Deepak Kumbhare, Megan Rajagopal, Jamie Toms, Anne Freelin, George Weistroffer, Nicholas McComb, Sindhu Karnam, Adel Azghadi, Kevin S Murnane, Mark S Baron, Kathryn L Holloway
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Next, all rats underwent unilateral implantation of a DBS electrode in the NBM. The experimental groups consisted of (a) normal, (b) untreated SAP-injected rats with cholinergic deficits, and (c) SAP rats receiving NBM DBS. The stimulation paradigms included testing different modes (tonic and burst) and durations (1 hr, 5 hr, and 24 hr/day) over 10 daily sessions. Memory was assessed using two established learning paradigms: novel object recognition and auditory operant chamber learning. Both normal and stimulated rats demonstrated improved performance in novel object recognition and auditory learning as compared to the unstimulated SAP group. The burst stimulation groups performed better than the tonic group. Increasing the daily stimulation duration to 24 hr did not further improve cognitive performance in an auditory recognition task and degraded the results on a novel object recognition task as compared with 5 hr. The present findings suggest that naturalistic NBM burst DBS may offer potential effective therapy for treating dementia and suggests potential strategies for the reevaluation of current human NBM stimulation paradigms. 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引用次数: 0
摘要
Meynert基底核(NBM)深部脑刺激(DBS)作为一种潜在的治疗痴呆症的方法已被初步研究。NBM胆碱能神经元的变性是许多形式的痴呆的病理特征。虽然NBM刺激已被证明可以改善学习,但NBM刺激的理想参数尚未阐明。本研究评估了不同刺激模式和持续时间对胆碱能缺陷痴呆大鼠模型学习的不同影响。将192-IgG saporin (SAP)或Dulbecco’s磷酸缓冲盐水注射到脑基底膜中,使大鼠产生痴呆。接下来,所有大鼠在脑基底区单侧植入DBS电极。实验组由(a)正常大鼠,(b)未治疗的SAP注射胆碱能缺陷大鼠和(c)接受NBM DBS的SAP大鼠组成。刺激模式包括测试不同的模式(强直和爆发)和持续时间(1小时,5小时和24小时/天),每天10次。记忆评估采用两种既定的学习范式:新物体识别和听觉操作室学习。与未受刺激的SAP组相比,正常和受刺激的大鼠在新物体识别和听觉学习方面的表现都有所改善。爆发刺激组表现优于强直刺激组。将每日刺激时间延长至24小时并没有进一步提高听觉识别任务中的认知表现,而且与5小时相比,在新物体识别任务中的结果有所下降。本研究结果表明,自然的脑脑损伤爆发DBS可能为治疗痴呆症提供潜在的有效治疗方法,并为重新评估当前人类脑脑损伤刺激范式提供了潜在的策略。(PsycInfo Database Record (c) 2025 APA,版权所有)。
Deep brain stimulation of nucleus basalis of meynert: Effect of stimulation mode and duration on learning in rat model of dementia.
Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has been preliminarily investigated as a potential treatment for dementia. The degeneration of NBM cholinergic neurons is a pathological feature of many forms of dementia. Although NBM stimulation has been demonstrated to improve learning, the ideal parameters for NBM stimulation have not been elucidated. This study assesses the differential effects of varying stimulation patterns and duration on learning in a dementia rat model with cholinergic deficits. 192-IgG saporin (SAP) or Dulbecco's phosphate buffered saline was injected into the NBM to produce dementia in rats. Next, all rats underwent unilateral implantation of a DBS electrode in the NBM. The experimental groups consisted of (a) normal, (b) untreated SAP-injected rats with cholinergic deficits, and (c) SAP rats receiving NBM DBS. The stimulation paradigms included testing different modes (tonic and burst) and durations (1 hr, 5 hr, and 24 hr/day) over 10 daily sessions. Memory was assessed using two established learning paradigms: novel object recognition and auditory operant chamber learning. Both normal and stimulated rats demonstrated improved performance in novel object recognition and auditory learning as compared to the unstimulated SAP group. The burst stimulation groups performed better than the tonic group. Increasing the daily stimulation duration to 24 hr did not further improve cognitive performance in an auditory recognition task and degraded the results on a novel object recognition task as compared with 5 hr. The present findings suggest that naturalistic NBM burst DBS may offer potential effective therapy for treating dementia and suggests potential strategies for the reevaluation of current human NBM stimulation paradigms. (PsycInfo Database Record (c) 2025 APA, all rights reserved).