Behavioral neuroscience最新文献_第3页

Prediction, perception, and psychosis: Application of associative learning theories to schizophrenia research. 预测、感知和精神病：联想学习理论在精神分裂症研究中的应用。

IF 1.6 4区医学

Behavioral neuroscience Pub Date : 2024-06-01 DOI: 10.1037/bne0000599

Riria Suzuki, Yutaka Kosaki

{"title":"Prediction, perception, and psychosis: Application of associative learning theories to schizophrenia research.","authors":"Riria Suzuki, Yutaka Kosaki","doi":"10.1037/bne0000599","DOIUrl":"https://doi.org/10.1037/bne0000599","url":null,"abstract":"In recent years, there have been significant advances in our understanding of the positive symptoms of schizophrenia, such as hallucinations and delusions. This progress has been significantly aided by the use of associative learning-based approaches in human subjects and preclinical animal models. Here, we first review experimental research focusing on the abnormal processing of absent stimuli using three different conditioning phenomena: conditioned hallucinations, mediated conditioning, and trace conditioning. We then review studies investigating the ability to reduce focal processing of physically present but informationally redundant stimuli using habituation, latent inhibition, and blocking. The results of these different lines of research are then summarized within the framework of Wagner's (1981) standard operating procedures model, an associative learning model with explicit reference to the internal representations of both present and absent stimuli. Within this framework, the central deficit associated with positive symptoms can be described as a failure to suppress the focal processing of both absent stimuli and present but irrelevant stimuli. This can explain the wide range of results obtained in different experimental settings. Finally, we briefly discuss the role of the hippocampus and its interaction with dopaminergic transmission in the emergence of such abnormal stimulus representations and learning. Overall, we hope that the theoretical framework and empirical findings offered by the associative learning approach will continue to facilitate and integrate analyses of schizophrenia conducted at the psychological and behavioral levels on the one hand, and at the neural and molecular levels on the other, by serving as a useful interface between them. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"138 3","pages":"195-211"},"PeriodicalIF":1.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of midbrain dopamine cells projecting to the insular cortex in mediated performance: Implications for animal models of reality testing. 投射到岛叶皮层的中脑多巴胺细胞在中介表现中的作用：对现实测试动物模型的启示

IF 1.6 4区医学

Behavioral neuroscience Pub Date : 2024-06-01 DOI: 10.1037/bne0000580

Benjamin R Fry, Victoria Fex, Akira Sawa, Minae Niwa, Alexander W Johnson

{"title":"The role of midbrain dopamine cells projecting to the insular cortex in mediated performance: Implications for animal models of reality testing.","authors":"Benjamin R Fry, Victoria Fex, Akira Sawa, Minae Niwa, Alexander W Johnson","doi":"10.1037/bne0000580","DOIUrl":"https://doi.org/10.1037/bne0000580","url":null,"abstract":"A growing body of literature indicates that mediated learning techniques have specific utility for tapping into reality testing in animal models of neuropsychiatric illness. In particular, recent work has shown that animal models that recapitulate various endophenotypes of schizophrenia are particularly vulnerable to impairments in reality testing when undergoing mediated learning. Multiple studies have indicated that these effects are dopamine receptor 2-dependent and correlated with aberrant insular cortex (IC) activity. However, until now, the connection between dopamine and the IC had not been investigated. Here, we utilized a novel intersectional approach to label mesencephalic dopamine cells that specifically project to the insular cortex in both wild-type controls and transgenic mice expressing the dominant-negative form of the Disrupted-in-Schizophrenia-1 (DISC-1) gene. Using these techniques, we identified a population of cells that project from the ventral tegmental area (VTA) to the IC. Afterward, we conducted multiple studies to test the necessity of this circuit in behaviors ranging from gustatory detection to the maintenance of effort and, finally, mediated performance. Our results indicate that perturbations of the DISC-1 genetic locus lead to a reduction in the number of cells in the VTA → IC circuit. Behaviorally, VTA → IC circuitry does not influence gustatory detection or motivation to acquire sucrose reward; however, inactivation of this circuit differentially suppresses Pavlovian approach behavior in wild-type and DISC-1 transgenic mice during mediated performance testing. Moreover, under these testing conditions, inactivation of this circuit predisposes wild-type (but not DISC-1) mice to display impaired reality testing. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"138 3","pages":"164-177"},"PeriodicalIF":1.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain electrical patterns associated with pleasure and emotion induced by tonal and atonal music. 调性音乐和无调性音乐诱发的与愉悦和情感相关的脑电模式。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2024-05-02 DOI: 10.1037/bne0000588

