Basic and Clinical Andrology最新文献

{"title":"Retrospective study of 115 patients with diabetes mellitus complicated by retrograde ejaculation.","authors":"Chuangui Li, Huan Wang, Siqi Li, Tianzi Zhang, Hao Li, Chongbo Wang","doi":"10.1186/s12610-026-00303-7","DOIUrl":"10.1186/s12610-026-00303-7","url":null,"abstract":"","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"36 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12927250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in primary versus secondary premature ejaculation: a comparative study.","authors":"Nuh Aldemir, İbrahim Üntan","doi":"10.1186/s12610-026-00304-6","DOIUrl":"10.1186/s12610-026-00304-6","url":null,"abstract":"","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"36 1","pages":"4"},"PeriodicalIF":2.0,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12903722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146177654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiodensity as a predictor: can penile and splenic Hounsfield units forecast clinical response to daily tadalafil?","authors":"Huseyin Hayit, Cumhur Yesildal, Omer Yilmaz, Yahya Barac, Kerem Bursali, Anil Yilmaz","doi":"10.1186/s12610-026-00302-8","DOIUrl":"10.1186/s12610-026-00302-8","url":null,"abstract":"","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"36 1","pages":"3"},"PeriodicalIF":2.0,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12892766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146163850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between a history of frequent masturbation and anxiety/depression in patients with psychogenic erectile dysfunction.","authors":"Jinlong Yang, Wenju Wu, Yilin Zhao, Junjie Liu","doi":"10.1186/s12610-026-00300-w","DOIUrl":"10.1186/s12610-026-00300-w","url":null,"abstract":"<p><strong>Background: </strong>Psychogenic erectile dysfunction patients accounted for a substantial percentage of younger erectile dysfunction ones. This cross-sectional observational study investigated the correlation between a history of frequent masturbation and anxiety/depression symptoms in patients with psychogenic erectile dysfunction .</p><p><strong>Results: </strong>Baseline characteristics showed significant between-group differences in age (the Frequent Masturbation History group younger, P < 0.05), but not in disease duration, residence, or lifestyle factors. The Frequent Masturbation History group demonstrated significantly higher anxiety (GAD-7: Z=-2.17, P = 0.030) and depression scores (PHQ-9: Z=-3.01, P = 0.003), alongside significantly lower psychological resilience (CD-RISC: Z=-2.53, P = 0.011) compared to the Non-Frequent Masturbation History group. These findings indicate that frequent masturbation history in psychogenic erectile dysfunction patients is associated with younger age, elevated anxiety/depression symptomatology, and reduced stress adaptability.</p><p><strong>Conclusions: </strong>Clinical implications suggest incorporating behavioral pattern assessment and psychological screening into psychogenic erectile dysfunction evaluations. Targeted interventions should focus on cognitive-behavioral therapy to address maladaptive beliefs, mindfulness training to reduce performance anxiety, and partner-involved support to disrupt the observed \"masturbation to anxiety/depression to erectile dysfunction\" cycle. Future longitudinal studies integrating biopsychosocial assessments are warranted to elucidate temporal relationships.</p>","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"36 1","pages":"2"},"PeriodicalIF":2.0,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12836828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146058975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of bovine pericardial tissue patch grafting for surgical correction of Peyronie's disease: a prospective single-center case series.","authors":"Pankaj M Joshi, Pawan Kandhari, Meritxell Costa, Saurabh Thakkar, Emmanuel Oyibo, Shreyas Bhadranawar, Sanjay Kulkarni","doi":"10.1186/s12610-025-00298-7","DOIUrl":"10.1186/s12610-025-00298-7","url":null,"abstract":"","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"36 1","pages":"1"},"PeriodicalIF":2.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12821321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNAJB13 polymorphisms and association with idiopathic asthenozoospermia in Sichuan, China.","authors":"Jiaoyu He, Zhuo Zhang, Yishan Ding, Chunlan Cheng, Ning Li, Tianjun Li, Xianqiong Zhao, Chengyue Wang, Xianping Ding","doi":"10.1186/s12610-025-00295-w","DOIUrl":"10.1186/s12610-025-00295-w","url":null,"abstract":"<p><strong>Background: </strong>The axonemal co-chaperone gene DNAJB13 is essential for sperm motility and structural integrity. This study aimed to investigate the association between coding variants in DNAJB13 and idiopathic asthenozoospermia (IAZS) in a cohort from Sichuan, China.