Behavioral neuroscience最新文献_第9页

Muscimol inactivation of dorsal striatum in young and aged male rats does not affect paired associates learning performance. 麝香草酚对幼年和老年雄性大鼠背侧纹状体的失活作用不会影响配对联想学习能力。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2023-12-01 Epub Date: 2023-06-15 DOI: 10.1037/bne0000561

Samantha M Smith, Elena L Garcia, Anna Montelongo, Caroline G Davidson, Denna Bakhtiar, Sarah D Lovett, Andrew P Maurer, Sara N Burke

{"title":"Muscimol inactivation of dorsal striatum in young and aged male rats does not affect paired associates learning performance.","authors":"Samantha M Smith, Elena L Garcia, Anna Montelongo, Caroline G Davidson, Denna Bakhtiar, Sarah D Lovett, Andrew P Maurer, Sara N Burke","doi":"10.1037/bne0000561","DOIUrl":"10.1037/bne0000561","url":null,"abstract":"Improving cognitive health for older adults requires understanding the neurobiology of age-related cognitive decline and the mechanisms underlying preserved cognition in old age. During spatial learning tasks, aged humans and rodents shift navigation preferences in favor of a stimulus-response learning strategy. This has been hypothesized to result from competitive interactions of the caudate nucleus/dorsal striatum (DS) memory system with the hippocampus (HPC)-dependent spatial/allocentric memory system. In support of this hypothesis, a recent study reported that inactivation of the DS in aged rodents rescued HPC-dependent spatial learning on a T-maze (Gardner, Gold, & Korol, 2020). Currently, it is unclear whether a shift from HPC-dependent to DS-dependent behavior also contributes to age-related cognitive decline outside of spatial learning and memory. To test the hypothesis that inactivation of the DS can restore age-related cognitive function outside of spatial behavior, the present study bilaterally inactivated the DS of young (n = 8) and aged (n = 7) rats during visuospatial paired associates learning (PAL). This study found that inactivation of the DS did not alter PAL performance in young or aged rats, but did alter a positive control, DS-dependent spatial navigation task. This observation suggests that elevated DS activity does not play a role in the decline of HPC-dependent PAL performance in aged male rats. Given the persistent tendencies of aged rodents toward DS-dependent learning, it will be worthwhile to explore further the coordination dynamics between the HPC and DS that may contribute to age-related cognitive decline. (PsycInfo Database Record (c) 2023 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"356-363"},"PeriodicalIF":1.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10721732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10156452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Negative attributes of mixed-valence memories strengthen over long retention intervals and the degree of enhancement is predicted by individual differences in state anxiety. 混合价记忆的负面属性在长的保留时间内会增强，增强的程度可以通过状态焦虑的个体差异来预测。

IF 1.6 4区医学

Behavioral neuroscience Pub Date : 2023-12-01 Epub Date: 2023-10-30 DOI: 10.1037/bne0000575

Louis D Matzel, Dylan W Crawford, Julia Bond, Kelsey M McKeen, Himali M Patel, Komal R Patel, Pranu Sharma, Ashley Swiecka, Alisha Tiwari

{"title":"Negative attributes of mixed-valence memories strengthen over long retention intervals and the degree of enhancement is predicted by individual differences in state anxiety.","authors":"Louis D Matzel, Dylan W Crawford, Julia Bond, Kelsey M McKeen, Himali M Patel, Komal R Patel, Pranu Sharma, Ashley Swiecka, Alisha Tiwari","doi":"10.1037/bne0000575","DOIUrl":"10.1037/bne0000575","url":null,"abstract":"Memories are multifaceted and can simultaneously contain positive and negative attributes. Here, we report that negative attributes of a mixed-valence memory dominate long-term recall. To induce a mixed-valence memory, running responses were randomly reinforced with either food (∼83% of trials) or footshock (∼17% of trials), or a noise conditioned stimulus (CS) was followed randomly with either food (∼80% of trials) or footshock (∼20% of trials). Control animals were consistently reinforced with only food. Mixed-valence training promoted unstable behavior (e.g., erratic approach and withdrawal from the food cup) and moderate levels of fear during the training regimens. After a 20-day retention interval, animals that were consistently reinforced with food exhibited intact approach responding, and similar responding was observed if animals were food deprived or satiated (i.e., the response was insensitive to motivation). However, animals that experienced the mixed-valence training expressed significantly enhanced and stable fear (consistent immobility) relative to the end of training, regardless of whether animals were food deprived or not, suggesting that fear transitioned to a state that was insensitive to motivation. The degree of fear expressed during long-term retention was predicted by measures of state anxiety obtained prior to the training, indicating that the enhancement of fear across the retention interval was related to individual differences in basal \"anxiety.\" These results suggest that negative attributes of memories dominate long-term recall, particularly in animals expressing an anxious phenotype, and these observations have direct implications for the chronic nature of anxiety disorders and the exacerbation of fear that accompanies posttraumatic stress disorder. (PsycInfo Database Record (c) 2023 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"380-391"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optogenetic inhibition of the caudal substantia nigra inflates behavioral responding to uncertain threat and safety. 尾黑质的光遗传学抑制使行为对不确定的威胁和安全性的反应增强。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2023-12-01 Epub Date: 2023-10-05 DOI: 10.1037/bne0000568

