操纵前额叶活动和多巴胺 D1 受体信号在食欲特征-阴性辨别学习任务中的影响

IF 1.6 4区 医学 Q3 BEHAVIORAL SCIENCES
Rebecca M Hock, Naana Owusu-Amoah, Lauren Waite, Charlotte Muir, Carl W Stevenson, Charlotte Bonardi, Helen J Cassaday
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引用次数: 0

摘要

健康的认知需要对联想学习进行抑制性调节;反之,抑制性辨别能力受损则与行为障碍有关。内侧前额叶皮层(mPFC)及其多巴胺支配是理解抑制和冲动的关键。因此,我们使用微量注射(a)γ-氨基丁酸-A 受体激动剂 muscimol(0.25 μg in 1.0 μl;N = 35),(b)多巴胺 D1 受体激动剂 SKF-81297(0.1 μg in 1.0 μl;N = 33),以及(c)多巴胺 D1 受体拮抗剂 SCH-23390(5 μg in 1.0 μl;N = 35)。条件刺激(CS)之后是食物,但在CS(A+)与抑制性线索(AX-)复合的试验中,食物传递被取消。差分(CS-前CS反应)被用来衡量学习效果。所有三项实验都显示了特征负性辨别(A+/AX-),即对 AX- 相对于 A+ 的反应减少。在实验 1 中,这种辨别力降低了,但在注射 muscimol 后却保持不变。同样,在实验2和3中,注射SKF-81297和SCH-23390都不会影响辨别能力的获得。与麝香草酚一样,SCH-23390也会减少差分反应,这与对学习(表达)的非特异性影响是一致的。因此,没有证据表明前边缘或下边缘皮层失活会损害特征阴性辨别学习,也没有证据表明多巴胺能调节内侧前额叶皮层的这种学习。这些结果将结合输注的非特异性效应以及在条件抑制的总和与延缓测试中的总体不一致表现进行讨论。(PsycInfo Database Record (c) 2024 APA, 版权所有)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of manipulating prefrontal activity and dopamine D1 receptor signaling in an appetitive feature-negative discrimination learning task.

Healthy cognition requires inhibitory modulation of associative learning; conversely, impaired inhibitory discrimination is implicated in behavioral disorders. The medial prefrontal cortex (mPFC) and its dopamine innervation are key to understanding inhibition and impulsivity. We therefore examined the role of prelimbic and infralimbic cortices in within-subjects appetitive feature-negative learning using microinfusions of (a) the gamma-aminobutyric acid-A receptor agonist muscimol (0.25 μg in 1.0 μl; N = 35), (b) the dopamine D1 receptor agonist SKF-81297 (0.1 μg in 1.0 μl; N = 33), and (c) the dopamine D1 receptor antagonist SCH-23390 (5 μg in 1.0 μl; N = 35). A conditioned stimulus (CS) was followed by food, but on trials on which the CS (A+) was compounded with the inhibitory cue (AX-), the food delivery was canceled. Difference scores (CS-preCS responding) were used to measure learning. All three experiments showed the feature-negative discrimination (A+/AX-), as decreased responding to AX- versus A+. This discrimination was reduced but preserved following muscimol infusions in Experiment 1. Similarly, in Experiments 2 and 3, infusions of SKF-81297 and SCH-23390 were both without effect on the acquisition of the discrimination. Like muscimol, SCH-23390 reduced difference score responding, consistent with nonspecific effects on the (expression of) learning. Thus, there was no evidence to suggest that inactivation of prelimbic or infralimbic cortices impaired feature-negative discrimination learning and no evidence for dopaminergic modulation of such learning in the medial prefrontal cortex either. These results are discussed in the context of the nonspecific effects of the infusions and the overall inconsistent performance in summation and retardation tests of conditioned inhibition. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

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来源期刊
Behavioral neuroscience
Behavioral neuroscience 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
51
审稿时长
6-12 weeks
期刊介绍: Behavioral Neuroscience publishes original research articles as well as reviews in the broad field of the neural bases of behavior.
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