Behavioral neuroscience最新文献

Structural neuroanatomy of semantic retrograde memory in older adults. 老年人语义逆行记忆的结构神经解剖学。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2026-05-07 DOI: 10.1037/bne0000652

Jasmine C Banos, Songyuan Tan, Isabel E Asp, Jamie Snytte, Mark W Bondi, Christine N Smith

{"title":"Structural neuroanatomy of semantic retrograde memory in older adults.","authors":"Jasmine C Banos, Songyuan Tan, Isabel E Asp, Jamie Snytte, Mark W Bondi, Christine N Smith","doi":"10.1037/bne0000652","DOIUrl":"10.1037/bne0000652","url":null,"abstract":"Studies of brain lesions or volumes indicate that the integrity of medial and lateral temporal lobe structures is important for news event memory accuracy, but the relationship between cortical thickness and news event memory accuracy has not yet been investigated in older adults. In a mixed sample of 70 older adults with variable cognitive abilities but without dementia, we investigated the relationship between cortical volume, hippocampal volume, and cortical thickness with news event recognition memory accuracy across the entire adult lifespan using the Retrograde Memory News Events Test. Partial Least Squares analysis was used to identify brain regions where news event memory accuracy scores significantly correlated with cortical volume, hippocampal volume, and cortical thickness. We found that mean news event memory accuracy significantly correlated with volume/thickness for a network of regions that included the hippocampus, medial/lateral temporal lobe, medial/lateral parietal lobe, and specific areas within the medial/lateral prefrontal cortex. Poorer performance was associated with a thinner cortex (and smaller volumes). Almost all regions in this network exhibited decreasing brain-behavior correlations as the age of memory increased; thus, retrieval of remote memories was less reliant on the network. We also found regions in this network that were not identified by the Retrograde Memory News Events Test posttest (a measure of episodic anterograde memory for the Retrograde Memory News Events Test content) nor traditional neuropsychological tests. The regions identified as uniquely contributing to news event memory overlap with regions known to exhibit increasing Alzheimer's disease pathology and cortical thinning when pathology begins to spread outside of the medial temporal lobe. (PsycInfo Database Record (c) 2026 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13155362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of cisplatin-induced olfactory aversion based on selection logic: A novel approach. 基于选择逻辑治疗顺铂诱导的嗅觉厌恶：一种新方法。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2026-05-04 DOI: 10.1037/bne0000653

Yong Yu, Yoshihisa Koyama, Shoichi Shimada

{"title":"Treatment of cisplatin-induced olfactory aversion based on selection logic: A novel approach.","authors":"Yong Yu, Yoshihisa Koyama, Shoichi Shimada","doi":"10.1037/bne0000653","DOIUrl":"https://doi.org/10.1037/bne0000653","url":null,"abstract":"Aversion can arise from a combination of unconditioned stimuli that induce physical discomfort, such as pain and nausea. Chemotherapy-induced side effects, including taste and olfactory aversion, can persist even after treatment has ended, thereby reducing the quality of life. Currently, however, no effective pharmacological interventions exist for treating chemotherapy-induced conditioned aversion learning. Therefore, elucidating its underlying mechanisms is of great importance. In this study, we investigated cisplatin-induced olfactory aversion learning using the two-bottle choice test. Cisplatin was found to induce aversive responses to neutral odorants, namely isoamyl acetate and benzaldehyde. Notably, we obtained two key findings. First, an odor solution that was not aversive in the two-bottle choice test (i.e., distilled water) became aversive to mice when compared with a third novel odor solution that had not been presented in the test. Second, when pairs of three odorants were alternated over an extended period, the mice occasionally shifted their aversive responses as the pairings changed. In clinical practice, patients are exposed to a variety of odors. Thus, the new insights gained from this study on olfactory aversion may help inform the development of novel treatments for chemotherapy-related side effects. (PsycInfo Database Record (c) 2026 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxytocin prevents cocaine-induced high-affect 50-kHz vocalizations in female rats. 催产素可以阻止可卡因引起的雌性大鼠50千赫的高影响发声。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2026-05-04 DOI: 10.1037/bne0000655