Kristina M Wright, Shannon Cieslewski, Amanda Chu, Michael A McDannald

{"title":"Optogenetic inhibition of the caudal substantia nigra inflates behavioral responding to uncertain threat and safety.","authors":"Kristina M Wright, Shannon Cieslewski, Amanda Chu, Michael A McDannald","doi":"10.1037/bne0000568","DOIUrl":"10.1037/bne0000568","url":null,"abstract":"Defensive responding is adaptive when it approximates the current threat but maladaptive when it exceeds the current threat. Here we asked if the substantia nigra, a region consistently implicated in reward, is necessary to show appropriate levels of defensive responding in Pavlovian fear discrimination. Rats received bilateral transduction of the caudal substantia nigra with halorhodopsin or a control fluorophore and bilateral ferrule implants. Rats then behaviorally discriminated cues predicting unique foot shock probabilities (danger, p = 1; uncertainty, p = .25; and safety, p = 0). Green-light illumination (532 nm) during cue presentation inflated defensive responding of halorhodopsin rats-measured by suppression of reward seeking-to uncertainty and safety beyond control levels. Green-light illumination outside of cue presentation had no impact on halorhodopsin or control rat responding. The results reveal caudal substantia nigra cue activity is necessary to inhibit defensive responding to nonthreatening and uncertain threat cues. (PsycInfo Database Record (c) 2023 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"347-355"},"PeriodicalIF":1.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10966587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41092472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrieval and savings of contextual fear memories across an extended retention interval in juvenile and adult male and female rats. 在幼年和成年雄性和雌性大鼠中，在延长的保留期内检索和保存上下文恐惧记忆。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2023-12-01 Epub Date: 2023-10-30 DOI: 10.1037/bne0000569

Natalie Odynocki, Zerah Isaacs, Andrew M Poulos

{"title":"Retrieval and savings of contextual fear memories across an extended retention interval in juvenile and adult male and female rats.","authors":"Natalie Odynocki, Zerah Isaacs, Andrew M Poulos","doi":"10.1037/bne0000569","DOIUrl":"10.1037/bne0000569","url":null,"abstract":"Adult rodents exhibit an exceptional ability to retrieve context fear memories across lengthy retention intervals. In contrast, these memories established in younger rodents are susceptible to significant forgetting. The present study aimed to examine the persistence of contextual fear memories established in juvenile and adult Long-Evans male and female rats. Testing 1-day after conditioning, adult males exhibited evidence for greater conditioning than juvenile males, while in females, conditioning did not differ between juvenile and adult rats. In adults, males displayed greater conditioning than females, while in juveniles, males and females reached similar conditioning levels. At the 60-day retention interval, adult sex differences were maintained; however, juvenile rats failed to retrieve this remote contextual fear memory. Next, we examined whether a savings test procedure could recover these remotely established juvenile memories. Following a 60-day retention test, the now adult rats were presented with an additional context-shock pairing to assess the level of savings. While this procedure produced greater conditioning in males than females, the relative savings of this early life memory were similar in males and females. The results of these experiments indicate that adult sex differences in contextual fear memory are maintained across an extended retention interval, while in juveniles, there were no significant sex differences. A novel finding in the present study was that both male and female rats failed to retrieve an initial juvenile memory following an extended retention interval. However, these memories were recovered with a single reminder of the original juvenile experience. (PsycInfo Database Record (c) 2023 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":" ","pages":"339-346"},"PeriodicalIF":1.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10841099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supplemental Material for Predictions About Reward Outcomes in Rhesus Monkeys 恒河猴奖励结果预测补充材料

4区医学

Behavioral neuroscience Pub Date : 2023-11-13 DOI: 10.1037/bne0000573.supp

引用次数: 0

Supplemental Material for Retrieval and Savings of Contextual Fear Memories Across an Extended Retention Interval in Juvenile and Adult Male and Female Rats 幼鼠和成年雄性和雌性大鼠在延长保留时间内检索和储存情境恐惧记忆的补充材料

4区医学

Behavioral neuroscience Pub Date : 2023-10-30 DOI: 10.1037/bne0000569.supp

引用次数: 0

Supplemental Material for Optogenetic Inhibition of the Caudal Substantia Nigra Inflates Behavioral Responding to Uncertain Threat and Safety 补充材料:光遗传学抑制尾侧黑质膨胀行为对不确定威胁和安全的反应

4区医学

Behavioral neuroscience Pub Date : 2023-10-05 DOI: 10.1037/bne0000568.supp

引用次数: 0

Supplemental Material for Can the Resting State Peak Alpha Frequency Explain the Relationship Between Temporal Resolution Power and Psychometric Intelligence? 静息状态α峰频率能否解释时间分辨能力与心理测量智力的关系?