Pablo Valdés-Alemán, Bernarda Téllez-Alanís, Adriana Zamudio-Gurrola

{"title":"Brain electrical patterns associated with pleasure and emotion induced by tonal and atonal music.","authors":"Pablo Valdés-Alemán, Bernarda Téllez-Alanís, Adriana Zamudio-Gurrola","doi":"10.1037/bne0000588","DOIUrl":"https://doi.org/10.1037/bne0000588","url":null,"abstract":"Several studies in the last 40 years have used electroencephalography (EEG) to recognize patterns of brain electrical activity correlated with emotions evoked by various stimuli. For example, the frontal alpha and theta asymmetry models to distinguish musical emotions and musical pleasure, respectively. Since these studies have used mainly tonal music, in this study, we decided to incorporate both tonal (n = 8) and atonal (n = 8) musical stimuli to observe the subjective and electrophysiological responses associated with valence, arousal, pleasure, and familiarity, from 25 nonmusician Mexican adults (10 females, 15 males; M = 37.8 years old, SD = 15.1). Our results showed that atonal music was perceived as less familiar and pleasurable than tonal music, according to the average subjective ratings. Interestingly, greater right hemispheric activity (alpha suppression) was associated with atonal music listening. Additionally, there was an increase of theta power at the right frontal cortex (F4) correlated with a decrease of pleasure ratings, in line with the frontal theta asymmetry (FTA) model. Finally, according to the model of frontal alpha asymmetry (FAA) to distinguish musical emotions, activation (alpha suppression) of the left frontal cortex (F3) was correlated with greater valence and arousal-that is, joyful music. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"91 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140829698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Less is more: Smaller hippocampal subfield volumes predict greater improvements in posttraumatic stress disorder symptoms over 2 years. 少即是多：海马亚区体积越小，预示着创伤后应激障碍症状在两年内的改善程度越大。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2024-04-25 DOI: 10.1037/bne0000578

Joseph DeGutis, Danielle R Sullivan, Sam Agnoli, Anna Stumps, Mark Logue, Emma Brown, Mieke Verfaellie, William Milberg, Regina McGlinchey, Michael Esterman

{"title":"Less is more: Smaller hippocampal subfield volumes predict greater improvements in posttraumatic stress disorder symptoms over 2 years.","authors":"Joseph DeGutis, Danielle R Sullivan, Sam Agnoli, Anna Stumps, Mark Logue, Emma Brown, Mieke Verfaellie, William Milberg, Regina McGlinchey, Michael Esterman","doi":"10.1037/bne0000578","DOIUrl":"https://doi.org/10.1037/bne0000578","url":null,"abstract":"Posttraumatic stress disorder (PTSD) is a heterogeneous disorder, and symptom severity varies over time. Neurobiological factors that predict PTSD symptoms and their chronicity remain unclear. This study investigated whether the volume of the hippocampus and its subfields, particularly cornu ammonis (CA) 1, CA3, and dentate gyrus, are associated with current PTSD symptoms and whether they predict PTSD symptom changes over 2 years. We examined clinical and structural magnetic resonance imaging measures from 252 trauma-exposed post-9/11 veterans (159 with Time 1 PTSD diagnosis) during assessments approximately 2 years apart. Automated hippocampal subfield segmentation was performed with FreeSurfer Version 7.1, producing 19 bilateral subfields. PTSD symptoms were measured at each assessment using the Clinician-Administered PTSD Scale-IV (CAPS). All models included total intracranial volume as a covariate. First, similar to previous reports, we showed that smaller overall hippocampal volume was associated with greater PTSD symptom severity at Time 1. Notably, when examining regions of interest (CA1, CA3, dentate gyrus), we found that smaller Time 1 hippocampal volumes in the bilateral CA1-body and CA2/3-body predicted decreased PTSD symptom severity at Time 2. These findings were not accounted for by combat exposure or treatment history. Additionally, both Time 1 CA1-body and CA2/3-body volume showed unique associations with changes in avoidance/numbing, but not with changes in reexperiencing or hyperarousal symptoms. This supports a more complex and nuanced relationship between hippocampal structure and PTSD symptoms, where during the posttrauma years bigger may not always mean better, and suggests that the CA1-body and CA2/3-body are important factors in the maintenance of PTSD symptoms. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"65 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140801316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indirect and direct cannabinoid agonists differentially affect mesolimbic dopamine release and related behaviors. 间接和直接大麻素激动剂对间叶多巴胺释放和相关行为的影响各不相同。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2024-04-25 DOI: 10.1037/bne0000582

