Behavioral neuroscience最新文献_第6页

A single dose of ketamine enhances early life stress-induced aggression with no effect on fear memory, anxiety-like behavior, or depression-like behavior in mice. 单剂量氯胺酮可增强小鼠早期生活压力诱导的攻击性，对小鼠的恐惧记忆、焦虑样行为或抑郁样行为没有影响。

IF 1.6 4区医学

Behavioral neuroscience Pub Date : 2023-10-01 Epub Date: 2023-06-15 DOI: 10.1037/bne0000560

Caitlyn J Bartsch, Sophia Aaflaq, Jessica T Jacobs, Molly Smith, Fletcher Summa, Savannah Skinner, Elana Qasem, Rylee Thompson, Zheng Li, Jacob C Nordman

{"title":"A single dose of ketamine enhances early life stress-induced aggression with no effect on fear memory, anxiety-like behavior, or depression-like behavior in mice.","authors":"Caitlyn J Bartsch, Sophia Aaflaq, Jessica T Jacobs, Molly Smith, Fletcher Summa, Savannah Skinner, Elana Qasem, Rylee Thompson, Zheng Li, Jacob C Nordman","doi":"10.1037/bne0000560","DOIUrl":"10.1037/bne0000560","url":null,"abstract":"Ketamine is a dissociative anesthetic that has been shown to have antidepressant effects in humans and has been proposed as a potential treatment for mood disorders such as posttraumatic stress disorder and aggression. However, previous studies from our lab and others have demonstrated that ketamine's effects are highly context- and dose-dependent. In a recent study, we found that 10 mg/kg ketamine could exacerbate the effects of early life stress on excessive aggression in mice. To further investigate, the effect of ketamine on moods, such as fear, anxiety, depression, and aggression, we used a mouse model of early life stress, involving chronic social isolation followed by acute traumatic stress in the form of noncontingent, unpredictable foot shock during adolescence. We find this is necessary to induce long-lasting excessive aggression in a novel environment. Seven- to eight-week-old socially isolated mice were given IP injections of 10 mg/kg ketamine 30 min before being subjected to foot shock and then assessed 7 days later for changes in sociability, aggression, mobility, anxiety-like behavior, and depression-like behavior. The results show that ketamine selectively increases long-lasting aggression in mice exposed to foot shock, but does not affect mood-related behaviors or locomotion. These findings suggest that during early life stress, ketamine may exert its effects by specifically targeting aggression brain circuitry that is distinct from brain circuits responsible for nonaggressive social or emotional behaviors. Therefore, while ketamine may be a promising treatment for various mood disorders, caution should be exercised when using ketamine to treat disorders associated with early life stress. (PsycInfo Database Record (c) 2023 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"137 5","pages":"281-288"},"PeriodicalIF":1.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10498269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supplemental Material for Electric Barrier-Induced Voluntary Abstinence Reduces Alcohol Seeking in Male, but Not Female, iP Rats 电屏障诱导的自愿戒酒在雄性大鼠中减少酒精寻求，而不是雌性大鼠

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2023-08-10 DOI: 10.1037/bne0000566.supp

引用次数: 0

The medial preoptic area and its projections to the ventral tegmental area and the periaqueductal gray are activated in response to social play behavior in juvenile rats. 幼年大鼠的内侧视前区及其向腹侧被盖区和下uctal灰质周围的投射会因社交游戏行为而被激活。

IF 1.6 4区医学

Behavioral neuroscience Pub Date : 2023-08-01 Epub Date: 2023-03-06 DOI: 10.1037/bne0000555

Changjiu Zhao, Lauren V Riters

{"title":"The medial preoptic area and its projections to the ventral tegmental area and the periaqueductal gray are activated in response to social play behavior in juvenile rats.","authors":"Changjiu Zhao, Lauren V Riters","doi":"10.1037/bne0000555","DOIUrl":"10.1037/bne0000555","url":null,"abstract":"The medial preoptic area (MPOA) is well known for its role in sexual and maternal behaviors. This region also plays an important role in affiliative social behaviors outside reproductive contexts. We recently demonstrated that the MPOA is a central nucleus in which opioids govern highly rewarding social play behavior in adolescent rats. However, the neural circuit mechanisms underlying MPOA-mediated social play remain largely unresolved. We hypothesized that the MPOA unites a complementary neural system through which social play induces reward via a projection to the ventral tegmental area (VTA) and reduces a negative affective state through a projection to the periaqueductal gray (PAG). To test whether the two projection pathways are activated in response to social play behavior, we combined retrograde tract tracing with immediate early gene (IEG) expression and immunofluorescent labeling to identify opioid-sensitive projection pathways from the MPOA to VTA and PAG that are activated after performance of social play. Retrograde tracer, fluoro-gold (FG), was microinjected into the VTA or PAG. IEG expression (i.e., Egr1) was assessed and triple immunofluorescent labeling for mu opioid receptor (MOR), Egr1, and FG in the MPOA was performed after social play. We revealed that play animals displayed an increase in neurons double labeled for Egr1 + FG and triple labeled for MOR + Egr1 + FG in the MPOA projecting to both the VTA and PAG when compared to no-play rats. The increased activation of projection neurons that express MORs from MPOA to VTA or PAG after social play suggests that opioids may act through these projection pathways to govern social play. (PsycInfo Database Record (c) 2023 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"137 4","pages":"223-235"},"PeriodicalIF":1.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10230877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The motivational role of the ventral striatum and amygdala in learning from gains and losses. 腹侧纹状体和杏仁核在从得失中学习中的激励作用。

