Behavioral neuroscience最新文献_第2页

Trait-level somatic anxiety modulates functional magnetic resonance imaging (fMRI) neural synchrony to naturalistic stimuli. 特质水平的躯体焦虑调节功能磁共振成像（fMRI）对自然刺激的神经同步。

IF 1.6 4区医学

Behavioral neuroscience Pub Date : 2024-12-01 DOI: 10.1037/bne0000615

Keva Klamer, Joshua Craig, Christina Haines, KiAnna Sullivan, Chelsea Ekstrand

{"title":"Trait-level somatic anxiety modulates functional magnetic resonance imaging (fMRI) neural synchrony to naturalistic stimuli.","authors":"Keva Klamer, Joshua Craig, Christina Haines, KiAnna Sullivan, Chelsea Ekstrand","doi":"10.1037/bne0000615","DOIUrl":"https://doi.org/10.1037/bne0000615","url":null,"abstract":"Somatic anxiety refers to the tendency to appraise situations as threatening, leading to heightened physiological arousal. Symptoms associated with higher levels of somatic anxiety that reflect autonomic arousal and perceptions of threat include elevated heartbeat perception, difficulty breathing, and palpitation. Somatic anxiety is generally associated with increased stimulus-driven attention; however, it is currently unknown how somatic anxiety modulates neural synchrony, measured by intersubject correlations (ISC), in response to complex audiovisual stimuli. The present study seeks to identify how differing levels of somatic anxiety are associated with neural synchrony during psychological processing of audiovisual stimuli, as measured by ISC and intersubject representational similarity analyses. We hypothesize that individuals with higher levels of somatic anxiety will show heightened ISC in response to an audiovisual stimulus in regions associated with stimulus-driven attention, including the superior parietal lobule, supplementary motor area, and precentral gyrus. Results from this study identified that higher levels of somatic anxiety are associated with widespread heightened ISC across the brain, including in regions associated with perceptual processing and stimulus-driven attention. Taken together, this research suggests that higher levels of somatic anxiety are associated with similar processing in brain regions involved in stimulus-driven attention and top-down processing, whereas lower levels of somatic anxiety are associated with similar processing in brain regions associated with higher level visual processing. These results collectively emphasize that somatic anxiety levels should be measured and controlled for during naturalistic functional magnetic resonance imaging paradigms, as this trait may have an influence on synchronous neurological activity. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"138 6","pages":"409-419"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Taste enhances the ability to express a preference for a congruent odor in rats. 味觉增强了大鼠表达对同类气味偏好的能力。

IF 1.6 4区医学

Behavioral neuroscience Pub Date : 2024-12-01 Epub Date: 2024-09-19 DOI: 10.1037/bne0000605

Yuan J F Cai, Isabella B Allar, Joost X Maier

{"title":"Taste enhances the ability to express a preference for a congruent odor in rats.","authors":"Yuan J F Cai, Isabella B Allar, Joost X Maier","doi":"10.1037/bne0000605","DOIUrl":"10.1037/bne0000605","url":null,"abstract":"Foods that make up a typical diet are characterized by a rich set of sensory qualities that are perceived through multiple different modalities. It is well known that multisensory aspects of food are integrated to create our perception of flavor, which in turn affects our behavioral responses to food. However, the principles underlying multisensory integration of flavor-related sensory signals and how they inform perceptual judgments remain poorly understood, partly due to lack of control over flavor experience in human subjects. Here, we used rats as a model to overcome this limitation and tested the hypothesis that taste can enhance discriminability of retronasal odor cues. In a series of two-bottle tests, animals chose between two odorized solutions after learning to associate one of the odors with saccharin. When odors were highly similar, animals showed little preference for the saccharin-associated odor. When adding saccharin to both bottles-rendering one of the solutions' congruent-animals' preference for the saccharin-associated odor was significantly enhanced. No effect of taste was observed when using dissimilar odor pairs or novel taste stimuli. These findings suggest that congruent taste stimuli selectively enhance odor identity representations, aiding in the discriminability of perceptually similar flavors. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"433-440"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N-tert-butoxycarbonyl-methylenedioxymethamphetamine, an methylenedioxymethamphetamine derivative, exhibits rewarding and reinforcing effects by increasing dopamine levels. N-tert-butoxycarbonyl-methylenedioxymethamphetamine 是一种亚甲二氧基甲基苯丙胺衍生物，可通过提高多巴胺水平产生奖赏和强化作用。