Elise B Cauley, Natalie E Cornejo, Grace T Le, Morgan O Lemler, Kah-Chung Leong, Matthew S Binder

{"title":"Oxytocin prevents cocaine-induced high-affect 50-kHz vocalizations in female rats.","authors":"Elise B Cauley, Natalie E Cornejo, Grace T Le, Morgan O Lemler, Kah-Chung Leong, Matthew S Binder","doi":"10.1037/bne0000655","DOIUrl":"https://doi.org/10.1037/bne0000655","url":null,"abstract":"Cocaine's reinforcing properties are a key factor underlying the broad prevalence of cocaine use disorder. Few behavioral measures are capable of assessing cocaine-induced euphoria in murine models, limiting effective treatment options. However, positive affective states can be measured in rats by assessing the production of high-frequency, 50-kHz, vocalizations. Oxytocin (OXT) has been shown to attenuate cocaine-mediated behaviors in rodent models; however, the effect of OXT on cocaine-induced euphoria remains unknown. We addressed this by randomly assigning female rats to saline-saline, saline-cocaine, OXT-saline, or OXT-cocaine conditions and then assessing ultrasonic vocalizations. We found that saline-cocaine animals emitted a significantly higher percentage of 50-kHz calls relative to the other conditions, indicative of cocaine's euphoric effects. Notably, an OXT pretreatment prevented the cocaine-induced increase in high-affect calls. We also found that OXT significantly increased call duration in cocaine animals, inducing aversivelike call properties and further suggesting that OXT may attenuate positive affective states. There were minimal differences in call bandwidth across groups and no significant differences in call amplitude. When assessing the ultrasonic vocalization's qualitative features, we found that cocaine led to an increased production of flat and short call types, both of which are associated with positive states, which were not attenuated by OXT. Altogether, we found that cocaine administration successfully produced a high affective state in female rats. Moreover, an OXT pretreatment was sufficient to decrease the rewarding effects of cocaine administration and therefore may play a vital role in treating those suffering from cocaine use disorder. (PsycInfo Database Record (c) 2026 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Explicitly unpaired procedure generates the inhibitory property of conditioned stimulus: Evidence from superconditioning and summation tests. 显性非配对过程产生条件刺激的抑制特性：来自超条件作用和求和试验的证据。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2026-04-01 DOI: 10.1037/bne0000645

Nam-Heon Kim, Su-Yeon Sim, Jung-Soo Han

{"title":"Explicitly unpaired procedure generates the inhibitory property of conditioned stimulus: Evidence from superconditioning and summation tests.","authors":"Nam-Heon Kim, Su-Yeon Sim, Jung-Soo Han","doi":"10.1037/bne0000645","DOIUrl":"10.1037/bne0000645","url":null,"abstract":"A previous study reported that explicitly unpairing a conditioned stimulus with an unconditioned stimulus generates the inhibitory property of the conditioned stimulus, as assessed by the retardation task, in an appetitive conditioning setting. This study conducted further experiments to demonstrate the conditioned inhibition induced by explicitly unpaired (EUP) training using the superconditioning and summation tests. In Phase 1, rats subjected to the EUP procedure received training in which light and food were explicitly unpaired. In Phase 2, rats in the EUP group for the superconditioning were trained with pairings of a light-tone compound and food. During the test phase, food-cup responses to either light or tone were measured. Food-cup responses to the tone in the EUP group were significantly higher than those in three control groups designed to rule out alternative explanations. For the summation test, rats in the EUP group underwent the same Phase 1 training as the superconditioning group, followed by Phase 2, which involved pairing the tone with food. In the test phase, food-cup responses to either the tone or the light + tone compound were measured. Food-cup responses to the tone in the EUP group were higher than those in the control group, but no difference was observed between the EUP and control groups for responses to the compound stimulus. These results indicate that EUP of the conditioned stimulus and unconditioned stimulus effectively generates superconditioning in appetitive conditioning. Superconditioning may provide a useful approach for investigating the neural mechanisms underlying appetitive conditioned inhibition. (PsycInfo Database Record (c) 2026 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"140 2","pages":"101-107"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A "personality test" for rats reveals subtle but distinct effects of sex and early life inflammation on brain and behavior. 一项针对老鼠的“性格测试”揭示了性别和早期生活炎症对大脑和行为的微妙但明显的影响。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2026-04-01 Epub Date: 2026-01-19 DOI: 10.1037/bne0000646