</p><p><strong>Methods: </strong>Sanger sequencing of all DNAJB13 exons was performed in 130 patients with IAZS and 120 fertile controls with strictly normal semen parameters according to World Health Organization (WHO) 5th edition criteria. Detected variants were analyzed for genotype and allele frequencies. The potential impact of a novel missense variant was assessed using evolutionary conservation analysis across mammalian orthologs and in silico prediction tools for structural and splicing effects.</p><p><strong>Results: </strong>Six coding variants were identified. Three variants (c.T279C, c.C882T, c.G927A) were common single nucleotide polymorphisms (SNPs ) with no significant differences between cases and controls. A novel missense variant, c.T272G (p.V91G), was detected exclusively in patients. Genotype distribution and allele frequency of this variant differed significantly between groups. Valine 91 was highly conserved, and computational modeling predicted that the p.V91G substitution would destabilize protein structure, disrupt hydrophobic core architecture, potentially interfere with RNA splicing regulatory elements, and impair DNAJB13 co-chaperone function in axonemal assembly.</p><p><strong>Conclusions: </strong>The c.T272G (p.V91G) in DNAJB13 is significantly associated with IAZS in the studied cohort and represents a potential high-risk genetic factor. Predicted detrimental effects on protein structure and function suggest a novel genetic mechanism underlying impaired sperm motility. Functional validation and replication studies in diverse populations are necessary to confirm its pathogenic role.</p>","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"35 1","pages":"49"},"PeriodicalIF":2.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12713253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145779982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of elevated sperm DNA fragmentation: a morphology-based approach to semen analysis.","authors":"Mahsa Kazemi, Ali Moradi, Fatemeh Bayat, Saghar Salehpour, Sarah Niakan, Hamid Nazarian","doi":"10.1186/s12610-025-00297-8","DOIUrl":"10.1186/s12610-025-00297-8","url":null,"abstract":"<p><strong>Background: </strong>Empirical evidence indicates that high levels of sperm DNA fragmentation (SDF) negatively impact the results of both natural conception and assisted reproductive technology (ART). However, there is a notable absence of detailed guidelines for clinicians on which patient groups should be tested for SDF based on their semen analysis results. The goal of this study was to determine which sperm categorizations and morphological subcategorizations should be tested for sperm DNA integrity.</p><p><strong>Results: </strong>Lowered sperm concentration, motility, progressive motility, and morphology, as well as a higher percentage of immature sperm, were linked to increased DNA Fragmentation Index (DFI) values. Higher DFI values were also found in semen samples from patients with two-sided varicoceles. The most significant intermediate correlation was identified between DFI and micro/partial head defects. Additionally, a low but significant correlation was observed in cases of combined oligo-astheno-teratozoospermia.</p><p><strong>Conclusion: </strong>Targeted DFI assessment is especially valuable for patients who have a two-sided varicocele, micro/partial head sperm defects, or combined oligo-astheno-teratozoospermia. Incorporating this assessment may enhance the diagnostic accuracy of male infertility evaluations.</p>","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"35 1","pages":"48"},"PeriodicalIF":2.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12703934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145761876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the semen microbiome for fertility in men with obesity using next-generation sequencing.","authors":"Elzem Nisa Alkan, Neslihan Hekim, Sezgin Gunes, Ramazan Asci, Ralf Henkel","doi":"10.1186/s12610-025-00294-x","DOIUrl":"10.1186/s12610-025-00294-x","url":null,"abstract":"<p><strong>Background: </strong>The study aimed to evaluate the microbial content and diversity in semen samples of men with obesity, determine the differences between infertile and fertile groups, and investigate the effect of seminal microbiota on semen parameters, sperm DNA fragmentation, sperm chromatin condensation, and total antioxidant capacity.