N-tert-butoxycarbonyl-methylenedioxymethamphetamine 是一种亚甲二氧基甲基苯丙胺衍生物,可通过提高多巴胺水平产生奖赏和强化作用。

IF 1.6 4区 医学 Q3 BEHAVIORAL SCIENCES
Behavioral neuroscience Pub Date : 2024-10-01 Epub Date: 2024-05-23 DOI:10.1037/bne0000593
Dong-Hyun Youn, Cheolmin Jo, Jin Mook Kim, Young-Ki Hong, Wonjong Lee, Seong Hye Park, Chan Hyeok Kwon, Sun-Ok Choi
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引用次数: 0

摘要

一种受 N 保护的亚甲二氧基甲基苯丙胺(MDMA),即 N-叔丁氧羰基-3,4-亚甲二氧基甲基苯丙胺(t-BOC-3,4-MDMA),含有叔丁氧羰基,可以在非法药物市场上不被发现。它是一种新型前体物质,不是化学中间体,可通过对 N-叔丁氧羰基的脱保护作用转化为受管制物质亚甲二氧基甲基苯丙胺。将这种化学物质归类为前体或精神药物是一个问题,因为它是一种前所未有的前体,可能具有滥用潜力。虽然亚甲二氧基甲基苯丙胺会通过多巴胺能传导产生奖赏和强化作用,但 t-BOC-3,4-亚甲二氧基甲基苯丙胺的滥用潜力还没有定性。本文旨在评估 t-BOC-3,4-亚甲二氧基甲基苯丙胺的滥用潜力。我们通过攀爬测试测定了剂量为 5 毫克/千克的药物对该药物的反应,并通过条件性位置偏好和自我给药测试评估了该药物的奖赏和强化特性。在条件性位置偏好试验中,腹腔注射 t-BOC-3,4-MDMA(5 毫克/千克)可明显改变小鼠的位置偏好。在自我给药模型中,以每公斤 0.5 毫克的剂量(静脉注射)给小鼠注射 t-BOC-3,4-MDMA,在固定比例的时间安排下,小鼠会在 2 小时内出现服药行为。此外,微透析实验证实,t-BOC-3,4-MDMA 会影响大鼠大脑(纹状体)的多巴胺水平。这些实验结果表明,t-BOC-3,4-MDMA 有可能被滥用。(PsycInfo Database Record (c) 2024 APA, 版权所有)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
N-tert-butoxycarbonyl-methylenedioxymethamphetamine, an methylenedioxymethamphetamine derivative, exhibits rewarding and reinforcing effects by increasing dopamine levels.

An N-protected methylenedioxymethamphetamine (MDMA), N-tert-butoxycarbonyl-3,4-methylenedioxymethamphetamine (t-BOC-3,4-MDMA), contains tert-butoxycarbonyl and can remain undetected in the illicit drug market. It is a new type of precursor substance that is not a chemical intermediate and can be converted into a controlled substance, MDMA, by deprotection of the N-tert-butoxycarbonyl group. Categorization of this chemical into a precursor or psychotropic substance is an issue because it is an unprecedented precursor that could have misuse potential. Although MDMA causes rewarding and reinforcing effect through dopaminergic transmission, the misuse potential of t-BOC-3,4-MDMA has not yet been characterized. Here, we aim to evaluate the misuse potential of t-BOC-3,4-MDMA. The response to the drug at a dose of 5 mg/kg was determined by a climbing test, and its rewarding and reinforcing properties were assessed through conditioned place preference and self-administration tests. In the conditioned place preference test, intraperitoneal administration of t-BOC-3,4-MDMA (5 mg/kg) significantly altered place preference in mice. In the self-administration models, t-BOC-3,4-MDMA induced drug-taking behavior at the dose of 0.5 mg/kg/infusion (intravenous) during 2 hr sessions under fixed-ratio schedules in mice. In addition, microdialysis experiments verified that t-BOC-3,4-MDMA impacted the dopamine levels of the brain (striatum) of rats. These experimental results indicate that t-BOC-3,4-MDMA has a potential for misuse. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

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来源期刊
Behavioral neuroscience
Behavioral neuroscience 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
51
审稿时长
6-12 weeks
期刊介绍: Behavioral Neuroscience publishes original research articles as well as reviews in the broad field of the neural bases of behavior.
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