Behavioral neuroscience最新文献

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Biased choice and incentive salience: Implications for addiction. 偏差选择和激励突出:对成瘾的影响。
IF 1.6 4区 医学
Behavioral neuroscience Pub Date : 2024-08-01 Epub Date: 2024-05-23 DOI: 10.1037/bne0000583
Mike E Le Pelley, Poppy Watson, Reinout W Wiers
{"title":"Biased choice and incentive salience: Implications for addiction.","authors":"Mike E Le Pelley, Poppy Watson, Reinout W Wiers","doi":"10.1037/bne0000583","DOIUrl":"10.1037/bne0000583","url":null,"abstract":"<p><p>Before we can make any choice, we must gather information from the environment about what our options are. This information-gathering process is critically mediated by attention, and our attention is, in turn, shaped by our previous experiences with-and learning about-stimuli and their consequences. In this review, we highlight studies demonstrating a rapid and automatic influence of reward learning on attentional capture and argue that these findings provide a human analog of sign-tracking behavior observed in nonhuman animals-wherein signals of reward gain incentive salience and become attractive targets for attention (and overt behavior) in their own right. We then consider the implications of this idea for understanding the drivers of cue-controlled behavior, with focus on addiction as a case in which choices with regard to reward-related stimuli can become injurious to health. We argue that motivated behavior in general-and addiction in particular-can be understood within a \"biased competition\" framework: Different options and outcomes compete for attentional priority as a function of top-down goals, bottom-up salience, and prior experience, and the winner of this competition becomes the target for subsequent outcome-directed and flexible behavior. Finally, we outline the implications of the biased-competition framework for cognitive, behavioral, and socioeconomic interventions for addiction. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"235-243"},"PeriodicalIF":1.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Translational approaches to the neurobiological study of conditional discrimination and inhibition: Implications for psychiatric disease. 条件辨别和抑制神经生物学研究的转化方法:对精神疾病的影响。
IF 1.6 4区 医学
Behavioral neuroscience Pub Date : 2024-08-01 Epub Date: 2024-06-24 DOI: 10.1037/bne0000594
Susan Sangha, Jacklynn M Fitzgerald
{"title":"Translational approaches to the neurobiological study of conditional discrimination and inhibition: Implications for psychiatric disease.","authors":"Susan Sangha, Jacklynn M Fitzgerald","doi":"10.1037/bne0000594","DOIUrl":"10.1037/bne0000594","url":null,"abstract":"<p><p>There is a growing number of studies investigating discriminatory fear conditioning and conditioned inhibition of fear to assess safety learning, in addition to extinction of cued fear. Despite all of these paradigms resulting in a reduction in fear expression, there are nuanced differences among them, which could be mediated through distinct behavioral and neural mechanisms. These differences could impact how we approach potential treatment options in clinical disorders with dysregulated fear responses. The objective of this review is to give an overview of the conditional discrimination and inhibition findings reported in both animal models and human neuropsychiatric disorders. Both behavioral and neural findings are reviewed among human and rodent studies that include conditional fear discrimination via conditional stimuli with and without reinforcement (CS+ vs. CS-, respectively) and/or conditional inhibition of fear through assessment of the fear response to a compound CS-/CS+ cue versus CS+. There are several parallels across species in behavioral fear expression as well as neural circuits promoting fear reduction in response to a CS- and/or CS-/CS+ compound cue. Continued and increased efforts to compare similar behavioral fear inhibition paradigms across species are needed to make breakthrough advances in our understanding and treatment approaches to individuals with fear disorders. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"244-259"},"PeriodicalIF":1.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resource-rational psychopathology. 资源理性精神病理学。
IF 1.6 4区 医学
Behavioral neuroscience Pub Date : 2024-08-01 Epub Date: 2024-05-16 DOI: 10.1037/bne0000600
