Behavioral neuroscience最新文献

{"title":"Voice changes in aging birdsong: A longitudinal study in adult male zebra finches.","authors":"Michelle L Gordon, Arpita Gulati, Robin A Samlan, Julie E Miller","doi":"10.1037/bne0000666","DOIUrl":"10.1037/bne0000666","url":null,"abstract":"<p><p>By 2030, 1.4 billion people worldwide will be 60 years or older. A significant proportion will experience changes in voice, which can indicate early signs of neurodegenerative disease. Most research and treatment studies have focused on the larynx because of its accessibility and known role in moderating pitch, loudness, and voice quality. Preclinical animal models offer important insight into brain mechanisms involved in aging vocalizations. Previously, we conducted a cross-sectional analysis in adult male zebra finches, discovering that song changes occur at transitional time points, between young adult, middle age, and older ages. Song changes are accompanied by reorganization of gene networks in a song-dedicated basal ganglia brain nucleus at middle age that degrade in old age. To more precisely examine how aging alters songs during these transitional time points, we followed individual male zebra finches longitudinally over adulthood. Measurements of aging human voice, including duration, intensity, smoothed cepstral peak prominence, and fundamental frequency (<i>f</i>_o mean, standard deviation, and coefficient of variation), were carried out on birdsong syllables. Our results show that changes in <i>f</i>_o mean and intensity are the measurements most sensitive to aging and consistent across multiple mornings in the finches. Notably, acoustic changes were also more pronounced in the transition from young adult to middle age, a time at which changes in aging human voice also emerge. Our findings strengthen the validity of the finch model for use in aging research and motivate future investigations exploring the relative contributions of laryngeal, respiratory, and brain mechanisms to aging vocalizations. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin feel in the brain: Oscillatory dynamics of active touch are modulated by commercial soap products.","authors":"Tyler Mari, Mark Randle, Syed Hasan Ali, Lucrezia Pacinotti, Margaret Scott, Jessica Henderson, Anna Thomas, Sen Soumitra, Simone Sethna, Timo Giesbrecht, Carl Roberts, Nicholas Fallon","doi":"10.1037/bne0000667","DOIUrl":"10.1037/bne0000667","url":null,"abstract":"<p><p>Previous research has demonstrated changes in neural oscillations associated with varying levels of roughness during active-touch exploration of surfaces. In the present study, we aimed to investigate changes in neural oscillatory activity and softness perception during touch exploration of skin. Two experiments were conducted. Study 1 evaluated active touch of artificial skin samples mounted to a purpose-built touch sensor, whereas Study 2 investigated active stroking of one's own forearm. In both experiments, the substrates were treated with commercially available bar soaps to deliver either a soft or draggy skin feel. Oscillatory brain activity was measured using a 129-channel electroencephalography system. In 31 participants, changes in oscillatory band power were evaluated in relevant frequency bands during touch exploration periods. For the artificial skin study, the soft condition led to lower alpha-band power over bilateral somatosensory cortices, which has previously been proposed as a marker of reduced roughness, compared to the draggy condition. Similar results were obtained during the self-touch paradigm, which additionally led to reduced theta-band changes over the frontal and central-parietal electrodes indicating modulation of activity involved in affective (pleasant) touch. Using a novel and highly controlled experimental approach using a novel artificial skin paradigm and active exploration during self-touch of participants own skin, we were able to demonstrate for the first time the neural correlates associated with softness perception of skin and their impact on brain activity associated with affective touch, thereby advancing our understanding of brain oscillatory activity during active-touch exploration of skin. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidomain mobility and cognition across the adult lifespan: Stride velocity and cadence are associated with executive function in older adulthood.","authors":"Grace Amadon, Ann J Lee, Jasmeet P Hayes, James A Onate, William J Kraemer, Deb A Kegelmeyer, Anne D Kloos, Scott M Hayes","doi":"10.1037/bne0000664","DOIUrl":"10.1037/bne0000664","url":null,"abstract":"<p><p>Gait speed has been associated with executive function in aging. To date, few studies have examined multiple mobility measures in parallel across the adult lifespan. Understanding how distinct aspects of mobility are associated with executive function may clarify modifiable behavioral targets to promote healthy aging. Community-dwelling adults (<i>N</i> = 223, <i>M</i>_age [<i>SD</i>] = 52.7 years [17.5], range = 18-85 years; 135 females) from the Fitness, Aging, Stress, and Traumatic Brain Injury Exposure Repository completed mobility