IF 1.6 4区医学

Behavioral neuroscience Pub Date : 2024-10-01 Epub Date: 2024-05-23 DOI: 10.1037/bne0000593

Dong-Hyun Youn, Cheolmin Jo, Jin Mook Kim, Young-Ki Hong, Wonjong Lee, Seong Hye Park, Chan Hyeok Kwon, Sun-Ok Choi

{"title":"N-tert-butoxycarbonyl-methylenedioxymethamphetamine, an methylenedioxymethamphetamine derivative, exhibits rewarding and reinforcing effects by increasing dopamine levels.","authors":"Dong-Hyun Youn, Cheolmin Jo, Jin Mook Kim, Young-Ki Hong, Wonjong Lee, Seong Hye Park, Chan Hyeok Kwon, Sun-Ok Choi","doi":"10.1037/bne0000593","DOIUrl":"10.1037/bne0000593","url":null,"abstract":"An N-protected methylenedioxymethamphetamine (MDMA), N-tert-butoxycarbonyl-3,4-methylenedioxymethamphetamine (t-BOC-3,4-MDMA), contains tert-butoxycarbonyl and can remain undetected in the illicit drug market. It is a new type of precursor substance that is not a chemical intermediate and can be converted into a controlled substance, MDMA, by deprotection of the N-tert-butoxycarbonyl group. Categorization of this chemical into a precursor or psychotropic substance is an issue because it is an unprecedented precursor that could have misuse potential. Although MDMA causes rewarding and reinforcing effect through dopaminergic transmission, the misuse potential of t-BOC-3,4-MDMA has not yet been characterized. Here, we aim to evaluate the misuse potential of t-BOC-3,4-MDMA. The response to the drug at a dose of 5 mg/kg was determined by a climbing test, and its rewarding and reinforcing properties were assessed through conditioned place preference and self-administration tests. In the conditioned place preference test, intraperitoneal administration of t-BOC-3,4-MDMA (5 mg/kg) significantly altered place preference in mice. In the self-administration models, t-BOC-3,4-MDMA induced drug-taking behavior at the dose of 0.5 mg/kg/infusion (intravenous) during 2 hr sessions under fixed-ratio schedules in mice. In addition, microdialysis experiments verified that t-BOC-3,4-MDMA impacted the dopamine levels of the brain (striatum) of rats. These experimental results indicate that t-BOC-3,4-MDMA has a potential for misuse. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"314-320"},"PeriodicalIF":1.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrophysiological and hemodynamic mechanisms underlying load modulations in visuospatial working memory: A functional near-infrared spectroscopy (fNIRS) and electroencephalogram (EEG) study. 视觉空间工作记忆负荷调节的电生理学和血液动力学机制：功能性近红外光谱（fNIRS）和脑电图（EEG）研究。

IF 1.6 4区医学

Behavioral neuroscience Pub Date : 2024-10-01 DOI: 10.1037/bne0000604

Lisa Zarantonello, Sabrina Brigadoi, Sami Schiff, Patrizia Silvia Bisiacchi, Simone Cutini, Sara Montagnese, Piero Amodio