IF 1.6 4区医学

Behavioral neuroscience Pub Date : 2023-08-01 Epub Date: 2023-05-04 DOI: 10.1037/bne0000558

Craig A Taswell, Miriam Janssen, Elisabeth A Murray, Bruno B Averbeck

{"title":"The motivational role of the ventral striatum and amygdala in learning from gains and losses.","authors":"Craig A Taswell, Miriam Janssen, Elisabeth A Murray, Bruno B Averbeck","doi":"10.1037/bne0000558","DOIUrl":"10.1037/bne0000558","url":null,"abstract":"The ventral striatum (VS) and amygdala are two structures often implicated as essential structures for learning. The literature addressing the contribution of these areas to learning, however, is not entirely consistent. We propose that these inconsistencies are due to learning environments and the effect they have on motivation. To differentiate aspects of learning from environmental factors that affect motivation, we ran a series of experiments with varying task factors. We compared monkeys (Macaca mulatta) with VS lesions, amygdala lesions, and unoperated controls on reinforcement learning (RL) tasks that involve learning from both gains and losses as well as from deterministic and stochastic schedules of reinforcement. We found that for all three groups, performance varied by experiment. All three groups modulated their behavior in the same directions, to varying degrees, across the three experiments. This behavioral modulation is why we find deficits in some experiments, but not others. The amount of effort animals exhibited differed depending on the learning environment. Our results suggest that the VS is important for the amount of effort animals will give in rich deterministic and relatively leaner stochastic learning enivornments. We also showed that monkeys with amygdala lesions can learn stimulus-based RL in stochastic environments and environments with loss and conditioned reinforcers. These results show that learning environments shape motivation and that the VS is essential for distinct aspects of motivated behavior. (PsycInfo Database Record (c) 2023 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"137 4","pages":"268-280"},"PeriodicalIF":1.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10662269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ketamine facilitates appetitive trace conditioning in mice: Further evidence for abnormal stimulus representation in schizophrenia model animals. 氯胺酮促进小鼠食欲调节:精神分裂症模型动物异常刺激表征的进一步证据。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2023-08-01 DOI: 10.1037/bne0000559

Riria Suzuki, Yutaka Kosaki

{"title":"Ketamine facilitates appetitive trace conditioning in mice: Further evidence for abnormal stimulus representation in schizophrenia model animals.","authors":"Riria Suzuki, Yutaka Kosaki","doi":"10.1037/bne0000559","DOIUrl":"https://doi.org/10.1037/bne0000559","url":null,"abstract":"Recent studies indicated that positive symptoms of schizophrenia, such as hallucination and delusion, can be modeled using Pavlovian conditioning procedures. Various schizophrenia model animals exhibit abnormally strong associative activations of absent stimuli (i.e., conditioned hallucination) and readily form further associations involving the absent cues (i.e., enhanced mediated conditioning). In the present study using mice, we examined whether the acquisition of appetitive trace conditioning, another Pavlovian task in which animals must form associations between two stimuli that never occur together, is facilitated by injections of ketamine, an N-methyl-D-aspartate-receptor antagonist and a known hallucinogen at low doses in humans and nonhuman animals. Ketamine administration before each conditioning session significantly enhanced the acquisition of 4-s trace conditioning but not delay conditioning. The trace conditioning-specific facilitatory effect of ketamine was replicated in subsequent experiments in which slightly modified procedures were used to enhance the overall levels of conditioned responses. Taken together, the current results demonstrated that low-dose ketamine promotes associative learning between stimuli over a temporal gap, which adds to existing literature illustrating aberrant learning involving absent stimuli in schizophrenia model animals. We discuss potential associative mechanisms through which ketamine promoted trace conditioning with reference to Wagner's (1981) Standard Operating Procedures model. (PsycInfo Database Record (c) 2023 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"137 4","pages":"236-253"},"PeriodicalIF":1.9,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9789248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Divergent risky decision-making and impulsivity behaviors in Lewis rat substrains with low genetic difference. Lewis大鼠低遗传差异亚系的风险决策和冲动行为差异。

