Karina Bermeo, Hector Castro, Antonio Barajas-Martínez, Valeria Nayely Hernandez-Serratos, Erick Mauricio Aceves-Rodriguez, Eduardo Martinez-Alonso, Carla Gabriela Soto-Muñoz, Carolina Hernandez-Cruz, Isabel Arenas, David E Garcia
{"title":"Vesicular monoamine transporter 2 density increases without changing D₂ receptors in the striatum body of the rat following a high-sucrose diet.","authors":"Karina Bermeo, Hector Castro, Antonio Barajas-Martínez, Valeria Nayely Hernandez-Serratos, Erick Mauricio Aceves-Rodriguez, Eduardo Martinez-Alonso, Carla Gabriela Soto-Muñoz, Carolina Hernandez-Cruz, Isabel Arenas, David E Garcia","doi":"10.1037/bne0000624","DOIUrl":null,"url":null,"abstract":"<p><p>High-sucrose diet (HSD) has been related to cognitive impairments and caloric imbalance. A common link among them all is the dopamine (DA) system. However, the impact of HSD on vesicular monoamine transporter 2 and dopamine D₂ receptor is controversial. This work aimed to investigate whether sucrose and caloric intake impact vesicular monoamine transporter 2 and D₂ receptor density in rats under HSD at 20 or 40 weeks of treatment. Vesicular monoamine transporter 2 density increases in the HSD-20 weeks group without altering sucrose and caloric consumption, while D₂ receptor density remains unchanged. These results support underlying changes in the DA system, particularly in the striatum body, induced by HSD. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Behavioral neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1037/bne0000624","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
High-sucrose diet (HSD) has been related to cognitive impairments and caloric imbalance. A common link among them all is the dopamine (DA) system. However, the impact of HSD on vesicular monoamine transporter 2 and dopamine D₂ receptor is controversial. This work aimed to investigate whether sucrose and caloric intake impact vesicular monoamine transporter 2 and D₂ receptor density in rats under HSD at 20 or 40 weeks of treatment. Vesicular monoamine transporter 2 density increases in the HSD-20 weeks group without altering sucrose and caloric consumption, while D₂ receptor density remains unchanged. These results support underlying changes in the DA system, particularly in the striatum body, induced by HSD. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
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