Bilal A Bari, Samuel J Gershman
{"title":"Resource-rational psychopathology.","authors":"Bilal A Bari, Samuel J Gershman","doi":"10.1037/bne0000600","DOIUrl":"10.1037/bne0000600","url":null,"abstract":"<p><p>Psychopathology is vast and diverse. Across distinct disease states, individuals exhibit symptoms that appear counter to the standard view of rationality (expected utility maximization). We argue that some aspects of psychopathology can be described as resource-rational, reflecting a rational trade-off between reward and cognitive resources. We review work on two theories of this kind: rational inattention, where a capacity limit applies to perceptual channels, and policy compression, where the capacity limit applies to action channels. We show how these theories can parsimoniously explain many forms of psychopathology, including affective, primary psychotic, and neurodevelopmental disorders, as well as many effects of psychoactive medications on these disorders. While there are important disorder-specific differences and the theories are by no means universal, we argue that resource rationality offers a useful new perspective on psychopathology. By emphasizing the role of cognitive resource constraints, this approach offers a more inclusive picture of rationality. Some aspects of psychopathology may reflect rational trade-offs rather than the breakdown of rationality. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"221-234"},"PeriodicalIF":1.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11423359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A psychological mechanism for the development of anxiety. 焦虑发展的心理机制
IF 1.9 4区 医学
Behavioral neuroscience Pub Date : 2024-08-01 DOI: 10.1037/bne0000607
Gonzalo P Urcelay
{"title":"A psychological mechanism for the development of anxiety.","authors":"Gonzalo P Urcelay","doi":"10.1037/bne0000607","DOIUrl":"https://doi.org/10.1037/bne0000607","url":null,"abstract":"Although numerous behavioral constructs have been proposed to account for anxiety disorders, how these disorders develop within an individual has been difficult to predict. In this perspective, I selectively review clinical and experimental evidence suggesting that avoidance (i.e., safety) behavior increases beliefs of threat or fear. The experimental evidence has been replicated numerous times, with different parameters, and shows that when human participants emit avoidance responses in the presence of a neutral stimulus, they later show heightened expectations of threat in the presence of the neutral stimulus. I interpret these findings as resulting from prediction errors as anticipated by the Rescorla-Wagner model, although other animal learning theories can also predict the phenomenon. I discuss some implications and offer a few novel predictions. The analysis presented here sheds light on a phenomenon of theoretical and clinical relevance which is accommodated by basic associative learning theory. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"10 1","pages":"281-290"},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142205601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fear attenuation collaborations to optimize translation. 减弱恐惧合作,优化翻译。
IF 1.6 4区 医学
Behavioral neuroscience Pub Date : 2024-06-01 DOI: 10.1037/bne0000581
Marie-H Monfils, Hongjoo J Lee, Marissa Raskin, Yael Niv, Jason Shumake, Michael J Telch, Jasper A J Smits, Michael W Otto
{"title":"Fear attenuation collaborations to optimize translation.","authors":"Marie-H Monfils, Hongjoo J Lee, Marissa Raskin, Yael Niv, Jason Shumake, Michael J Telch, Jasper A J Smits, Michael W Otto","doi":"10.1037/bne0000581","DOIUrl":"10.1037/bne0000581","url":null,"abstract":"<p><p>Here, we describe the efforts we dedicated to the challenge of modifying entrenched emotionally laden memories. In recent years, through a number of collaborations and using a combination of behavioral, molecular, and computational approaches, we: (a) developed novel approaches to fear attenuation that engage mechanisms that differ from those engaged during extinction (Monfils), (b) examined whether our approaches can generalize to other reinforcers (Lee, Gonzales, Chaudhri, Cofresi, and Monfils), (c) derived principled explanations for the differential outcomes of our approaches (Niv, Gershman, Song, and Monfils), (d) developed better assessment metrics to evaluate outcome success (Shumake and Monfils), (e) identified biomarkers that can explain significant variance in our outcomes of interest (Shumake and Monfils), and (f) developed better basic research assays and translated efforts to the clinic (Smits, Telch, Otto, Shumake, and Monfils). We briefly highlight each of these milestones and conclude with final remarks and extracted principles. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"138 3","pages":"152-163"},"PeriodicalIF":1.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction, perception, and psychosis: Application of associative learning theories to schizophrenia research. 预测、感知和精神病:联想学习理论在精神分裂症研究中的应用。
IF 1.6 4区 医学
Behavioral neuroscience Pub Date : 2024-06-01 DOI: 10.1037/bne0000599
Riria Suzuki, Yutaka Kosaki
{"title":"Prediction, perception, and psychosis: Application of associative learning theories to schizophrenia research.","authors":"Riria Suzuki, Yutaka Kosaki","doi":"10.1037/bne0000599","DOIUrl":"https://doi.org/10.1037/bne0000599","url":null,"abstract":"<p><p>In recent years, there have been significant advances in our understanding of the positive symptoms of schizophrenia, such as hallucinations and delusions. This progress has been significantly aided by the use of associative learning-based approaches in human subjects and preclinical animal models. Here, we first review experimental research focusing on the abnormal processing of absent stimuli using three different conditioning phenomena: conditioned hallucinations, mediated conditioning, and trace conditioning. We then review studies investigating the ability to reduce focal processing of physically present but informationally redundant stimuli using habituation, latent inhibition, and blocking. The results of these different lines of research are then summarized within the framework of Wagner's (1981) standard operating procedures model, an associative learning model with explicit reference to the internal representations of both present and absent stimuli. Within this framework, the central deficit associated with positive symptoms can be described as a failure to suppress the focal processing of both absent stimuli and present but irrelevant stimuli. This can explain the wide range of results obtained in different experimental settings. Finally, we briefly discuss the role of the hippocampus and its interaction with dopaminergic transmission in the emergence of such abnormal stimulus representations and learning. Overall, we hope that the theoretical framework and empirical findings offered by the associative learning approach will continue to facilitate and integrate analyses of schizophrenia conducted at the psychological and behavioral levels on the one hand, and at the neural and molecular levels on the other, by serving as a useful interface between them. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"138 3","pages":"195-211"},"PeriodicalIF":1.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of midbrain dopamine cells projecting to the insular cortex in mediated performance: Implications for animal models of reality testing. 投射到岛叶皮层的中脑多巴胺细胞在中介表现中的作用:对现实测试动物模型的启示
IF 1.6 4区 医学
Behavioral neuroscience Pub Date : 2024-06-01 DOI: 10.1037/bne0000580
Benjamin R Fry, Victoria Fex, Akira Sawa, Minae Niwa, Alexander W Johnson
{"title":"The role of midbrain dopamine cells projecting to the insular cortex in mediated performance: Implications for animal models of reality testing.","authors":"Benjamin R Fry, Victoria Fex, Akira Sawa, Minae Niwa, Alexander W Johnson","doi":"10.1037/bne0000580","DOIUrl":"https://doi.org/10.1037/bne0000580","url":null,"abstract":"<p><p>A growing body of literature indicates that mediated learning techniques have specific utility for tapping into reality testing in animal models of neuropsychiatric illness. In particular, recent work has shown that animal models that recapitulate various endophenotypes of schizophrenia are particularly vulnerable to impairments in reality testing when undergoing mediated learning. Multiple studies have indicated that these effects are dopamine receptor 2-dependent and correlated with aberrant insular cortex (IC) activity. However, until now, the connection between dopamine and the IC had not been investigated. Here, we utilized a novel intersectional approach to label mesencephalic dopamine cells that specifically project to the