Karina Bermeo, Hector Castro, Antonio Barajas-Martínez, Valeria Nayely Hernandez-Serratos, Erick Mauricio Aceves-Rodriguez, Eduardo Martinez-Alonso, Carla Gabriela Soto-Muñoz, Carolina Hernandez-Cruz, Isabel Arenas, David E Garcia
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引用次数: 0
摘要
高糖饮食（HSD）与认知障碍和热量失衡有关。它们之间的共同纽带是多巴胺（DA）系统。然而，HSD对水疱单胺转运蛋白2和多巴胺d2受体的影响尚存争议。本研究旨在研究糖和热量摄入是否会影响HSD大鼠在治疗20或40周时的囊泡单胺转运蛋白2和d2受体密度。在不改变蔗糖和热量消耗的情况下，HSD-20周组水疱单胺转运蛋白2密度增加，而d2受体密度保持不变。这些结果支持了HSD诱导的DA系统，特别是纹状体的潜在变化。（PsycInfo Database Record (c) 2025 APA，版权所有）。
Vesicular monoamine transporter 2 density increases without changing D₂ receptors in the striatum body of the rat following a high-sucrose diet.
High-sucrose diet (HSD) has been related to cognitive impairments and caloric imbalance. A common link among them all is the dopamine (DA) system. However, the impact of HSD on vesicular monoamine transporter 2 and dopamine D₂ receptor is controversial. This work aimed to investigate whether sucrose and caloric intake impact vesicular monoamine transporter 2 and D₂ receptor density in rats under HSD at 20 or 40 weeks of treatment. Vesicular monoamine transporter 2 density increases in the HSD-20 weeks group without altering sucrose and caloric consumption, while D₂ receptor density remains unchanged. These results support underlying changes in the DA system, particularly in the striatum body, induced by HSD. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
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