IF 1.6 4区医学

Behavioral neuroscience Pub Date : 2023-08-01 Epub Date: 2023-04-27 DOI: 10.1037/bne0000557

Daniel B K Gabriel, Anna E Liley, Hunter T Franks, Grace L Minnes, Monika Tutaj, Melinda R Dwinell, Tristan V de Jong, Robert W Williams, Megan K Mulligan, Hao Chen, Nicholas W Simon

{"title":"Divergent risky decision-making and impulsivity behaviors in Lewis rat substrains with low genetic difference.","authors":"Daniel B K Gabriel, Anna E Liley, Hunter T Franks, Grace L Minnes, Monika Tutaj, Melinda R Dwinell, Tristan V de Jong, Robert W Williams, Megan K Mulligan, Hao Chen, Nicholas W Simon","doi":"10.1037/bne0000557","DOIUrl":"10.1037/bne0000557","url":null,"abstract":"Substance use disorder (SUD) is associated with a cluster of cognitive disturbances that engender vulnerability to ongoing drug seeking and relapse. Two of these endophenotypes-risky decision-making and impulsivity-are amplified in individuals with SUD and are augmented by repeated exposure to illicit drugs. Identifying genetic factors underlying variability in these behavioral patterns is critical for early identification, prevention, and treatment of SUD-vulnerable individuals. Here, we compared risky decision-making and different facets of impulsivity between two fully inbred substrains of Lewis rats-LEW/NCrl and LEW/NHsd. We performed whole genome sequencing of both substrains to identify almost all relevant variants. We observed substantial differences in risky decision-making and impulsive behaviors. Relative to LEW/NHsd, the LEW/NCrl substrain accepts higher risk options in a decision-making task and higher rates of premature responses in the differential reinforcement of low rates of responding task. These phenotypic differences were more pronounced in females than males. We defined a total of ∼9,000 polymorphisms between these substrains at 40× whole genome short-read coverage. Roughly half of variants are located within a single 1.5 Mb region of Chromosome 8, but none impact protein-coding regions. In contrast, other variants are widely distributed, and of these, 38 are predicted to cause protein-coding variants. In conclusion, Lewis rat substrains differ significantly in risk-taking and impulsivity and only a small number of easily mapped variants are likely to be causal. Sequencing combined with a reduced complexity cross should enable identification of one or more variants underlying multiple complex addiction-relevant behaviors. (PsycInfo Database Record (c) 2023 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"137 4","pages":"254-267"},"PeriodicalIF":1.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10524952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10167752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supplemental Material for Proteome Analysis Indicates Participation of the Dorsal Hippocampal Formation in Fear-Motivated Memory in a Time-Dependent Manner 蛋白质组分析的补充材料表明背侧海马的形成以时间依赖的方式参与恐惧动机记忆

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2023-07-06 DOI: 10.1037/bne0000563.supp

引用次数: 0

Examination of onset trajectories and persistence of binge-like eating behavior in mice after intermittent palatable food exposure. 间歇性可口食物暴露后小鼠暴饮性进食行为的发作轨迹和持续性的检查。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2023-06-01 Epub Date: 2023-02-23 DOI: 10.1037/bne0000550

Britny A Hildebrandt, Hayley Fisher, Susanne E Ahmari

{"title":"Examination of onset trajectories and persistence of binge-like eating behavior in mice after intermittent palatable food exposure.","authors":"Britny A Hildebrandt, Hayley Fisher, Susanne E Ahmari","doi":"10.1037/bne0000550","DOIUrl":"10.1037/bne0000550","url":null,"abstract":"Binge eating is a persistent behavior associated with a chronic course of illness and poor treatment outcomes. While clinical research is unable to capture the full course of binge eating, preclinical approaches offer the opportunity to examine binge-like eating from onset through chronic durations, allowing identification of factors contributing to binge eating persistence. The present study quantified the trajectories of binge-like eating onset and modeled cycles of abstinence/relapse to develop a translational model for binge eating persistence. Adult male and female C57Bl6/J mice were randomized to a binge-like palatable food access schedule (daily 2-hr, 3×/week) or continuous, nonbinge like palatable food access for 12 days (Experiment 1). Persistence of palatable food consumption in both binge-like palatable food access groups was then examined across three cycles of forced abstinence and reexposure to palatable food (incubation) to model the persistence of binge eating in clinical populations. Mice with daily 2-hr palatable food access escalated their intake more than mice in the 3×/week or continuous groups (Experiment 1). This pattern was more pronounced in females. In addition, this pattern of palatable food intake reemerged across multiple cycles of behavioral incubation (Experiment 2). These findings provide a model of binge-like eating in mice that can be used in future studies examining both environmental factors and neural mechanisms contributing to binge eating persistence. (PsycInfo Database Record (c) 2023 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"137 3","pages":"170-177"},"PeriodicalIF":1.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9481828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of striatal dopamine on Pavlovian bias. A large [¹⁸F]-DOPA PET study. 纹状体多巴胺对巴甫洛夫偏向的影响。一项大型[¹⁸F]-多巴PET研究。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2023-06-01 DOI: 10.1037/bne0000547