4区医学

Behavioral neuroscience Pub Date : 2023-10-05 DOI: 10.1037/bne0000571.supp

引用次数: 0

Proteome analysis indicates participation of the dorsal hippocampal formation in fear-motivated memory in a time-dependent manner. 蛋白质组分析表明背侧海马结构以时间依赖的方式参与恐惧动机记忆。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2023-10-01 Epub Date: 2023-07-06 DOI: 10.1037/bne0000563

Renan Barretta Gaiardo, Amanda Paula Pedroso, Eliane Beraldi Ribeiro, Alexandre Keiji Tashima, Monica Marques Telles, Suzete Maria Cerutti

{"title":"Proteome analysis indicates participation of the dorsal hippocampal formation in fear-motivated memory in a time-dependent manner.","authors":"Renan Barretta Gaiardo, Amanda Paula Pedroso, Eliane Beraldi Ribeiro, Alexandre Keiji Tashima, Monica Marques Telles, Suzete Maria Cerutti","doi":"10.1037/bne0000563","DOIUrl":"10.1037/bne0000563","url":null,"abstract":"Our previous behavioral and molecular data indicate a central role of the dorsal hippocampal formation (dHF) in recent conditioned lick suppression memory. The purpose of this study was to investigate the role of the dHF in recent and remote memory of conditioned lick suppression employing proteomic analysis. Two or 40 days after conditioning, the rats were subjected to a retention test and were then euthanized after 24 hr for dHF collection. We identified 1,165 proteins and quantified 265 proteins. Upregulation of five proteins and downregulation of 21 proteins were found on postconditioning Day 2. Additionally, four proteins were upregulated and 21 proteins were downregulated on postconditioning Day 40. Integrated pathway analysis of the proteomics data indicated changes in the myelin sheath, neuron generation and differentiation, regulation of neurogenesis and synaptic vesicle transport, axonal development, and the growth cone. Our findings provide further support for the role of the dHF in conditioned lick suppression memory and novel insights into the molecular changes that are correlated with recent and remote memory in the dHF, which may be a target for cognitive enhancers. (PsycInfo Database Record (c) 2023 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"137 5","pages":"303-318"},"PeriodicalIF":1.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10122515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mental representations mediate aversive learning in humans. 心理表征介导人类的厌恶学习。

IF 1.5 4区医学

Behavioral neuroscience Pub Date : 2023-10-01 Epub Date: 2023-07-06 DOI: 10.1037/bne0000565

Xiaolin Qiao, Lauren Wolters, James D Howard

{"title":"Mental representations mediate aversive learning in humans.","authors":"Xiaolin Qiao, Lauren Wolters, James D Howard","doi":"10.1037/bne0000565","DOIUrl":"10.1037/bne0000565","url":null,"abstract":"Mental representations of stimuli that are not physically present are critical for a range of cognitive capacities, including perception, memory, and learning. Overly robust mental representations, however, can contribute to hallucinations in healthy individuals and those diagnosed with psychotic illness. Measuring the strength of mental representations can thus provide insight into how the contents of the mind influence both adaptive and maladaptive behaviors. In rodents, the robustness of mental representations has been tested using the representation-mediated learning (RML) task, in which animals respond less to a cue after a stimulus that has previously been associated with this cue has been paired with illness. This suggests that the mental representation of the cue enters into a negative association during aversive learning, even though the cue is not physically present. Here, we developed a human version of the RML task in which participants initially learned associations between two visual symbols and two different appetitive food odors. Preference for the food odors was then tested immediately before and after a session in which one symbol was paired with an aversive noise. We observed that mediated learning, in the form of selective decrease in preference for the odor previously paired with the noise-predicting symbol, was directly proportional to direct aversive learning for the symbols themselves. These findings suggest that a mental representation of the odor entered into a negative association with the sound and pave the way for future studies aimed at characterizing the neural circuits of mediated learning in the human brain. (PsycInfo Database Record (c) 2023 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"137 5","pages":"319-329"},"PeriodicalIF":1.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10122514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0