Behavioral neuroscience最新文献

Renewal of conditioned fear in a third context after either extinction or counterconditioning: Testing the effects of sex and hormones. 在第三种情境下，条件恐惧在消失或对抗后的重新出现：测试性和激素的影响。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2025-09-11 DOI: 10.1037/bne0000631

Samantha K Moriarty, Hannah L Schoenberg, Emily A Rocco, Neil E Winterbauer, Sayamwong E Hammack, Donna J Toufexis, Travis P Todd

{"title":"Renewal of conditioned fear in a third context after either extinction or counterconditioning: Testing the effects of sex and hormones.","authors":"Samantha K Moriarty, Hannah L Schoenberg, Emily A Rocco, Neil E Winterbauer, Sayamwong E Hammack, Donna J Toufexis, Travis P Todd","doi":"10.1037/bne0000631","DOIUrl":"https://doi.org/10.1037/bne0000631","url":null,"abstract":"A series of experiments tested the role of sex and cycling ovarian hormones in the renewal of conditioned freezing after either extinction or counterconditioning. In all experiments, conditioning occurred in Context A, response reduction (extinction or counterconditioning) occurred in Context B, and renewal occurred in a familiar yet neutral Context C. Experiment 1a compared renewal after extinction for male and female rats. Both groups demonstrated robust renewal. This finding was replicated in Experiment 1b, which also included a group of ovariectomized female rats to test a potential role of cycling ovarian hormones. Renewal was present and did not differ between groups. Experiment 2 extended these findings to examine renewal after aversive-to-appetitive counterconditioning. Once again, renewal did not differ between male and female rats (Experiment 2a), nor between male, intact female, and ovariectomized female rats (Experiment 2b). For all experiments, summation testing failed to detect differential context-U.S. associations between Contexts B and C. We discuss the role for cycling ovarian hormones in renewal, noting methodological differences with prior studies, and we also discuss how contexts can influence behavior during either extinction or counterconditioning. (PsycInfo Database Record (c) 2025 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dopaminergic responses to identity prediction errors depend differently on the orbitofrontal cortex and hippocampus. 多巴胺能对身份预测误差的反应依赖于眶额皮质和海马体。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2025-09-01 DOI: 10.1037/bne0000633

Yuji K Takahashi, Zhewei Zhang, Thorsten Kahnt, Geoffrey Schoenbaum

{"title":"Dopaminergic responses to identity prediction errors depend differently on the orbitofrontal cortex and hippocampus.","authors":"Yuji K Takahashi, Zhewei Zhang, Thorsten Kahnt, Geoffrey Schoenbaum","doi":"10.1037/bne0000633","DOIUrl":"10.1037/bne0000633","url":null,"abstract":"Adaptive behavior depends on the ability to predict specific events, particularly those related to rewards. Armed with such associative information, we can infer the current value of predicted rewards based on changing circumstances and desires. To support this ability, neural systems must represent both the value and identity of predicted rewards, and these representations must be updated when they change. Here we tested whether prediction error signaling of dopamine neurons depends on two areas known to represent the specifics of rewarding events, the hippocampus (HC) and orbitofrontal cortex (OFC). We monitored the spiking activity of dopamine neurons in rat ventral tegmental area during changes in the number or flavor of expected rewards designed to induce errors in the prediction of reward value or reward identity, respectively. In control animals, dopamine neurons registered both error types, transiently increasing firing to additional drops of reward or changes in reward flavor. These canonical firing signatures of value and identity prediction errors were altered in rats with ipsilateral neurotoxic lesions of either HC or OFC. Specifically, HC lesions caused a failure to register either type of prediction error, whereas OFC lesions caused abnormally persistent signaling of identity prediction errors and much more subtle effects on signaling of value errors. These results demonstrate that HC and OFC contribute distinct types of information to the computation of prediction errors signaled by ventral tegmental area dopamine neurons. (PsycInfo Database Record (c) 2025 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144940532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paraventricular thalamic inputs to the ventral pallidum shape reward seeking during threat and fear responding in extinction. 室旁丘脑对腹侧苍白球的输入决定了威胁时的奖励寻求和消失时的恐惧反应。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2025-09-01 DOI: 10.1037/bne0000630

