Behavioral neuroscience最新文献

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Variability in odor hedonic perception: A challenge for neurosensory and behavioral research. 气味享乐感的可变性:神经感觉和行为研究面临的挑战。
IF 1.9 4区 医学
Behavioral neuroscience Pub Date : 2024-04-18 DOI: 10.1037/bne0000595
Charlotte Bontempi, Gérard Brand, Laurence Jacquot
{"title":"Variability in odor hedonic perception: A challenge for neurosensory and behavioral research.","authors":"Charlotte Bontempi, Gérard Brand, Laurence Jacquot","doi":"10.1037/bne0000595","DOIUrl":"https://doi.org/10.1037/bne0000595","url":null,"abstract":"Odor hedonic perception (pleasant/unpleasant character) is considered to be the first and one of the most important dimensions in olfaction and is known to be highly variable and dependent on several factors related to the stimulus, individual characteristics, and context. Although numerous experimental studies have been published on this topic, there is no comprehensive general review on the variability in odor hedonic perception. Therefore, the aim of this article was to describe and detail all the factors involved in the variability in odor hedonic perception. Stimulus properties-related variability includes the concentration/intensity and the physicochemical properties. Individual-related variability includes sex, age, and physiological state characteristics, while context-related variability involves factors associated with the stimulation context, such as stimulation pathway, exposure frequency, verbal influences, cross-modal associations, hedonic contrast, and cultural background. Subsequently, a section is devoted to the brain processing of odor hedonicity, although its role in odor hedonic variability is largely unknown. Finally, the article discusses the relationship between the hedonic qualities of odors and the resulting behavioral responses in both animals and humans. (PsycInfo Database Record (c) 2024 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"15 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140630837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psilocybe cubensis extract potently prevents fear memory recall and freezing behavior in short- but not long-term in a rat model of posttraumatic stress disorder. 在创伤后应激障碍大鼠模型中,西洛贝提取物能有效防止恐惧记忆回忆和冻结行为的短期而非长期发生。
IF 1.9 4区 医学
Behavioral neuroscience Pub Date : 2024-04-01 Epub Date: 2024-01-18 DOI: 10.1037/bne0000579
Zahra Ghofrani-Jahromi, Sarah Nouri-Darehno, Mehrsa Rahimi-Danesh, Nastaran Talaee, Eghbal Jasemi, Ali Razmi, Salar Vaseghi
{"title":"Psilocybe cubensis extract potently prevents fear memory recall and freezing behavior in short- but not long-term in a rat model of posttraumatic stress disorder.","authors":"Zahra Ghofrani-Jahromi, Sarah Nouri-Darehno, Mehrsa Rahimi-Danesh, Nastaran Talaee, Eghbal Jasemi, Ali Razmi, Salar Vaseghi","doi":"10.1037/bne0000579","DOIUrl":"10.1037/bne0000579","url":null,"abstract":"<p><p>Psilocybe cubensis is a species of psilocybin mushroom (magic mushroom) of moderate potency whose principal active compounds are psilocybin and psilocin. Recent studies have shown the significant procognitive and mood-enhancer effects of Psilocybe cubensis. However, evidence is so limited, especially in preclinical studies. We aimed to investigate the effect of Psilocybe cubensis extract on posttraumatic stress disorder (PTSD)-like behavior, pain perception, locomotor activity, and anxiety in a rat model of PTSD. Male rats were exposed to three consecutive shocks (0.8 mA, 3 s interval) paired with three sounds broadcasted 3 s before delivering shocks (75 dB, 3 s). After 1, 3, or 21 days, freezing rate was measured in the fear-conditioning apparatus. Open filed test and hot plate were used to assess locomotor activity and anxiety, and pain subthreshold, respectively. Psilocybe cubensis was injected intraperitoneal at the dose of 25 mg/kg (single administration) before (pretrain) or after (posttrain) shocks, or before the test (pretest). Results showed psilocybin potently alleviated PTSD symptom is short- but not long-term after the induction of PTSD. Psilocybe cubensis decreased locomotor activity only in a short period after administration. Psilocybe cubensis also increased pain subthreshold and decreased anxiety. In conclusion, Psilocybe cubensis effects on PTSD-like behavior and locomotor activity seem to be remained in short-term, while Psilocybe cubensis effects on pain subthreshold and anxiety remained long-term. This is the first study evaluating the effect of Psilocybe cubensis on PTSD-like behavior in rats in three different time protocols (1, 3, and 21 days after fear conditioning). (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"73-84"},"PeriodicalIF":1.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139485082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kamin blocking is disrupted by low-dose ketamine in mice: Further implications for aberrant stimulus processing in schizophrenia. 小鼠体内低剂量氯胺酮破坏Kamin阻断:对精神分裂症异常刺激处理的进一步启示。