insular cortex in both wild-type controls and transgenic mice expressing the dominant-negative form of the Disrupted-in-Schizophrenia-1 (DISC-1) gene. Using these techniques, we identified a population of cells that project from the ventral tegmental area (VTA) to the IC. Afterward, we conducted multiple studies to test the necessity of this circuit in behaviors ranging from gustatory detection to the maintenance of effort and, finally, mediated performance. Our results indicate that perturbations of the DISC-1 genetic locus lead to a reduction in the number of cells in the VTA → IC circuit. Behaviorally, VTA → IC circuitry does not influence gustatory detection or motivation to acquire sucrose reward; however, inactivation of this circuit differentially suppresses Pavlovian approach behavior in wild-type and DISC-1 transgenic mice during mediated performance testing. Moreover, under these testing conditions, inactivation of this circuit predisposes wild-type (but not DISC-1) mice to display impaired reality testing. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"138 3","pages":"164-177"},"PeriodicalIF":1.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain electrical patterns associated with pleasure and emotion induced by tonal and atonal music. 调性音乐和无调性音乐诱发的与愉悦和情感相关的脑电模式。
IF 1.9 4区 医学
Behavioral neuroscience Pub Date : 2024-05-02 DOI: 10.1037/bne0000588
Pablo Valdés-Alemán, Bernarda Téllez-Alanís, Adriana Zamudio-Gurrola
{"title":"Brain electrical patterns associated with pleasure and emotion induced by tonal and atonal music.","authors":"Pablo Valdés-Alemán, Bernarda Téllez-Alanís, Adriana Zamudio-Gurrola","doi":"10.1037/bne0000588","DOIUrl":"https://doi.org/10.1037/bne0000588","url":null,"abstract":"Several studies in the last 40 years have used electroencephalography (EEG) to recognize patterns of brain electrical activity correlated with emotions evoked by various stimuli. For example, the frontal alpha and theta asymmetry models to distinguish musical emotions and musical pleasure, respectively. Since these studies have used mainly tonal music, in this study, we decided to incorporate both tonal (<i>n</i> = 8) and atonal (<i>n</i> = 8) musical stimuli to observe the subjective and electrophysiological responses associated with valence, arousal, pleasure, and familiarity, from 25 nonmusician Mexican adults (10 females, 15 males; <i>M</i> = 37.8 years old, <i>SD</i> = 15.1). Our results showed that atonal music was perceived as less familiar and pleasurable than tonal music, according to the average subjective ratings. Interestingly, greater right hemispheric activity (alpha suppression) was associated with atonal music listening. Additionally, there was an increase of theta power at the right frontal cortex (F4) correlated with a decrease of pleasure ratings, in line with the frontal theta asymmetry (FTA) model. Finally, according to the model of frontal alpha asymmetry (FAA) to distinguish musical emotions, activation (alpha suppression) of the left frontal cortex (F3) was correlated with greater valence and arousal-that is, joyful music. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"91 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140829698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Less is more: Smaller hippocampal subfield volumes predict greater improvements in posttraumatic stress disorder symptoms over 2 years. 少即是多:海马亚区体积越小,预示着创伤后应激障碍症状在两年内的改善程度越大。
IF 1.9 4区 医学
Behavioral neuroscience Pub Date : 2024-04-25 DOI: 10.1037/bne0000578
Joseph DeGutis, Danielle R Sullivan, Sam Agnoli, Anna Stumps, Mark Logue, Emma Brown, Mieke Verfaellie, William Milberg, Regina McGlinchey, Michael Esterman
{"title":"Less is more: Smaller hippocampal subfield volumes predict greater improvements in posttraumatic stress disorder symptoms over 2 years.","authors":"Joseph DeGutis, Danielle R Sullivan, Sam Agnoli, Anna Stumps, Mark Logue, Emma Brown, Mieke Verfaellie, William Milberg, Regina McGlinchey, Michael Esterman","doi":"10.1037/bne0000578","DOIUrl":"https://doi.org/10.1037/bne0000578","url":null,"abstract":"Posttraumatic stress disorder (PTSD) is a heterogeneous disorder, and symptom severity varies over time. Neurobiological factors that predict PTSD symptoms and their chronicity remain unclear. This study investigated whether the volume of the hippocampus and its subfields, particularly cornu