Mahsa Moaddab, Suhui Qian, Jacob B Boyce, Nicholas T Gordon, Aleah M DuBois, Anaise C Fitzpatrick, Kaiyuan Zheng, Michael A McDannald

{"title":"Paraventricular thalamic inputs to the ventral pallidum shape reward seeking during threat and fear responding in extinction.","authors":"Mahsa Moaddab, Suhui Qian, Jacob B Boyce, Nicholas T Gordon, Aleah M DuBois, Anaise C Fitzpatrick, Kaiyuan Zheng, Michael A McDannald","doi":"10.1037/bne0000630","DOIUrl":"10.1037/bne0000630","url":null,"abstract":"Environmental threats are typically encountered when animals are searching for food and other necessities. Adaptive behavior must balance competition between fear behavior and reward seeking. We gave rats local neuronal deletions of the ventral pallidum (VP) or specifically deleted paraventricular thalamic nucleus (PVT) neurons projecting directly to the VP. Rats were then assessed in a conditioned suppression procedure in which cues predicting unique foot shock probabilities were presented during, but independent from, reward seeking. Foot shock introduction generally suppressed reward seeking in rats, and recovery from shock introduction was facilitated in rats with VP or PVT → VP pathway deletions. Discriminative fear was observed in controls, and this fear responding reduced over a single extinction session. VP deletion enhanced extinction fear responding, and PVT → VP pathway deletion abolished within-session fear reductions. The results demonstrate the VP and its inputs from the PVT shape reward seeking in threat settings and govern fear extinction responding. (PsycInfo Database Record (c) 2025 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12498559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144940482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conditioned place preferences for virtual reality cannabis cues. 虚拟现实大麻线索的条件偏好。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2025-09-01 DOI: 10.1037/bne0000634

Skyler M Sklenarik, Christopher N Burrows, Robert S Astur

{"title":"Conditioned place preferences for virtual reality cannabis cues.","authors":"Skyler M Sklenarik, Christopher N Burrows, Robert S Astur","doi":"10.1037/bne0000634","DOIUrl":"10.1037/bne0000634","url":null,"abstract":"This study investigated whether 221 undergraduates (123 males, 98 females) with varying levels of cannabis use displayed a conditioned place preference (CPP) for a virtual reality (VR) room that previously contained virtual cannabis stimuli compared to a neutral VR room that was not paired with cannabis cues. We hypothesized that cannabis-using participants (n = 180) would spend a greater amount of time in, report greater subjective enjoyment in, and explicitly prefer a VR room that was previously paired with virtual cannabis stimuli relative to a neutral room, while participants with nonuse (n = 41) would not. Overall, participants did not demonstrate an implicit or explicit CPP for a VR room that was previously paired with cannabis cues. Interestingly, however, participants with recent cannabis use (n = 41) exhibited a significant implicit CPP for the cannabis-cue-paired VR room, while participants with nonrecent cannabis use (n = 113) did not. Furthermore, relative to males with cannabis use (n = 93), females with cannabis use (n = 87) demonstrated a significant explicit CPP for the cannabis-cue-paired context as well as significantly greater cannabis cravings. These findings elucidate the need for further research on the role of acute cannabis intoxication, sex, and cue-induced cravings in modulating CPP for cannabis-associated contexts. (PsycInfo Database Record (c) 2025 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144940515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patterns of prefrontal cortical activity associated with attention-demanding and motor aspects of dual-task walking as measured with functional near-infrared spectroscopy. 用功能近红外光谱测量双任务行走中与注意力要求和运动方面相关的前额皮质活动模式。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2025-09-01 DOI: 10.1037/bne0000629

Rini I Kaplan, Jaimie Girnis, Alissa Sebastian, Nishaat Mukadam, Courtney Guida, Terry D Ellis, Alice Cronin-Golomb, Meryem A Yücel