Kevin M Honeywell, Timothy G Freels, Megan A McWain, Abigail S Chaffin, Hunter G Nolen, Helen J Sable, Deranda B Lester

{"title":"Indirect and direct cannabinoid agonists differentially affect mesolimbic dopamine release and related behaviors.","authors":"Kevin M Honeywell, Timothy G Freels, Megan A McWain, Abigail S Chaffin, Hunter G Nolen, Helen J Sable, Deranda B Lester","doi":"10.1037/bne0000582","DOIUrl":"https://doi.org/10.1037/bne0000582","url":null,"abstract":"The cannabinoid system is being researched as a potential pharmaceutical target for a multitude of disorders. The present study examined the effect of indirect and direct cannabinoid agonists on mesolimbic dopamine release and related behaviors in C57BL/6J (B6) mice. The indirect cannabinoid agonist N-arachidonoyl serotonin (AA-5-HT) indirectly agonizes the cannabinoid system by preventing the metabolism of endocannabinoids through fatty acid amide hydrolase inhibition while also inhibiting transient receptor potential vanilloid Type 1 channels. Effects of AA-5-HT were compared with the direct cannabinoid receptor Type 1 agonist arachidonoyl-2'-chloroethylamide (ACEA). In Experiment 1, mice were pretreated with seven daily injections of AA-5-HT, ACEA, or vehicle prior to assessments of locomotor activity using open field (OF) testing and phasic dopamine release using in vivo fixed potential amperometry. Chronic exposure to AA-5-HT did not alter locomotor activity or mesolimbic dopamine functioning. Chronic exposure to ACEA decreased rearing and decreased phasic dopamine release while increasing the dopaminergic response to cocaine. In Experiment 2, mice underwent AA-5-HT, ACEA, or vehicle conditioned place preference, then saccharin preference testing, a measure commonly associated with anhedonia. Mice did not develop a conditioned place preference or aversion for AA-5-HT or ACEA, and repeated exposure to AA-5-HT or ACEA did not alter saccharin preference. Altogether, the findings suggest that neither of these drugs induce behaviors that are classically associated with abuse liability in mice; however, direct cannabinoid receptor Type 1 agonism may play more of a role in mediating mesolimbic dopamine functioning than indirect cannabinoid agonism. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"39 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140801168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organization of spontaneous spatial behaviors under dark conditions is unaffected in adult male and female long-Evans rats after moderate prenatal alcohol exposure. 成年雄性和雌性长Evans大鼠在产前适度接触酒精后，其在黑暗条件下的自发空间行为组织不受影响。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2024-04-18 DOI: 10.1037/bne0000589

Ericka A Schaeffer, Ariyana LaCour, Tia N Donaldson, David N Linsenbardt, Suzy Davies, Daniel D Savage, Douglas G Wallace, Benjamin J Clark