IF 1.9 4区 医学
Behavioral neuroscience Pub Date : 2024-02-01 Epub Date: 2023-09-28 DOI: 10.1037/bne0000572
Riria Suzuki, Kenji Yamaguchi, Yutaka Kosaki
{"title":"Kamin blocking is disrupted by low-dose ketamine in mice: Further implications for aberrant stimulus processing in schizophrenia.","authors":"Riria Suzuki, Kenji Yamaguchi, Yutaka Kosaki","doi":"10.1037/bne0000572","DOIUrl":"10.1037/bne0000572","url":null,"abstract":"<p><p>Previous studies have shown that low doses of ketamine, an N-methyl-D-aspartate receptor antagonist, produce aberrantly strong internal representations of associatively activated but absent stimuli in humans and nonhuman animals, suggesting the validity of ketamine treatment as a preclinical model of the positive symptoms of schizophrenia, including hallucinations and delusions. However, whether acute ketamine treatment also impairs the ability to ignore present but informationally redundant stimuli, which is another hallmark of schizophrenia, remains unclear. Accordingly, the present study investigated whether injections of low-dose ketamine attenuate Kamin blocking in an appetitive conditioning preparation in mice. Mice in the blocking group were initially trained with A+ conditioning (i.e., conditioned stimulus A paired with a sucrose solution), followed by compound AX+ training, before the conditioned responses to the cue X were tested in extinction. The animals in the control group received B+ training before the AX+ training. Half of the mice in each group received an injection of 16 mg/kg ketamine before each compound conditioning session and the extinction test, whereas the other half received saline. The results showed a reliable blocking effect in the saline-treated mice, whereas the blocking effect was absent in the ketamine-treated mice. Specifically, the absence of blocking was due to the ketamine-treated mice learning about the blocked cues. This finding further validates the use of low-dose ketamine as a preclinical model of schizophrenia. It also suggests a possible link between hallucination-like aberrant processing of absent events and a reduced ability to suppress attentional processing of task-irrelevant stimuli. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"30-42"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41116040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictions about reward outcomes in rhesus monkeys. 对恒河猴奖励结果的预测。
IF 1.6 4区 医学
Behavioral neuroscience Pub Date : 2024-02-01 Epub Date: 2023-12-07 DOI: 10.1037/bne0000573
Yiyun Huang, Hayoung Chang, Laurie R Santos, Alexandra G Rosati
{"title":"Predictions about reward outcomes in rhesus monkeys.","authors":"Yiyun Huang, Hayoung Chang, Laurie R Santos, Alexandra G Rosati","doi":"10.1037/bne0000573","DOIUrl":"10.1037/bne0000573","url":null,"abstract":"<p><p>Human infants and nonhuman animals respond to surprising events by looking longer at unexpected than expected situations. These looking responses provide core cognitive evidence that nonverbal minds make predictions about possible outcomes and detect when these predictions fail to match reality. We propose that this phenomenon has crucial parallels with the processes of reward prediction error, indexing the difference between expected and actual reward outcomes. Most work on reward prediction errors to date involves neurobiological techniques that cannot be implemented in many relevant populations, so we developed a novel behavioral task to assess monkeys' predictions about reward outcomes using looking time responses. In Study 1, we tested how semi-free-ranging monkeys (<i>n</i> = 210) responded to <i>positive error</i> (more rewards than expected), <i>negative error</i> (less rewards than expected), and a <i>number control</i>. We found that monkeys looked longer at a given reward when it was unexpectedly large or small, compared to when the same quantity was expected. In Study 2, we compared responses in the <i>positive error</i> condition in monkeys ranging from infancy to old age (<i>n</i> = 363), to assess lifespan changes in sensitivity to reward predictions. We found that adolescent monkeys showed heightened responses to unexpected rewards, similar to patterns seen in humans, but showed no changes during aging. These results suggest that monkeys' looking responses can be used to track their predictions about rewards, and that monkeys share some developmental signatures of reward sensitivity with humans, providing a new approach to access cognitive processes underlying reward-based decision making. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"43-58"},"PeriodicalIF":1.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138497714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can the resting state peak alpha frequency explain the relationship between temporal resolution power and psychometric intelligence? 静息状态的峰值阿尔法频率能解释时间分辨能力和心理智力之间的关系吗?