{"title":"Patterns of prefrontal cortical activity associated with attention-demanding and motor aspects of dual-task walking as measured with functional near-infrared spectroscopy.","authors":"Rini I Kaplan, Jaimie Girnis, Alissa Sebastian, Nishaat Mukadam, Courtney Guida, Terry D Ellis, Alice Cronin-Golomb, Meryem A Yücel","doi":"10.1037/bne0000629","DOIUrl":"10.1037/bne0000629","url":null,"abstract":"The ability to engage in everyday tasks, such as walking, requires the integration of cognitive and motor processes. How these processes integrate may be discernable through the relation of brain activity patterns to behavioral performance, particularly in the prefrontal cortex (PFC), examination of which has been restricted because of the limitations in experimental design. We related behavior (cognition, walking) to brain activity, as measured by functional near-infrared spectroscopy, under dual-task conditions (cognition while walking) in healthy young adults. Our probe design enabled us to examine eight regions of interest across PFC and motor cortex to identify key areas related to behavior. Healthy young adults (N = 19) engaged in standing cognition (Serial 3 subtraction), single-task walking, and dual-task walking. We used functional near-infrared spectroscopy to identify regions associated with increases or decreases in activity under dual-task relative to the other conditions. We observed differences in brain activity patterns by task across multiple regions of interest, mostly in PFC. Specifically, more lateral regions were related to attention-demanding tasks, whereas motor tasks were related to relatively medial regions. Our results relate behavior to brain activity, as measured by functional near-infrared spectroscopy, under dual-task conditions. Our finding of relatively lateral PFC activity during attention-demanding tasks provides insights into behavioral and brain processes during experimental analogues of everyday activity, bringing us closer to understanding behavior-brain relations in the real world. (PsycInfo Database Record (c) 2025 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144940537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemogenetic modulation of PAC1-expressing neurons in the bed nucleus of the stria terminalis (BNST) alters anxiety-related behaviors in male mice. 终纹床核中表达pac1的神经元的化学发生调节改变了雄性小鼠焦虑相关行为。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2025-09-01 DOI: 10.1037/bne0000632

Mahafuza Aktar, Ava Cardarelli, Victor May, Sayamwong E Hammack

{"title":"Chemogenetic modulation of PAC1-expressing neurons in the bed nucleus of the stria terminalis (BNST) alters anxiety-related behaviors in male mice.","authors":"Mahafuza Aktar, Ava Cardarelli, Victor May, Sayamwong E Hammack","doi":"10.1037/bne0000632","DOIUrl":"10.1037/bne0000632","url":null,"abstract":"Pituitary adenylate cyclase-activating polypeptide (PACAP, ADCYAP1) is a highly conserved neuropeptide that plays essential roles in numerous physiological functions, and central PACAP signaling has been associated with mechanisms regulating stress-induced psychopathologies. PACAP binds to several receptor subtypes, including PAC1 (ADCYAP1R1), VPAC1 (VIPR1), and VPAC2 (VIPR2), to activate several signaling cascades that can alter neuronal excitability and enhance indices of neuroplasticity, and much of our prior work has suggested that the anxiogenic effects of bed nucleus of the stria terminalis (BNST) PACAP depend on the activation of PAC1 receptors. To complement our previous work that evaluated the roles of BNST PACAP expression and secretion in anxiety-related responses, we employed in the current work chemogenetic approaches in male PAC1-Ires-Cre mice to directly and specifically modulate the activities of BNST PAC1 receptor-expressing neurons. Inhibition of BNST PAC1 receptor neuron activity with clozapine-N-oxide significantly increased open arm exploration without reducing total locomotor activity; conversely, stimulating BNST PAC1 receptor function significantly reduced open arm exploratory activities. In sum, these data are consistent with our prior work suggesting a key role for BNST PACAP receptor activation in anxiety and stress; further, these observations importantly clarify the neural circuits involved in anxiety-like behaviors. (PsycInfo Database Record (c) 2025 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144940575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep brain stimulation of nucleus basalis of meynert: Effect of stimulation mode and duration on learning in rat model of dementia. 脑深部刺激梅氏基底核：刺激方式和持续时间对痴呆大鼠学习的影响。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2025-08-01 Epub Date: 2025-06-09 DOI: 10.1037/bne0000625