Sydney E Ashton, Adam T Brockett, Paul Sharalla, Naru Kang, Matthew R Roesch, Margaret M McCarthy

{"title":"A \"personality test\" for rats reveals subtle but distinct effects of sex and early life inflammation on brain and behavior.","authors":"Sydney E Ashton, Adam T Brockett, Paul Sharalla, Naru Kang, Matthew R Roesch, Margaret M McCarthy","doi":"10.1037/bne0000646","DOIUrl":"10.1037/bne0000646","url":null,"abstract":"Early life inflammation has long been associated with increased risk of later neuropsychiatric developmental disorder (NDD) diagnosis in humans. However, despite converging lines of evidence implicating the immune system in NDD etiology combined with reported sex differences in NDD diagnosis rates and the increasingly appreciated role of traditionally immune-associated factors in the sexual differentiation of the brain, a direct link connecting these three processes remains elusive. Here, we sought to characterize the enduring effects of early life inflammation in male and female rats exposed to the viral mimetic polyinosinic:polycytidylic acid (poly(I:C), 5 mg/kg) on Postnatal Day 8 (P8) and P10, a sensitive period we previously identified. We assessed a variety of behaviors-from juvenile social play to adult reward-guided decision making-and recorded from single neurons in nucleus accumbens as rats performed a task commonly used to assess cognitive control. All assessments were performed in the same animals allowing for exploratory factor analysis, which identified five factors that together reveal novel connections between behavioral measures across the lifespan and neural activity patterns. Collectively, this work suggests that viral-mediated inflammation at this developmental timepoint is not a robust risk factor for an NDD-like phenotype in rats. However, factor analysis revealed that sex and early life inflammation shifted two distinct modalities of rat \"personality,\" highlighting the utility of combining modern neuroscience approaches with the study of complex, naturalistic behaviors. Future work should directly test these putative factor associations to determine the extent to which early life behavior may be predictive of adult cognition. (PsycInfo Database Record (c) 2026 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"108-137"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146008641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting dopamine D2 receptors to alter fear extinction in adolescent rats. 以多巴胺D2受体为目标改变青春期大鼠的恐惧消退。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2026-04-01 DOI: 10.1037/bne0000641

Emily Wall, Rick Richardson

{"title":"Targeting dopamine D2 receptors to alter fear extinction in adolescent rats.","authors":"Emily Wall, Rick Richardson","doi":"10.1037/bne0000641","DOIUrl":"10.1037/bne0000641","url":null,"abstract":"Anxiety disorders emerging in adolescence are especially challenging to treat, partly due to adolescents having poor extinction recall and high relapse rates following exposure therapy, relative to other ages. Despite its clear clinical significance, little work has examined treatments to enhance extinction in adolescence. Dopamine, a key neurotransmitter involved in learning and memory, plays a critical role in fear extinction in adults, but its role in extinction in adolescents has not been well-explored. In a series of experiments, we investigated the effects of sulpiride, a dopamine antagonist, on extinction recall in male and female adolescent rats. Animals underwent Pavlovian fear conditioning followed by extinction training the next day, where animals were injected with either sulpiride or saline 15 min prior. On the next day animals were tested for their extinction recall. Sulpiride-treated male adolescents exhibited impaired extinction recall (Experiment 1), while sulpiride enhanced extinction recall in female adolescents (Experiment 2). However, these results were not replicated in a follow-up experiment that also included a sulpiride-no extinction control group (Experiment 3). Further, in contrast to what has been reported in past studies with adults, we did not observe any effect of sulpiride on adult female and male extinction recall (Experiment 4). Overall, these findings suggest that sulpiride may have sex-specific effects on extinction recall in adolescence, as has been reported in adults, though these effects appear to not be robust. (PsycInfo Database Record (c) 2026 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"140 2","pages":"65-74"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rat model of oral hormonal contraception: Effects on drug preference and gonadal function. 口服激素避孕大鼠模型：对药物偏好和性腺功能的影响。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2026-04-01 Epub Date: 2025-12-15 DOI: 10.1037/bne0000643