IF 1.9 4区 医学
Behavioral neuroscience Pub Date : 2024-02-01 Epub Date: 2023-10-05 DOI: 10.1037/bne0000571
Lisa M Makowski, Stefan J Troche
{"title":"Can the resting state peak alpha frequency explain the relationship between temporal resolution power and psychometric intelligence?","authors":"Lisa M Makowski, Stefan J Troche","doi":"10.1037/bne0000571","DOIUrl":"10.1037/bne0000571","url":null,"abstract":"<p><p>The temporal resolution power (TRP) hypothesis states that individuals with higher TRP, as reflected by a higher performance on several psychophysical timing tasks, perform better on intelligence tests due to their ability to process information faster and coordinate their mental operations more effectively. It is proposed that these differences in TRP are related to the rate of a master clock based on neural oscillations. The present study aimed to investigate whether the peak alpha frequency (PAF) measured via electroencephalography (EEG) reflects a psychophysiological measure of this rate and its potential role in explaining the relationship between TRP and psychometric intelligence. A sample of 129 young adults (<i>M</i> = 23.0, <i>SD</i> = 3.1) completed a short version of Raven's Advanced Progressives Matrices and three timing tasks. PAF was measured using EEG before each timing task during two resting states with eyes closed (EC) and eyes open (EO), respectively. From these PAF measurements, four latent PAF variables were extracted, differing in resting state (EC, EO) and electrode cluster (frontal/central, parietal/occipital). The results confirmed a strong association between TRP and psychometric intelligence (<i>r</i> = .56, <i>p</i> < .01), as previously reported in other studies. Additionally, we found a positive association between intelligence and a latent PAF variable extracted from frontal/central electrodes in the EO resting state conditions (<i>r</i> = .27, <i>p</i> < .05). However, there was no association between TRP and PAF. This indicates that PAF does not reflect the underlying psychophysiological mechanism that links TRP to intelligence. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"15-29"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41099759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphine exposure during adolescence induces enduring social changes dependent on adolescent stage of exposure, sex, and social test. 青少年时期接触吗啡会诱发持久的社会变化,这取决于接触吗啡的青少年阶段、性别和社会测试。
IF 1.9 4区 医学
Behavioral neuroscience Pub Date : 2024-02-01 Epub Date: 2023-12-21 DOI: 10.1037/bne0000567
David N King'uyu, Erin L Edgar, Christopher Figueroa, J M Kirkland, Ashley M Kopec
{"title":"Morphine exposure during adolescence induces enduring social changes dependent on adolescent stage of exposure, sex, and social test.","authors":"David N King'uyu, Erin L Edgar, Christopher Figueroa, J M Kirkland, Ashley M Kopec","doi":"10.1037/bne0000567","DOIUrl":"10.1037/bne0000567","url":null,"abstract":"<p><p>Drug exposure during adolescence, when the \"reward\" circuitry of the brain is developing, can permanently impact reward-related behavior into adulthood. Epidemiological studies show that opioid treatment during adolescence, such as pain management for a dental procedure or surgery, increases the incidence of psychiatric illness including substance use disorders. Moreover, the opioid epidemic currently in the United States is affecting younger individuals raising the impetus to understand the pathogenesis of the negative effects of opioids. One reward-related behavior that develops during adolescence is social behavior. We previously demonstrated that developmental changes in the nucleus accumbens reward region regulate social development in rats during sex-specific adolescent periods: early to mid-adolescence in males (postnatal day, P30-40) and preearly adolescence in females (P20-30). We thus hypothesized that the developmental stage of morphine exposure will differentially impact social behavior development such that drug administered during the female critical period would result in adult sociability deficits in females, but not males, and morphine administered during the male critical period would result in adult sociability deficits in males, but not females. We found that morphine exposure during the female critical period primarily resulted in deficits in sociability in females, while morphine exposure during the male critical period primarily resulted in deficits in sociability primarily in males. However, depending on the test performed and the social parameter measured, social alterations could be found in both sexes that received morphine exposure at either adolescent stage. These data indicate that when drug exposure occurs during adolescence, and how the endpoint data are measured, will play a large role in determining the effects of drug exposures on social development. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"59-71"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electric barrier-induced voluntary abstinence reduces alcohol seeking in male, but not female, iP rats. 电屏障诱导的自愿戒酒会减少雄性iP大鼠对酒精的寻求,但不会减少雌性iP大鼠对酒精的寻求。
IF 1.9 4区 医学
Behavioral neuroscience Pub Date : 2024-02-01 Epub Date: 2023-08-17 DOI: 10.1037/bne0000566
Xavier J Maddern, Andrew J Lawrence, Erin J Campbell
{"title":"Electric barrier-induced voluntary abstinence reduces alcohol seeking in male, but not female, iP rats.","authors":"Xavier J Maddern, Andrew J Lawrence, Erin J Campbell","doi":"10.1037/bne0000566","DOIUrl":"10.1037/bne0000566","url":null,"abstract":"<p><p>Maintaining abstinence and preventing relapse are key to the successful recovery from alcohol use disorder. There are two main ways individuals with alcohol use disorder abstain from alcohol use: forced (e.g., incarceration) and voluntary. Voluntary abstinence is often evoked due to the negative consequences associated with excessive alcohol consumption. This study investigated relapse-like behavior to alcohol seeking following acute, forced, and voluntary abstinence. Male rats had increased operant self-administration responding throughout training compared to females; however, females consumed greater amounts of alcohol in g/kg. Both male and female rats achieved voluntary abstinence, which was induced using an electric barrier on the operant chamber floor with alcohol readily available during this period. Interestingly, male rats that underwent voluntary abstinence displayed reduced alcohol seeking compared to males in the acute and forced abstinence groups. This difference in alcohol seeking behavior across abstinence groups was not observed in female rats. Quantification of neuronal activation (Fos protein) revealed numerous brain regions (e.g., ventral subiculum and lateral habenula) to be associated with the reduced reinstatement propensity seen in male rats that underwent voluntary abstinence. Additionally, hierarchical clustering found enhanced functional connectivity and coordination in the male voluntary abstinence group compared to the male forced abstinence group. Collectively, these data implicate a sexual dimorphism in the effect that voluntary abstinence, at least in the model employed here, has on relapse-like behavior. This maybe driven by reduced neuronal activation at a network level and enhanced functional connectivity and integration. (PsycInfo Database Record (c) 2024 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"1-14"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10014350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Supplemental Material for Morphine Exposure During Adolescence Induces Enduring Social Changes Dependent on Adolescent Stage of Exposure, Sex, and Social Test 补充材料:青春期吗啡暴露诱发的持久社会变化取决于青少年的暴露阶段、性别和社会测试
IF 1.9 4区 医学
Behavioral neuroscience Pub Date : 2023-12-14 DOI: 10.1037/bne0000567.supp
{"title":"Supplemental Material for Morphine Exposure During Adolescence Induces Enduring Social Changes Dependent on Adolescent Stage of Exposure, Sex, and Social Test","authors":"","doi":"10.1037/bne0000567.supp","DOIUrl":"https://doi.org/10.1037/bne0000567.supp","url":null,"abstract":"","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"19 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138971533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prelimbic cortex inactivation prevents ABA renewal based on stress state. 吸收前皮层失活阻止基于应激状态的ABA更新。
IF 1.9 4区 医学
Behavioral neuroscience Pub Date : 2023-12-01 Epub Date: 2023-10-12 DOI: 10.1037/bne0000570
Callum M P Thomas, Mark E Bouton, John T Green
