adult lifespan, evidenced by age-related increases in the relationship between PFC activity and positive memory vividness. During initial memory recognition, greater dorsomedial PFC activity among older adults predicted a subsequent increase in positive memory vividness after elaboration. Opposite patterns emerged in posterior sensorimotor and occipital regions that deactivated more strongly for vivid positive memories among older adults. These findings corroborate prior evidence of Age × Valence interactions in parametric modulation by vividness while also providing new evidence for a preparatory role of the PFC in shaping elaboration outcomes. (PsycInfo Database Record (c) 2026 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of mobility and frailty risk with wayfinding ability in aging. 老年人寻路能力与行动能力和衰弱风险的关系。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2026-09-24 DOI: 10.1037/bne0000672

Alexis N Chargo, Cheryl L Dahle, Nora E Fritz, Ana M Daugherty

{"title":"Associations of mobility and frailty risk with wayfinding ability in aging.","authors":"Alexis N Chargo, Cheryl L Dahle, Nora E Fritz, Ana M Daugherty","doi":"10.1037/bne0000672","DOIUrl":"10.1037/bne0000672","url":null,"abstract":"Older adults frequently report difficulties with community wayfinding, which may be exacerbated by age-related mobility decline; however, the intersection of these processes to support navigation as a fundamental behavior for independent functioning is poorly understood. Beyond impaired locomotion, preclinical mobility decline among middle-aged and older adults is associated with cognitive decline that may affect wayfinding. The present study examined associations of mobility, grip strength as an indicator of frailty risk, multidomain cognition, and wayfinding performance on a seated virtual navigation paradigm, along with self-reported strategy preference, in a sample of 74 healthy, cognitively normal (Mini-Mental State Examination; M = 28.76, SD = 0.95) middle-aged and older adults (aged 53-89 years; M = 70.82, SD = 8; 70.3% female). Worse mobility was associated with poorer memory for environmental details. This association was partially mediated by domain-specific cognition, and processing speed had the largest unique contribution. Weaker grip strength-reflecting increased frailty risk-was associated with worse navigation efficiency in locating the hidden platform during the task, and this effect was largely independent of other cognitive correlates. Mobility and frailty risk were associated with self-reported navigation strategy preference in the real world. Individual differences in visuospatial immediate recall and delayed associative recall contributed to this association, although mediation was not supported. Taken together, mobility and frailty risk were differentially associated with wayfinding deficits in aging, which was partially shared with domain-specific cognition. Continued study can explore mobility and frailty as modifiable risk factors to maintain wayfinding ability and promote independence into late life. (PsycInfo Database Record (c) 2026 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13614522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Male mice are particularly vulnerable to cognitive impairment following mild traumatic brain injury. 雄性小鼠在轻度创伤性脑损伤后特别容易出现认知障碍。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2026-09-03 DOI: 10.1037/bne0000669

James T Neal, Aimee Bertolli, Georgina M Aldridge, Eric B Emmons

{"title":"Male mice are particularly vulnerable to cognitive impairment following mild traumatic brain injury.","authors":"James T Neal, Aimee Bertolli, Georgina M Aldridge, Eric B Emmons","doi":"10.1037/bne0000669","DOIUrl":"10.1037/bne0000669","url":null,"abstract":"Traumatic brain injuries (TBIs) result from impact to or rapid displacement of the brain and can lead to various neurological deficits involving working memory, decision making, and anxiety. While large-scale effects of brain damage are well-described for more severe TBIs, less is known about the extent and duration of cognitive deficits at the mild level. Interval timing can provide a helpful window into cognition in mice and humans. Interval-timing behavior is impaired in a wide range of neuropsychiatric disease states, but less is known about whether it is impaired by mild TBI (mTBI). Furthermore, novel object recognition and the Barnes maze tests are valuable assays for evaluating spatial learning, working memory, and anxietylike behavior in mice. Here, we employed a weight-drop model of mTBI to investigate cognitive and behavioral changes resulting from mTBI treatment. mTBI mice were not consistently impaired in either interval timing or novel object recognition, but they demonstrated impaired spatial memory in the Barnes maze. Interestingly, between-sex comparisons revealed impairments in male mTBI mice in the interval-timing task, suggesting that male and female mice may be differently affected by mTBIs. (PsycInfo Database Record (c) 2026 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13719230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure and function of word laterality in early childhood. 幼儿词汇偏侧性的结构与功能。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2026-08-13 DOI: 10.1037/bne0000662

Leah DiRubio, Jin Li, Kelly Hiersche, Nii-Ayi Aryeetey, Anna Quatrale, Jaclyn Caccese, Zeynep Saygin

{"title":"Structure and function of word laterality in early childhood.","authors":"Leah DiRubio, Jin Li, Kelly Hiersche, Nii-Ayi Aryeetey, Anna Quatrale, Jaclyn Caccese, Zeynep Saygin","doi":"10.1037/bne0000662","DOIUrl":"10.1037/bne0000662","url":null,"abstract":"Many of the brain's functional regions display lateralization, meaning they are more specialized to one hemisphere than the other. The visual word form area (VWFA) is one such region; its specialization for written scripts, which develops only after literacy, is consistently dominant on the left in adults. The experience-dependent nature of the VWFA makes it a prime opportunity to investigate the development of functional laterality in the human brain. Therefore, we ask, \"What neural correlates relate to the development of word laterality in children?\" We tested two potential sources of this word laterality: (a) structural connectivity (s-connectivity) of the VWFA with the high-level language network in frontal and temporal cortices and (b) activation in these language regions. To do so, we scanned reading children (4-13 years) on a visual functional magnetic resonance imaging localizer to define the VWFA and its word selectivity and a separate auditory functional magnetic resonance imaging localizer to define language regions and their linguistic selectivity, and we collected diffusion-weighted imaging to examine white matter connectivity. Probabilistic tractography was used to quantify white matter connections between our subject-specific functional regions. VWFA word laterality was predicted by the positive interaction between laterality of s-connectivity to temporal language regions and laterality of temporal language regions' selectivity, suggesting that the VWFA tends to be more left-lateralized when both temporal language areas are left-lateralized and the VWFA has strong s-connectivity to that left-lateralized language network. More generally, our findings suggest that both s-connectivity to related regions and activation patterns in those connected regions may play a role in the development of functional laterality, and shed light on the development of the neural circuitry that underlies reading. (PsycInfo Database Record (c) 2026 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148766160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0