Deepak Kumbhare, Megan Rajagopal, Jamie Toms, Anne Freelin, George Weistroffer, Nicholas McComb, Sindhu Karnam, Adel Azghadi, Kevin S Murnane, Mark S Baron, Kathryn L Holloway

{"title":"Deep brain stimulation of nucleus basalis of meynert: Effect of stimulation mode and duration on learning in rat model of dementia.","authors":"Deepak Kumbhare, Megan Rajagopal, Jamie Toms, Anne Freelin, George Weistroffer, Nicholas McComb, Sindhu Karnam, Adel Azghadi, Kevin S Murnane, Mark S Baron, Kathryn L Holloway","doi":"10.1037/bne0000625","DOIUrl":"10.1037/bne0000625","url":null,"abstract":"Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has been preliminarily investigated as a potential treatment for dementia. The degeneration of NBM cholinergic neurons is a pathological feature of many forms of dementia. Although NBM stimulation has been demonstrated to improve learning, the ideal parameters for NBM stimulation have not been elucidated. This study assesses the differential effects of varying stimulation patterns and duration on learning in a dementia rat model with cholinergic deficits. 192-IgG saporin (SAP) or Dulbecco's phosphate buffered saline was injected into the NBM to produce dementia in rats. Next, all rats underwent unilateral implantation of a DBS electrode in the NBM. The experimental groups consisted of (a) normal, (b) untreated SAP-injected rats with cholinergic deficits, and (c) SAP rats receiving NBM DBS. The stimulation paradigms included testing different modes (tonic and burst) and durations (1 hr, 5 hr, and 24 hr/day) over 10 daily sessions. Memory was assessed using two established learning paradigms: novel object recognition and auditory operant chamber learning. Both normal and stimulated rats demonstrated improved performance in novel object recognition and auditory learning as compared to the unstimulated SAP group. The burst stimulation groups performed better than the tonic group. Increasing the daily stimulation duration to 24 hr did not further improve cognitive performance in an auditory recognition task and degraded the results on a novel object recognition task as compared with 5 hr. The present findings suggest that naturalistic NBM burst DBS may offer potential effective therapy for treating dementia and suggests potential strategies for the reevaluation of current human NBM stimulation paradigms. (PsycInfo Database Record (c) 2025 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"202-215"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anatomical connectivity-based parcellation of the human orbitofrontal cortex. 基于解剖学连接的人眶额皮质分割。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2025-08-01 DOI: 10.1037/bne0000628

Shiloh L Echevarria-Cooper, Thorsten Kahnt

{"title":"Anatomical connectivity-based parcellation of the human orbitofrontal cortex.","authors":"Shiloh L Echevarria-Cooper, Thorsten Kahnt","doi":"10.1037/bne0000628","DOIUrl":"10.1037/bne0000628","url":null,"abstract":"The orbitofrontal cortex (OFC) is critical for learning and decision making, but its organization in terms of anatomical connections to other brain areas is not well understood in humans. Here we used diffusion magnetic resonance imaging and probabilistic tractography to characterize the cortical and subcortical white matter connections of the human OFC. We found widespread connectivity of the OFC with frontal and temporal cortices, anterior cingulate, insula, olfactory cortex, as well as the striatum, hippocampus, amygdala, and thalamic nuclei. We then used k-means clustering to parcellate the OFC into different subregions based on these connections, revealing a medial-lateral division with two clusters, and a separation into medial, lateral-anterior, and lateral-posterior subdivisions with three clusters. Higher order parcellations revealed more complex subdivisions mirroring cytoarchitectural boundaries of the primate OFC. Analysis of the white matter connectivity of the medial and lateral OFC clusters revealed differences in their connectivity patterns with frontal cortices, insula, olfactory cortex, anterior cingulate cortex, as well as the striatum and several thalamic nuclei. In addition, lateral-anterior and lateral-posterior OFC clusters showed different connectivity strengths with several frontal cortices, anterior cingulate cortex, insula, and the caudate. These findings suggest parallels between the anatomical organization of the human and macaque OFC and may help to elucidate how the OFC contributes to adaptive behavior. (PsycInfo Database Record (c) 2025 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"139 4-5","pages":"229-243"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12268599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early contingency information enhances human punishment sensitivity when punishment is frequent but not rare. 当惩罚频繁但不罕见时，早期偶然性信息增强了人类的惩罚敏感性。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2025-08-01 DOI: 10.1037/bne0000627