{"title":"Prelimbic cortex inactivation prevents ABA renewal based on stress state.","authors":"Callum M P Thomas, Mark E Bouton, John T Green","doi":"10.1037/bne0000570","DOIUrl":"10.1037/bne0000570","url":null,"abstract":"<p><p>Our recent research suggests that the interoceptive state associated with stress can function as a contextual stimulus for operant behavior. In the present experiment, we investigated the role of the rodent prelimbic cortex (PL), a brain region that is critical in contextual control of operant behavior, in the ability of a stressed state to produce ABA renewal of an extinguished operant response. Rats were trained to perform a lever press response for a food pellet reward during daily sessions that followed exposure to a stressor that changed each day. The response was then extinguished in the absence of stress. ABA renewal of extinguished responding occurred following exposure to another stressor (different from any used during acquisition) in control rats but not in rats that received a PL-inactivating infusion (baclofen/muscimol). Results confirm that the interoceptive state of stress can play the role of a contextual stimulus and initiate renewal (relapse) of an inhibited behavior when stress has previously been associated with the behavior. In conjunction with our previous work, the present results support the hypothesis that the PL is important for contexts, both exteroceptive and interoceptive, to exert such control over operant behavior. (PsycInfo Database Record (c) 2023 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"373-379"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10872701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41189690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are reactions to frustrative nonreward in other animals a model for human anger? Neurobehavioral implications and therapeutic applications. 其他动物对沮丧的不回应的反应是人类愤怒的模型吗?神经行为学意义和治疗应用。
IF 1.9 4区 医学
Behavioral neuroscience Pub Date : 2023-12-01 Epub Date: 2023-10-30 DOI: 10.1037/bne0000574
M Potegal
{"title":"Are reactions to frustrative nonreward in other animals a model for human anger? Neurobehavioral implications and therapeutic applications.","authors":"M Potegal","doi":"10.1037/bne0000574","DOIUrl":"10.1037/bne0000574","url":null,"abstract":"<p><p>Anger is a powerful and mostly deleterious emotion that can impair an individual's health and social relationships and that imposes considerable costs on society at large. It is a constituent of multiple psychopathologies, most notably intermittent explosive disorder. Excessive anger can drive injurious and even lethal reactive aggression. To understand its biobehavioral origins and develop appropriate therapeutic interventions, an animal model of human anger would be quite useful. The phenomena of aggression provoked by frustrative nonreward (FNR) in other animals, including species of fish, birds, and mammals, resemble those in people in whom it elicits subjectively experienced anger. The brief history presented here traces the original, overgeneralized frustration-aggression hypothesis for humans through to the discovery of operant schedule-induced attack in birds, rodents, and ourselves to the current status of FNR as a cross-species, transdiagnostic construct within the National Institute of Health Research Domain Criteria. Brain circuitry that is activated by frustration, generates felt anger and motivates reactive aggression includes discomfort reactions likely instantiated in the insula and cingulate gyrus of the salience network and reward expectancy/prediction error mediated by the ventral striatum and other structures. Caveats in establishing a paradigm for other animals that most closely matches FNR-induced anger in people include avoiding confounds with other aggression-provoking stimuli and situations, providing evidence for aggressive motivation, as well as behavior, and demonstrating activation of homologous brain structures. With appropriate regard for these caveats, developing such paradigms appears to be the best route to advancing psychopharmacological and deep brain stimulation treatments for excessive anger. (PsycInfo Database Record (c) 2023 APA, all rights reserved).</p>","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"364-372"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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