Acute early life stress alters threat processing in adult rats.

IF 1.6 4区 医学 Q3 BEHAVIORAL SCIENCES
Brianna L Minshall, Allison Z Peguero, Katelyn M Scheive, Catherine F Wasylyshyn, Dragana I Claflin, Jennifer J Quinn
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引用次数: 0

Abstract

Individuals diagnosed with stress-related psychiatric disorders in adulthood are likely to have experienced early life stress, suggesting that early adversity is an important vulnerability factor in the subsequent development of trauma- and anxiety-related psychiatric illness. It is important to develop animal models of psychiatric dysfunction to determine evident vulnerability considerations, potential biomarkers, and novel treatment avenues to improve the human condition. In our model of acute early life stress (aELS), 15 footshocks are delivered in a single session on postnatal day 17. The following experiments investigated the persistent impacts of our aELS procedure on stress-enhanced fear learning, anxiety-related behaviors, maintenance of fear, and resistance to extinction in adult male and female rats. The findings from these experiments demonstrate that our aELS procedure yields enhanced fear learning and increased anxiety. This enhanced fear is maintained over time, yet it extinguishes normally. Taken together, these results demonstrate that exposure to 15 footshocks during a single session early in life (postnatal day 17) recapitulates a number of important features of trauma- and anxiety-related disorder symptomatology, but not others. Future studies are needed to determine the persistent physiological phenotypes resulting from aELS and the neurobiological mechanisms that mediate these long-term changes. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

急性早期生活压力会改变成年大鼠的威胁处理能力。
成年后被诊断出患有与压力相关的精神疾病的人很可能在早年经历过生活压力,这表明早年的逆境是日后患上与创伤和焦虑相关的精神疾病的重要易感因素。开发精神功能障碍的动物模型,以确定明显的易感因素、潜在的生物标志物和新的治疗途径,从而改善人类的状况,这一点非常重要。在我们的急性早期生活应激(aELS)模型中,在出生后第 17 天一次性给予 15 次足震。接下来的实验研究了我们的 aELS 程序对成年雄性和雌性大鼠的应激增强恐惧学习、焦虑相关行为、恐惧维持和抗灭绝能力的持续影响。这些实验结果表明,我们的 aELS 程序会增强恐惧学习和焦虑。这种增强的恐惧会随着时间的推移而维持,但却能正常熄灭。综上所述,这些结果表明,在生命早期(出生后第 17 天)单次暴露于 15 次脚震可重现创伤和焦虑相关障碍症状的一些重要特征,但不能重现其他症状。今后还需要进行研究,以确定 AELS 导致的持续性生理表型以及介导这些长期变化的神经生物学机制。(PsycInfo Database Record (c) 2024 APA,保留所有权利)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Behavioral neuroscience
Behavioral neuroscience 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
51
审稿时长
6-12 weeks
期刊介绍: Behavioral Neuroscience publishes original research articles as well as reviews in the broad field of the neural bases of behavior.
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