Kelly Gaetani, Philip Jean-Richard-Dit-Bressel, Gavan P McNally

{"title":"Early contingency information enhances human punishment sensitivity when punishment is frequent but not rare.","authors":"Kelly Gaetani, Philip Jean-Richard-Dit-Bressel, Gavan P McNally","doi":"10.1037/bne0000627","DOIUrl":"10.1037/bne0000627","url":null,"abstract":"Individuals differ in sensitivity to the adverse consequences of their actions. We have shown that these differences can be linked to differences in correctly learning causal relationships between actions and their negative consequences. To further assess this, here we used a conditioned punishment task in 195 participants. Explicit punishment contingency information was provided before or after participants had experienced strong (40%) or weak (10%) punishment contingencies. We found the same phenotypes of human punishment learning reported previously (Jean-Richard-Dit-Bressel et al., 2021; Jean-Richard-Dit-Bressel et al., 2023). Early provision of punishment contingency information promoted punishment avoidance under strong punishment contingencies but was relatively ineffective under weak punishment contingencies. This persistent punishment insensitivity despite early contingency information was not due to habit learning or failure to understand the associative task structure. Rather, persistent insensitivity to punishment was due to a failure in integrating punishment contingency knowledge with action selection. (PsycInfo Database Record (c) 2025 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"139 4-5","pages":"216-228"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gonadectomy maintains goal-directed responding in female rats and accelerates habit formation in male rats. 性腺切除术维持了雌性大鼠的目标导向反应，并加速了雄性大鼠的习惯形成。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2025-08-01 Epub Date: 2025-04-07 DOI: 10.1037/bne0000622

Zaidan Mohammed, Hannah Schoenberg, Sarah VonDoepp, Russell Dougherty, Adina Kraus, Ella Hilton-Vanosdall, Sarah Van Horn, Francesca Carasi-Schwartz, Daisy Powers, Donna Toufexis

{"title":"Gonadectomy maintains goal-directed responding in female rats and accelerates habit formation in male rats.","authors":"Zaidan Mohammed, Hannah Schoenberg, Sarah VonDoepp, Russell Dougherty, Adina Kraus, Ella Hilton-Vanosdall, Sarah Van Horn, Francesca Carasi-Schwartz, Daisy Powers, Donna Toufexis","doi":"10.1037/bne0000622","DOIUrl":"10.1037/bne0000622","url":null,"abstract":"We have previously demonstrated that gonadally intact female rats become habitual following around 120 response-outcome (R-Os) exposures during operant training. This rapid development of habit does not occur in gonadally intact male rats, which remain goal-directed up to at least 320 R-Os. The present study sought to examine the effect of removing gonadal hormones on the acquisition and expression of goal-directed and habitual behaviors separately in both male and female rats. To accomplish this, separate experimental groups of adult Long-Evans rats were utilized, including intact and ovariectomized (OVX) females, as well as intact and castrated (CAST) males. All groups were trained to 240 R-Os, and one half of each experimental group was subjected to a reinforcer devaluation procedure, while the remaining half served as nondevalued controls. An extinction test was then used to determine habitual versus goal-directed behavior. Results found intact females trained to 240 R-Os showed habit and intact males trained to 240 R-Os showed goal-directed behavior. Results also found that ovariectomy disrupts habit in female rats, keeping them goal-directed at 240 R-Os, while castration in male rats produced habitual responding at 240 R-Os, thus effectively reversing the sex differences observed in intact rats at 240 R-Os. An additional experiment was done in OVX and CAST males trained to 160 R-Os to determine if gonadectomy altered goal/habit behavior earlier in instrumental learning. Results showed that both OVX females and CAST males were goal-directed at 160 R-Os. Overall, these results indicate the lack of ovarian hormones effectively delays habit in female rats, and lack of testicular hormones produces earlier habit in males. (PsycInfo Database Record (c) 2025 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"179-192"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0