Adriana Vasquez, Payton E Antonacci, Gahyun Kim, Heba Ajmal, Rashi Agarwal, Aihan Nguyen, Juan M Dominguez, Marie-H Monfils, Hongjoo J Lee

{"title":"A rat model of oral hormonal contraception: Effects on drug preference and gonadal function.","authors":"Adriana Vasquez, Payton E Antonacci, Gahyun Kim, Heba Ajmal, Rashi Agarwal, Aihan Nguyen, Juan M Dominguez, Marie-H Monfils, Hongjoo J Lee","doi":"10.1037/bne0000643","DOIUrl":"10.1037/bne0000643","url":null,"abstract":"Gonadal hormones (e.g., estradiol and progesterone) influence response to, and preference for, drugs in females; however, how hormonal contraceptives, synthetic hormones that decrease gonadal hormone levels, affect drug preference is not known. The current experiment investigated whether oral administration of levonorgestrel (LNG), a synthetic progestin used in hormonal contraceptives, would lead to a reduction in amphetamine (AMPH) preference. Female rats were tested for their AMPH preference over 3 days (which also served as extinction sessions) after receiving oral administration of LNG (250 μg, 500 μg, or 2 mg) or during an estrous cycle stage associated with higher levels of gonadal hormones (i.e., proestrus/estrus). Our results show that AMPH preference was reduced for females on 500 μg and 2 mg of LNG across extinction sessions. Interestingly, only the 2 mg LNG dose led to a disruption in the naturally occurring estrous cycle. Uterine horn width, an index of estrogen exposure, was decreased in all LNG groups, but only the 500 μg and 2 mg LNG groups showed suppression of gonadal hormones, suggesting that both doses are sufficient for contraceptive use in rats. Our study demonstrates an effective and noninvasive oral LNG administration method in a rat model and further shows reduced AMPH preference by LNG. (PsycInfo Database Record (c) 2026 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"90-100"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12994744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145755123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular and systemic sequelae of adolescent social stress: An overview of rodent research. 青少年社会压力的细胞和系统后遗症：啮齿动物研究综述。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2026-03-12 DOI: 10.1037/bne0000650

Carlos Novoa, Thomas J Gould

{"title":"Cellular and systemic sequelae of adolescent social stress: An overview of rodent research.","authors":"Carlos Novoa, Thomas J Gould","doi":"10.1037/bne0000650","DOIUrl":"https://doi.org/10.1037/bne0000650","url":null,"abstract":"Early exposure to stress is associated with biological processes that precede cellular senescence and an increased risk of age-related diseases. Adolescence is a period of heightened susceptibility to social environment-related stressors. This developmental stage is also associated with the onset of psychiatric disorders and the adoption of behaviors that can affect long-term health trajectories. In this review, we aimed to assess the progress of rodent research on the relationship between adolescent social stress and later disease-related sequels and cellular senescence. We present a synthesis of 35 peer-reviewed articles indexed in PubMed before July 2025, selected from a web search based on the terms (social stress) AND (senescence OR DNA damage OR telomere OR inflammation) AND (adolescence OR juvenile OR youth OR early life) AND (mice OR mouse OR murine OR rat OR rodent). Adolescent social stress results in decreased social behaviors and increased anxietylike and depressionlike responses. In addition, enduring alterations in physiological responses to acute stress challenges and broad sequelae on neural, cardiovascular, endocrine, and gastrointestinal systems associated with inflammation were found. Sex differences in stress susceptibility were observed across all domains. However, despite the theoretical framework linking stress to aging, our synthesis reveals that direct evidence regarding telomere dynamics and DNA damage in this specific developmental window remains limited in rodent research. Consequently, this review provides an overview of biological mechanisms linking psychosocial stress during adolescence to chronic disease states while identifying the scarcity of direct senescence data as an important gap for future investigation. (PsycInfo Database Record (c) 2026 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paired associates learning performance in rats requires the nucleus reuniens. 大鼠配对同伴的学习表现需要核团聚。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2026-03-12 DOI: 10.1037/bne0000649