{"title":"Electrophysiological and hemodynamic mechanisms underlying load modulations in visuospatial working memory: A functional near-infrared spectroscopy (fNIRS) and electroencephalogram (EEG) study.","authors":"Lisa Zarantonello, Sabrina Brigadoi, Sami Schiff, Patrizia Silvia Bisiacchi, Simone Cutini, Sara Montagnese, Piero Amodio","doi":"10.1037/bne0000604","DOIUrl":"https://doi.org/10.1037/bne0000604","url":null,"abstract":"The n-back task has been widely used to study working memory. Previous studies investigating the electrophysiological (electroencephalogram [EEG]) and hemodynamic correlates (functional near-infrared spectroscopy [fNIRS]) of the n-back task have been generally based on verbal stimuli and only investigated EEG frequency bands. We simultaneously acquired the EEG and fNIRS in 35 participants (16 males; age = 26.4 ± 4.3 years; educational attainment = 18 ± 2 years) during a visuospatial n-back task. The task encompassed a control condition and a low (requiring to recall one previous stimulus) and a high (requiring to recall two previous stimuli) working memory load experimental conditions. Accuracy decreased and reaction times slowed in the high compared to both low load and control conditions. Regarding EEG, P3a showed higher amplitude in the experimental conditions compared to the control one, and P3b exhibited higher amplitude in the low compared to the high load condition. Regarding fNIRS, the high load condition showed higher deoxygenated hemoglobin compared to the control one. Moreover, the central frontopolar cortex showed higher activation compared with the left frontal cortex. Our study showed that working memory load during a visuospatial n-back task influenced behavioral and electrophysiological indices. Even if the load effect was only observed for deoxygenated hemoglobin on hemodynamic data, this was in line with previous studies and coherent with its electrophysiological correlates. Thus, our study confirms that EEG and fNIRS can be successfully used in multimodal acquisitions, but also highlights that future studies are needed to develop a novel version of the task. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"138 5","pages":"331-341"},"PeriodicalIF":1.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renewal of conditioned fear in male and female rats. 雄性和雌性大鼠条件性恐惧的延续

IF 1.6 4区医学

Behavioral neuroscience Pub Date : 2024-10-01 Epub Date: 2024-05-16 DOI: 10.1037/bne0000598

Hannah L Schoenberg, Samantha K Moriarty, Neil E Winterbauer, Sayamwong E Hammack, Donna J Toufexis, Travis P Todd

{"title":"Renewal of conditioned fear in male and female rats.","authors":"Hannah L Schoenberg, Samantha K Moriarty, Neil E Winterbauer, Sayamwong E Hammack, Donna J Toufexis, Travis P Todd","doi":"10.1037/bne0000598","DOIUrl":"10.1037/bne0000598","url":null,"abstract":"Pavlovian extinction reduces the performance of conditioned responses and occurs when the conditioned stimulus (CS) is repeatedly presented in the absence of the unconditioned stimulus (US). However, when the CS is experienced in a context that is different from the extinction context, there is a recovery of the conditioned response, a phenomenon known as renewal. There is some evidence that the renewal of appetitive conditioning is influenced by sex, with females failing to exhibit renewed responding. Further, there is recent evidence that renewal of fear might also not occur in female rats. In both appetitive and fear preparations, the lack of renewal in females has been postulated to be related to cycling ovarian hormones. Therefore, in Experiments 1 and 2, we directly compared fear renewal in males and females (Experiment 1) as well as ovariectomized (OVX) females (Experiment 2) when conditioning occurred in Context A, extinction in B, and testing in A (ABA renewal). Experiments 3 and 4 examined renewal when conditioning and extinction occurred in A and testing occurred in B (AAB renewal). In all experiments, renewal was not significantly different between male and female rats. Further, in Experiments 2 and 4, renewal did not differ between males, intact females, and OVX females. Additionally, in each experiment, there was no evidence that context excitation and/or inhibition contributed to renewal; instead suggesting that renewal was controlled by an occasion-setting mechanism. Overall, these results suggest little evidence for the role of sex in renewal of conditioned freezing and also indicate that cycling ovarian hormones have little role in the strength of renewal in female rats. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"366-381"},"PeriodicalIF":1.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in behavior and glutamic acid decarboxylase in Long Evans rats after prolonged social isolation beginning in adolescence. Long Evans 大鼠从青春期开始长期与社会隔离后的行为和谷氨酸脱羧酶的性别差异。

IF 1.6 4区医学

Behavioral neuroscience Pub Date : 2024-10-01 Epub Date: 2024-05-23 DOI: 10.1037/bne0000596

