哌醋甲酯对野生型帕金森大鼠和前驱型帕金森大鼠社交性超声波发声的影响各不相同。

IF 1.6 4区 医学 Q3 BEHAVIORAL SCIENCES
Sarah A Lechner, Cynthia A Kelm-Nelson, Michelle R Ciucci
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引用次数: 0

摘要

人们对帕金森病(PD)的前驱症状(包括发声交流障碍)知之甚少,而且对目前的药物治疗反应不佳。去甲肾上腺素功能障碍涉及帕金森病的早期症状;因此,针对去甲肾上腺素的药物疗法可能有助于治疗前驱症状。本研究使用了一种经过验证的前驱型帕金森病转化啮齿动物模型--雄性 Pink1-/- 大鼠,这种大鼠早在 2 个月大时就表现出超声发声(USV)障碍。这项临床前研究的目的是调查哌醋甲酯对 USV 参数的剂量依赖性(2.5、5.0、7.5、10 毫克/千克)反应,假设哌醋甲酯会增加发声输出。由于哌醋甲酯是一种已知有不良副作用的精神兴奋剂,我们还假设,潜在的副作用包括焦虑行为和自发活动会以剂量依赖的方式增加。为此,我们采用随机受试者内设计,给野生型(WT)大鼠和 Pink1-/- 大鼠注射了一定剂量的载体(生理盐水)和哌醋甲酯,然后评估了 USV、焦虑行为(空场)和肢体运动(圆筒)活动。结果表明,哌醋甲酯不会改变 Pink1-/- 大鼠的 USV 发射;但是,哌醋甲酯会增加 WT 大鼠的发声总数和频率调制呼叫的持续时间。正如预期的那样,哌醋甲酯剂量依赖性地影响了 WT 大鼠和 Pink1-/- 大鼠的自发运动,而哌醋甲酯增加了 Pink1-/- 大鼠的焦虑,却没有增加 WT 大鼠的焦虑。这项研究表明,Pink1-/-大鼠和 WT 大鼠对精神兴奋剂的反应存在差异。(PsycInfo Database Record (c) 2024 APA,保留所有权利)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Methylphenidate differentially affects the social ultrasonic vocalizations of wild-type and prodromal Parkinsonian rats.

Prodromal signs of Parkinson's disease (PD), including vocal communication deficits, are poorly understood and do not respond adequately to current pharmacologic treatments. Norepinephrine dysfunction is involved early in PD; thus, drug therapies targeting norepinephrine may be useful as a treatment of prodromal signs. This study used a validated, translational rodent model of prodromal PD, the male Pink1-/- rat, which exhibits ultrasonic vocalization (USV) deficits as early as 2 months of age. The purpose of this preclinical study was to investigate a dose-dependent (2.5, 5.0, 7.5, 10 mg/kg) response of methylphenidate on USV parameters with the hypothesis that methylphenidate would increase vocalization output. Because methylphenidate is a psychostimulant with known adverse side effects, we also hypothesized that potential side effects including anxietylike behavior and spontaneous activity would be increased in a dose-dependent manner. To accomplish this, wild-type (WT) and Pink1-/- rats were administered a dose of a vehicle (saline) and a methylphenidate dose in a randomized within-subjects design and then assessed for USVs, anxiety behavior (open field), and limb motor (cylinder) activity. The results suggest that methylphenidate does not alter USV emissions in Pink1-/- rats; however, methylphenidate increased the total number of vocalizations and duration of frequency-modulated calls in WT rats. Methylphenidate dose dependently influenced spontaneous movements in both WT and Pink1-/- rats, as expected, while methylphenidate increased anxiety in Pink1-/- rats and not WT rats. This study demonstrates a difference in response to a psychostimulant between Pink1-/- rats and WT rats. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

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来源期刊
Behavioral neuroscience
Behavioral neuroscience 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
51
审稿时长
6-12 weeks
期刊介绍: Behavioral Neuroscience publishes original research articles as well as reviews in the broad field of the neural bases of behavior.
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