Cristina Besosa, Aden Baksh, Riley Braden, Sophia Tomczak, Sarah Lovett, Andrew P Maurer, Sara N Burke

{"title":"Paired associates learning performance in rats requires the nucleus reuniens.","authors":"Cristina Besosa, Aden Baksh, Riley Braden, Sophia Tomczak, Sarah Lovett, Andrew P Maurer, Sara N Burke","doi":"10.1037/bne0000649","DOIUrl":"10.1037/bne0000649","url":null,"abstract":"Hospitalizations and deaths related to mental health disorders have increased in recent decades, highlighting the need for improved understanding of the neurocircuitry underlying cognitive dysfunction. Dysfunction in neural coordination between the hippocampus (HPC) and prefrontal cortex (PFC) is widely reported to be a signature of many mental health disorders. This circuit is crucial for many forms of adaptive behavior, with the nucleus reuniens (RE) of the thalamus hypothesized to be a critical hub that coordinates HPC-PFC interactions in the service of cognition. This study examined the role of the RE in associative memory by assessing the impact of its inactivation in male and female rats performing the Paired Associates Learning task, a touchscreen-based visuospatial memory paradigm with translational relevance for human mental health disorders. Using muscimol inactivation, we found that RE suppression significantly impaired Paired Associates Learning performance, supporting its role in HPC-PFC circuit coordination. Modulating nicotinic receptors in the RE with an agonist also produced significant deficits; however, we did not see any significant behavioral effects with an antagonist. These findings suggest that the RE is critical for Paired Associates Learning task performance, and its functional contribution may be modulated by cholinergic nicotinic signaling, but additional studies are necessary to test the robustness of this observation. Understanding RE's role in cognition may inform therapeutic strategies for psychiatric and neurological disorders characterized by HPC-PFC dysfunction. (PsycInfo Database Record (c) 2026 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12987544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From forgetting to remembering: Context-dependent memory recovery after postretrieval disruption. 从遗忘到记忆：情境依赖的记忆恢复。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2026-03-12 DOI: 10.1037/bne0000651

Joaquín M Alfei

{"title":"From forgetting to remembering: Context-dependent memory recovery after postretrieval disruption.","authors":"Joaquín M Alfei","doi":"10.1037/bne0000651","DOIUrl":"https://doi.org/10.1037/bne0000651","url":null,"abstract":"Memories are dynamic and can be made vulnerable to disruption upon reactivation, resulting in a long-lasting attenuation of conditioned responses (i.e., cue-dependent amnesia). Traditionally, cue-dependent amnesia has been studied using AAA between-subjects designs, where a memory is trained for context A, reactivated, and tested with the same context. Using contextual fear conditioning in rats and midazolam as the amnestic agent, we have recently observed that amnesia can be observed when memories are reactivated by a generalization stimulus (context B) and tested with the same generalization stimulus (ABB design). However, this amnestic intervention does not affect the fear expression when animals are tested with the original stimulus (ABA design) or a novel generalization stimulus (ABC design). Methodologically, however, evaluating whether amnesia is reversed, rather than simply not expressed, requires tracking changes in responding within the same individuals across contexts and time. This avoids the ambiguity inherent to between-group comparisons, which may confound memory retention with retrieval differences driven by contextual or procedural variability. Here, using an ABB, ABA, and ABC within-subjects design and employing a gold standard amnestic manipulation-protein synthesis inhibition via cycloheximide-the interplay between memory retention and amnesia expression in different contexts was assessed. The results indicate that amnesia is expressed only when cycloheximide-animals are re-exposed to the reactivation context, regardless of when this re-exposure occurs within the experimental timeline. The implications of these findings for a reconsolidation-based account of postreactivation amnesia are discussed. (PsycInfo Database Record (c) 2026 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0