and cognitive testing. Spatiotemporal gait and static balance were assessed using LEGSys and BalanSens accelerometer sensors. A composite measure of executive function was derived from subtests of the Wechsler Adult Intelligence Scale-IV (Digit Span backward, sequencing) and Delis-Kaplan Executive Function System (Trail Making Test-number-letter switching, color-word interference-inhibition, inhibition switching). Relative importance analyses explored contributions of mobility measures to executive function in relatively older adults (55+ years) and relatively younger adults (18-54 years). Hierarchical linear regressions examined mobility-executive function associations in each age group. Static balance contributed to executive function in both groups, whereas gait cycle measures explained variance in executive function among older adults. Among older adults, stride velocity (β = 0.13, <i>p</i> = .028) and cadence (β = 0.12, <i>p</i> = .048) explained an additional 3.4% and 2.8% of variance in executive function beyond age and education. No associations were observed among younger adults. Mobility and cognition relationships may differ across adulthood. In older adulthood, cadence emerged as a distinct mobility marker of executive function beyond gait speed, underscoring distinct features of gait as potential modifiable lifestyle variables important for healthy aging. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of cisplatin-induced olfactory aversion based on selection logic: A novel approach.","authors":"Yong Yu, Yoshihisa Koyama, Shoichi Shimada","doi":"10.1037/bne0000653","DOIUrl":"10.1037/bne0000653","url":null,"abstract":"<p><p>Aversion can arise from a combination of unconditioned stimuli that induce physical discomfort, such as pain and nausea. Chemotherapy-induced side effects, including taste and olfactory aversion, can persist even after treatment has ended, thereby reducing the quality of life. Currently, however, no effective pharmacological interventions exist for treating chemotherapy-induced conditioned aversion learning. Therefore, elucidating its underlying mechanisms is of great importance. In this study, we investigated cisplatin-induced olfactory aversion learning using the two-bottle choice test. Cisplatin was found to induce aversive responses to neutral odorants, namely isoamyl acetate and benzaldehyde. Notably, we obtained two key findings. First, an odor solution that was not aversive in the two-bottle choice test (i.e., distilled water) became aversive to mice when compared with a third novel odor solution that had not been presented in the test. Second, when pairs of three odorants were alternated over an extended period, the mice occasionally shifted their aversive responses as the pairings changed. In clinical practice, patients are exposed to a variety of odors. Thus, the new insights gained from this study on olfactory aversion may help inform the development of novel treatments for chemotherapy-related side effects. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"236-246"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxytocin prevents cocaine-induced high-affect 50-kHz vocalizations in female rats.","authors":"Elise B Cauley, Natalie E Cornejo, Grace T Le, Morgan O Lemler, Kah-Chung Leong, Matthew S Binder","doi":"10.1037/bne0000655","DOIUrl":"10.1037/bne0000655","url":null,"abstract":"<p><p>Cocaine's reinforcing properties are a key factor underlying the broad prevalence of cocaine use disorder. Few behavioral measures are capable of assessing cocaine-induced euphoria in murine models, limiting effective treatment options. However, positive affective states can be measured in rats by assessing the production of high-frequency, 50-kHz, vocalizations. Oxytocin (OXT) has been shown to attenuate cocaine-mediated behaviors in rodent models; however, the effect of OXT on cocaine-induced euphoria remains unknown. We addressed this by randomly assigning female rats to saline-saline, saline-cocaine, OXT-saline, or OXT-cocaine conditions and then assessing ultrasonic vocalizations. We found that saline-cocaine animals emitted a significantly higher percentage of 50-kHz calls relative to the other conditions, indicative of cocaine's euphoric effects. Notably, an OXT pretreatment prevented the cocaine-induced increase in high-affect calls. We also found that OXT significantly increased call duration in cocaine animals, inducing aversivelike call properties and further suggesting that OXT may attenuate positive affective states. There were minimal differences in call bandwidth across groups and no significant differences in call amplitude. When assessing the ultrasonic vocalization's qualitative features, we found that cocaine led to an increased production of flat and short call types, both of which are associated with positive states, which were not attenuated by OXT. Altogether, we found that cocaine administration successfully produced a high affective state in female rats. Moreover, an OXT pretreatment was sufficient to decrease the rewarding effects of cocaine administration and therefore may play a vital role in treating those suffering from cocaine use disorder. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"247-254"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defensive antinociception and antipredatory responses in prey threatened by distinct odoriferous cues from Felis silvestris catus.","authors":"Moe Yamashita, Priscila Medeiros, Ohana Turcato Macacare, Yara Bezerra de Paiva, Audrey Franceschi Biagioni, Norberto Cysne Coimbra","doi":"10.1037/bne0000657","DOIUrl":"10.1037/bne0000657","url":null,"abstract":"<p><p>Fear, an adaptive response to danger situation, is vital for the survival of both human beings and rodents. Predator odor-related cues and contextual fear work as valuable models for studying neurobiological circuits, providing insights into unconditioned and conditioned fear-related behavioral and physiological responses, including fear-related antinociception. This study investigated whether a fear paradigm based on predator odor cues could trigger the defensive antinociceptive phenomenon. Our findings indicate that while both the exposure to different predator odor cues and the re-exposure to the experimental context elicit similar defensive behaviors, such as the head-out response (an inhibitory avoidance behavior), only the exposure to the predator odor cues induced defensive antinociception. Notably, during the re-exposure to the experimental context, the endogenous pain modulatory system is not recruited, suggesting that defensive antinociception is not universally elicited by all fear-related reactions. Instead, defensive antinociception appears to be modulated by distinct neural circuits and olfactory perception-dependent mechanisms that adjust dynamically according to threat imminence. Thus, antinociception emerges as part of the immediate defensive response to a threatening odor cue, rather than as a consequence of fear memory retrieval. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"267-277"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148249012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of behaviors during food consumption under novelty and threat learning in male and female rats.","authors":"Margaret G Keefe, Rebecca Shteyn, Gorica D Petrovich","doi":"10.1037/bne0000654","DOIUrl":"10.1037/bne0000654","url":null,"abstract":"<p><p>Fear and anxiety are related but distinct responses to imminent versus uncertain threat. Suppression of eating under novelty is an evolutionarily conserved, cross-species model of anxiety, and it is beneficial to determine if this behavior can predict individual differences in fear learning and memory. The present study examined behaviors during novelty-induced suppression of eating and fear learning and memory in male and female rats, and determined which behaviors correlate across the two paradigms. Experiment 1a tested consumption of novel versus familiar food in a novel or familiar context across two sessions. During the first session, subjects in the novel context consumed less familiar food than those in the familiar context, demonstrating novelty-induced hypophagia. Novel food consumption did not differ by context. During the second session, all subjects increased consumption and reduced latency to eat, indicating habituation. Females consumed more novel food than males and more novel than familiar food. Experiment 1b tested Pavlovian auditory fear conditioning, extinction, and renewal. Behavioral responses were categorized under freezing, mobility, or neutral. Freezing increased during acquisition, decreased during extinction, and was renewed in the original acquisition context, confirming learning and memory in both sexes. In contrast, mobility behaviors increased during extinction and were not conditioned nor renewed. Neutral behaviors were high at baseline and suppressed during cue presentations. Lower novel food consumption correlated with higher freezing and lower mobility during extinction in males, but not females. This suggests that individual differences in novelty-induced anxiety can predict behavior during fear extinction in male rats. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"140 4","pages":"217-235"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148389820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampal communication with the anterior olfactory nucleus is necessary for context-dependent odor memory.","authors":"Norma A Hernandez, Yan-Yu Yang, Christiane Linster, David M Smith","doi":"10.1037/bne0000659","DOIUrl":"10.1037/bne0000659","url":null,"abstract":"<p><p>The hippocampus plays a critical role in contextual learning and memory processes. The ability to associate memories and behaviors with the learning context likely involves interactions between the hippocampus and other brain regions where the basic elements of the memory may be encoded. Here, we examined interactions of the hippocampus and the olfactory system using a contextually cued conditional discrimination task that required rats to remember that one odor from a pair of odor cues is rewarded in one context, but the opposite odor is rewarded in a different context. We used muscimol to inactivate the anterior olfactory nucleus, a key target for hippocampal output to the olfactory system, and the ventral hippocampus. We also performed crossed-hemisphere inactivation of the anterior olfactory nucleus in one hemisphere and the hippocampus in the other. All three inactivation procedures severely impaired performance. These results indicate that interactions between the hippocampus and anterior olfactory nucleus are critical for context-dependent odor memory. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"211-216"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13271158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148248999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological sex and normative cognitive aging across spatial learning, flexibility, and working memory in Fischer 344 rats.","authors":"Zahra Faghihi, David J Horovitz, Lori A Newman, Peter J Vento, Joseph A McQuail","doi":"10.1037/bne0000656","DOIUrl":"10.1037/bne0000656","url":null,"abstract":"<p><p>Aging is associated with decline in spatial learning, cognitive flexibility, and working memory, yet the extent to which biological sex modulates changes in cognitive function remains unresolved. While sex differences are evident in pathological brain aging, sparse insights from healthy aging populations suggest that sex effects on cognition are modest and domain specific. To systematically test effects of biological sex across the lifespan on specific aspects of cognitive function, we examined age- and sex-related changes in spatial cognition in a large cohort of Fischer 344 rats (<i>N</i> = 373), including young (4-8 months), middle-aged (12-16 months), and older aged (22-26 months) males and females. Rats were assessed on spatial reference learning, reversal learning, and working memory versions of the Morris water maze, with performance quantified using proximity-based measures, providing sensitive, individualized indices of spatial learning. Across all tasks, age accounted for the largest proportion of variance, with older rats exhibiting impairments in spatial learning, flexibility, and working memory relative to young adults. In contrast, effects of sex or interactions with age were limited to certain aspects of performance and were substantially smaller relative to age and training effects. Specifically, a female-specific association between spatial reference memory and reversal learning was observed despite comparable overall performance. Performance on visible-platform control trials did not indicate gross sensorimotor impairments that would account for age-related spatial deficits. Together, findings demonstrate age is the primary determinant of spatial cognitive decline under normative conditions, while sex-related influences, if present, are subtle and task dependent. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"255-266"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13271161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148248944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taste exposure during different developmental phases impacts aversion learning in adult rats.","authors":"Bailey Tanner, Hanna M Gemmell, Kaliana C Reifsnyder, Katherine Headley, Joost X Maier, Veronica L Flores","doi":"10.1037/bne0000648","DOIUrl":"10.1037/bne0000648","url":null,"abstract":"<p><p>Associating a taste with a positive or negative consequence is a robust form of learning that benefits survival by shaping future taste decisions. A robust example is conditioned taste aversion (CTA), wherein tastes associated with malaise are later avoided (Garcia et al., 1955; Lubow, 2009; Reilly & Bornovalova, 2005; Reilly & Schachtman, 2009). One factor that can modulate the strength of CTA learning is previous exposure to the conditioned taste. For example, familiarity with a taste weakens future learning toward that taste (Lubow, 1973, 2009; Lubow & Moore, 1959), demonstrating that even mere exposures to taste impact future plasticity. Taste exposure is ubiquitous in everyday life and begins in-utero. Recently, research has suggested that experience during specific periods of early life development can also induce preference and familiarity toward stimuli later in life, thus it is important to understand whether experience with tastes have differential effects on learning across the lifetime. Here, we explore for the first time whether sucrose exposure during different developmental stages in Long Evans rats (N = 55) differentially impacts sucrose-CTA learning in adulthood. Such an effect would suggest the existence of unique plasticity mechanisms that are influenced by taste exposure across different development phases. Interestingly, we report an enhancement of aversion learning in adult rats who were exposed to sucrose through their mother, either during gestation or lactation. These findings suggest that taste exposure during specific phases of early development holds unique significance for neuroplasticity and learning in adulthood. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"140 3","pages":"190-200"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13196420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}