{"title":"Organization of spontaneous spatial behaviors under dark conditions is unaffected in adult male and female long-Evans rats after moderate prenatal alcohol exposure.","authors":"Ericka A Schaeffer, Ariyana LaCour, Tia N Donaldson, David N Linsenbardt, Suzy Davies, Daniel D Savage, Douglas G Wallace, Benjamin J Clark","doi":"10.1037/bne0000589","DOIUrl":"https://doi.org/10.1037/bne0000589","url":null,"abstract":"Prenatal alcohol exposure can produce disruptions in a wide range of cognitive functions, but it is especially detrimental to spatial navigation. In open environments, rodents organize their spatial behaviors around centralized locations, termed home bases, from which they make circuitous and slow locomotor trips (progressions) into the rest of the environment. Open-field behaviors are organized even under darkened test conditions, suggesting a role for self-motion cues (vestibular, motor, etc.). The impact of moderate prenatal alcohol exposure (mPAE) on the organization of spontaneous open-field behaviors under darkened conditions has not been investigated. Here we tested adult female and male rats with mPAE or saccharin control exposure in a circular open field for 30 min in a testing room that was made completely dark. While general locomotion, as measured by reductions in travel distance and increased stop duration, decreased across the test session, the organization of these behaviors, as measured by stop duration, home base establishment, home base stability, progression accuracy, and scaling of peak speeds with progression length, did not differ between mPAE and saccharin control rats. Together, the findings strongly suggest that spontaneous movement organization in relation to self-motion cues remains intact in adult mPAE rats. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"164 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140623521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging role of the lateral habenula in conditioned inhibition and depression. 外侧哈文脑在条件性抑制和抑郁中的新作用

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2024-04-18 DOI: 10.1037/bne0000586

In-Beom Jin, Nam-Heon Kim, Jung-Soo Han

{"title":"Emerging role of the lateral habenula in conditioned inhibition and depression.","authors":"In-Beom Jin, Nam-Heon Kim, Jung-Soo Han","doi":"10.1037/bne0000586","DOIUrl":"https://doi.org/10.1037/bne0000586","url":null,"abstract":"Associating a neutral conditioned stimulus (CS) with the absence of a biologically significant unconditioned stimulus (US) confers conditioned inhibitory properties upon the CS, referred to as conditioned inhibition. Conditioned inhibition and conditioned excitation, an association of a CS with the presence of the US, are fundamental components of associative learning. While the neural substrates of conditioned excitation are well established, those of conditioned inhibition remain poorly understood. Recent research has shed light on the lateral habenula (LHb) engagement in conditioned inhibition, along with the midbrain dopaminergic neurons. This article reviews behavioral tasks conducted to assess conditioned inhibition and how experimental LHb manipulations affect performance in these tasks. These results underscore the critical role of the LHb in conditioned inhibition. Intriguingly, stress increases LHb reactivity and impairs performances in tasks consisting of a component of conditioned inhibition in animals. Dysfunction of the LHb is observed in patients with depression. The ability of an organism to perform conditioned inhibition is closely linked to altered neuronal activity in the LHb, which has implications for mental disorders. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"3 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140630767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naturalistic housing condition promotes behavioral flexibility and increases resilience to stress in rats. 自然的饲养条件可促进大鼠行为的灵活性，并增强其对压力的适应能力。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2024-04-18 DOI: 10.1037/bne0000597

Nicoli Caratti, Ana Paula Crestani, Jordana Griebler Luft, Lucas de Oliveira Alvares

引用次数: 0

Translational research in punishment learning. 惩罚性学习的转化研究。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2024-04-18 DOI: 10.1037/bne0000587

Philip Jean-Richard-Dit-Bressel, Kelly Gaetani, Lilith Zeng, Gabrielle Weidemann, Gavan P McNally

引用次数: 0

Mediated learning: A computational rendering of ketamine-induced symptoms. 中介学习：氯胺酮诱发症状的计算呈现。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2024-04-18 DOI: 10.1037/bne0000591

Esther Mondragón

引用次数: 0