Basic and Clinical Andrology最新文献

{"title":"Glucose/potassium ratio and a novel combined model for the differential diagnosis of testicular torsion: a retrospective study.","authors":"Yasin Aktaş, Adem Tunçekin","doi":"10.1186/s12610-026-00313-5","DOIUrl":"https://doi.org/10.1186/s12610-026-00313-5","url":null,"abstract":"<p><strong>Background: </strong>It is challenging to distinguish between testicular torsion (TT) and epididymorchitis (EO) due to their overlapping symptoms. This study evaluated the diagnostic value of the glucose/potassium ratio (GPR) and a combined model for distinguishing between TT, EO, and non-specific acute scrotal pain. This retrospective study included 373 patients, who were divided into three groups: TT (n = 103), EO (n = 120), and non-specific pain controls (n = 150). GPR and systemic inflammatory indices were calculated from admission blood samples. A combined model incorporating independent predictors (age, GPR, and white blood cell (WBC) count) was constructed using binary logistic regression. Diagnostic performance was assessed using a receiver operating characteristic (ROC) curve and multivariate logistic regression analysis.</p><p><strong>Results: </strong>The median GPR was highest in the TT group (23.6), followed by the EO group (21.0) and the control group (20.4) (p < 0.001). A GPR cut-off value of > 21.8 was associated with a 3.52-fold increased risk of testicular torsion (OR: 3.52, 95% CI: 1.97-6.25; p < 0.001). Although the GPR demonstrated the greatest accuracy among the individual markers (AUC: 0.738), the combined model produced superior diagnostic results, with an AUC of 0.839 (sensitivity: 75.6%; specificity: 81.5%; positive predictive value (PPV): 60.9%; negative predictive value (NPV): 89.7%). Multivariate analysis identified the following as independent predictors of testicular torsion: younger age (OR: 0.92); higher WBC count (OR: 1.30); and higher GPR levels (OR: 1.14).</p><p><strong>Conclusions: </strong>GPR appears to be a biomarker that could reflect specific metabolic stress in testicular ischaemia, which is distinct from the inflammatory response in EO. The combined model demonstrated the highest diagnostic accuracy in our cohort, suggesting its potential usefulness as an adjunctive triage tool. However, these findings are preliminary and require external validation in future prospective, multicentre studies before routine clinical implementation.</p>","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"36 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13137708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic amelioration of heat stress-induced testicular damage and impaired fertility by sesame seed oil and α-lipoic acid in male rats.","authors":"Ali Hashemi, Ali Soleimanzadeh, Esmail Ayen, Mazdak Razi, Hadi Keshipour","doi":"10.1186/s12610-026-00306-4","DOIUrl":"10.1186/s12610-026-00306-4","url":null,"abstract":"","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"36 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microscopic ligation combined with shunt procedure versus microsurgical varicocelectomy for nutcracker syndrome and left varicocele: a randomized controlled trial.","authors":"Ke Dou, Xinchen Zeng, Qi Yang, Yutao Li, Lei Wang, Tao Song, Juncheng Yao","doi":"10.1186/s12610-026-00312-6","DOIUrl":"https://doi.org/10.1186/s12610-026-00312-6","url":null,"abstract":"","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"36 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors of c-TESE success in eastern algerian patients with non-obstructive azoospermia: role of histology, hormones, and testicular volume.","authors":"Besma Hibat Allah Nourine, Leyla Ounis, Malak Hamoul, Fatima Zohra Haddad, Abdelali Zoghmar","doi":"10.1186/s12610-026-00311-7","DOIUrl":"10.1186/s12610-026-00311-7","url":null,"abstract":"","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"36 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13081357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147687922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testicular shear wave elastography in varicocele: measurement strategy and clinical application.","authors":"Lisu Zhang, Yi Li, Lingyan Zhang, Yinying Liang, Yumin Zhuo, Jun Huang","doi":"10.1186/s12610-026-00310-8","DOIUrl":"10.1186/s12610-026-00310-8","url":null,"abstract":"","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"36 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Divergent long-term trends in semen quality and reproductive hormones across the COVID-19 pandemic era in infertile men: an age-stratified retrospective study.","authors":"Peilian Li, Shuang Liu, Ke Chen, Yang Gao","doi":"10.1186/s12610-026-00309-1","DOIUrl":"10.1186/s12610-026-00309-1","url":null,"abstract":"","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"36 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13020235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147519712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of sperm DNA fragmentation index with semen quality and ART outcomes: real-world evidence from a retrospective cohort.","authors":"Chaofeng Wei, Qihui Liang, Danqi Liu, Yi Yu, Yihe Wei, Yuan Li, Haicui Wu, Fang Lian","doi":"10.1186/s12610-026-00308-2","DOIUrl":"10.1186/s12610-026-00308-2","url":null,"abstract":"","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"36 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13003730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Chronic