Dopamine D1 receptor activation is involved in overcoming boundary conditions for destabilizing and updating object memories.

IF 1.6 4区 医学 Q3 BEHAVIORAL SCIENCES
Olivia S O'Neill, Andrew E Huff, Kristen H Jardine, Boyer D Winters
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引用次数: 0

Abstract

Consolidated long-term memories can be modified when destabilized at reactivation (RA). This must be followed by an upregulation of protein synthesis to return the memory to a stable state. Reconsolidation is suggested to maintain the relevance of stored memories, preserving behavioral flexibility. Older or strongly encoded memories resist reconsolidation because of biological boundary conditions and destabilization of such memories is more likely in the presence of prediction error at reactivation. The neurotransmitter dopamine (DA), which has been implicated in prediction error, has been linked to destabilization using appetitive or aversive memory paradigms. However, more neutral memories also undergo modification to adapt to changing environments. Evidence suggests that a salient novel cue presented at reactivation can trigger destabilization of boundary condition-protected object memories, but DA has not yet been implicated in this process. Using male rats in a modified spontaneous object recognition task, we report that systemic administration of the D1 receptor (D1R) antagonist SCH23390 blocked recently encoded and novelty-induced relatively remote object memory destabilization. Further, systemic administration of the D1R agonist SKF38393 promoted destabilization of relatively remote memory traces in the absence of salient novelty at reactivation. Finally, systemic D1R antagonism and agonism blocked and promoted integrative memory updating, respectively, in the postreactivation object memory modification task. This work therefore advances current knowledge related to the role of DA in the dynamic nature of memory storage. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

多巴胺D1受体的激活参与了客体记忆不稳定和更新的边界条件的克服。
巩固的长期记忆可以在再激活时不稳定(RA)时被修改。这必须伴随着蛋白质合成的上调,以使记忆恢复到稳定状态。重新巩固被认为是为了保持存储记忆的相关性,保持行为的灵活性。由于生物边界条件和再激活时预测错误的存在,较老的或强烈编码的记忆抵抗再巩固。神经递质多巴胺(DA)与预测误差有关,与食欲或厌恶记忆范式的不稳定有关。然而,更多的中性记忆也会经历修改以适应不断变化的环境。有证据表明,在再激活时出现的显著新线索可以触发边界条件保护的对象记忆的不稳定,但DA尚未涉及这一过程。利用雄性大鼠进行改良的自发物体识别任务,我们报告了D1受体(D1R)拮抗剂SCH23390的全身管理阻断了最近编码和新奇诱导的相对远程物体记忆不稳定。此外,系统给药D1R激动剂SKF38393促进相对远的记忆痕迹的不稳定,在再激活时没有显著的新新性。最后,在激活后客体记忆修正任务中,系统D1R拮抗和激动作用分别阻断和促进了整合记忆的更新。因此,这项工作推进了当前有关DA在记忆存储动态特性中的作用的知识。(PsycInfo Database Record (c) 2025 APA,版权所有)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Behavioral neuroscience
Behavioral neuroscience 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
51
审稿时长
6-12 weeks
期刊介绍: Behavioral Neuroscience publishes original research articles as well as reviews in the broad field of the neural bases of behavior.
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