Ping Chen, Dirk E M Geurts, Jessica I Määttä, Ruben van den Bosch, Lieke Hofmans, Danae Papadopetraki, Hanneke den Ouden, Roshan Cools

{"title":"Effect of striatal dopamine on Pavlovian bias. A large [¹⁸F]-DOPA PET study.","authors":"Ping Chen, Dirk E M Geurts, Jessica I Määttä, Ruben van den Bosch, Lieke Hofmans, Danae Papadopetraki, Hanneke den Ouden, Roshan Cools","doi":"10.1037/bne0000547","DOIUrl":"https://doi.org/10.1037/bne0000547","url":null,"abstract":"Interaction between Pavlovian and instrumental control systems is key for adaptive motivated behavior, but also plays an important role in various neuropsychiatric disorders, including depression, addiction, and anxiety. Here, we employed the flouorodopa positron emission tomography ([¹⁸F]-DOPA PET) in healthy participants (N = 100) to assess whether dopamine synthesis capacity (Ki), specifically in the ventral striatum, accounts for individual variation in Pavlovian-to-instrumental transfer (PIT). Surprisingly, this was not the case. Rather, the relationship of ventral striatal Ki with PIT depended on working memory (WM) capacity. Ventral striatal dopamine boosted the effects of Pavlovian cues on instrumental responding to a greater degree in participants with higher WM capacity. Caution is warranted to interpret this post hoc four-way interaction given the modest sample size. Nonetheless, these results chime with prior findings demonstrating that dopaminergic drugs boost Pavlovian biases to a greater degree in participants with greater WM capacity and highlight the importance of interactions between striatal dopamine and WM capacity. (PsycInfo Database Record (c) 2023 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"137 3","pages":"184-195"},"PeriodicalIF":1.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9472227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The role of the anterior cingulate cortex in aggression and impulsivity. 前扣带皮层在攻击性和冲动性中的作用。

IF 1.9 4区医学

Behavioral neuroscience Pub Date : 2023-06-01 DOI: 10.1037/bne0000552

Ilias Chaibi, Otmane Bouchatta, Mohamed Bennis, Saadia Ba-M'hamed

{"title":"The role of the anterior cingulate cortex in aggression and impulsivity.","authors":"Ilias Chaibi, Otmane Bouchatta, Mohamed Bennis, Saadia Ba-M'hamed","doi":"10.1037/bne0000552","DOIUrl":"https://doi.org/10.1037/bne0000552","url":null,"abstract":"Aggression is a complex social behavior that evolved in the context of defending a territory, fighting for limited resources, and competing for mates and protection. Although aggression considered as a negative or undesirable emotion is an essential part of many species' repertoire of social behaviors. For humans, the motivations, actions, and limits of aggressive acts are not always clear. However, uncontrolled aggression may have destructive consequences, and it develops inappropriately into violence. At the neural level, several studies demonstrated that aggression is related to cortical abnormalities, including the anterior cingulate cortex (ACC). This review summarizes the state of the literature regarding the involvement of ACC in the neurobiology of aggression and impulsivity. We will first review structural and neuroanatomical studies, including volumetric and functional investigations of aggression. Next, we will discuss the neurochemical and neuropharmacological studies of aggression related to the ACC. We will focus mainly on the gamma-aminobutyric acid/glutamate balance, as well as the serotoninergic system. Finally, we will try to integrate these results and reconcile discrepancies in the field and suggest recommendations for future studies. (PsycInfo Database Record (c) 2023 APA, all rights reserved).","PeriodicalId":8739,"journal":{"name":"Behavioral neuroscience","volume":"137 3","pages":"155-169"},"PeriodicalIF":1.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9842778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1