scrotal content pain and viral orchiepididymitis: an overlooked hypothesis linking infection and Wallerian degeneration.","authors":"Thiago A Teixeira, Eduardo Zinoni Pato, Maria Christina W Avellar, Raul Sanchez, Igor V Coimbra, Joël R Drevet, Jorge Hallak","doi":"10.1186/s12610-026-00307-3","DOIUrl":"10.1186/s12610-026-00307-3","url":null,"abstract":"","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"36 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12994245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zika virus and male reproductive health: essential updates for andrologists and fertility specialists.","authors":"Ayaz Khan, Michael George, Ian Pearce, Vaibhav Modgil, Theodora Stasinou","doi":"10.1186/s12610-026-00305-5","DOIUrl":"10.1186/s12610-026-00305-5","url":null,"abstract":"<p><strong>Background: </strong>Zika virus (ZIKV), a mosquito-borne flavivirus, remains a concern for reproductive health despite the waning of the 2015-2016 epidemic. Unique among arboviruses, ZIKV can be sexually transmitted, with viral RNA persisting in semen beyond the acute phase, posing potential risks to male fertility and assisted reproduction. This narrative review provides clinicians with a contemporary understanding of ZIKV epidemiology, virology, and its implications for male reproductive care.</p><p><strong>Results: </strong>ZIKV transmission has stabilised into low-level endemicity in Central and South America, with Europe reporting sporadic travel-associated cases. Persistence in semen is underpinned by infection of immune-privileged testicular tissues, including Sertoli, Leydig, and germ cells, enabling RNA detection for months post-infection even after systemic symptoms resolve. While replication-competent virus is rarely isolated beyond 4-6 weeks, viral RNA has been detected in semen over 180 days in rare cases. Clinically, ZIKV infection is associated with transient declines in sperm count, motility, and increased DNA fragmentation, likely mediated by inflammation, blood-testis barrier disruption, and impaired testosterone biosynthesis. Human studies suggest recovery of semen quality in most cases, but animal models demonstrate more persistent testicular damage and subfertility, supporting potential long-term reproductive impact. Current WHO guidance recommends a 3-month deferral from conception for men with confirmed or suspected ZIKV exposure. In assisted reproduction, cryopreserved semen from recently exposed individuals may retain viral RNA, requiring stringent handling and closed-system storage. Routine semen PCR testing is not widely adopted due to sensitivity limitations and inability to distinguish infectivity; thus, risk stratification based on travel and exposure history remains central to decision-making. In clinical practice, this risk stratification typically applies to men undergoing fertility assessment with recent travel to ZIKV-endemic regions, particularly in Central or South America, with compatible symptom history or recent onset infertility.</p><p><strong>Conclusions: </strong>ZIKV remains a relevant consideration in andrology and fertility practice, particularly in regions with ongoing endemic transmission and in individuals with travel-related exposure. Awareness of its virological properties, reproductive implications, and guidance for pre-conception counselling, laboratory practice, and semen storage is crucial. With appropriate precautions and patient education, most couples can safely proceed with fertility planning following ZIKV exposure.</p>","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"36 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic scrotal content pain and viral orchiepididymitis: an overlooked hypothesis linking infection and Wallerian degeneration.","authors":"Thiago A Teixeira, Eduardo Zinoni Pato, Maria Christina W Avellar, Raul Sanchez, Igor V Coimbra, Joël R Drevet, Jorge Hallak","doi":"10.1186/s12610-026-00301-9","DOIUrl":"10.1186/s12610-026-00301-9","url":null,"abstract":"<p><strong>Background: </strong>Chronic scrotal content pain (CSCP) is a challenging clinical condition, often undiagnosed, and marked by persistent or intermittent pain that may be localized or generalized and significantly affect quality of life. Wallerian degeneration, an inflammatory process involving axonal degeneration, may underlie the mechanism. While bacterial infections are recognized contributors to CSCP, the role of viral infections is less understood.</p><p><strong>Methods: </strong>We systematically searched PubMed, MEDLINE, and Web of Science for studies reporting associations between viral infections and scrotal or testicular pain. Of 142 identified records, 61 met the inclusion criteria and were analyzed qualitatively.</p><p><strong>Results: </strong>Our review assesses whether testicular or epididymal viral infections might contribute to CSCP. The literature points to a possible link, though definitive histopathological evidence remains scarce. Tissue biopsies may provide greater diagnostic clarity and inform treatment decisions.</p><p><strong>Conclusions: </strong>Additional research is needed to understand how viral infections affect testicular function, semen quality, and fertility, to improve patient outcomes globally.</p>","PeriodicalId":8730,"journal":{"name":"Basic and Clinical Andrology","volume":"36 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}