Shannon M Harding, Aaron R Van Dyke, Matthew Little, Matthew G LaClair

{"title":"Sex differences in behavior and glutamic acid decarboxylase in Long Evans rats after prolonged social isolation beginning in adolescence.","authors":"Shannon M Harding, Aaron R Van Dyke, Matthew Little, Matthew G LaClair","doi":"10.1037/bne0000596","DOIUrl":"10.1037/bne0000596","url":null,"abstract":"Social isolation can have long-term effects on brain development and behavior and increases the risk of developing clinical conditions, including anxiety disorders. One modulator of the stress response is gamma-aminobutyric acid, an inhibitory neurotransmitter synthesized by glutamic acid decarboxylase (GAD). This study examined sex differences in behavior and GAD expression following prolonged social isolation beginning in adolescence in Long Evans rats. Males and females were equally divided into group-housed (GH) and socially isolated conditions on Postnatal Day 28 (n = 8 per group). Beginning 5 weeks later, tests were conducted for anxietylike behaviors (open-field test and elevated plus maze), social interactions (sociability test), and spatial memory (novel object location). Sex differences in behavior were observed, with GH females showing fewer anxietylike behaviors in the open-field test and elevated plus maze and spending more time with objects (sociability task) compared to GH males. Isolation had no effect on males but increased anxiety and reduced neophilic measures in females, removing sex differences. On the sociability task, all groups spent more time with novel rats compared to objects, suggesting social interest was retained after isolation. In the hippocampus, isolation reduced GAD in both sexes, and sex differences were seen (F > M). However, no group differences in behavior were observed in the hippocampal-dependent novel object location task. Our findings suggest that prolonged social isolation beginning in adolescence is anxiogenic for female Long Evans rats. Furthermore, sex and housing impact hippocampal GABA-ergic activity, which may have important implications in the treatment of anxiety disorders. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"321-330"},"PeriodicalIF":1.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of supplementation with omega-3 fatty acids after maternal dietary deficiency on adolescent anxiety and microglial morphology. 母亲饮食不足后补充欧米伽-3 脂肪酸对青少年焦虑症和微神经胶质细胞形态的影响。

IF 1.6 4区医学

Behavioral neuroscience Pub Date : 2024-10-01 Epub Date: 2024-06-06 DOI: 10.1037/bne0000584

Alina P Bogachuk, David S Jacobs, Bita Moghaddam

{"title":"Impact of supplementation with omega-3 fatty acids after maternal dietary deficiency on adolescent anxiety and microglial morphology.","authors":"Alina P Bogachuk, David S Jacobs, Bita Moghaddam","doi":"10.1037/bne0000584","DOIUrl":"10.1037/bne0000584","url":null,"abstract":"Dietary maternal deficiency in omega-3 polyunsaturated fatty acids (n-3 PUFA) is a potential risk factor for the development of anxiety and other mood disorders in children and adolescents. Here, we used a previously characterized maternal n-3 PUFA dietary deficiency model in rats to determine the impact of postweaning supplementation on adolescent anxiety-like behaviors. We focused on two models of anxiety: innate anxiety tested by the elevated plus maze and a novel operant model of learned anxiety where animals learn that actions may be associated with a variable probability of harm. Given that recent basic and clinical studies have associated anxiety and other adverse effects of n-3 PUFA deficiency on inflammatory processes and microglial structure and function, we also assessed the impact of our dietary deficiency model and supplementation on adolescent microglial morphology in multiple brain regions. We found that the male and female adolescent n-3 PUFA-deficient groups exhibit increased innate anxiety, but only females showed enhanced learned anxiety. Supplementation after weaning did not significantly affect innate anxiety but ameliorated learned anxiety in females. Thus, the beneficial effects of supplementation on adolescent anxiety may be sex-specific and depend on the type of anxiety. We also found that n-3 PUFA deficiency influences microglia function in adolescents in the amygdala and nigrostriatal, but not mesolimbic, brain regions. Collectively, these data suggest that while n-3 PUFA dietary supplementation may be effective in reducing adolescent anxiety, this effect is context-, sex-, and brain network-specific. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"353-365"},"PeriodicalIF":1.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling impaired insight after drug use in rodents. 啮齿动物吸毒后洞察力受损的模型。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2024-08-01 DOI: 10.1037/bne0000606