ammonis (CA) 1, CA3, and dentate gyrus, are associated with current PTSD symptoms and whether they predict PTSD symptom changes over 2 years. We examined clinical and structural magnetic resonance imaging measures from 252 trauma-exposed post-9/11 veterans (159 with Time 1 PTSD diagnosis) during assessments approximately 2 years apart. Automated hippocampal subfield segmentation was performed with FreeSurfer Version 7.1, producing 19 bilateral subfields. PTSD symptoms were measured at each assessment using the Clinician-Administered PTSD Scale-IV (CAPS). All models included total intracranial volume as a covariate. First, similar to previous reports, we showed that smaller overall hippocampal volume was associated with greater PTSD symptom severity at Time 1. Notably, when examining regions of interest (CA1, CA3, dentate gyrus), we found that smaller Time 1 hippocampal volumes in the bilateral CA1-body and CA2/3-body predicted decreased PTSD symptom severity at Time 2. These findings were not accounted for by combat exposure or treatment history. Additionally, both Time 1 CA1-body and CA2/3-body volume showed unique associations with changes in avoidance/numbing, but not with changes in reexperiencing or hyperarousal symptoms. This supports a more complex and nuanced relationship between hippocampal structure and PTSD symptoms, where during the posttrauma years bigger may not always mean better, and suggests that the CA1-body and CA2/3-body are important factors in the maintenance of PTSD symptoms. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"65 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140801316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Indirect and direct cannabinoid agonists differentially affect mesolimbic dopamine release and related behaviors. 间接和直接大麻素激动剂对间叶多巴胺释放和相关行为的影响各不相同。
IF 1.9 4区 医学
Behavioral neuroscience Pub Date : 2024-04-25 DOI: 10.1037/bne0000582
Kevin M Honeywell, Timothy G Freels, Megan A McWain, Abigail S Chaffin, Hunter G Nolen, Helen J Sable, Deranda B Lester
{"title":"Indirect and direct cannabinoid agonists differentially affect mesolimbic dopamine release and related behaviors.","authors":"Kevin M Honeywell, Timothy G Freels, Megan A McWain, Abigail S Chaffin, Hunter G Nolen, Helen J Sable, Deranda B Lester","doi":"10.1037/bne0000582","DOIUrl":"https://doi.org/10.1037/bne0000582","url":null,"abstract":"The cannabinoid system is being researched as a potential pharmaceutical target for a multitude of disorders. The present study examined the effect of indirect and direct cannabinoid agonists on mesolimbic dopamine release and related behaviors in C57BL/6J (B6) mice. The indirect cannabinoid agonist N-arachidonoyl serotonin (AA-5-HT) indirectly agonizes the cannabinoid system by preventing the metabolism of endocannabinoids through fatty acid amide hydrolase inhibition while also inhibiting transient receptor potential vanilloid Type 1 channels. Effects of AA-5-HT were compared with the direct cannabinoid receptor Type 1 agonist arachidonoyl-2'-chloroethylamide (ACEA). In Experiment 1, mice were pretreated with seven daily injections of AA-5-HT, ACEA, or vehicle prior to assessments of locomotor activity using open field (OF) testing and phasic dopamine release using in vivo fixed potential amperometry. Chronic exposure to AA-5-HT did not alter locomotor activity or mesolimbic dopamine functioning. Chronic exposure to ACEA decreased rearing and decreased phasic dopamine release while increasing the dopaminergic response to cocaine. In Experiment 2, mice underwent AA-5-HT, ACEA, or vehicle conditioned place preference, then saccharin preference testing, a measure commonly associated with anhedonia. Mice did not develop a conditioned place preference or aversion for AA-5-HT or ACEA, and repeated exposure to AA-5-HT or ACEA did not alter saccharin preference. Altogether, the findings suggest that neither of these drugs induce behaviors that are classically associated with abuse liability in mice; however, direct cannabinoid receptor Type 1 agonism may play more of a role in mediating mesolimbic dopamine functioning than indirect cannabinoid agonism. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"39 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140801168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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