</p><p><strong>Results: </strong>The study included thirteen infertile men with obesity as subjects and five fertile men with obesity as the control group (aged 18-55 years, body mass index > 30 kg/m²). The most abundant bacteria in both groups were seen to be belonging to the phylum of Bacillota, Pseudomonadota, Actinomycetota and Bacteroidota. The most common bacteria at the genus level were Pseudescherichia, Staphylococcus, Paenibacillus, Streptococcus, Klebsiella, and Moraxella, which had similar distributions in both groups. A negative correlation was observed between the percentage of aniline-positive sperm and motility (p < 0.0001), sperm concentration (p = 0.0001) and total sperm count (p = 0.001). It was found that Brevibacterium, Paenibacillus, Alistipes, Lactiplantibacillus, Rhizobacter, Sphingomonas and Venlonella genera were correlated with sperm DNA fragmentation; Pantoea, Devosia, Bacteroides, Acidovorax were correlated with total antioxidant capacity, Fusobacterium was correlated with the histone-rich sperm, and Corynebacterium, Hydrogenophaga, and Paenalcagenes were associated with body mass index.</p><p><strong>Conclusion: </strong>Bacterial species in semen may play a role in male infertility by affecting semen quality, sperm DNA fragmentation or total antioxidant capacity.</p>","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"35 1","pages":"47"},"PeriodicalIF":2.0,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12679728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145686600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring sexual myths and influencing factors among Muslim men in Turkey: a cross-sectional analysis.","authors":"Aysu Yıldız Karaahmet, Fatma Şule Bilgiç, Shahla Shafaati Laleh","doi":"10.1186/s12610-025-00296-9","DOIUrl":"10.1186/s12610-025-00296-9","url":null,"abstract":"","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"35 1","pages":"46"},"PeriodicalIF":2.0,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12673704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145666852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gaps in diagnosis and unmet healthcare needs in male sexual dysfunction and chronic health conditions: insights from a German population-based study.","authors":"Elena Mühle, Selina M Kronthaler, Carlotta Oesterling, Tatjana Tissen-Diabaté, Klaus M Beier, Jörg Neymeyer, Thorsten Schlomm, Laura Hatzler","doi":"10.1186/s12610-025-00293-y","DOIUrl":"10.1186/s12610-025-00293-y","url":null,"abstract":"<p><strong>Background: </strong>Chronic health conditions (CHC), both somatic and mental, increase the risk of sexual dysfunctions (SD) in men, which are associated with reduced quality of life. Despite existing guidelines, help-seeking remains low due to barriers such as shame and limited access, with many turning to anonymous sources. Representative data on care pathways and treatment preferences across SD domains and CHC subgroups is lacking. This study examines SD diagnoses, help-seeking, and treatment preferences in men with and without CHC meeting ICD-11 SD criteria to inform more tailored care.</p><p><strong>Results: </strong>Of all N = 1815 (unweighted N = 1787) cis-men, n = 265 (16.6%) fulfilled positive ICD-11 SD criteria and were included in this study (mean age 49.2; SD = 16.9 years). CHC were present in 74.1% of men, of whom 23.2% had self-reported SD. While the internet remains the most used information source, urologists were the preferred information sources and dialogue partners for sexual health concerns. Men with mental health conditions (MH +) valued psychotherapists and psychiatrists more highly in this regard. Shame was the most cited barrier to help-seeking, particularly present in men with MH + , with 50.4%. Only 46.6% of men with SD symptoms meeting the ICD-11 criteria reported an SD diagnosis. Previous therapy was rare, with 3-4 months of waiting times. Medication was the most commonly used treatment in the past. As preferred treatment, men with CHC prioritized medication (42.6% vs. 36.7% in men without CHC), whereas men without CHC also favored relaxation methods (29.3%). Desired treatment goals included improved sexual and relationship satisfaction. Digital tools such as apps or websites were also of interest, with reimbursement considered essential.</p><p><strong>Conclusion: </strong>Despite the high burden, SD diagnoses remain rare, and help-seeking behaviors vary, especially between men with somatic versus mental CHC. Regular healthcare contact may offer opportunities to address sexual health in trusted settings. Interventions should target both sexual and relationship satisfaction. Digital solutions can help close treatment gaps and improve access to specialized care. However, given low interest and adherence-particularly among men with CHC-tailored approaches are essential. Reimbursement within the German healthcare system is needed to lower financial barriers.</p>","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"35 1","pages":"45"},"PeriodicalIF":2.0,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12636151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145562488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}