Marios Chris Panayi,Geoffrey Schoenbaum

引用次数: 0

Leveraging individual differences in cue-reward learning to investigate the psychological and neural basis of shared psychiatric symptomatology: The sign-tracker/goal-tracker model. 利用线索-奖赏学习的个体差异研究共同精神症状的心理和神经基础：标志追踪者/目标追踪者模型。

IF 1.6 4区医学

Behavioral neuroscience Pub Date : 2024-08-01 Epub Date: 2024-05-16 DOI: 10.1037/bne0000590

Princess C Felix, Shelly B Flagel

{"title":"Leveraging individual differences in cue-reward learning to investigate the psychological and neural basis of shared psychiatric symptomatology: The sign-tracker/goal-tracker model.","authors":"Princess C Felix, Shelly B Flagel","doi":"10.1037/bne0000590","DOIUrl":"10.1037/bne0000590","url":null,"abstract":"In our modern environment, we are bombarded with stimuli or cues that exert significant influence over our actions. The extent to which such cues attain control over or disrupt goal-directed behavior is dependent on several factors, including one's inherent tendencies. Using a rodent model, we have shown that individuals vary in the value they place on stimuli associated with reward. Some individuals, termed \"goal-trackers,\" primarily attribute predictive value to reward cues, whereas others, termed \"sign-trackers,\" attribute predictive and incentive value. Thus, for sign-trackers, the reward cue is transformed into an incentive stimulus that is capable of eliciting maladaptive behaviors. The sign-tracker/goal-tracker animal model has allowed us to refine our understanding of behavioral and computational theories related to reward learning and to parse the underlying neural processes. Further, the neurobehavioral profile of sign-trackers is relevant to several psychiatric disorders, including substance use disorder, impulse control disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, and posttraumatic stress disorder. This model, therefore, can advance our understanding of the psychological and neurobiological mechanisms that contribute to individual differences in vulnerability to psychopathology. Notably, initial attempts at translation-capturing individual variability in the propensity to sign-track in humans-have been promising and in line with what we have learned from the animal model. In this review, we highlight the pivotal role played by the sign-tracker/goal-tracker animal model in enriching our understanding of the psychological and neural basis of motivated behavior and psychiatric symptomatology. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"260-271"},"PeriodicalIF":1.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond reconsolidation: The need for a broad theoretical approach in clinical translations of research on retrieval-induced plasticity. 超越再巩固：在对检索诱导可塑性研究进行临床转化时，需要采用广泛的理论方法。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2024-08-01 DOI: 10.1037/bne0000602

K Matthew Lattal

{"title":"Beyond reconsolidation: The need for a broad theoretical approach in clinical translations of research on retrieval-induced plasticity.","authors":"K Matthew Lattal","doi":"10.1037/bne0000602","DOIUrl":"https://doi.org/10.1037/bne0000602","url":null,"abstract":"Experimental findings showing that retrieved memories are labile and vulnerable to disruption have led to important theoretical ideas at a basic science level that have been applied to the clinic at a translational level. At a theoretical level, these findings suggest that retrieved memories can be modulated by behavioral or pharmacological treatments as they are reconsolidated and returned to storage. At a clinical level, these findings suggest that treatments that target reconsolidation may help dampen or even erase especially problematic memories, such as those associated with trauma. However, there are many caveats to these effects and issues that need to be considered when thinking broadly about retrieval-induced plasticity and extensions into the clinic. First, performance during a memory test often does not reflect the entirety of the animal's knowledge about a situation; asking questions in different ways may reveal the presence of a memory that was thought to be eliminated. Second, although reconsolidation and extinction are often treated as competing processes, there is abundant evidence that extinction can progress through associative and nonassociative changes in the original memory that are often described in terms of reconsolidation effects. Third, targeting a reconsolidation process as a therapeutic may not be helpful in disorders like posttraumatic stress disorder, in which traumatic experiences induce a cascade of symptoms that are self-perpetuating and may ultimately maintain themselves long after trauma. Underlying all of these challenges is the need for a rich theoretical framework focused on retrieval-induced plasticity that is informed by developments in associative learning theory. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"59 1","pages":"272-280"},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142205600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0